GREMLIN Database
YFLA - Uncharacterized transporter YflA
UniProt: O34708 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 471 (436)
Sequences: 3787 (2362)
Seq/√Len: 113.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_V318_A4.7551.00
121_H439_L4.1031.00
224_G316_T3.5511.00
139_I428_A3.5101.00
114_S436_V3.3101.00
232_L235_V3.2841.00
315_T319_F3.0711.00
124_E141_K3.0361.00
143_L431_L2.9931.00
113_F440_Y2.9301.00
240_S244_S2.9061.00
40_F106_L2.8401.00
226_L230_M2.8041.00
239_F243_F2.7691.00
234_S237_A2.6941.00
209_T366_S2.6421.00
34_L437_K2.5961.00
9_E13_D2.5511.00
27_T430_L2.5411.00
208_V212_V2.4901.00
375_G391_I2.4191.00
140_T146_K2.4171.00
241_L245_N2.4031.00
151_F155_A2.3961.00
156_L378_Q2.3521.00
191_A396_L2.3221.00
218_G222_G2.2701.00
10_H14_W2.2381.00
5_L412_G2.2121.00
122_Y435_K2.2031.00
178_T357_S2.1701.00
237_A240_S2.1081.00
27_T426_V2.1031.00
139_I149_G2.0711.00
29_L107_F2.0641.00
204_R207_K2.0581.00
195_G396_L2.0281.00
140_T381_F2.0251.00
238_F322_L1.9831.00
82_N309_D1.9811.00
12_S416_L1.9761.00
248_T251_S1.9721.00
34_L434_R1.9491.00
294_H442_E1.9351.00
8_I416_L1.9161.00
150_V382_L1.8731.00
30_Y433_S1.8611.00
98_V242_V1.8541.00
389_H392_K1.8431.00
229_L232_L1.8381.00
408_K412_G1.8271.00
193_L361_V1.8161.00
45_Y48_K1.8131.00
188_I192_F1.7961.00
8_I412_G1.7821.00
294_H446_S1.7801.00
191_A400_I1.7721.00
423_V427_I1.7661.00
44_L48_K1.7651.00
184_I400_I1.7351.00
334_N342_A1.7281.00
307_V311_L1.7261.00
126_N130_E1.7001.00
212_V362_F1.6911.00
267_W270_A1.6751.00
155_A420_F1.6711.00
376_V392_K1.6701.00
90_I98_V1.6591.00
293_D297_R1.6521.00
296_V439_L1.6431.00
84_V336_P1.6391.00
32_T39_Q1.6301.00
238_F319_F1.6231.00
68_Q206_G1.6051.00
45_Y443_F1.5931.00
240_S243_F1.5821.00
92_F267_W1.5761.00
256_F259_A1.5731.00
345_Q353_G1.5601.00
16_W419_V1.5441.00
36_K441_T1.5361.00
379_A383_F1.5351.00
41_R444_F1.5311.00
140_T150_V1.5021.00
195_G199_I1.4911.00
222_G226_L1.4851.00
146_K149_G1.4811.00
228_V235_V1.4731.00
434_R438_A1.4651.00
24_L273_L1.4611.00
253_V256_F1.4551.00
230_M233_S1.4501.00
439_L442_E1.4501.00
119_A288_A1.4491.00
230_M347_Y1.4481.00
152_F421_I1.4471.00
235_V238_F1.4471.00
71_T209_T1.4401.00
254_G258_G1.4391.00
442_E446_S1.4371.00
6_V9_E1.4351.00
185_Y189_G1.4261.00
182_N185_Y1.4251.00
198_V372_I1.4191.00
109_M307_V1.4161.00
78_I313_I1.4121.00
32_T37_G1.4121.00
228_V323_A1.4031.00
445_T449_Y1.4021.00
287_H302_S1.4011.00
187_G403_A1.3971.00
45_Y49_Q1.3971.00
389_H393_F1.3941.00
228_V319_F1.3881.00
172_S186_A1.3841.00
171_V190_I1.3791.00
7_W11_I1.3791.00
23_L430_L1.3771.00
393_F397_A1.3761.00
34_L433_S1.3731.00
102_W315_T1.3721.00
224_G320_I1.3671.00
121_H435_K1.3631.00
68_Q210_E1.3611.00
35_L38_F1.3561.00
241_L322_L1.3491.00
150_V154_V1.3451.00
11_I416_L1.3311.00
80_A360_L1.3311.00
18_P22_I1.3291.00
66_P292_T1.3291.00
245_N249_S1.3211.00
238_F323_A1.3141.00
139_I148_L1.3121.00
30_Y34_L1.3030.99
437_K441_T1.3010.99
5_L9_E1.2990.99
166_V414_L1.2880.99
228_V232_L1.2850.99
236_P240_S1.2740.99
36_K444_F1.2730.99
413_V417_A1.2650.99
182_N186_A1.2580.99
229_L233_S1.2520.99
207_K210_E1.2460.99
181_F186_A1.2440.99
233_S236_P1.2360.99
280_M422_V1.2350.99
289_A373_F1.2320.99
168_G403_A1.2290.99
8_I409_A1.2230.99
67_L71_T1.2170.99
193_L365_V1.2050.99
329_G333_S1.2040.99
43_P47_F1.1940.99
400_I404_A1.1910.99
184_I188_I1.1900.99
368_I399_I1.1840.99
435_K438_A1.1810.99
152_F284_P1.1780.99
39_Q110_A1.1710.99
106_L311_L1.1680.99
112_K116_S1.1670.99
125_K131_Y1.1660.99
70_L308_I1.1660.99
147_W151_F1.1660.99
65_T68_Q1.1620.99
37_G40_F1.1610.99
324_S347_Y1.1610.99
42_Y444_F1.1580.99
142_G432_L1.1530.99
226_L348_F1.1460.99
321_V340_T1.1440.99
208_V369_M1.1420.99
163_S371_V1.1380.99
286_A374_Y1.1330.99
207_K211_F1.1310.99
30_Y437_K1.1310.99
225_L229_L1.1290.99
11_I14_W1.1290.99
83_I337_A1.1280.99
10_H13_D1.1270.99
324_S343_A1.1270.99
157_I379_A1.1240.99
116_S302_S1.1200.98
383_F387_A1.1200.98
221_A225_L1.1170.98
23_L423_V1.1160.98
31_F114_S1.1160.98
241_L244_S1.1140.98
317_T340_T1.1110.98
244_S250_S1.1080.98
187_G400_I1.1050.98
22_I26_G1.0990.98
342_A346_H1.0980.98
245_N248_T1.0910.98
126_N132_V1.0890.98
235_V239_F1.0840.98
326_V342_A1.0790.98
138_Y428_A1.0760.98
6_V10_H1.0750.98
43_P307_V1.0720.98
231_N323_A1.0700.98
379_A387_A1.0650.98
342_A345_Q1.0630.98
104_I269_F1.0610.98
144_R147_W1.0600.98
42_Y300_F1.0580.98
72_S202_V1.0560.98
117_V299_G1.0560.98
173_V338_A1.0460.98
84_V170_S1.0420.98
221_A316_T1.0380.97
231_N234_S1.0370.97
117_V296_V1.0320.97
185_Y188_I1.0300.97
113_F296_V1.0280.97
255_G259_A1.0240.97
321_V339_L1.0210.97
354_Y358_V1.0190.97
194_I365_V1.0180.97
227_I347_Y1.0160.97
91_M339_L1.0150.97
76_S370_V1.0130.97
232_L236_P1.0130.97
143_L147_W1.0100.97
113_F117_V1.0090.97
422_V426_V1.0050.97
7_W10_H1.0000.97
25_T104_I0.9930.97
401_I405_G0.9910.97
338_A342_A0.9900.97
200_G204_R0.9890.97
304_I308_I0.9820.96
170_S360_L0.9790.96
50_T301_W0.9780.96
212_V366_S0.9760.96
237_A241_L0.9750.96
355_F359_S0.9750.96
68_Q207_K0.9740.96
259_A262_A0.9700.96
66_P301_W0.9680.96
146_K150_V0.9670.96
192_F196_L0.9670.96
42_Y45_Y0.9640.96
87_P340_T0.9640.96
440_Y444_F0.9610.96
109_M311_L0.9570.96
386_L390_V0.9570.96
318_A322_L0.9560.96
277_E282_T0.9550.96
441_T445_T0.9480.96
215_L219_A0.9450.96
176_A183_K0.9430.96
251_S254_G0.9410.96
227_I344_F0.9390.95
348_F351_G0.9380.95
46_I303_V0.9340.95
132_V377_K0.9330.95
135_P284_P0.9310.95
46_I304_I0.9280.95
87_P321_V0.9280.95
275_S309_D0.9270.95
253_V257_A0.9260.95
90_I322_L0.9250.95
20_L419_V0.9200.95
102_W239_F0.9170.95
25_T273_L0.9170.95
234_S323_A0.9170.95
397_A401_I0.9100.95
47_F304_I0.9030.94
228_V238_F0.9010.94
124_E140_T0.9000.94
252_A255_G0.8990.94
156_L421_I0.8980.94
63_T291_M0.8960.94
177_E338_A0.8960.94
163_S280_M0.8940.94
86_V314_C0.8940.94
35_L437_K0.8930.94
45_Y447_E0.8900.94
90_I318_A0.8900.94
4_L7_W0.8880.94
148_L428_A0.8870.94
95_P241_L0.8850.94
158_V417_A0.8840.94
278_A306_I0.8820.94
203_K207_K0.8800.94
293_D443_F0.8760.93
139_I147_W0.8750.93
435_K439_L0.8750.93
173_V176_A0.8740.93
163_S418_L0.8730.93
116_S305_G0.8720.93
323_A347_Y0.8700.93
388_G392_K0.8700.93
131_Y291_M0.8690.93
313_I316_T0.8670.93
250_S256_F0.8660.93
352_G356_V0.8610.93
430_L433_S0.8600.93
194_I368_I0.8600.93
84_V87_P0.8560.93
21_I25_T0.8560.93
23_L27_T0.8540.93
109_M303_V0.8540.93
169_N411_W0.8530.93
394_V397_A0.8490.92
90_I327_W0.8490.92
174_S341_T0.8470.92
77_T112_K0.8470.92
252_A256_F0.8450.92
92_F257_A0.8440.92
88_A267_W0.8400.92
179_F354_Y0.8400.92
165_M405_G0.8370.92
83_I356_V0.8330.92
226_L229_L0.8330.92
256_F260_A0.8320.92
90_I321_V0.8310.92
316_T320_I0.8290.91
386_L389_H0.8280.91
219_A359_S0.8280.91
433_S437_K0.8280.91
114_S117_V0.8260.91
120_V123_R0.8260.91
307_V312_I0.8250.91
74_L78_I0.8240.91
412_G416_L0.8220.91
223_A359_S0.8190.91
9_E412_G0.8160.91
34_L37_G0.8150.91
99_F247_F0.8150.91
335_D338_A0.8120.91
325_G328_T0.8080.90
175_L361_V0.8050.90
4_L8_I0.8050.90
213_V216_M0.8050.90
227_I320_I0.8040.90
233_S237_A0.8030.90
135_P138_Y0.8020.90
431_L434_R0.7990.90
82_N275_S0.7990.90
32_T40_F0.7990.90
99_F103_L0.7960.90
31_F429_L0.7950.90
311_L315_T0.7940.90
284_P288_A0.7930.90
197_V208_V0.7920.89
241_L327_W0.7900.89
205_I373_F0.7890.89
49_Q301_W0.7850.89
124_E132_V0.7840.89
377_K380_E0.7840.89
133_G288_A0.7830.89
28_G108_A0.7820.89
302_S305_G0.7810.89
176_A186_A0.7800.89
64_V206_G0.7800.89
297_R443_F0.7790.89
239_F319_F0.7790.89
194_I399_I0.7770.89
436_V440_Y0.7750.88
78_I217_A0.7700.88
114_S437_K0.7700.88
292_T297_R0.7690.88
245_N250_S0.7680.88
345_Q349_G0.7680.88
164_I414_L0.7640.88
387_A390_V0.7610.88
257_A260_A0.7580.87
38_F440_Y0.7580.87
77_T302_S0.7550.87
15_L423_V0.7540.87
354_Y357_S0.7530.87
70_L301_W0.7510.87
168_G368_I0.7510.87
187_G404_A0.7500.87
170_S337_A0.7480.87
46_I300_F0.7470.87
255_G262_A0.7450.86
202_V205_I0.7450.86
155_A424_P0.7440.86
26_G430_L0.7440.86
173_V177_E0.7440.86
175_L186_A0.7420.86
35_L440_Y0.7410.86
112_K283_A0.7400.86
161_I394_V0.7390.86
5_L409_A0.7390.86
211_F215_L0.7370.86
88_A91_M0.7350.86
239_F315_T0.7320.85
249_S252_A0.7300.85
324_S327_W0.7270.85
371_V418_L0.7270.85
148_L151_F0.7240.85
15_L19_P0.7240.85
301_W305_G0.7220.85
19_P22_I0.7220.85
202_V373_F0.7210.85
14_W18_P0.7180.84
184_I404_A0.7170.84
38_F42_Y0.7170.84
88_A261_L0.7160.84
434_R441_T0.7140.84
257_A261_L0.7140.84
18_P21_I0.7120.84
49_Q443_F0.7110.84
91_M335_D0.7110.84
20_L422_V0.7110.84
230_M234_S0.7110.84
223_A348_F0.7100.84
287_H305_G0.7090.84
166_V411_W0.7080.83
147_W150_V0.7070.83
235_V319_F0.7060.83
213_V217_A0.7060.83
75_S306_I0.7050.83
126_N377_K0.7040.83
242_V318_A0.7030.83
28_G107_F0.7030.83
253_V259_A0.7020.83
345_Q350_S0.7000.83
223_A355_F0.7000.83
50_T304_I0.6990.83
76_S371_V0.6990.83
163_S414_L0.6970.83
199_I389_H0.6950.82
441_T444_F0.6940.82
398_A401_I0.6890.82
21_I273_L0.6880.82
116_S287_H0.6870.82
174_S337_A0.6860.82
108_A111_I0.6850.81
4_L409_A0.6850.81
71_T210_E0.6830.81
127_E385_R0.6830.81
351_G354_Y0.6790.81
80_A170_S0.6790.81
275_S310_T0.6790.81
78_I308_I0.6790.81
165_M168_G0.6770.81
72_S370_V0.6760.81
36_K44_L0.6760.81
217_A313_I0.6710.80
57_K60_G0.6690.80
216_M275_S0.6630.79
150_V153_S0.6620.79
282_T371_V0.6620.79
40_F44_L0.6610.79
434_R437_K0.6600.79
294_H443_F0.6600.79
179_F186_A0.6580.79
405_G410_I0.6550.78
83_I363_F0.6540.78
337_A360_L0.6530.78
7_W14_W0.6500.78
163_S422_V0.6500.78
191_A195_G0.6490.78
244_S248_T0.6470.78
80_A364_V0.6470.78
37_G106_L0.6450.77
341_T345_Q0.6450.77
5_L408_K0.6440.77
249_S253_V0.6430.77
252_A260_A0.6430.77
114_S440_Y0.6430.77
31_F433_S0.6430.77
225_L228_V0.6420.77
243_F322_L0.6420.77
221_A224_G0.6420.77
164_I395_Y0.6420.77
256_F261_L0.6400.77
117_V436_V0.6400.77
4_L9_E0.6380.77
136_M378_Q0.6370.77
98_V102_W0.6360.76
180_S183_K0.6350.76
244_S249_S0.6330.76
231_N347_Y0.6330.76
35_L114_S0.6330.76
252_A259_A0.6320.76
76_S280_M0.6310.76
164_I371_V0.6300.76
320_I344_F0.6280.76
280_M418_L0.6260.75
38_F110_A0.6240.75
70_L305_G0.6230.75
219_A358_V0.6230.75
275_S311_L0.6210.75
350_S353_G0.6190.74
431_L435_K0.6180.74
63_T131_Y0.6170.74
171_V364_V0.6170.74
61_E125_K0.6160.74
319_F323_A0.6150.74
391_I395_Y0.6140.74
234_S238_F0.6140.74
49_Q297_R0.6140.74
187_G191_A0.6130.74
390_V393_F0.6110.74
88_A407_A0.6100.73
103_L243_F0.6100.73
357_S361_V0.6070.73
356_V359_S0.6050.73
8_I12_S0.6050.73
119_A284_P0.6050.73
249_S259_A0.6050.73
113_F436_V0.6040.73
50_T308_I0.6040.73
220_Y224_G0.5990.72
434_R439_L0.5980.72
150_V381_F0.5970.72
193_L196_L0.5950.72
324_S328_T0.5940.71
132_V380_E0.5930.71
77_T287_H0.5920.71
154_V157_I0.5900.71
36_K434_R0.5880.71
171_V361_V0.5880.71
194_I198_V0.5880.71
445_T448_Q0.5870.71
296_V436_V0.5870.71
401_I404_A0.5850.70
160_L282_T0.5840.70
15_L416_L0.5810.70
308_I312_I0.5810.70
236_P239_F0.5790.70
397_A400_I0.5780.69
219_A223_A0.5760.69
102_W243_F0.5750.69
130_E203_K0.5750.69
142_G145_M0.5750.69
64_V289_A0.5740.69
136_M285_I0.5740.69
117_V439_L0.5730.69
287_H298_Q0.5720.69
84_V360_L0.5720.69
138_Y425_N0.5710.68
159_E418_L0.5690.68
186_A190_I0.5690.68
121_H438_A0.5690.68
139_I145_M0.5680.68
232_L237_A0.5680.68
427_I431_L0.5670.68
15_L422_V0.5660.68
101_M310_T0.5660.68
188_I400_I0.5660.68
151_F154_V0.5650.68
165_M410_I0.5630.67
135_P285_I0.5630.67
324_S329_G0.5630.67
367_T371_V0.5620.67
20_L423_V0.5620.67
197_V365_V0.5570.67
31_F436_V0.5570.67
172_S403_A0.5570.67
105_A310_T0.5570.67
76_S367_T0.5560.66
227_I324_S0.5550.66
99_F243_F0.5550.66
62_G292_T0.5540.66
88_A411_W0.5530.66
27_T31_F0.5530.66
368_I395_Y0.5530.66
80_A171_V0.5520.66
66_P290_A0.5520.66
104_I273_L0.5510.66
446_S449_Y0.5510.66
117_V440_Y0.5490.65
153_S382_L0.5480.65
112_K123_R0.5460.65
176_A180_S0.5460.65
326_V339_L0.5460.65
105_A108_A0.5450.65
164_I391_I0.5450.65
84_V335_D0.5450.65
256_F327_W0.5440.65
242_V322_L0.5440.65
249_S260_A0.5430.65
43_P109_M0.5430.65
283_A374_Y0.5420.64
443_F447_E0.5410.64
204_R292_T0.5410.64
42_Y448_Q0.5410.64
114_S429_L0.5400.64
202_V206_G0.5400.64
250_S253_V0.5400.64
20_L416_L0.5380.64
148_L431_L0.5370.64
274_Y414_L0.5370.64
442_E445_T0.5350.63
360_L367_T0.5350.63
373_F391_I0.5330.63
64_V72_S0.5330.63
326_V346_H0.5330.63
111_I283_A0.5330.63
380_E385_R0.5310.63
379_A390_V0.5310.63
173_V183_K0.5310.63
77_T116_S0.5300.63
88_A336_P0.5300.63
327_W343_A0.5300.63
76_S159_E0.5290.63
198_V392_K0.5290.63
288_A392_K0.5270.62
175_L179_F0.5270.62
183_K186_A0.5260.62
245_N260_A0.5250.62
143_L428_A0.5250.62
248_T252_A0.5250.62
340_T343_A0.5240.62
283_A343_A0.5240.62
62_G291_M0.5220.62
234_S241_L0.5220.62
104_I352_G0.5220.62
360_L364_V0.5220.62
48_K51_I0.5210.61
98_V315_T0.5200.61
119_A283_A0.5190.61
46_I50_T0.5190.61
161_I395_Y0.5180.61
114_S433_S0.5180.61
227_I346_H0.5170.61
248_T256_F0.5170.61
83_I340_T0.5150.61
160_L164_I0.5150.61
70_L74_L0.5140.60
86_V275_S0.5140.60
95_P327_W0.5140.60
298_Q306_I0.5130.60
38_F300_F0.5130.60
73_A77_T0.5130.60
111_I276_N0.5120.60
221_A312_I0.5110.60
170_S336_P0.5110.60
82_N97_A0.5100.60
117_V278_A0.5100.60
186_A189_G0.5090.60
23_L427_I0.5070.59
444_F448_Q0.5070.59
159_E422_V0.5060.59
77_T283_A0.5050.59
91_M338_A0.5040.59
420_F424_P0.5040.59
159_E164_I0.5040.59
38_F113_F0.5040.59
126_N385_R0.5020.59
38_F43_P0.5010.58
178_T353_G0.5010.58
46_I301_W0.5000.58
49_Q300_F0.5000.58
41_R44_L0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7792 99.9 0.858 Contact Map
3giaA 1 0.7813 99.9 0.866 Contact Map
4djkA 2 0.7707 99.6 0.894 Contact Map
2xq2A 2 0.8471 98.2 0.942 Contact Map
4wgvA 2 0.7389 98.2 0.943 Contact Map
3dh4A 3 0.8004 98.1 0.943 Contact Map
4us3A 1 0.7983 97 0.955 Contact Map
2jlnA 1 0.7941 96.7 0.956 Contact Map
2a65A 2 0.8025 96.2 0.958 Contact Map
4xp4A 1 0.8217 95.5 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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