GREMLIN Database
YTPB - Tetraprenyl-beta-curcumene synthase
UniProt: O34707 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (346)
Sequences: 206 (179)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_N129_Q10.6591.00
38_N128_E7.8471.00
241_I290_L4.7881.00
285_K288_E4.6121.00
73_C218_A4.0380.99
172_H183_R4.0270.99
101_D126_R3.8060.98
93_R262_D3.7120.98
53_T57_E3.4600.96
84_S109_M3.3550.96
319_Q322_M3.1960.94
115_V143_Q3.1010.93
80_Y213_I3.0750.93
117_A143_Q3.0390.92
104_M124_Q2.6600.86
236_S293_I2.6220.85
168_D171_V2.5280.83
11_M339_F2.4660.81
15_Y343_N2.3760.79
84_S262_D2.3590.78
11_M266_C2.3460.78
32_K137_E2.3140.77
23_H57_E2.2310.74
23_H53_T2.2030.73
155_I213_I2.0670.68
172_H175_V2.0660.68
184_L200_W2.0360.67
149_I220_S2.0270.67
48_S82_T1.9850.65
95_T128_E1.9540.64
266_C339_F1.9400.63
104_M125_F1.8580.60
312_S348_R1.8450.59
214_F244_L1.8420.59
161_E234_R1.8410.59
14_V95_T1.8300.58
90_L102_F1.7940.57
240_Y266_C1.7570.55
93_R260_E1.7560.55
111_D120_Q1.7530.55
113_L279_L1.7270.54
153_D157_P1.6990.52
84_S93_R1.6770.52
65_L218_A1.6700.51
208_G263_L1.6520.50
38_N130_D1.6470.50
214_F262_D1.6380.50
175_V183_R1.6280.49
43_A51_D1.6230.49
96_S126_R1.6080.48
143_Q171_V1.5750.47
48_S214_F1.5560.46
241_I303_N1.5550.46
130_D271_S1.5430.45
130_D213_I1.5200.44
334_G347_Y1.5140.44
103_R171_V1.5130.44
80_Y163_C1.5090.44
219_Y242_Q1.4800.43
48_S93_R1.4780.43
113_L159_L1.4770.43
172_H347_Y1.4670.42
100_Q125_F1.4360.41
231_K235_D1.4340.41
13_K17_D1.4310.41
240_Y289_H1.4280.40
275_M317_A1.4230.40
154_M227_E1.4180.40
107_A124_Q1.4050.39
201_Y242_Q1.3970.39
63_A150_E1.3810.38
37_H132_S1.3810.38
60_G185_E1.3770.38
119_L136_H1.3730.38
16_R118_E1.3710.38
308_G347_Y1.3570.37
76_F215_C1.3530.37
215_C219_Y1.3520.37
241_I312_S1.3450.37
82_T306_L1.3390.37
115_V349_K1.3380.37
172_H308_G1.3260.36
84_S214_F1.3230.36
214_F306_L1.3220.36
169_L263_L1.3120.36
169_L208_G1.3110.35
92_D265_F1.3090.35
73_C221_F1.3020.35
254_Q266_C1.2990.35
48_S262_D1.2910.35
287_D303_N1.2880.35
300_R307_L1.2730.34
250_Y265_F1.2610.33
84_S306_L1.2600.33
262_D306_L1.2520.33
93_R214_F1.2470.33
59_G250_Y1.2320.32
69_Q72_K1.2290.32
38_N127_E1.2250.32
57_E165_Y1.2230.32
285_K321_E1.2200.32
30_K53_T1.2180.32
41_L105_L1.2140.32
76_F217_V1.2080.31
109_M262_D1.2050.31
116_G143_Q1.1850.30
31_Q284_H1.1820.30
96_S101_D1.1780.30
275_M294_P1.1650.30
8_F312_S1.1610.30
94_S301_L1.1610.30
213_I306_L1.1570.29
104_M107_A1.1550.29
76_F80_Y1.1550.29
172_H179_E1.1540.29
155_I159_L1.1420.29
195_L198_M1.1400.29
154_M157_P1.1400.29
99_P178_H1.1390.29
33_S37_H1.1370.29
344_G348_R1.1340.29
246_I265_F1.1320.28
48_S244_L1.1230.28
207_A325_L1.1210.28
316_V326_A1.1200.28
24_Q228_S1.1180.28
79_A82_T1.1140.28
198_M206_C1.1040.27
46_T177_E1.1030.27
59_G265_F1.0920.27
275_M301_L1.0890.27
44_Q246_I1.0800.27
18_I63_A1.0760.26
179_E219_Y1.0750.26
263_L298_F1.0730.26
246_I250_Y1.0610.26
19_F338_L1.0610.26
97_L177_E1.0590.26
287_D304_R1.0570.26
71_Q218_A1.0560.26
11_M15_Y1.0310.25
53_T61_I1.0310.25
96_S339_F1.0290.25
227_E292_G1.0270.25
201_Y334_G1.0260.25
167_C191_Y1.0240.25
56_C263_L1.0230.25
90_L123_Y1.0210.25
99_P126_R1.0200.25
179_E183_R1.0200.25
169_L205_A1.0200.25
244_L262_D1.0150.24
11_M343_N1.0130.24
301_L333_S1.0120.24
95_T260_E1.0120.24
49_I109_M1.0080.24
96_S340_F1.0020.24
29_W79_A1.0010.24
118_E231_K0.9990.24
232_K321_E0.9990.24
6_H125_F0.9950.24
114_T117_A0.9930.24
44_Q59_G0.9910.24
284_H338_L0.9850.23
208_G214_F0.9850.23
292_G296_E0.9820.23
334_G337_S0.9810.23
161_E194_E0.9800.23
12_A341_Y0.9780.23
91_C262_D0.9750.23
312_S345_R0.9750.23
76_F219_Y0.9700.23
132_S191_Y0.9690.23
55_H92_D0.9680.23
92_D250_Y0.9670.23
34_E227_E0.9670.23
165_Y198_M0.9660.23
5_E18_I0.9660.23
26_L163_C0.9660.23
76_F242_Q0.9620.23
152_Y156_K0.9610.23
27_D228_S0.9600.23
31_Q34_E0.9570.23
75_E144_R0.9570.23
241_I258_L0.9530.22
54_F173_K0.9500.22
129_Q165_Y0.9440.22
15_Y301_L0.9430.22
72_K148_S0.9380.22
93_R261_G0.9360.22
101_D340_F0.9360.22
270_Q274_E0.9340.22
89_N102_F0.9300.22
167_C308_G0.9300.22
74_V309_V0.9270.22
76_F213_I0.9240.21
271_S318_G0.9240.21
301_L312_S0.9220.21
93_R306_L0.9180.21
76_F188_F0.9160.21
236_S329_L0.9130.21
82_T214_F0.9100.21
309_V344_G0.9100.21
130_D235_D0.9080.21
207_A267_S0.9070.21
201_Y303_N0.8980.21
88_D253_D0.8930.21
307_L338_L0.8910.21
282_F334_G0.8880.20
84_S244_L0.8870.20
175_V347_Y0.8850.20
11_M61_I0.8850.20
173_K265_F0.8820.20
8_F12_A0.8800.20
28_I115_V0.8760.20
12_A280_E0.8750.20
60_G320_K0.8750.20
117_A154_M0.8740.20
255_E258_L0.8700.20
182_P186_K0.8700.20
159_L217_V0.8660.20
297_N301_L0.8660.20
158_Y230_A0.8610.20
286_A294_P0.8570.20
166_Y245_H0.8550.19
62_L109_M0.8500.19
28_I137_E0.8470.19
54_F265_F0.8450.19
104_M198_M0.8440.19
94_S343_N0.8430.19
210_T250_Y0.8400.19
54_F210_T0.8390.19
210_T265_F0.8350.19
247_L290_L0.8350.19
39_S147_G0.8330.19
173_K250_Y0.8300.19
60_G207_A0.8290.19
218_A221_F0.8280.19
216_L248_L0.8230.19
15_Y266_C0.8210.19
95_T262_D0.8210.19
268_Y298_F0.8120.18
7_P117_A0.8110.18
59_G92_D0.8110.18
95_T108_S0.8080.18
64_L145_V0.8070.18
84_S89_N0.8070.18
110_Q163_C0.8070.18
56_C298_F0.8030.18
173_K210_T0.8000.18
73_C150_E0.7990.18
208_G262_D0.7990.18
59_G246_I0.7990.18
19_F345_R0.7980.18
274_E342_I0.7960.18
151_H308_G0.7960.18
31_Q157_P0.7940.18
75_E293_I0.7940.18
32_K35_S0.7930.18
97_L108_S0.7870.18
103_R168_D0.7870.18
175_V201_Y0.7870.18
92_D246_I0.7860.18
148_S290_L0.7840.18
22_V266_C0.7800.17
84_S208_G0.7800.17
55_H250_Y0.7790.17
22_V60_G0.7780.17
179_E242_Q0.7750.17
19_F322_M0.7720.17
126_R340_F0.7710.17
43_A60_G0.7650.17
96_S266_C0.7640.17
251_L319_Q0.7620.17
94_S101_D0.7610.17
285_K289_H0.7610.17
159_L213_I0.7600.17
55_H265_F0.7590.17
54_F250_Y0.7580.17
5_E318_G0.7580.17
125_F255_E0.7570.17
17_D64_L0.7560.17
118_E223_P0.7550.17
140_K194_E0.7530.17
136_H140_K0.7530.17
293_I336_T0.7500.17
26_L82_T0.7490.17
31_Q323_G0.7480.17
24_Q297_N0.7460.17
104_M275_M0.7450.17
27_D223_P0.7440.17
290_L312_S0.7440.17
136_H230_A0.7420.16
217_V242_Q0.7410.16
75_E207_A0.7350.16
152_Y214_F0.7320.16
229_T308_G0.7320.16
326_A331_K0.7310.16
145_V217_V0.7310.16
308_G350_F0.7310.16
104_M236_S0.7290.16
9_G178_H0.7290.16
92_D166_Y0.7260.16
29_W113_L0.7260.16
59_G173_K0.7250.16
139_V246_I0.7250.16
21_L70_K0.7240.16
74_V215_C0.7240.16
240_Y295_H0.7170.16
279_L348_R0.7150.16
11_M240_Y0.7150.16
118_E228_S0.7120.16
192_E286_A0.7090.16
173_K245_H0.7090.16
36_I42_K0.7000.15
16_R28_I0.7000.15
83_I91_C0.7000.15
11_M254_Q0.6970.15
198_M294_P0.6970.15
24_Q270_Q0.6950.15
80_Y330_I0.6940.15
54_F59_G0.6930.15
131_D278_R0.6930.15
59_G315_K0.6920.15
108_S267_S0.6920.15
64_L76_F0.6910.15
309_V330_I0.6900.15
16_R143_Q0.6860.15
76_F201_Y0.6850.15
276_M325_L0.6830.15
22_V105_L0.6810.15
282_F341_Y0.6780.15
26_L306_L0.6770.15
81_Q210_T0.6750.15
156_K160_L0.6750.15
114_T143_Q0.6740.15
164_G284_H0.6740.15
100_Q130_D0.6740.15
77_I169_L0.6710.15
118_E193_S0.6710.15
20_P135_L0.6710.15
74_V115_V0.6700.15
31_Q39_S0.6680.15
213_I283_I0.6680.15
196_P234_R0.6670.15
65_L201_Y0.6600.15
5_E317_A0.6600.15
92_D106_H0.6590.15
14_V340_F0.6570.14
210_T246_I0.6570.14
139_V171_V0.6560.14
186_K274_E0.6560.14
55_H246_I0.6520.14
173_K246_I0.6510.14
31_Q231_K0.6500.14
15_Y101_D0.6500.14
95_T340_F0.6500.14
160_L163_C0.6490.14
230_A290_L0.6490.14
252_I315_K0.6490.14
32_K328_K0.6490.14
95_T109_M0.6480.14
225_F230_A0.6470.14
8_F28_I0.6460.14
91_C102_F0.6460.14
301_L343_N0.6450.14
62_L312_S0.6440.14
146_L206_C0.6410.14
251_L324_R0.6400.14
175_V340_F0.6380.14
86_Y170_Q0.6340.14
346_A349_K0.6330.14
47_A93_R0.6320.14
16_R223_P0.6290.14
73_C77_I0.6290.14
119_L140_K0.6280.14
286_A309_V0.6280.14
245_H264_N0.6270.14
139_V143_Q0.6270.14
146_L308_G0.6250.14
92_D210_T0.6220.14
324_R349_K0.6220.14
28_I233_I0.6210.14
35_S259_L0.6210.14
11_M14_V0.6200.14
42_K200_W0.6190.14
93_R244_L0.6190.14
92_D173_K0.6170.14
147_G235_D0.6170.14
59_G210_T0.6160.14
25_E140_K0.6150.14
52_K55_H0.6150.14
24_Q320_K0.6140.14
169_L214_F0.6140.14
25_E75_E0.6130.14
15_Y126_R0.6120.14
48_S84_S0.6110.13
153_D186_K0.6100.13
55_H85_D0.6090.13
304_R329_L0.6070.13
243_G282_F0.6070.13
89_N169_L0.6060.13
201_Y347_Y0.6030.13
33_S42_K0.6020.13
17_D73_C0.6000.13
182_P292_G0.6000.13
118_E271_S0.5990.13
232_K342_I0.5980.13
55_H59_G0.5980.13
8_F197_E0.5970.13
10_L56_C0.5960.13
140_K189_T0.5950.13
106_H174_H0.5950.13
334_G346_A0.5940.13
189_T192_E0.5940.13
125_F228_S0.5900.13
32_K72_K0.5860.13
8_F51_D0.5860.13
66_S242_Q0.5860.13
166_Y265_F0.5840.13
106_H265_F0.5820.13
94_S126_R0.5800.13
29_W137_E0.5770.13
326_A330_I0.5750.13
181_V185_E0.5740.13
9_G331_K0.5740.13
25_E290_L0.5740.13
91_C94_S0.5730.13
41_L48_S0.5720.13
39_S291_Q0.5720.13
93_R109_M0.5700.13
188_F251_L0.5690.13
19_F309_V0.5690.13
148_S342_I0.5680.13
213_I304_R0.5680.13
185_E188_F0.5680.13
266_C309_V0.5680.13
7_P62_L0.5670.13
62_L103_R0.5670.13
238_F311_L0.5660.13
183_R347_Y0.5650.13
227_E241_I0.5650.13
106_H256_E0.5650.13
57_E61_I0.5640.13
9_G230_A0.5630.13
286_A326_A0.5620.12
73_C215_C0.5620.12
150_E221_F0.5600.12
96_S99_P0.5580.12
31_Q153_D0.5580.12
54_F246_I0.5580.12
216_L260_E0.5570.12
285_K327_K0.5570.12
162_L263_L0.5570.12
69_Q235_D0.5570.12
140_K292_G0.5550.12
52_K92_D0.5550.12
168_D268_Y0.5530.12
301_L341_Y0.5530.12
163_C213_I0.5520.12
15_Y96_S0.5460.12
155_I303_N0.5450.12
95_T126_R0.5440.12
197_E291_Q0.5430.12
286_A348_R0.5430.12
66_S201_Y0.5420.12
65_L279_L0.5410.12
25_E288_E0.5410.12
283_I331_K0.5390.12
223_P296_E0.5390.12
102_F123_Y0.5390.12
136_H321_E0.5390.12
92_D245_H0.5380.12
309_V337_S0.5380.12
46_T132_S0.5380.12
245_H315_K0.5370.12
156_K193_S0.5370.12
241_I286_A0.5360.12
155_I247_L0.5360.12
43_A197_E0.5350.12
88_D249_D0.5340.12
74_V308_G0.5320.12
5_E346_A0.5320.12
136_H285_K0.5320.12
301_L340_F0.5300.12
73_C76_F0.5300.12
126_R175_V0.5280.12
42_K233_I0.5280.12
6_H61_I0.5270.12
54_F92_D0.5270.12
191_Y288_E0.5260.12
31_Q220_S0.5250.12
263_L268_Y0.5250.12
286_A339_F0.5230.12
25_E28_I0.5220.12
173_K306_L0.5210.12
100_Q197_E0.5200.12
6_H297_N0.5200.12
232_K284_H0.5190.12
271_S321_E0.5190.12
92_D102_F0.5190.12
51_D177_E0.5150.12
201_Y219_Y0.5140.12
106_H210_T0.5130.12
92_D252_I0.5120.12
50_R68_S0.5120.12
27_D31_Q0.5110.12
35_S69_Q0.5100.12
178_H349_K0.5090.11
94_S340_F0.5060.11
8_F186_K0.5050.11
236_S241_I0.5050.11
41_L134_Y0.5050.11
51_D317_A0.5040.11
103_R164_G0.5020.11
61_I307_L0.5010.11
22_V254_Q0.5010.11
165_Y263_L0.5010.11
176_I182_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kwdA 2 0.7766 81.7 0.973 Contact Map
1ps1A 1 0.7766 81.2 0.973 Contact Map
3kb9A 1 0.8474 80 0.973 Contact Map
1di1A 1 0.7602 79.9 0.973 Contact Map
4qhpA 1 0.8174 79.6 0.973 Contact Map
3b34A 1 0.812 73.6 0.975 Contact Map
4okzA 1 0.8583 73.5 0.975 Contact Map
4mc3A 1 0.7411 58.8 0.977 Contact Map
3llwA 2 0.3651 47.8 0.978 Contact Map
3pkoA 2 0.4387 42.6 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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