GREMLIN Database
AMYD - Putative ABC transporter permease protein AmyD
UniProt: O34706 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (255)
Sequences: 70201 (45754)
Seq/√Len: 2865.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_Q213_T4.0281.00
80_K84_H3.2461.00
201_Q210_Q3.0571.00
186_L190_Q3.0041.00
77_H80_K2.6341.00
78_I259_F2.6081.00
47_T66_Y2.5831.00
106_Q197_Y2.5501.00
92_F174_T2.5051.00
206_K209_Q2.5011.00
188_G222_S2.4851.00
200_A210_Q2.4791.00
88_G170_V2.4761.00
197_Y215_T2.4591.00
254_Q262_D2.4151.00
76_W80_K2.4011.00
67_E71_S2.3741.00
64_A67_E2.3321.00
90_T227_I2.3221.00
207_Q210_Q2.2941.00
208_G212_F2.2111.00
185_Y223_I2.2021.00
269_D272_Y2.1811.00
64_A68_R2.1621.00
108_I111_K2.1291.00
205_A209_Q2.0631.00
209_Q212_F2.0131.00
98_L211_F1.9991.00
181_A226_N1.9321.00
105_N190_Q1.9301.00
45_L49_T1.9241.00
189_L219_L1.9201.00
196_Y218_L1.9201.00
200_A205_A1.8831.00
84_H166_P1.8751.00
41_V45_L1.8431.00
289_F293_A1.8251.00
115_R186_L1.7971.00
98_L219_L1.7931.00
77_H81_N1.7661.00
94_N227_I1.7611.00
201_Q207_Q1.7161.00
197_Y210_Q1.6841.00
86_G231_I1.6731.00
97_G181_A1.6541.00
68_R272_Y1.6421.00
84_H88_G1.6261.00
89_S234_G1.6131.00
100_Y182_M1.5961.00
98_L185_Y1.5941.00
104_L182_M1.5771.00
166_P253_S1.5751.00
197_Y201_Q1.5521.00
26_I30_L1.4991.00
44_T278_I1.4681.00
194_K197_Y1.4581.00
259_F263_L1.4491.00
38_Y42_K1.4491.00
107_S111_K1.4481.00
247_G252_A1.4311.00
110_T113_V1.4311.00
68_R71_S1.4041.00
181_A230_N1.3911.00
42_K46_I1.3901.00
63_F67_E1.3771.00
101_A185_Y1.3701.00
105_N186_L1.3681.00
74_D77_H1.3641.00
85_Y255_S1.3551.00
216_L223_I1.3491.00
62_G65_Q1.3471.00
238_F242_I1.3251.00
189_L215_T1.3151.00
225_I229_I1.3061.00
93_Q230_N1.2961.00
185_Y226_N1.2761.00
95_V99_L1.2741.00
106_Q194_K1.2741.00
263_L267_R1.2721.00
194_K198_E1.2721.00
245_T253_S1.2631.00
248_G252_A1.2591.00
200_A214_I1.2401.00
195_D198_E1.2371.00
238_F261_Y1.2361.00
263_L269_D1.2321.00
240_V244_L1.2221.00
98_L223_I1.2211.00
102_L189_L1.2131.00
137_F168_I1.2071.00
82_T256_M1.2021.00
53_G60_W1.1931.00
254_Q259_F1.1861.00
172_I244_L1.1741.00
30_L34_V1.1661.00
113_V116_T1.1661.00
206_K210_Q1.1601.00
19_S23_W1.1571.00
88_G91_F1.1551.00
21_L25_Y1.1511.00
192_I218_L1.1491.00
91_F95_V1.1401.00
81_N84_H1.1351.00
94_N223_I1.1251.00
20_S24_M1.1161.00
220_M224_T1.1071.00
262_D266_K1.0951.00
170_V174_T1.0841.00
50_N53_G1.0801.00
18_Q21_L1.0781.00
169_I241_I1.0781.00
185_Y222_S1.0651.00
43_G278_I1.0541.00
166_P170_V1.0531.00
113_V117_I1.0461.00
23_W27_P1.0381.00
42_K45_L1.0311.00
293_A296_K1.0281.00
290_C294_Y1.0261.00
178_V182_M1.0241.00
197_Y207_Q1.0241.00
92_F170_V1.0231.00
255_S258_T1.0211.00
254_Q258_T1.0171.00
88_G92_F1.0131.00
105_N189_L1.0121.00
89_S93_Q1.0121.00
241_I255_S1.0111.00
20_S23_W1.0101.00
138_S141_G1.0061.00
135_F139_Y1.0021.00
184_V226_N1.0001.00
218_L221_P0.9981.00
264_Y273_A0.9981.00
70_F76_W0.9961.00
102_L211_F0.9931.00
66_Y278_I0.9921.00
102_L207_Q0.9881.00
83_L87_L0.9861.00
259_F276_Q0.9841.00
99_L103_L0.9711.00
247_G253_S0.9651.00
79_L256_M0.9601.00
210_Q213_T0.9571.00
23_W26_I0.9571.00
237_L240_V0.9541.00
167_W171_M0.9521.00
89_S173_N0.9501.00
22_W26_I0.9441.00
111_K190_Q0.9391.00
205_A210_Q0.9381.00
84_H167_W0.9331.00
91_F227_I0.9171.00
84_H87_L0.9051.00
237_L241_I0.9041.00
85_Y166_P0.9011.00
133_W244_L0.9001.00
65_Q271_G0.8991.00
242_I258_T0.8961.00
18_Q22_W0.8941.00
143_A167_W0.8921.00
68_R72_D0.8841.00
173_N234_G0.8781.00
81_N166_P0.8771.00
101_A105_N0.8761.00
46_I274_A0.8701.00
87_L91_F0.8691.00
25_Y29_L0.8641.00
109_K112_A0.8641.00
72_D76_W0.8581.00
89_S170_V0.8571.00
167_W170_V0.8571.00
259_F262_D0.8531.00
188_G219_L0.8531.00
75_T276_Q0.8511.00
290_C293_A0.8491.00
46_I49_T0.8481.00
33_L37_I0.8481.00
97_G182_M0.8441.00
69_L279_F0.8411.00
220_M223_I0.8401.00
212_F216_L0.8361.00
172_I240_V0.8361.00
185_Y219_L0.8351.00
219_L222_S0.8331.00
52_N55_S0.8321.00
49_T53_G0.8321.00
79_L83_L0.8311.00
92_F95_V0.8281.00
119_Y183_V0.8241.00
211_F216_L0.8241.00
263_L276_Q0.8191.00
47_T51_W0.8171.00
104_L115_R0.8151.00
85_Y173_N0.8111.00
112_A115_R0.8111.00
93_Q97_G0.8101.00
230_N234_G0.8041.00
133_W172_I0.8011.00
181_A185_Y0.8001.00
210_Q215_T0.7971.00
80_K83_L0.7921.00
126_P176_Q0.7911.00
205_A213_T0.7901.00
88_G174_T0.7891.00
286_I290_C0.7861.00
103_L108_I0.7761.00
196_Y214_I0.7731.00
51_W55_S0.7711.00
48_F61_V0.7671.00
207_Q211_F0.7671.00
38_Y41_V0.7661.00
101_A182_M0.7661.00
101_A189_L0.7621.00
248_G254_Q0.7571.00
284_I288_S0.7501.00
68_R269_D0.7501.00
134_Y138_S0.7461.00
73_P77_H0.7411.00
143_A146_D0.7381.00
43_G274_A0.7331.00
263_L272_Y0.7311.00
93_Q177_Y0.7301.00
48_F62_G0.7281.00
93_Q181_A0.7261.00
130_G239_D0.7261.00
130_G243_A0.7241.00
272_Y276_Q0.7191.00
63_F66_Y0.7181.00
192_I219_L0.7131.00
256_M280_M0.7111.00
46_I50_N0.7101.00
291_A294_Y0.7081.00
50_N59_Q0.7061.00
97_G185_Y0.7031.00
211_F215_T0.7021.00
78_I256_M0.7021.00
104_L114_T0.6991.00
27_P30_L0.6971.00
50_N60_W0.6971.00
119_Y122_V0.6931.00
78_I81_N0.6931.00
94_N185_Y0.6921.00
65_Q68_R0.6921.00
86_G90_T0.6911.00
185_Y189_L0.6911.00
90_T231_I0.6911.00
260_M276_Q0.6901.00
53_G56_Q0.6861.00
24_M27_P0.6861.00
43_G277_G0.6851.00
237_L255_S0.6851.00
76_W79_L0.6841.00
67_E70_F0.6831.00
177_Y230_N0.6831.00
104_L186_L0.6821.00
93_Q234_G0.6811.00
126_P239_D0.6811.00
60_W63_F0.6801.00
245_T254_Q0.6761.00
194_K201_Q0.6751.00
274_A278_I0.6741.00
223_I226_N0.6721.00
53_G59_Q0.6711.00
258_T262_D0.6711.00
24_M28_A0.6681.00
168_I172_I0.6681.00
274_A277_G0.6641.00
100_Y178_V0.6551.00
49_T58_Y0.6541.00
169_I245_T0.6511.00
199_A203_D0.6511.00
241_I258_T0.6501.00
220_M294_Y0.6491.00
32_V36_M0.6461.00
82_T257_S0.6451.00
129_M175_Y0.6411.00
177_Y233_G0.6381.00
257_S280_M0.6351.00
22_W25_Y0.6331.00
90_T94_N0.6321.00
135_F138_S0.6301.00
222_S226_N0.6291.00
19_S22_W0.6261.00
61_V64_A0.6241.00
96_V174_T0.6231.00
271_G274_A0.6221.00
285_L289_F0.6201.00
199_A202_M0.6191.00
110_T114_T0.6191.00
215_T218_L0.6181.00
168_I244_L0.6171.00
33_L36_M0.6161.00
85_Y169_I0.6161.00
138_S144_L0.6161.00
223_I227_I0.6141.00
145_N247_G0.6131.00
107_S112_A0.6121.00
52_N56_Q0.6111.00
108_I114_T0.6111.00
81_N253_S0.6101.00
100_Y118_V0.6081.00
85_Y170_V0.6061.00
184_V222_S0.6051.00
270_A274_A0.6051.00
69_L272_Y0.6031.00
261_Y265_F0.6031.00
133_W136_F0.5981.00
29_L33_L0.5981.00
280_M284_I0.5981.00
127_L243_A0.5931.00
51_W58_Y0.5911.00
73_P76_W0.5891.00
89_S174_T0.5831.00
82_T235_L0.5781.00
69_L276_Q0.5781.00
118_V179_G0.5751.00
115_R183_V0.5741.00
109_K113_V0.5731.00
232_I236_K0.5721.00
248_G253_S0.5701.00
122_V179_G0.5671.00
60_W64_A0.5621.00
224_T227_I0.5611.00
86_G234_G0.5601.00
74_D259_F0.5591.00
210_Q214_I0.5581.00
28_A32_V0.5571.00
270_A273_A0.5551.00
169_I173_N0.5531.00
101_A186_L0.5511.00
35_F39_P0.5491.00
47_T275_T0.5491.00
137_F144_L0.5481.00
66_Y275_T0.5481.00
74_D254_Q0.5461.00
93_Q174_T0.5461.00
239_D243_A0.5451.00
37_I41_V0.5441.00
173_N237_L0.5431.00
141_G146_D0.5411.00
233_G236_K0.5401.00
116_T120_L0.5381.00
283_V286_I0.5371.00
227_I230_N0.5361.00
85_Y89_S0.5351.00
102_L215_T0.5341.00
212_F215_T0.5341.00
192_I197_Y0.5331.00
112_A116_T0.5331.00
34_V38_Y0.5331.00
94_N98_L0.5321.00
206_K212_F0.5321.00
142_G145_N0.5311.00
86_G235_L0.5291.00
117_I121_P0.5251.00
90_T95_V0.5251.00
21_L24_M0.5251.00
62_G66_Y0.5241.00
122_V180_I0.5241.00
239_D242_I0.5221.00
26_I29_L0.5211.00
49_T60_W0.5201.00
121_P179_G0.5181.00
81_N255_S0.5161.00
198_E201_Q0.5161.00
289_F292_L0.5161.00
96_V178_V0.5141.00
46_I51_W0.5131.00
58_Y61_V0.5131.00
108_I112_A0.5121.00
288_S292_L0.5111.00
94_N99_L0.5101.00
136_F144_L0.5091.00
130_G134_Y0.5071.00
126_P130_G0.5061.00
39_P43_G0.5051.00
115_R190_Q0.5041.00
107_S194_K0.5031.00
100_Y103_L0.5021.00
97_G178_V0.5001.00
49_T59_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.9241 100 0.314 Contact Map
2onkC 2 0.8251 100 0.331 Contact Map
3d31C 2 0.8152 100 0.348 Contact Map
3rlfF 1 0.9406 100 0.367 Contact Map
3rlfG 1 0.8779 100 0.399 Contact Map
4tquN 1 0.8647 100 0.404 Contact Map
4ymuD 2 0.7063 99.9 0.524 Contact Map
3tuiA 2 0.6865 99.9 0.544 Contact Map
2wdqC 1 0.3663 25.9 0.942 Contact Map
2kogA 1 0.1518 25.5 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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