GREMLIN Database
PLBAC - Phospholipase YtpA
UniProt: O34705 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (239)
Sequences: 57233 (48146)
Seq/√Len: 3114.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_F108_G4.7651.00
46_P67_E4.1041.00
29_L248_F3.3731.00
69_D97_W3.0941.00
204_G232_E3.0511.00
229_R250_A3.0481.00
113_S206_D2.8981.00
231_W250_A2.8711.00
83_F107_T2.7851.00
81_P107_T2.7311.00
242_P246_D2.6891.00
112_S247_V2.5561.00
204_G230_E2.2721.00
97_W101_Q2.2061.00
69_D101_Q2.2011.00
218_F226_K2.1901.00
69_D73_D2.1741.00
72_I82_V2.1201.00
69_D105_R2.0891.00
32_M248_F2.0831.00
84_L94_A2.0671.00
91_G114_P1.9981.00
11_A83_F1.9681.00
73_D105_R1.9641.00
12_V39_H1.9571.00
12_V41_V1.9511.00
37_G252_R1.9021.00
234_L242_P1.8911.00
96_E100_Q1.8571.00
98_V109_I1.8481.00
211_K230_E1.8451.00
11_A107_T1.8051.00
17_H45_L1.7321.00
216_K220_G1.7081.00
83_F255_T1.7041.00
198_L221_V1.6891.00
16_I45_L1.6861.00
21_E25_R1.6821.00
43_G68_V1.6811.00
12_V77_T1.6771.00
83_F110_I1.6751.00
45_L93_V1.6611.00
199_L229_R1.6581.00
250_A253_A1.6551.00
38_Y83_F1.6541.00
16_I68_V1.6481.00
68_V97_W1.6271.00
65_I96_E1.6121.00
17_H48_Q1.5841.00
94_A109_I1.5781.00
101_Q104_P1.5101.00
32_M252_R1.5081.00
66_D100_Q1.4931.00
97_W106_I1.4731.00
23_H50_T1.4731.00
111_L114_P1.4651.00
246_D250_A1.4481.00
62_Q100_Q1.4451.00
101_Q105_R1.4221.00
87_H239_F1.3961.00
96_E99_K1.3871.00
23_H44_D1.3721.00
95_I111_L1.3661.00
41_V71_W1.3641.00
202_Q214_V1.3521.00
30_I42_M1.3511.00
199_L254_F1.3481.00
15_I85_L1.3461.00
97_W105_R1.3451.00
249_K253_A1.3411.00
73_D101_Q1.3331.00
110_I251_A1.3321.00
60_S63_E1.3321.00
20_S48_Q1.3201.00
23_H42_M1.2931.00
85_L112_S1.2731.00
32_M35_S1.2721.00
11_A38_Y1.2711.00
71_W75_A1.2681.00
246_D249_K1.2331.00
110_I199_L1.2251.00
16_I94_A1.2241.00
231_W234_L1.2061.00
15_I40_V1.2031.00
11_A81_P1.1851.00
13_I38_Y1.1751.00
18_G88_S1.1651.00
77_T82_V1.1641.00
20_S88_S1.1601.00
202_Q230_E1.1401.00
138_P141_K1.1351.00
218_F228_Y1.1261.00
211_K215_I1.1201.00
215_I219_N1.1131.00
202_Q228_Y1.1031.00
227_A250_A1.0681.00
14_V72_I1.0651.00
82_V106_I1.0501.00
221_V226_K1.0491.00
140_L143_D1.0491.00
44_D49_G1.0481.00
201_M231_W1.0441.00
41_V75_A1.0341.00
32_M245_E1.0331.00
88_S236_H1.0281.00
43_G71_W1.0211.00
77_T81_P1.0191.00
85_L251_A1.0181.00
34_R37_G1.0161.00
154_N157_V1.0101.00
108_G197_P1.0061.00
169_R172_S0.9931.00
87_H237_E0.9901.00
25_R239_F0.9891.00
199_L227_A0.9861.00
235_Y241_E0.9851.00
216_K219_N0.9811.00
16_I84_L0.9801.00
112_S239_F0.9771.00
124_K128_L0.9761.00
202_Q211_K0.9721.00
86_G94_A0.9651.00
126_L130_S0.9641.00
45_L89_M0.9601.00
234_L241_E0.9581.00
160_A164_D0.9571.00
69_D100_Q0.9521.00
231_W246_D0.9491.00
112_S238_I0.9461.00
7_D10_V0.9431.00
247_V251_A0.9431.00
34_R40_V0.9351.00
215_I228_Y0.9331.00
14_V82_V0.9331.00
10_V39_H0.9321.00
72_I97_W0.9311.00
174_R178_E0.9311.00
215_I230_E0.9291.00
176_Y180_L0.9241.00
65_I93_V0.9161.00
27_K42_M0.9121.00
38_Y255_T0.9111.00
229_R246_D0.9061.00
72_I77_T0.9041.00
192_A220_G0.9021.00
28_W31_E0.8991.00
245_E249_K0.8991.00
201_M250_A0.8821.00
62_Q96_E0.8811.00
82_V105_R0.8811.00
215_I218_F0.8771.00
173_V176_Y0.8761.00
76_R80_L0.8691.00
229_R253_A0.8671.00
222_A225_N0.8661.00
159_E163_N0.8641.00
172_S175_W0.8641.00
168_V172_S0.8581.00
178_E181_K0.8541.00
200_V226_K0.8491.00
179_L182_T0.8371.00
16_I43_G0.8351.00
30_I40_V0.8331.00
31_E34_R0.8281.00
64_Y89_M0.8271.00
159_E162_Q0.8261.00
204_G233_G0.8231.00
98_V106_I0.8201.00
13_I85_L0.8191.00
19_A89_M0.8051.00
109_I198_L0.8041.00
70_A74_K0.8031.00
8_R39_H0.8021.00
127_D131_K0.8001.00
182_T185_S0.7981.00
171_V175_W0.7951.00
23_H43_G0.7931.00
12_V82_V0.7871.00
201_M247_V0.7841.00
15_I26_Y0.7821.00
113_S238_I0.7801.00
137_A141_K0.7801.00
234_L238_I0.7801.00
13_I40_V0.7791.00
11_A108_G0.7791.00
214_V228_Y0.7791.00
113_S203_A0.7781.00
172_S176_Y0.7761.00
213_M216_K0.7721.00
70_A73_D0.7711.00
174_R177_R0.7651.00
176_Y179_L0.7601.00
65_I100_Q0.7581.00
155_E158_I0.7551.00
138_P142_V0.7531.00
27_K31_E0.7531.00
179_L183_I0.7521.00
125_A129_A0.7521.00
85_L110_I0.7511.00
87_H113_S0.7511.00
183_I186_A0.7501.00
44_D50_T0.7491.00
45_L64_Y0.7451.00
63_E66_D0.7451.00
133_L137_A0.7451.00
169_R176_Y0.7401.00
175_W179_L0.7361.00
86_G91_G0.7351.00
160_A163_N0.7331.00
69_D72_I0.7301.00
248_F252_R0.7301.00
158_I161_D0.7291.00
92_L115_C0.7291.00
139_S143_D0.7271.00
12_V38_Y0.7271.00
156_D159_E0.7231.00
137_A140_L0.7221.00
108_G255_T0.7221.00
244_R248_F0.7111.00
24_G27_K0.7111.00
231_W242_P0.7101.00
157_V160_A0.7091.00
110_I255_T0.7071.00
84_L106_I0.7061.00
124_K127_D0.7041.00
156_D160_A0.7011.00
161_D165_S0.7011.00
95_I116_L0.7001.00
170_K174_R0.7001.00
221_V225_N0.7001.00
169_R173_V0.7001.00
134_N138_P0.7001.00
173_V177_R0.6991.00
135_V139_S0.6971.00
178_E182_T0.6971.00
99_K193_F0.6951.00
113_S202_Q0.6941.00
14_V84_L0.6941.00
30_I34_R0.6941.00
162_Q165_S0.6941.00
127_D130_S0.6791.00
180_L183_I0.6771.00
14_V68_V0.6761.00
66_D69_D0.6761.00
58_I63_E0.6721.00
31_E35_S0.6711.00
190_T193_F0.6711.00
98_V196_V0.6701.00
204_G211_K0.6651.00
182_T186_A0.6631.00
151_A154_N0.6621.00
175_W180_L0.6611.00
46_P64_Y0.6601.00
45_L48_Q0.6601.00
162_Q166_L0.6581.00
106_I196_V0.6581.00
205_D233_G0.6551.00
38_Y252_R0.6531.00
66_D70_A0.6531.00
84_L97_W0.6521.00
37_G40_V0.6501.00
161_D166_L0.6501.00
9_P39_H0.6471.00
77_T80_L0.6471.00
135_V138_P0.6441.00
108_G254_F0.6441.00
181_K185_S0.6441.00
177_R181_K0.6421.00
82_V107_T0.6401.00
212_T215_I0.6371.00
161_D164_D0.6311.00
123_N127_D0.6301.00
183_I187_M0.6291.00
233_G242_P0.6271.00
87_H112_S0.6211.00
128_L131_K0.6191.00
39_H77_T0.6191.00
126_L129_A0.6191.00
163_N166_L0.6171.00
175_W178_E0.6171.00
29_L32_M0.6141.00
17_H43_G0.6061.00
155_E159_E0.6061.00
33_W251_A0.6051.00
170_K173_V0.6041.00
242_P245_E0.6021.00
167_Y172_S0.5981.00
132_G136_I0.5941.00
150_M153_R0.5931.00
13_I83_F0.5931.00
65_I97_W0.5911.00
111_L200_V0.5891.00
123_N126_L0.5871.00
171_V176_Y0.5871.00
136_I140_L0.5871.00
148_I151_A0.5871.00
181_K184_E0.5851.00
35_S252_R0.5841.00
62_Q66_D0.5841.00
41_V77_T0.5831.00
76_R81_P0.5821.00
158_I164_D0.5821.00
86_G90_G0.5771.00
133_L138_P0.5771.00
249_K252_R0.5761.00
167_Y170_K0.5761.00
132_G135_V0.5751.00
203_A238_I0.5731.00
171_V179_L0.5731.00
171_V174_R0.5701.00
21_E240_N0.5701.00
158_I162_Q0.5691.00
160_A165_S0.5681.00
172_S183_I0.5671.00
154_N158_I0.5611.00
13_I255_T0.5591.00
200_V228_Y0.5541.00
200_V214_V0.5521.00
194_L221_V0.5511.00
139_S142_V0.5501.00
28_W244_R0.5501.00
160_A166_L0.5491.00
65_I69_D0.5481.00
125_A128_L0.5451.00
25_R87_H0.5441.00
20_S89_M0.5431.00
222_A226_K0.5421.00
238_I247_V0.5411.00
13_I33_W0.5401.00
122_V126_L0.5391.00
80_L105_R0.5391.00
128_L132_G0.5381.00
168_V171_V0.5381.00
14_V43_G0.5361.00
95_I114_P0.5331.00
71_W74_K0.5311.00
10_V38_Y0.5261.00
72_I105_R0.5241.00
167_Y175_W0.5231.00
133_L140_L0.5201.00
239_F247_V0.5191.00
135_V140_L0.5141.00
44_D51_T0.5141.00
158_I163_N0.5141.00
237_E240_N0.5131.00
137_A142_V0.5121.00
19_A48_Q0.5091.00
194_L198_L0.5071.00
18_G87_H0.5041.00
64_Y93_V0.5041.00
7_D39_H0.5031.00
26_Y30_I0.5031.00
201_M229_R0.5031.00
136_I143_D0.5031.00
154_N160_A0.5011.00
157_V162_Q0.5011.00
195_K222_A0.5001.00
159_E165_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ns4A 1 0.9151 100 0.166 Contact Map
3bf7A 1 0.9498 100 0.172 Contact Map
4inzA 1 0.9459 100 0.175 Contact Map
4opmA 2 0.9691 100 0.177 Contact Map
2xmzA 1 0.9653 100 0.179 Contact Map
3om8A 4 0.9382 100 0.18 Contact Map
1womA 1 0.9614 100 0.181 Contact Map
3v48A 2 0.9614 100 0.183 Contact Map
4psuA 1 0.9498 100 0.184 Contact Map
3oosA 1 0.9421 100 0.184 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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