GREMLIN Database
YJOB - Uncharacterized ATPase YjoB
UniProt: O34703 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 423 (345)
Sequences: 7844 (5116)
Seq/√Len: 275.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
344_L362_K4.6491.00
348_K361_I4.1211.00
340_E366_K3.9561.00
178_I181_E3.1581.00
85_T88_Y3.0971.00
182_V185_S2.9571.00
41_G44_Y2.9391.00
363_N367_L2.9001.00
184_R191_P2.8451.00
46_L49_S2.8431.00
85_T89_D2.7391.00
84_K88_Y2.6781.00
36_L64_V2.6701.00
258_S262_I2.5981.00
259_S262_I2.5841.00
348_K358_E2.5651.00
104_R116_A2.4691.00
186_Q242_G2.3851.00
377_G381_V2.3541.00
185_S242_G2.3421.00
259_S263_E2.3421.00
41_G45_E2.3241.00
180_R184_R2.2891.00
310_G329_F2.2381.00
339_D342_L2.2161.00
357_S360_E2.1841.00
128_I131_F2.1321.00
40_Y68_S2.1281.00
258_S263_E2.1251.00
370_G373_F2.1091.00
260_E263_E2.1001.00
79_E83_K2.0631.00
224_L329_F2.0161.00
75_A79_E2.0141.00
258_S264_E1.9921.00
91_D95_P1.9871.00
345_E349_M1.9771.00
265_V269_A1.9611.00
135_F139_D1.9521.00
260_E264_E1.9411.00
86_F89_D1.9401.00
102_S106_S1.9041.00
345_E348_K1.8691.00
62_E66_S1.8631.00
259_S264_E1.8431.00
84_K87_A1.8001.00
135_F138_N1.7681.00
258_S261_T1.7561.00
347_M376_L1.7441.00
344_L348_K1.7221.00
96_D120_I1.7091.00
45_E48_A1.7051.00
114_G119_R1.6851.00
43_F61_V1.6811.00
76_Y80_K1.6531.00
110_Y114_G1.6331.00
119_R122_Y1.6111.00
117_F120_I1.5931.00
96_D99_V1.5741.00
129_M133_C1.5681.00
224_L282_I1.5681.00
55_E59_L1.5671.00
120_I124_Q1.5561.00
184_R194_K1.5411.00
96_D100_H1.5371.00
154_W157_S1.5341.00
375_Q378_E1.5281.00
128_I135_F1.5181.00
161_V164_F1.5171.00
93_K120_I1.5101.00
352_F356_L1.5061.00
160_K164_F1.5051.00
269_A273_A1.4961.00
285_M293_F1.4921.00
381_V385_L1.4891.00
48_A51_D1.4591.00
151_P157_S1.4581.00
153_L157_S1.4511.00
127_S130_S1.4461.00
356_L360_E1.4381.00
340_E362_K1.4371.00
80_K83_K1.4361.00
267_Q271_R1.4291.00
69_L73_H1.4241.00
69_L72_E1.4151.00
314_Y317_E1.4111.00
169_G305_G1.4091.00
111_P114_G1.4001.00
265_V268_A1.3961.00
369_E372_S1.3781.00
53_N56_Y1.3751.00
40_Y43_F1.3681.00
127_S131_F1.3631.00
278_V311_T1.3611.00
178_I182_V1.3611.00
159_R163_V1.3461.00
266_F269_A1.3391.00
118_A122_Y1.3341.00
128_I138_N1.3341.00
59_L62_E1.3231.00
225_L335_I1.3201.00
152_R157_S1.3081.00
95_P99_V1.3071.00
170_G247_P1.2871.00
137_V141_K1.2771.00
268_A277_L1.2761.00
240_I309_I1.2641.00
131_F135_F1.2621.00
153_L156_K1.2621.00
133_C137_V1.2601.00
132_D136_A1.2591.00
344_L358_E1.2581.00
134_L138_N1.2441.00
151_P156_K1.2401.00
296_T308_L1.2381.00
380_Y384_A1.2381.00
180_R195_K1.2351.00
130_S134_L1.2251.00
249_A277_L1.2131.00
369_E373_F1.2111.00
379_L383_S1.2071.00
98_T102_S1.2041.00
158_K161_V1.2001.00
130_S133_C1.1991.00
150_R153_L1.1911.00
131_F141_K1.1821.00
131_F138_N1.1811.00
350_R353_G1.1751.00
104_R107_V1.1661.00
70_E73_H1.1601.00
207_S213_Q1.1591.00
59_L63_D1.1531.00
138_N141_K1.1481.00
237_V278_V1.1361.00
247_P272_L1.1361.00
33_E75_A1.1271.00
347_M361_I1.1261.00
194_K236_L1.1251.00
71_P75_A1.1191.00
117_F124_Q1.1101.00
127_S135_F1.1071.00
72_E76_Y1.1071.00
174_E178_I1.1061.00
78_F82_E1.1061.00
377_G380_Y1.1031.00
92_E95_P1.0971.00
136_A139_D1.0961.00
363_N366_K1.0961.00
98_T101_K1.0951.00
100_H120_I1.0931.00
96_D119_R1.0921.00
146_L153_L1.0901.00
158_K164_F1.0861.00
139_D142_M1.0861.00
381_V384_A1.0811.00
237_V309_I1.0811.00
376_L381_V1.0701.00
33_E37_Y1.0681.00
265_V273_A1.0681.00
33_E71_P1.0671.00
46_L50_D1.0581.00
182_V243_S1.0571.00
354_I380_Y1.0551.00
268_A273_A1.0491.00
35_T38_D1.0441.00
93_K97_Y1.0431.00
269_A272_L1.0361.00
180_R202_D1.0341.00
126_G130_S1.0271.00
362_K366_K1.0261.00
128_I139_D1.0241.00
72_E75_A1.0241.00
251_W277_L1.0221.00
43_F57_W1.0181.00
117_F121_P1.0151.00
150_R155_E1.0141.00
195_K199_R1.0101.00
77_I81_L1.0081.00
50_D53_N1.0051.00
129_M132_D1.0021.00
213_Q220_K0.9971.00
222_G297_L0.9961.00
108_Y111_P0.9941.00
76_Y79_E0.9891.00
136_A140_E0.9861.00
78_F81_L0.9851.00
37_Y40_Y0.9811.00
364_A368_T0.9811.00
358_E362_K0.9781.00
74_V78_F0.9691.00
84_K89_D0.9661.00
142_M145_F0.9651.00
253_I279_I0.9631.00
261_T264_E0.9621.00
65_R69_L0.9611.00
186_Q235_T0.9601.00
44_Y47_Y0.9591.00
96_D115_V0.9541.00
281_D313_N0.9531.00
179_V243_S0.9511.00
99_V111_P0.9511.00
42_V45_E0.9501.00
359_G362_K0.9491.00
94_E98_T0.9481.00
368_T373_F0.9421.00
195_K382_S0.9361.00
100_H103_I0.9321.00
249_A272_L0.9301.00
58_E61_V0.9281.00
150_R157_S0.9241.00
374_A385_L0.9231.00
216_D246_A0.9211.00
52_P56_Y0.9211.00
268_A272_L0.9081.00
73_H77_I0.9081.00
376_L379_L0.9051.00
248_V276_V0.8991.00
91_D94_E0.8991.00
44_Y48_A0.8981.00
257_T291_S0.8941.00
127_S134_L0.8911.00
376_L380_Y0.8901.00
256_F261_T0.8861.00
268_A271_R0.8851.00
73_H76_Y0.8851.00
68_S72_E0.8821.00
159_R164_F0.8791.00
293_F296_T0.8761.00
236_L335_I0.8761.00
146_L150_R0.8651.00
282_I310_G0.8651.00
122_Y125_D0.8611.00
103_I108_Y0.8581.00
107_V110_Y0.8581.00
152_R156_K0.8571.00
191_P195_K0.8561.00
344_L361_I0.8561.00
114_G118_A0.8531.00
128_I141_K0.8521.00
186_Q239_S0.8501.00
190_N193_L0.8451.00
79_E82_E0.8431.00
127_S138_N0.8421.00
249_A275_A0.8411.00
281_D328_R0.8371.00
57_W61_V0.8371.00
292_F296_T0.8371.00
56_Y60_L0.8371.00
151_P155_E0.8371.00
34_E38_D0.8361.00
144_A150_R0.8341.00
145_F149_V0.8341.00
113_K116_A0.8270.99
131_F134_L0.8210.99
43_F47_Y0.8190.99
35_T63_D0.8190.99
117_F122_Y0.8160.99
180_R198_Y0.8130.99
38_D41_G0.8110.99
116_A120_I0.8110.99
128_I134_L0.8060.99
225_L309_I0.8000.99
120_I123_F0.8000.99
364_A379_L0.7980.99
374_A380_Y0.7950.99
94_E97_Y0.7900.99
265_V272_L0.7890.99
296_T302_S0.7870.99
188_I349_M0.7870.99
50_D54_T0.7860.99
133_C136_A0.7860.99
159_R162_T0.7850.99
158_K162_T0.7840.99
368_T372_S0.7840.99
45_E51_D0.7840.99
192_L336_G0.7830.99
186_Q245_D0.7810.99
39_Q60_L0.7760.99
128_I132_D0.7750.99
170_G178_I0.7730.99
139_D143_R0.7720.99
138_N142_M0.7650.99
113_K117_F0.7630.99
131_F139_D0.7600.99
56_Y59_L0.7590.99
130_S141_K0.7570.99
119_R123_F0.7550.99
61_V65_R0.7520.99
239_S242_G0.7520.99
45_E49_S0.7510.99
48_A53_N0.7500.99
121_P125_D0.7500.99
134_L137_V0.7490.99
53_N57_W0.7380.99
374_A381_V0.7380.99
54_T57_W0.7380.99
36_L40_Y0.7370.99
168_D171_T0.7370.99
121_P124_Q0.7340.99
377_G385_L0.7330.99
97_Y101_K0.7320.99
379_L385_L0.7310.99
36_L67_G0.7310.99
143_R150_R0.7290.99
183_Q239_S0.7280.99
51_D55_E0.7250.99
91_D96_D0.7220.99
152_R155_E0.7180.99
188_I345_E0.7180.99
137_V140_E0.7170.99
47_Y50_D0.7150.99
378_E385_L0.7140.99
226_Y312_T0.7060.98
72_E79_E0.7060.98
135_F141_K0.7050.98
132_D135_F0.7040.98
99_V103_I0.7030.98
115_V121_P0.7030.98
145_F148_G0.7030.98
336_G342_L0.7020.98
207_S210_S0.6990.98
36_L71_P0.6980.98
93_K104_R0.6970.98
70_E74_V0.6950.98
156_K166_D0.6940.98
347_M364_A0.6930.98
293_F297_L0.6930.98
182_V242_G0.6930.98
62_E65_R0.6920.98
148_G153_L0.6910.98
360_E368_T0.6900.98
60_L64_V0.6890.98
97_Y124_Q0.6890.98
66_S70_E0.6870.98
116_A124_Q0.6860.98
145_F150_R0.6830.98
256_F264_E0.6820.98
267_Q273_A0.6810.98
127_S139_D0.6800.98
112_E117_F0.6790.98
63_D66_S0.6770.98
192_L195_K0.6770.98
96_D123_F0.6770.98
234_T281_D0.6740.98
226_Y332_A0.6700.98
130_S138_N0.6680.98
72_E77_I0.6670.98
101_K104_R0.6670.98
159_R165_T0.6670.98
321_G328_R0.6660.98
93_K96_D0.6650.98
42_V56_Y0.6630.98
142_M150_R0.6620.98
60_L63_D0.6610.98
127_S141_K0.6600.98
172_S175_Q0.6580.97
225_L240_I0.6570.97
133_C141_K0.6530.97
280_E313_N0.6520.97
88_Y91_D0.6520.97
265_V270_R0.6510.97
134_L141_K0.6510.97
181_E184_R0.6510.97
290_R319_D0.6490.97
90_E93_K0.6470.97
130_S135_F0.6470.97
244_I307_F0.6450.97
341_E344_L0.6430.97
160_K163_V0.6420.97
117_F123_F0.6420.97
150_R154_W0.6420.97
323_M332_A0.6410.97
48_A56_Y0.6400.97
37_Y41_G0.6390.97
95_P98_T0.6390.97
298_D328_R0.6370.97
234_T280_E0.6360.97
344_L365_A0.6350.97
118_A124_Q0.6340.97
110_Y113_K0.6310.97
315_P332_A0.6280.97
367_L379_L0.6270.97
280_E328_R0.6250.97
196_E331_R0.6240.97
347_M365_A0.6210.96
99_V102_S0.6200.96
313_N328_R0.6200.96
237_V248_V0.6190.96
40_Y45_E0.6170.96
179_V198_Y0.6140.96
92_E119_R0.6130.96
170_G174_E0.6110.96
248_V278_V0.6110.96
100_H107_V0.6100.96
64_V68_S0.6090.96
54_T58_E0.6080.96
77_I80_K0.6080.96
103_I106_S0.6070.96
149_V153_L0.6050.96
67_G70_E0.6050.96
115_V124_Q0.6030.96
158_K163_V0.6020.96
206_H384_A0.6020.96
126_G131_F0.6020.96
216_D353_G0.6020.96
360_E363_N0.6020.96
76_Y83_K0.6000.96
134_L139_D0.6000.96
158_K165_T0.5990.96
40_Y44_Y0.5970.96
36_L68_S0.5960.96
74_V81_L0.5960.96
126_G134_L0.5920.95
114_G117_F0.5890.95
368_T376_L0.5880.95
132_D139_D0.5880.95
58_E63_D0.5870.95
171_T174_E0.5870.95
95_P102_S0.5860.95
49_S53_N0.5860.95
294_L313_N0.5850.95
92_E96_D0.5840.95
115_V118_A0.5840.95
118_A123_F0.5830.95
114_G121_P0.5780.95
56_Y63_D0.5780.95
351_G356_L0.5760.95
129_M134_L0.5740.95
342_L345_E0.5740.95
111_P115_V0.5740.95
151_P154_W0.5730.94
141_K144_A0.5730.94
115_V119_R0.5710.94
365_A368_T0.5710.94
375_Q379_L0.5700.94
374_A384_A0.5700.94
73_H78_F0.5680.94
287_E319_D0.5680.94
74_V77_I0.5650.94
146_L149_V0.5650.94
136_A143_R0.5630.94
147_E150_R0.5620.94
140_E143_R0.5620.94
132_D138_N0.5620.94
41_G48_A0.5610.94
45_E50_D0.5600.94
103_I107_V0.5600.94
51_D59_L0.5590.94
191_P342_L0.5590.94
209_K212_Y0.5570.94
248_V252_Q0.5570.94
202_D243_S0.5500.93
41_G49_S0.5500.93
257_T260_E0.5480.93
196_E202_D0.5470.93
129_M139_D0.5470.93
116_A119_R0.5460.93
224_L332_A0.5460.93
149_V154_W0.5460.93
352_F376_L0.5450.93
340_E344_L0.5450.93
67_G73_H0.5450.93
96_D103_I0.5430.93
340_E365_A0.5420.93
159_R168_D0.5420.93
372_S375_Q0.5410.93
100_H115_V0.5400.93
377_G382_S0.5400.93
357_S361_I0.5390.93
100_H116_A0.5380.92
198_Y202_D0.5370.92
47_Y51_D0.5370.92
130_S137_V0.5360.92
356_L361_I0.5320.92
144_A149_V0.5320.92
68_S71_P0.5300.92
238_K300_A0.5300.92
348_K352_F0.5300.92
39_Q43_F0.5290.92
58_E62_E0.5280.92
41_G47_Y0.5270.92
375_Q381_V0.5270.92
132_D140_E0.5270.92
61_V64_V0.5260.92
161_V165_T0.5260.92
247_P273_A0.5250.92
150_R156_K0.5250.92
273_A305_G0.5250.92
337_L372_S0.5240.91
87_A94_E0.5240.91
52_P55_E0.5210.91
378_E381_V0.5200.91
96_D101_K0.5190.91
132_D137_V0.5170.91
100_H112_E0.5170.91
129_M136_A0.5160.91
100_H105_N0.5150.91
338_P343_R0.5150.91
213_Q216_D0.5150.91
47_Y61_V0.5130.91
323_M334_E0.5130.91
131_F137_V0.5120.90
53_N64_V0.5120.90
68_S78_F0.5100.90
210_S214_T0.5100.90
97_Y100_H0.5090.90
120_I125_D0.5080.90
72_E80_K0.5080.90
118_A121_P0.5080.90
70_E77_I0.5080.90
122_Y126_G0.5070.90
66_S69_L0.5050.90
127_S132_D0.5030.90
100_H104_R0.5030.90
73_H79_E0.5020.90
322_L329_F0.5020.90
131_F140_E0.5010.90
167_G172_S0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cr2L 1 0.8038 100 0.431 Contact Map
2ce7A 3 0.5816 100 0.441 Contact Map
4cr2J 1 0.8274 100 0.443 Contact Map
4ww0A 4 0.591 100 0.454 Contact Map
3cf2A 3 0.7494 100 0.477 Contact Map
4cr2M 1 0.8109 100 0.478 Contact Map
4cr2I 1 0.773 100 0.491 Contact Map
2x8aA 1 0.5248 100 0.493 Contact Map
4cr2H 1 0.7778 100 0.493 Contact Map
3cf0A 3 0.5863 100 0.497 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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