GREMLIN Database
YOAU - Uncharacterized HTH-type transcriptional regulator YoaU
UniProt: O34701 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (278)
Sequences: 79351 (57706)
Seq/√Len: 3460.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_Q77_I3.7431.00
17_K26_E3.4191.00
13_K26_E2.6901.00
70_L84_V2.5871.00
159_Q286_K2.5801.00
160_L263_D2.4121.00
99_G144_V2.3761.00
47_L63_I2.3381.00
12_V72_R2.3051.00
95_K126_E2.2511.00
160_L163_N2.2161.00
163_N263_D2.2121.00
12_V16_E2.1961.00
167_V241_N2.1891.00
10_I37_A2.1611.00
70_L77_I2.1591.00
13_K17_K2.1221.00
95_K124_R2.0921.00
97_K126_E2.0311.00
165_Y241_N2.0051.00
230_V237_G2.0051.00
115_A284_V1.9891.00
163_N261_T1.9821.00
15_G60_L1.9691.00
74_M78_E1.9361.00
227_I247_V1.9241.00
10_I34_V1.8801.00
68_L72_R1.8791.00
13_K16_E1.8781.00
184_D187_T1.8721.00
16_E72_R1.8551.00
15_G68_L1.8451.00
22_E25_K1.8291.00
12_V68_L1.8161.00
231_K247_V1.7381.00
66_E84_V1.7291.00
70_L73_Q1.7181.00
158_N265_G1.7121.00
191_D217_N1.7011.00
17_K22_E1.6891.00
193_I235_G1.6791.00
51_I59_M1.6601.00
19_N22_E1.6371.00
138_W143_T1.6361.00
67_I81_I1.5951.00
159_Q268_A1.5611.00
7_H44_S1.5261.00
12_V71_A1.5181.00
7_H40_N1.5071.00
77_I80_K1.5011.00
70_L80_K1.4991.00
106_T224_E1.4981.00
53_D59_M1.4981.00
157_E270_S1.4951.00
20_I38_I1.4901.00
30_S33_A1.4821.00
7_H37_A1.4811.00
16_E26_E1.4801.00
138_W144_V1.4421.00
13_K27_L1.4381.00
268_A282_V1.4381.00
97_K128_I1.4311.00
157_E268_A1.4141.00
200_E204_S1.4101.00
149_A267_I1.4031.00
137_G141_D1.3981.00
119_N284_V1.3921.00
69_L73_Q1.3831.00
167_V255_D1.3821.00
116_F123_I1.3801.00
48_K51_I1.3781.00
74_M81_I1.3761.00
282_V286_K1.3701.00
116_F281_F1.3661.00
274_I278_A1.3571.00
139_V147_G1.3541.00
11_F68_L1.3511.00
91_L122_L1.3421.00
266_V282_V1.3411.00
5_M78_E1.3331.00
70_L81_I1.3211.00
160_L265_G1.3191.00
21_T31_Q1.3141.00
226_L237_G1.3121.00
164_D242_F1.3081.00
62_D65_K1.3071.00
93_N122_L1.3061.00
12_V75_K1.3051.00
67_I82_Y1.2981.00
280_E283_K1.2941.00
228_N231_K1.2881.00
4_N7_H1.2841.00
29_I33_A1.2791.00
66_E70_L1.2731.00
54_K57_G1.2731.00
10_I29_I1.2671.00
146_I266_V1.2641.00
114_A232_N1.2611.00
180_E187_T1.2601.00
36_K40_N1.2571.00
170_I236_I1.2531.00
115_A119_N1.2311.00
146_I278_A1.2301.00
117_R217_N1.2221.00
170_I254_K1.2111.00
201_I205_N1.2071.00
66_E69_L1.2071.00
130_G138_W1.2011.00
114_A118_S1.1971.00
111_Q232_N1.1821.00
73_Q80_K1.1751.00
172_P252_I1.1691.00
11_F15_G1.1651.00
8_L71_A1.1601.00
44_S82_Y1.1591.00
36_K39_K1.1541.00
11_F50_L1.1481.00
182_H257_F1.1481.00
65_K69_L1.1461.00
117_R191_D1.1391.00
241_N245_S1.1341.00
228_N232_N1.1341.00
158_N267_I1.1321.00
140_E155_P1.1291.00
120_Y280_E1.1131.00
181_K254_K1.1111.00
183_V187_T1.1111.00
151_S265_G1.1071.00
13_K23_A1.1071.00
251_L255_D1.1021.00
159_Q282_V1.1011.00
74_M77_I1.0981.00
128_I138_W1.0931.00
191_D215_K1.0901.00
39_K43_S1.0861.00
231_K252_I1.0821.00
37_A40_N1.0821.00
227_I231_K1.0671.00
96_V281_F1.0541.00
165_Y261_T1.0491.00
78_E82_Y1.0441.00
126_E219_T1.0391.00
172_P250_Q1.0331.00
171_P233_N1.0321.00
35_S39_K1.0261.00
105_S129_E1.0251.00
279_H283_K1.0241.00
82_Y86_N1.0231.00
20_I58_L1.0221.00
6_N9_H1.0151.00
76_G80_K1.0131.00
63_I66_E0.9971.00
14_V23_A0.9931.00
116_F120_Y0.9891.00
116_F284_V0.9831.00
115_A118_S0.9751.00
170_I174_R0.9751.00
67_I71_A0.9701.00
9_H79_S0.9661.00
241_N255_D0.9591.00
73_Q76_G0.9571.00
23_A34_V0.9491.00
40_N43_S0.9481.00
201_I204_S0.9481.00
114_A234_L0.9461.00
112_A285_L0.9461.00
60_L64_G0.9451.00
11_F49_L0.9411.00
193_I226_L0.9401.00
194_F216_E0.9371.00
14_V20_I0.9361.00
283_K286_K0.9321.00
157_E160_L0.9321.00
169_V244_L0.9311.00
66_E88_E0.9291.00
174_R177_L0.9271.00
15_G50_L0.9211.00
18_L59_M0.9201.00
231_K250_Q0.9171.00
29_I34_V0.9131.00
220_V226_L0.9121.00
11_F41_L0.9101.00
22_E26_E0.9091.00
200_E206_A0.9071.00
168_A236_I0.9021.00
206_A210_Y0.9021.00
79_S82_Y0.9001.00
78_E81_I0.8981.00
275_T278_A0.8951.00
80_K84_V0.8941.00
10_I27_L0.8911.00
138_W141_D0.8911.00
207_F212_I0.8891.00
69_L72_R0.8861.00
220_V229_M0.8841.00
6_N37_A0.8821.00
53_D57_G0.8811.00
102_P222_N0.8811.00
247_V250_Q0.8791.00
11_F60_L0.8751.00
276_P280_E0.8701.00
112_A284_V0.8691.00
21_T25_K0.8671.00
17_K23_A0.8661.00
245_S249_H0.8641.00
47_L85_A0.8611.00
9_H13_K0.8601.00
94_G277_A0.8571.00
77_I81_I0.8551.00
176_E181_K0.8551.00
167_V253_K0.8531.00
63_I88_E0.8521.00
247_V252_I0.8521.00
117_R234_L0.8441.00
79_S83_Q0.8421.00
18_L57_G0.8421.00
9_H12_V0.8401.00
15_G18_L0.8381.00
98_I146_I0.8371.00
136_K140_E0.8361.00
16_E68_L0.8311.00
174_R178_K0.8301.00
14_V50_L0.8291.00
99_G147_G0.8291.00
65_K68_L0.8241.00
248_P251_L0.8221.00
269_H272_E0.8161.00
151_S263_D0.8161.00
174_R191_D0.8141.00
165_Y255_D0.8141.00
128_I144_V0.8131.00
50_L58_L0.8121.00
186_E189_Q0.8121.00
81_I85_A0.8111.00
173_Q233_N0.8071.00
229_M234_L0.8061.00
31_Q35_S0.8031.00
63_I85_A0.8021.00
14_V38_I0.8011.00
274_I279_H0.8001.00
171_P174_R0.7981.00
27_L34_V0.7971.00
171_P234_L0.7951.00
14_V34_V0.7931.00
165_Y259_R0.7911.00
144_V147_G0.7901.00
206_A209_Q0.7891.00
99_G149_A0.7881.00
202_A205_N0.7841.00
222_N225_T0.7831.00
246_S250_Q0.7771.00
71_A74_M0.7751.00
280_E284_V0.7711.00
72_R76_G0.7701.00
100_S105_S0.7621.00
191_D216_E0.7621.00
184_D257_F0.7611.00
5_M75_K0.7611.00
116_F280_E0.7571.00
252_I255_D0.7531.00
20_I34_V0.7531.00
39_K48_K0.7491.00
202_A206_A0.7461.00
62_D66_E0.7461.00
169_V253_K0.7441.00
244_L247_V0.7431.00
123_I277_A0.7411.00
187_T190_D0.7401.00
124_R215_K0.7401.00
156_F267_I0.7391.00
106_T228_N0.7371.00
11_F67_I0.7371.00
51_I61_T0.7371.00
140_E156_F0.7371.00
7_H10_I0.7361.00
196_K219_T0.7331.00
142_R269_H0.7331.00
205_N209_Q0.7321.00
145_D278_A0.7311.00
203_M206_A0.7301.00
9_H75_K0.7301.00
111_Q114_A0.7291.00
169_V239_I0.7241.00
18_L65_K0.7221.00
15_G64_G0.7211.00
11_F64_G0.7211.00
168_A238_I0.7181.00
60_L65_K0.7171.00
192_L214_L0.7131.00
203_M207_F0.7131.00
155_P270_S0.7111.00
70_L74_M0.7061.00
6_N40_N0.7051.00
201_I207_F0.7011.00
92_L120_Y0.6981.00
204_S208_S0.6961.00
146_I281_F0.6921.00
179_L191_D0.6921.00
86_N89_N0.6911.00
97_K145_D0.6891.00
176_E180_E0.6891.00
15_G65_K0.6871.00
174_R236_I0.6871.00
94_G123_I0.6851.00
169_V237_G0.6821.00
174_R179_L0.6821.00
25_K28_F0.6811.00
33_A37_A0.6701.00
244_L248_P0.6661.00
272_E275_T0.6651.00
53_D56_H0.6651.00
51_I57_G0.6641.00
170_I176_E0.6631.00
189_Q212_I0.6631.00
251_L254_K0.6591.00
173_Q178_K0.6551.00
63_I67_I0.6551.00
59_M65_K0.6521.00
169_V248_P0.6451.00
67_I85_A0.6441.00
201_I206_A0.6421.00
75_K79_S0.6411.00
276_P279_H0.6411.00
119_N280_E0.6391.00
124_R219_T0.6361.00
218_L229_M0.6351.00
109_M112_A0.6341.00
80_K83_Q0.6281.00
97_K144_V0.6261.00
129_E221_Q0.6251.00
42_E52_R0.6241.00
205_N208_S0.6231.00
192_L236_I0.6211.00
150_A262_R0.6201.00
45_L67_I0.6131.00
281_F285_L0.6091.00
139_V156_F0.6091.00
177_L180_E0.6091.00
195_C226_L0.6081.00
240_S243_T0.6061.00
146_I282_V0.6061.00
196_K221_Q0.5991.00
102_P131_T0.5961.00
200_E205_N0.5921.00
220_V225_T0.5861.00
96_V146_I0.5851.00
176_E179_L0.5831.00
6_N10_I0.5811.00
84_V87_R0.5801.00
140_E143_T0.5791.00
14_V19_N0.5781.00
114_A117_R0.5771.00
66_E85_A0.5751.00
110_P114_A0.5751.00
120_Y123_I0.5731.00
108_I112_A0.5711.00
111_Q115_A0.5701.00
45_L48_K0.5701.00
76_G79_S0.5691.00
99_G130_G0.5691.00
277_A280_E0.5681.00
99_G128_I0.5681.00
170_I177_L0.5681.00
20_I31_Q0.5671.00
93_N124_R0.5641.00
23_A27_L0.5631.00
166_M238_I0.5631.00
83_Q87_R0.5621.00
200_E219_T0.5601.00
139_V267_I0.5591.00
186_E210_Y0.5561.00
100_S109_M0.5541.00
173_Q177_L0.5471.00
47_L51_I0.5421.00
168_A188_Y0.5411.00
100_S127_L0.5401.00
45_L85_A0.5381.00
50_L60_L0.5371.00
168_A192_L0.5351.00
268_A279_H0.5351.00
278_A282_V0.5341.00
48_K63_I0.5331.00
224_E228_N0.5311.00
192_L195_C0.5301.00
279_H282_V0.5301.00
8_L67_I0.5301.00
94_G122_L0.5301.00
111_Q228_N0.5291.00
81_I84_V0.5281.00
251_L256_I0.5281.00
18_L58_L0.5251.00
226_L230_V0.5251.00
71_A75_K0.5241.00
246_S249_H0.5221.00
40_N44_S0.5221.00
268_A274_I0.5211.00
33_A36_K0.5211.00
12_V79_S0.5201.00
38_I42_E0.5181.00
164_D262_R0.5181.00
204_S207_F0.5161.00
101_F104_V0.5161.00
45_L82_Y0.5151.00
83_Q86_N0.5151.00
32_P35_S0.5151.00
148_I285_L0.5141.00
32_P36_K0.5141.00
106_T222_N0.5131.00
99_G138_W0.5121.00
4_N40_N0.5071.00
47_L89_N0.5071.00
92_L122_L0.5041.00
87_R92_L0.5031.00
74_M82_Y0.5011.00
207_F210_Y0.5001.00
207_F214_L0.5001.00
239_I244_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9862 100 0.12 Contact Map
1ixcA 4 0.9828 100 0.122 Contact Map
2h98A 2 0.6759 100 0.128 Contact Map
2h9bA 2 0.6759 100 0.129 Contact Map
3fzvA 4 0.969 100 0.129 Contact Map
1uthA 2 0.7379 100 0.137 Contact Map
3fxqA 3 0.9828 100 0.138 Contact Map
1al3A 1 0.6931 100 0.138 Contact Map
4x6gA 4 0.9862 100 0.151 Contact Map
3hhgA 3 0.9828 100 0.152 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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