GREMLIN Database
YTAB - Uncharacterized membrane protein YtaB
UniProt: O34694 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 155 (147)
Sequences: 1745 (1371)
Seq/√Len: 113.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_A141_A4.3241.00
94_F107_D3.7191.00
115_A140_S3.6591.00
64_I126_S3.5491.00
40_W145_F3.2931.00
45_T49_I3.0891.00
102_L151_N2.8641.00
105_S148_F2.5591.00
15_Y56_A2.4211.00
118_L133_L2.3161.00
80_T121_I2.2041.00
149_T152_S2.1011.00
105_S147_S2.0221.00
61_S133_L2.0121.00
87_L114_T1.9681.00
119_L130_S1.8971.00
17_L89_Q1.8911.00
148_F152_S1.8371.00
31_W101_L1.8141.00
112_A140_S1.7941.00
108_C144_T1.7501.00
69_F74_A1.7161.00
149_T153_M1.6841.00
123_K130_S1.6601.00
7_A63_A1.6191.00
118_L122_A1.5821.00
37_K41_T1.5181.00
14_T81_L1.5101.00
31_W99_K1.4911.00
94_F104_A1.4611.00
112_A144_T1.4601.00
62_A78_W1.4291.00
80_T117_V1.4261.00
131_Y134_L1.3911.00
36_K153_M1.3201.00
55_F88_N1.2880.99
119_L133_L1.2820.99
119_L137_F1.2710.99
10_V62_A1.2700.99
32_Y41_T1.2380.99
40_W149_T1.2380.99
108_C147_S1.2360.99
39_D149_T1.2150.99
65_V122_A1.2030.99
52_A56_A1.1970.99
87_L107_D1.1940.99
68_A126_S1.1790.99
33_N44_G1.1740.99
15_Y18_F1.1700.99
14_T59_S1.1540.99
31_W41_T1.1520.99
77_F125_Y1.1500.99
145_F149_T1.1360.99
62_A81_L1.1200.98
61_S129_A1.1150.98
11_F59_S1.0930.98
117_V121_I1.0860.98
111_V136_Y1.0740.98
116_I137_F1.0690.98
58_I62_A1.0670.98
11_F15_Y1.0670.98
39_D145_F1.0590.98
101_L151_N1.0490.98
101_L150_I1.0460.98
123_K131_Y1.0370.97
61_S118_L1.0310.97
14_T62_A1.0260.97
123_K127_R1.0110.97
45_T48_G1.0080.97
65_V125_Y1.0010.97
138_L142_F0.9930.97
76_S121_I0.9860.97
105_S144_T0.9860.97
86_V90_A0.9720.96
10_V81_L0.9580.96
90_A107_D0.9570.96
100_N103_A0.9550.96
104_A107_D0.9540.96
81_L122_A0.9530.96
91_F147_S0.9470.96
112_A115_A0.9330.95
10_V66_Y0.9320.95
18_F59_S0.9250.95
64_I67_A0.9170.95
37_K150_I0.9150.95
93_Y98_Q0.9060.94
31_W37_K0.9060.94
17_L21_A0.8970.94
111_V115_A0.8860.94
88_N136_Y0.8780.93
50_I54_L0.8760.93
134_L138_L0.8710.93
63_A67_A0.8700.93
100_N104_A0.8680.93
38_P149_T0.8620.93
91_F95_Q0.8610.93
28_D44_G0.8600.93
21_A24_L0.8550.93
65_V77_F0.8520.92
87_L110_L0.8500.92
40_W142_F0.8320.92
25_F92_S0.8280.91
19_S23_Y0.8210.91
84_N118_L0.8200.91
78_W82_L0.8180.91
79_F83_I0.8140.91
128_A131_Y0.8070.90
71_F74_A0.8050.90
85_Y89_Q0.8030.90
122_A130_S0.7980.90
77_F122_A0.7950.90
127_R131_Y0.7880.89
112_A137_F0.7870.89
144_T148_F0.7810.89
77_F118_L0.7720.88
24_L97_T0.7710.88
31_W44_G0.7700.88
49_I53_I0.7690.88
54_L58_I0.7680.88
41_T150_I0.7680.88
69_F125_Y0.7640.88
14_T58_I0.7590.87
89_Q93_Y0.7550.87
28_D33_N0.7510.87
46_A50_I0.7490.87
95_Q150_I0.7480.87
121_I124_K0.7460.86
15_Y21_A0.7430.86
48_G52_A0.7430.86
20_A24_L0.7410.86
21_A25_F0.7410.86
116_I120_I0.7370.86
62_A66_Y0.7320.85
25_F28_D0.7300.85
21_A89_Q0.7260.85
70_S74_A0.7250.85
84_N115_A0.7220.85
7_A11_F0.7210.85
143_A146_L0.7160.84
94_F103_A0.7150.84
109_L113_I0.7130.84
98_Q101_L0.7040.83
38_P153_M0.7040.83
41_T142_F0.7030.83
31_W35_L0.7010.83
38_P46_A0.6960.82
7_A60_L0.6890.82
19_S22_G0.6870.82
11_F18_F0.6860.81
112_A116_I0.6800.81
84_N88_N0.6790.81
120_I124_K0.6750.80
142_F145_F0.6740.80
84_N114_T0.6730.80
61_S65_V0.6670.80
80_T118_L0.6620.79
49_I52_A0.6610.79
132_L135_P0.6610.79
47_I91_F0.6590.79
80_T114_T0.6550.78
59_S63_A0.6510.78
120_I131_Y0.6460.77
28_D31_W0.6450.77
36_K79_F0.6450.77
115_A118_L0.6420.77
105_S109_L0.6400.77
55_F136_Y0.6390.77
68_A74_A0.6380.77
137_F140_S0.6300.76
66_Y78_W0.6270.75
57_L61_S0.6230.75
30_E34_S0.6210.75
48_G143_A0.6120.74
46_A49_I0.6090.73
77_F121_I0.6040.73
14_T17_L0.6010.72
40_W153_M0.6000.72
82_L86_V0.5980.72
29_Q33_N0.5980.72
83_I114_T0.5960.72
55_F89_Q0.5910.71
55_F58_I0.5910.71
81_L85_Y0.5910.71
84_N87_L0.5900.71
59_S62_A0.5880.71
107_D114_T0.5780.69
58_I118_L0.5720.69
21_A93_Y0.5720.69
59_S89_Q0.5700.68
94_F100_N0.5700.68
10_V63_A0.5680.68
7_A10_V0.5660.68
18_F89_Q0.5640.67
58_I85_Y0.5640.67
18_F21_A0.5620.67
107_D110_L0.5530.66
108_C140_S0.5520.66
102_L106_L0.5500.66
55_F93_Y0.5460.65
16_A19_S0.5450.65
61_S122_A0.5400.64
81_L133_L0.5380.64
58_I84_N0.5360.64
76_S83_I0.5360.64
46_A142_F0.5350.63
69_F75_K0.5300.63
54_L88_N0.5300.63
84_N111_V0.5260.62
9_A13_I0.5230.62
13_I17_L0.5220.62
10_V14_T0.5220.62
122_A129_A0.5220.62
142_F146_L0.5140.60
76_S79_F0.5130.60
57_L60_L0.5070.59
22_G26_P0.5060.59
89_Q92_S0.5050.59
39_D152_S0.5010.58
41_T49_I0.5000.58
83_I86_V0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ryoA 1 0.9677 100 0.12 Contact Map
4uc1A 3 0.9742 100 0.158 Contact Map
2mgyA 1 1 100 0.179 Contact Map
1yewC 1 0.5742 46.5 0.922 Contact Map
4phzK 1 0.7484 22.2 0.934 Contact Map
4ev6A 3 0.4129 6 0.949 Contact Map
4i0uA 4 0.4 4.7 0.951 Contact Map
3b5dA 2 0.6516 3.9 0.953 Contact Map
3dh4A 3 0.4323 2.7 0.957 Contact Map
4cadC 1 0.7419 1.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.