MHQA - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

MHQA - Putative ring-cleaving dioxygenase MhqA

UniProt:	O34689	Sequences: MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMYHLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQVTHSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVELTVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRERQGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELSTDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (303)
Sequences:	1307 (851)
Seq/√Len:	48.9

BACSU - MHQA MHQO MHQE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
89_A	150_F	4.326	1.00
59_L	82_L	3.929	1.00
84_V	90_L	3.880	1.00
290_E	293_Q	3.630	1.00
94_K	106_G	3.599	1.00
17_Q	21_D	3.595	1.00
169_L	195_L	3.517	1.00
230_R	278_D	3.506	1.00
50_D	54_N	3.435	1.00
21_D	25_K	3.232	1.00
262_A	276_S	3.182	1.00
158_V	227_V	2.914	1.00
180_E	183_R	2.848	1.00
234_E	261_K	2.838	1.00
9_V	158_V	2.751	1.00
287_N	290_E	2.700	1.00
283_M	288_L	2.582	1.00
88_E	130_A	2.508	1.00
92_Y	146_I	2.491	1.00
97_F	104_H	2.429	1.00
231_V	275_L	2.393	1.00
194_I	207_H	2.372	1.00
92_Y	96_R	2.306	1.00
4_N	232_R	2.280	1.00
95_E	99_E	2.239	1.00
70_F	223_S	2.220	1.00
49_G	58_E	2.138	1.00
47_F	58_E	2.135	1.00
12_L	67_I	2.118	1.00
18_K	122_E	2.078	1.00
179_T	196_E	2.064	1.00
109_K	114_D	2.047	1.00
180_E	195_L	2.045	1.00
304_R	307_E	1.965	0.99
26_V	100_Q	1.922	0.99
181_I	196_E	1.909	0.99
67_I	221_K	1.904	0.99
211_R	214_L	1.840	0.99
238_A	254_I	1.821	0.99
110_R	127_V	1.814	0.99
266_R	272_L	1.813	0.99
170_H	174_N	1.803	0.99
29_L	82_L	1.792	0.99
165_A	210_E	1.764	0.99
302_E	305_R	1.746	0.99
38_Q	47_F	1.687	0.98
297_L	305_R	1.684	0.98
86_G	132_E	1.683	0.98
82_L	155_L	1.661	0.98
147_P	150_F	1.648	0.98
169_L	208_L	1.644	0.98
103_T	119_Q	1.644	0.98
184_E	190_G	1.638	0.98
40_E	43_M	1.623	0.98
180_E	193_V	1.617	0.98
15_D	65_P	1.594	0.97
23_Y	126_L	1.591	0.97
78_S	161_T	1.538	0.97
233_D	236_E	1.521	0.97
84_V	128_L	1.520	0.97
47_F	259_Y	1.518	0.97
234_E	238_A	1.475	0.96
35_S	259_Y	1.474	0.96
105_S	117_A	1.468	0.96
72_A	119_Q	1.459	0.96
74_T	163_P	1.446	0.95
14_A	221_K	1.430	0.95
12_L	40_E	1.425	0.95
30_K	141_V	1.424	0.95
19_N	48_Y	1.423	0.95
301_L	304_R	1.401	0.95
235_E	239_G	1.399	0.95
11_A	124_Q	1.389	0.94
232_R	236_E	1.379	0.94
86_G	130_A	1.378	0.94
241_H	245_S	1.360	0.94
183_R	193_V	1.344	0.93
113_R	207_H	1.340	0.93
184_E	207_H	1.333	0.93
171_V	176_L	1.329	0.93
51_E	288_L	1.323	0.93
20_L	31_L	1.313	0.92
113_R	194_I	1.312	0.92
178_F	229_F	1.304	0.92
36_V	301_L	1.290	0.92
169_L	180_E	1.290	0.92
26_V	121_H	1.287	0.92
13_T	16_A	1.286	0.92
43_M	64_I	1.286	0.92
192_A	209_I	1.283	0.92
258_Y	299_P	1.278	0.91
165_A	193_V	1.271	0.91
105_S	119_Q	1.266	0.91
265_F	275_L	1.264	0.91
19_N	61_F	1.252	0.91
259_Y	296_A	1.246	0.90
35_S	38_Q	1.246	0.90
251_N	263_L	1.238	0.90
94_K	98_E	1.232	0.90
98_E	104_H	1.231	0.90
9_V	80_I	1.227	0.90
243_I	247_E	1.222	0.89
77_I	271_I	1.218	0.89
184_E	194_I	1.217	0.89
52_V	288_L	1.212	0.89
31_L	46_L	1.205	0.89
32_V	49_G	1.201	0.89
83_R	131_D	1.186	0.88
74_T	214_L	1.178	0.88
91_H	95_E	1.178	0.88
97_F	128_L	1.175	0.88
33_K	286_E	1.166	0.87
82_L	152_F	1.161	0.87
81_G	129_T	1.160	0.87
109_K	112_G	1.160	0.87
160_L	168_T	1.155	0.87
14_A	122_E	1.152	0.86
94_K	116_L	1.144	0.86
285_D	291_L	1.143	0.86
13_T	63_E	1.127	0.85
92_Y	147_P	1.118	0.85
80_I	224_V	1.111	0.84
259_Y	282_F	1.104	0.84
12_L	64_I	1.098	0.84
15_D	18_K	1.097	0.84
38_Q	258_Y	1.094	0.83
304_R	308_I	1.093	0.83
242_R	246_R	1.089	0.83
77_I	224_V	1.083	0.83
10_S	64_I	1.074	0.82
91_H	94_K	1.072	0.82
307_E	311_K	1.064	0.82
231_V	236_E	1.061	0.82
40_E	64_I	1.061	0.82
83_R	156_G	1.059	0.81
27_L	152_F	1.059	0.81
219_Q	223_S	1.054	0.81
241_H	255_V	1.038	0.80
23_Y	61_F	1.036	0.80
50_D	53_A	1.036	0.80
9_V	155_L	1.029	0.80
11_A	59_L	1.027	0.79
76_S	217_E	1.025	0.79
81_G	156_G	1.025	0.79
46_L	315_I	1.025	0.79
160_L	271_I	1.018	0.79
172_L	273_F	1.013	0.78
10_S	43_M	1.010	0.78
20_L	315_I	1.005	0.78
16_A	43_M	1.000	0.78
117_A	127_V	0.995	0.77
38_Q	58_E	0.994	0.77
240_W	275_L	0.982	0.76
38_Q	296_A	0.979	0.76
305_R	309_E	0.976	0.76
297_L	302_E	0.973	0.76
242_R	245_S	0.969	0.75
130_A	203_A	0.968	0.75
303_H	308_I	0.968	0.75
113_R	205_E	0.950	0.74
241_H	254_I	0.950	0.74
237_L	262_A	0.948	0.74
79_S	127_V	0.940	0.73
95_E	98_E	0.936	0.73
115_I	127_V	0.934	0.73
144_S	151_S	0.932	0.72
33_K	259_Y	0.928	0.72
206_I	229_F	0.927	0.72
36_V	297_L	0.923	0.72
18_K	21_D	0.922	0.72
21_D	192_A	0.916	0.71
97_F	100_Q	0.915	0.71
81_G	159_E	0.910	0.71
168_T	267_E	0.906	0.70
86_G	89_A	0.906	0.70
286_E	291_L	0.904	0.70
183_R	190_G	0.892	0.69
209_I	214_L	0.891	0.69
16_A	46_L	0.891	0.69
92_Y	143_Q	0.890	0.69
47_F	296_A	0.885	0.68
255_V	263_L	0.874	0.67
237_L	254_I	0.870	0.67
92_Y	145_G	0.869	0.67
43_M	63_E	0.866	0.67
53_A	57_T	0.864	0.67
302_E	308_I	0.861	0.66
34_K	44_Y	0.860	0.66
283_M	291_L	0.859	0.66
6_I	77_I	0.849	0.65
258_Y	296_A	0.849	0.65
50_D	55_P	0.844	0.65
79_S	119_Q	0.841	0.64
50_D	288_L	0.838	0.64
70_F	217_E	0.837	0.64
239_G	242_R	0.833	0.64
237_L	255_V	0.831	0.63
281_G	292_G	0.829	0.63
312_L	315_I	0.827	0.63
300_Y	308_I	0.825	0.63
228_A	276_S	0.823	0.63
12_L	219_Q	0.821	0.63
71_H	218_R	0.821	0.63
37_N	62_F	0.820	0.62
253_G	258_Y	0.818	0.62
114_D	130_A	0.817	0.62
38_Q	255_V	0.813	0.62
15_D	313_K	0.813	0.62
14_A	57_T	0.812	0.62
35_S	58_E	0.809	0.61
92_Y	150_F	0.807	0.61
119_Q	123_G	0.802	0.61
194_I	205_E	0.801	0.61
300_Y	303_H	0.800	0.61
228_A	262_A	0.796	0.60
12_L	43_M	0.795	0.60
85_P	88_E	0.794	0.60
204_T	240_W	0.794	0.60
256_E	300_Y	0.791	0.60
119_Q	125_R	0.791	0.60
16_A	34_K	0.789	0.59
238_A	241_H	0.788	0.59
307_E	310_A	0.787	0.59
166_E	170_H	0.784	0.59
52_V	283_M	0.774	0.58
169_L	173_T	0.772	0.58
36_V	300_Y	0.771	0.58
13_T	46_L	0.770	0.58
96_R	100_Q	0.768	0.57
183_R	191_T	0.767	0.57
241_H	251_N	0.767	0.57
46_L	129_T	0.765	0.57
143_Q	146_I	0.765	0.57
92_Y	144_S	0.763	0.57
159_E	209_I	0.762	0.57
10_S	217_E	0.760	0.57
306_A	310_A	0.759	0.56
5_G	28_G	0.758	0.56
181_I	205_E	0.756	0.56
241_H	252_S	0.755	0.56
122_E	221_K	0.753	0.56
63_E	313_K	0.753	0.56
68_A	71_H	0.753	0.56
83_R	138_G	0.753	0.56
39_D	44_Y	0.750	0.56
254_I	261_K	0.750	0.56
113_R	198_G	0.746	0.55
106_G	116_L	0.745	0.55
111_A	184_E	0.744	0.55
67_I	315_I	0.743	0.55
39_D	224_V	0.741	0.55
61_F	280_P	0.741	0.55
39_D	62_F	0.741	0.55
44_Y	225_H	0.737	0.54
162_V	165_A	0.734	0.54
50_D	56_G	0.722	0.53
23_Y	59_L	0.722	0.53
260_F	264_Y	0.718	0.52
72_A	76_S	0.717	0.52
20_L	231_V	0.713	0.52
176_L	243_I	0.712	0.52
71_H	116_L	0.710	0.52
258_Y	300_Y	0.707	0.51
33_K	285_D	0.704	0.51
4_N	231_V	0.703	0.51
171_V	265_F	0.702	0.51
25_K	100_Q	0.700	0.51
110_R	207_H	0.700	0.51
198_G	201_G	0.699	0.50
93_W	228_A	0.699	0.50
305_R	308_I	0.697	0.50
36_V	305_R	0.688	0.49
184_E	192_A	0.688	0.49
142_K	147_P	0.688	0.49
267_E	270_G	0.687	0.49
231_V	237_L	0.686	0.49
99_E	104_H	0.685	0.49
105_S	116_L	0.684	0.49
111_A	182_S	0.683	0.49
175_I	243_I	0.680	0.48
162_V	201_G	0.677	0.48
259_Y	292_G	0.677	0.48
30_K	293_Q	0.676	0.48
158_V	178_F	0.672	0.48
38_Q	253_G	0.669	0.47
301_L	308_I	0.668	0.47
217_E	223_S	0.667	0.47
262_A	279_G	0.667	0.47
97_F	102_V	0.663	0.47
97_F	126_L	0.660	0.46
80_I	124_Q	0.660	0.46
13_T	122_E	0.658	0.46
258_Y	308_I	0.655	0.46
265_F	273_F	0.655	0.46
69_P	221_K	0.653	0.46
32_V	292_G	0.653	0.46
237_L	263_L	0.652	0.46
252_S	272_L	0.652	0.46
170_H	208_L	0.652	0.46
148_E	153_R	0.652	0.46
55_P	230_R	0.651	0.46
171_V	268_P	0.649	0.45
63_E	217_E	0.648	0.45
64_I	221_K	0.648	0.45
38_Q	259_Y	0.645	0.45
76_S	124_Q	0.643	0.45
72_A	125_R	0.643	0.45
59_L	80_I	0.642	0.45
241_H	263_L	0.642	0.45
295_I	309_E	0.640	0.44
19_N	267_E	0.639	0.44
244_I	265_F	0.639	0.44
95_E	148_E	0.638	0.44
17_Q	313_K	0.637	0.44
174_N	208_L	0.637	0.44
285_D	292_G	0.637	0.44
71_H	215_P	0.636	0.44
158_V	206_I	0.635	0.44
164_Y	210_E	0.634	0.44
57_T	204_T	0.631	0.44
23_Y	120_D	0.630	0.43
142_K	148_E	0.627	0.43
17_Q	25_K	0.626	0.43
72_A	223_S	0.625	0.43
64_I	219_Q	0.624	0.43
32_V	291_L	0.624	0.43
171_V	208_L	0.622	0.43
69_P	208_L	0.621	0.43
45_H	60_T	0.620	0.42
35_S	296_A	0.620	0.42
170_H	247_E	0.619	0.42
175_I	208_L	0.617	0.42
248_G	251_N	0.617	0.42
21_D	26_V	0.616	0.42
20_L	24_K	0.615	0.42
168_T	227_V	0.614	0.42
262_A	284_V	0.612	0.42
99_E	235_E	0.611	0.42
84_V	116_L	0.609	0.41
19_N	122_E	0.606	0.41
76_S	223_S	0.605	0.41
30_K	291_L	0.604	0.41
54_N	108_S	0.603	0.41
37_N	305_R	0.602	0.41
51_E	151_S	0.602	0.41
49_G	57_T	0.601	0.41
176_L	238_A	0.599	0.40
31_L	176_L	0.596	0.40
89_A	96_R	0.596	0.40
135_K	138_G	0.595	0.40
268_P	271_I	0.594	0.40
70_F	151_S	0.593	0.40
84_V	158_V	0.593	0.40
265_F	272_L	0.592	0.40
287_N	293_Q	0.589	0.39
6_I	155_L	0.589	0.39
43_M	221_K	0.588	0.39
116_L	310_A	0.587	0.39
4_N	199_E	0.586	0.39
84_V	94_K	0.582	0.39
245_S	248_G	0.582	0.39
75_N	252_S	0.581	0.39
100_Q	146_I	0.580	0.39
245_S	251_N	0.580	0.39
234_E	279_G	0.578	0.38
123_G	272_L	0.578	0.38
162_V	167_P	0.578	0.38
300_Y	304_R	0.576	0.38
106_G	114_D	0.576	0.38
70_F	127_V	0.575	0.38
164_Y	170_H	0.574	0.38
166_E	210_E	0.574	0.38
34_K	309_E	0.573	0.38
42_T	242_R	0.573	0.38
82_L	271_I	0.573	0.38
91_H	116_L	0.572	0.38
251_N	255_V	0.571	0.38
264_Y	274_E	0.571	0.38
58_E	258_Y	0.569	0.38
168_T	269_N	0.569	0.38
261_K	275_L	0.569	0.38
286_E	292_G	0.569	0.38
126_L	160_L	0.566	0.37
49_G	231_V	0.565	0.37
125_R	230_R	0.563	0.37
259_Y	286_E	0.560	0.37
36_V	43_M	0.560	0.37
231_V	262_A	0.557	0.36
180_E	208_L	0.555	0.36
68_A	221_K	0.554	0.36
75_N	163_P	0.553	0.36
111_A	194_I	0.553	0.36
259_Y	285_D	0.552	0.36
110_R	115_I	0.552	0.36
288_L	291_L	0.550	0.36
66_R	223_S	0.549	0.36
177_G	206_I	0.546	0.35
280_P	285_D	0.546	0.35
281_G	285_D	0.545	0.35
218_R	308_I	0.545	0.35
213_D	268_P	0.544	0.35
105_S	108_S	0.540	0.35
258_Y	284_V	0.540	0.35
176_L	247_E	0.540	0.35
159_E	192_A	0.538	0.35
23_Y	267_E	0.538	0.35
93_W	262_A	0.537	0.35
5_G	10_S	0.536	0.34
16_A	65_P	0.535	0.34
233_D	279_G	0.535	0.34
83_R	253_G	0.534	0.34
229_F	273_F	0.533	0.34
288_L	293_Q	0.533	0.34
134_G	138_G	0.531	0.34
6_I	118_F	0.531	0.34
58_E	282_F	0.531	0.34
191_T	211_R	0.530	0.34
63_E	269_N	0.529	0.34
260_F	274_E	0.529	0.34
103_T	213_D	0.526	0.34
28_G	50_D	0.523	0.33
96_R	104_H	0.523	0.33
29_L	283_M	0.521	0.33
193_V	210_E	0.520	0.33
165_A	208_L	0.519	0.33
61_F	120_D	0.518	0.33
85_P	152_F	0.518	0.33
79_S	117_A	0.518	0.33
48_Y	223_S	0.517	0.33
32_V	58_E	0.516	0.33
10_S	63_E	0.516	0.33
6_I	178_F	0.515	0.33
29_L	59_L	0.514	0.32
62_F	308_I	0.514	0.32
157_P	201_G	0.513	0.32
6_I	10_S	0.512	0.32
163_P	214_L	0.512	0.32
41_P	311_K	0.511	0.32
11_A	224_V	0.510	0.32
228_A	264_Y	0.510	0.32
224_V	263_L	0.508	0.32
50_D	309_E	0.508	0.32
160_L	216_R	0.508	0.32
245_S	310_A	0.506	0.32
120_D	267_E	0.506	0.32
47_F	63_E	0.506	0.32
280_P	286_E	0.505	0.32
55_P	278_D	0.505	0.32
166_E	169_L	0.504	0.32
49_G	263_L	0.503	0.31
100_Q	104_H	0.502	0.31
157_P	161_T	0.500	0.31
172_L	208_L	0.500	0.31
78_S	159_E	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3oajA	2	0.9652	100	0.44	Contact Map
4huzA	2	0.962	100	0.567	Contact Map
1zswA	1	0.981	100	0.587	Contact Map
3e0rA	1	0.7342	100	0.729	Contact Map
2ehzA	5	0.8829	100	0.754	Contact Map
3vb0A	1	0.8386	100	0.756	Contact Map
4ro6A	1	0.8418	100	0.757	Contact Map
2zyqA	2	0.8608	100	0.758	Contact Map
3hpyA	4	0.8513	100	0.758	Contact Map
1mpyA	3	0.9019	100	0.759	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.