GREMLIN Database
MHQA - Putative ring-cleaving dioxygenase MhqA
UniProt: O34689 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (303)
Sequences: 1307 (851)
Seq/√Len: 48.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_A150_F4.3261.00
59_L82_L3.9291.00
84_V90_L3.8801.00
290_E293_Q3.6301.00
94_K106_G3.5991.00
17_Q21_D3.5951.00
169_L195_L3.5171.00
230_R278_D3.5061.00
50_D54_N3.4351.00
21_D25_K3.2321.00
262_A276_S3.1821.00
158_V227_V2.9141.00
180_E183_R2.8481.00
234_E261_K2.8381.00
9_V158_V2.7511.00
287_N290_E2.7001.00
283_M288_L2.5821.00
88_E130_A2.5081.00
92_Y146_I2.4911.00
97_F104_H2.4291.00
231_V275_L2.3931.00
194_I207_H2.3721.00
92_Y96_R2.3061.00
4_N232_R2.2801.00
95_E99_E2.2391.00
70_F223_S2.2201.00
49_G58_E2.1381.00
47_F58_E2.1351.00
12_L67_I2.1181.00
18_K122_E2.0781.00
179_T196_E2.0641.00
109_K114_D2.0471.00
180_E195_L2.0451.00
304_R307_E1.9650.99
26_V100_Q1.9220.99
181_I196_E1.9090.99
67_I221_K1.9040.99
211_R214_L1.8400.99
238_A254_I1.8210.99
110_R127_V1.8140.99
266_R272_L1.8130.99
170_H174_N1.8030.99
29_L82_L1.7920.99
165_A210_E1.7640.99
302_E305_R1.7460.99
38_Q47_F1.6870.98
297_L305_R1.6840.98
86_G132_E1.6830.98
82_L155_L1.6610.98
147_P150_F1.6480.98
169_L208_L1.6440.98
103_T119_Q1.6440.98
184_E190_G1.6380.98
40_E43_M1.6230.98
180_E193_V1.6170.98
15_D65_P1.5940.97
23_Y126_L1.5910.97
78_S161_T1.5380.97
233_D236_E1.5210.97
84_V128_L1.5200.97
47_F259_Y1.5180.97
234_E238_A1.4750.96
35_S259_Y1.4740.96
105_S117_A1.4680.96
72_A119_Q1.4590.96
74_T163_P1.4460.95
14_A221_K1.4300.95
12_L40_E1.4250.95
30_K141_V1.4240.95
19_N48_Y1.4230.95
301_L304_R1.4010.95
235_E239_G1.3990.95
11_A124_Q1.3890.94
232_R236_E1.3790.94
86_G130_A1.3780.94
241_H245_S1.3600.94
183_R193_V1.3440.93
113_R207_H1.3400.93
184_E207_H1.3330.93
171_V176_L1.3290.93
51_E288_L1.3230.93
20_L31_L1.3130.92
113_R194_I1.3120.92
178_F229_F1.3040.92
36_V301_L1.2900.92
169_L180_E1.2900.92
26_V121_H1.2870.92
13_T16_A1.2860.92
43_M64_I1.2860.92
192_A209_I1.2830.92
258_Y299_P1.2780.91
165_A193_V1.2710.91
105_S119_Q1.2660.91
265_F275_L1.2640.91
19_N61_F1.2520.91
259_Y296_A1.2460.90
35_S38_Q1.2460.90
251_N263_L1.2380.90
94_K98_E1.2320.90
98_E104_H1.2310.90
9_V80_I1.2270.90
243_I247_E1.2220.89
77_I271_I1.2180.89
184_E194_I1.2170.89
52_V288_L1.2120.89
31_L46_L1.2050.89
32_V49_G1.2010.89
83_R131_D1.1860.88
74_T214_L1.1780.88
91_H95_E1.1780.88
97_F128_L1.1750.88
33_K286_E1.1660.87
82_L152_F1.1610.87
81_G129_T1.1600.87
109_K112_G1.1600.87
160_L168_T1.1550.87
14_A122_E1.1520.86
94_K116_L1.1440.86
285_D291_L1.1430.86
13_T63_E1.1270.85
92_Y147_P1.1180.85
80_I224_V1.1110.84
259_Y282_F1.1040.84
12_L64_I1.0980.84
15_D18_K1.0970.84
38_Q258_Y1.0940.83
304_R308_I1.0930.83
242_R246_R1.0890.83
77_I224_V1.0830.83
10_S64_I1.0740.82
91_H94_K1.0720.82
307_E311_K1.0640.82
231_V236_E1.0610.82
40_E64_I1.0610.82
83_R156_G1.0590.81
27_L152_F1.0590.81
219_Q223_S1.0540.81
241_H255_V1.0380.80
23_Y61_F1.0360.80
50_D53_A1.0360.80
9_V155_L1.0290.80
11_A59_L1.0270.79
76_S217_E1.0250.79
81_G156_G1.0250.79
46_L315_I1.0250.79
160_L271_I1.0180.79
172_L273_F1.0130.78
10_S43_M1.0100.78
20_L315_I1.0050.78
16_A43_M1.0000.78
117_A127_V0.9950.77
38_Q58_E0.9940.77
240_W275_L0.9820.76
38_Q296_A0.9790.76
305_R309_E0.9760.76
297_L302_E0.9730.76
242_R245_S0.9690.75
130_A203_A0.9680.75
303_H308_I0.9680.75
113_R205_E0.9500.74
241_H254_I0.9500.74
237_L262_A0.9480.74
79_S127_V0.9400.73
95_E98_E0.9360.73
115_I127_V0.9340.73
144_S151_S0.9320.72
33_K259_Y0.9280.72
206_I229_F0.9270.72
36_V297_L0.9230.72
18_K21_D0.9220.72
21_D192_A0.9160.71
97_F100_Q0.9150.71
81_G159_E0.9100.71
168_T267_E0.9060.70
86_G89_A0.9060.70
286_E291_L0.9040.70
183_R190_G0.8920.69
209_I214_L0.8910.69
16_A46_L0.8910.69
92_Y143_Q0.8900.69
47_F296_A0.8850.68
255_V263_L0.8740.67
237_L254_I0.8700.67
92_Y145_G0.8690.67
43_M63_E0.8660.67
53_A57_T0.8640.67
302_E308_I0.8610.66
34_K44_Y0.8600.66
283_M291_L0.8590.66
6_I77_I0.8490.65
258_Y296_A0.8490.65
50_D55_P0.8440.65
79_S119_Q0.8410.64
50_D288_L0.8380.64
70_F217_E0.8370.64
239_G242_R0.8330.64
237_L255_V0.8310.63
281_G292_G0.8290.63
312_L315_I0.8270.63
300_Y308_I0.8250.63
228_A276_S0.8230.63
12_L219_Q0.8210.63
71_H218_R0.8210.63
37_N62_F0.8200.62
253_G258_Y0.8180.62
114_D130_A0.8170.62
38_Q255_V0.8130.62
15_D313_K0.8130.62
14_A57_T0.8120.62
35_S58_E0.8090.61
92_Y150_F0.8070.61
119_Q123_G0.8020.61
194_I205_E0.8010.61
300_Y303_H0.8000.61
228_A262_A0.7960.60
12_L43_M0.7950.60
85_P88_E0.7940.60
204_T240_W0.7940.60
256_E300_Y0.7910.60
119_Q125_R0.7910.60
16_A34_K0.7890.59
238_A241_H0.7880.59
307_E310_A0.7870.59
166_E170_H0.7840.59
52_V283_M0.7740.58
169_L173_T0.7720.58
36_V300_Y0.7710.58
13_T46_L0.7700.58
96_R100_Q0.7680.57
183_R191_T0.7670.57
241_H251_N0.7670.57
46_L129_T0.7650.57
143_Q146_I0.7650.57
92_Y144_S0.7630.57
159_E209_I0.7620.57
10_S217_E0.7600.57
306_A310_A0.7590.56
5_G28_G0.7580.56
181_I205_E0.7560.56
241_H252_S0.7550.56
122_E221_K0.7530.56
63_E313_K0.7530.56
68_A71_H0.7530.56
83_R138_G0.7530.56
39_D44_Y0.7500.56
254_I261_K0.7500.56
113_R198_G0.7460.55
106_G116_L0.7450.55
111_A184_E0.7440.55
67_I315_I0.7430.55
39_D224_V0.7410.55
61_F280_P0.7410.55
39_D62_F0.7410.55
44_Y225_H0.7370.54
162_V165_A0.7340.54
50_D56_G0.7220.53
23_Y59_L0.7220.53
260_F264_Y0.7180.52
72_A76_S0.7170.52
20_L231_V0.7130.52
176_L243_I0.7120.52
71_H116_L0.7100.52
258_Y300_Y0.7070.51
33_K285_D0.7040.51
4_N231_V0.7030.51
171_V265_F0.7020.51
25_K100_Q0.7000.51
110_R207_H0.7000.51
198_G201_G0.6990.50
93_W228_A0.6990.50
305_R308_I0.6970.50
36_V305_R0.6880.49
184_E192_A0.6880.49
142_K147_P0.6880.49
267_E270_G0.6870.49
231_V237_L0.6860.49
99_E104_H0.6850.49
105_S116_L0.6840.49
111_A182_S0.6830.49
175_I243_I0.6800.48
162_V201_G0.6770.48
259_Y292_G0.6770.48
30_K293_Q0.6760.48
158_V178_F0.6720.48
38_Q253_G0.6690.47
301_L308_I0.6680.47
217_E223_S0.6670.47
262_A279_G0.6670.47
97_F102_V0.6630.47
97_F126_L0.6600.46
80_I124_Q0.6600.46
13_T122_E0.6580.46
258_Y308_I0.6550.46
265_F273_F0.6550.46
69_P221_K0.6530.46
32_V292_G0.6530.46
237_L263_L0.6520.46
252_S272_L0.6520.46
170_H208_L0.6520.46
148_E153_R0.6520.46
55_P230_R0.6510.46
171_V268_P0.6490.45
63_E217_E0.6480.45
64_I221_K0.6480.45
38_Q259_Y0.6450.45
76_S124_Q0.6430.45
72_A125_R0.6430.45
59_L80_I0.6420.45
241_H263_L0.6420.45
295_I309_E0.6400.44
19_N267_E0.6390.44
244_I265_F0.6390.44
95_E148_E0.6380.44
17_Q313_K0.6370.44
174_N208_L0.6370.44
285_D292_G0.6370.44
71_H215_P0.6360.44
158_V206_I0.6350.44
164_Y210_E0.6340.44
57_T204_T0.6310.44
23_Y120_D0.6300.43
142_K148_E0.6270.43
17_Q25_K0.6260.43
72_A223_S0.6250.43
64_I219_Q0.6240.43
32_V291_L0.6240.43
171_V208_L0.6220.43
69_P208_L0.6210.43
45_H60_T0.6200.42
35_S296_A0.6200.42
170_H247_E0.6190.42
175_I208_L0.6170.42
248_G251_N0.6170.42
21_D26_V0.6160.42
20_L24_K0.6150.42
168_T227_V0.6140.42
262_A284_V0.6120.42
99_E235_E0.6110.42
84_V116_L0.6090.41
19_N122_E0.6060.41
76_S223_S0.6050.41
30_K291_L0.6040.41
54_N108_S0.6030.41
37_N305_R0.6020.41
51_E151_S0.6020.41
49_G57_T0.6010.41
176_L238_A0.5990.40
31_L176_L0.5960.40
89_A96_R0.5960.40
135_K138_G0.5950.40
268_P271_I0.5940.40
70_F151_S0.5930.40
84_V158_V0.5930.40
265_F272_L0.5920.40
287_N293_Q0.5890.39
6_I155_L0.5890.39
43_M221_K0.5880.39
116_L310_A0.5870.39
4_N199_E0.5860.39
84_V94_K0.5820.39
245_S248_G0.5820.39
75_N252_S0.5810.39
100_Q146_I0.5800.39
245_S251_N0.5800.39
234_E279_G0.5780.38
123_G272_L0.5780.38
162_V167_P0.5780.38
300_Y304_R0.5760.38
106_G114_D0.5760.38
70_F127_V0.5750.38
164_Y170_H0.5740.38
166_E210_E0.5740.38
34_K309_E0.5730.38
42_T242_R0.5730.38
82_L271_I0.5730.38
91_H116_L0.5720.38
251_N255_V0.5710.38
264_Y274_E0.5710.38
58_E258_Y0.5690.38
168_T269_N0.5690.38
261_K275_L0.5690.38
286_E292_G0.5690.38
126_L160_L0.5660.37
49_G231_V0.5650.37
125_R230_R0.5630.37
259_Y286_E0.5600.37
36_V43_M0.5600.37
231_V262_A0.5570.36
180_E208_L0.5550.36
68_A221_K0.5540.36
75_N163_P0.5530.36
111_A194_I0.5530.36
259_Y285_D0.5520.36
110_R115_I0.5520.36
288_L291_L0.5500.36
66_R223_S0.5490.36
177_G206_I0.5460.35
280_P285_D0.5460.35
281_G285_D0.5450.35
218_R308_I0.5450.35
213_D268_P0.5440.35
105_S108_S0.5400.35
258_Y284_V0.5400.35
176_L247_E0.5400.35
159_E192_A0.5380.35
23_Y267_E0.5380.35
93_W262_A0.5370.35
5_G10_S0.5360.34
16_A65_P0.5350.34
233_D279_G0.5350.34
83_R253_G0.5340.34
229_F273_F0.5330.34
288_L293_Q0.5330.34
134_G138_G0.5310.34
6_I118_F0.5310.34
58_E282_F0.5310.34
191_T211_R0.5300.34
63_E269_N0.5290.34
260_F274_E0.5290.34
103_T213_D0.5260.34
28_G50_D0.5230.33
96_R104_H0.5230.33
29_L283_M0.5210.33
193_V210_E0.5200.33
165_A208_L0.5190.33
61_F120_D0.5180.33
85_P152_F0.5180.33
79_S117_A0.5180.33
48_Y223_S0.5170.33
32_V58_E0.5160.33
10_S63_E0.5160.33
6_I178_F0.5150.33
29_L59_L0.5140.32
62_F308_I0.5140.32
157_P201_G0.5130.32
6_I10_S0.5120.32
163_P214_L0.5120.32
41_P311_K0.5110.32
11_A224_V0.5100.32
228_A264_Y0.5100.32
224_V263_L0.5080.32
50_D309_E0.5080.32
160_L216_R0.5080.32
245_S310_A0.5060.32
120_D267_E0.5060.32
47_F63_E0.5060.32
280_P286_E0.5050.32
55_P278_D0.5050.32
166_E169_L0.5040.32
49_G263_L0.5030.31
100_Q104_H0.5020.31
157_P161_T0.5000.31
172_L208_L0.5000.31
78_S159_E0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oajA 2 0.9652 100 0.44 Contact Map
4huzA 2 0.962 100 0.567 Contact Map
1zswA 1 0.981 100 0.587 Contact Map
3e0rA 1 0.7342 100 0.729 Contact Map
2ehzA 5 0.8829 100 0.754 Contact Map
3vb0A 1 0.8386 100 0.756 Contact Map
4ro6A 1 0.8418 100 0.757 Contact Map
2zyqA 2 0.8608 100 0.758 Contact Map
3hpyA 4 0.8513 100 0.758 Contact Map
1mpyA 3 0.9019 100 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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