GREMLIN Database
YBCC - UPF0753 protein YbcC
UniProt: O34688 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 871 (683)
Sequences: 410 (336)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
570_P660_A9.1211.00
388_S630_D8.9921.00
552_V619_A6.5961.00
556_R623_E6.3521.00
553_N623_E6.1611.00
575_C636_A5.5331.00
756_I831_I5.1301.00
760_G829_I4.7701.00
440_S603_N4.6731.00
555_A611_C4.1561.00
570_P657_A4.0101.00
580_Q639_N3.8630.99
392_Q569_A3.5960.99
810_W813_V3.5910.99
621_L626_K3.5350.99
368_Y717_A3.0650.97
189_D192_Q3.0440.97
838_V861_S3.0350.97
726_L832_Q3.0070.97
441_L740_N3.0000.96
603_N616_V2.8340.95
657_A660_A2.8000.95
586_Y809_P2.7600.94
415_E740_N2.7590.94
643_D679_R2.7310.94
259_L266_A2.7300.94
394_A417_I2.7260.94
281_A285_E2.7230.94
551_K613_L2.6990.94
753_A844_H2.6590.93
828_L860_A2.6330.93
572_V633_F2.6160.92
393_L573_V2.6110.92
849_L853_Q2.5630.92
233_A285_E2.5290.91
787_T798_Q2.5270.91
393_L575_C2.4380.89
565_T568_I2.4180.89
573_V668_M2.3750.88
547_T550_E2.3470.88
394_A574_I2.3360.87
568_I628_P2.3120.87
399_V590_L2.3000.86
237_L288_A2.2830.86
721_I759_P2.2660.86
634_A705_S2.2520.85
555_A610_L2.2140.84
441_L607_L2.2090.84
590_L812_S2.1840.83
556_R560_K2.1470.82
797_M802_S2.1460.82
764_Q768_L2.1120.81
601_G637_E2.0820.80
771_Y775_V2.0520.79
403_P675_V2.0360.79
605_R649_Y2.0180.78
364_W825_L2.0010.77
718_A736_A1.9850.77
207_A252_Q1.9840.77
361_L786_A1.9780.77
176_L413_P1.9340.75
417_I562_M1.9160.74
176_L791_T1.8980.73
684_P777_P1.8870.73
255_L368_Y1.8690.72
721_I763_A1.8350.71
204_F720_I1.8350.71
753_A845_D1.8270.70
421_G600_G1.8170.70
591_D606_V1.8060.70
582_T712_G1.8060.70
717_A735_R1.8050.69
776_A813_V1.8030.69
444_I600_G1.8000.69
572_V631_T1.7790.68
611_C723_K1.7580.67
364_W367_T1.7240.66
632_V654_S1.7240.66
713_L812_S1.7200.66
204_F281_A1.7150.65
181_I802_S1.7110.65
503_A794_L1.7080.65
251_I855_G1.6830.64
723_K832_Q1.6780.64
229_W292_S1.6690.63
568_I627_I1.6640.63
451_I591_D1.6640.63
399_V713_L1.6600.63
664_I668_M1.6600.63
713_L765_W1.6560.63
241_L255_L1.6490.62
395_F424_G1.6470.62
509_P563_G1.6340.61
570_P630_D1.6280.61
607_L611_C1.6020.60
555_A607_L1.5990.60
399_V734_G1.5980.60
481_K590_L1.5860.59
704_W759_P1.5810.59
624_G727_T1.5810.59
397_I739_H1.5790.59
588_A748_S1.5760.59
401_S713_L1.5680.58
397_I600_G1.5590.58
429_T440_S1.5580.58
243_A299_K1.5580.58
236_A292_S1.5540.57
760_G848_F1.5500.57
585_P790_V1.5400.57
788_Q798_Q1.5380.57
221_K836_E1.5240.56
189_D193_A1.5230.56
210_H249_S1.5120.55
568_I625_I1.5090.55
711_W734_G1.4980.55
713_L759_P1.4970.55
644_E698_N1.4830.54
189_D195_W1.4800.54
207_A755_I1.4720.53
251_I258_H1.4710.53
193_A604_A1.4500.52
757_V845_D1.4470.52
703_D706_E1.4440.52
616_V701_A1.4420.52
563_G864_P1.4410.52
421_G424_G1.4400.52
649_Y707_I1.4330.51
632_V657_A1.4250.51
507_F657_A1.4240.51
394_A729_D1.4230.51
204_F289_V1.4120.50
361_L758_G1.4060.50
571_L720_I1.4020.50
555_A723_K1.4010.50
401_S765_W1.4010.50
596_G825_L1.3990.49
237_L503_A1.3970.49
205_Y242_F1.3950.49
603_N751_L1.3920.49
401_S711_W1.3870.49
589_A655_E1.3870.49
587_S590_L1.3850.49
590_L713_L1.3840.49
213_Q451_I1.3830.49
759_P765_W1.3810.48
491_P704_W1.3790.48
401_S759_P1.3740.48
590_L834_P1.3680.48
558_A740_N1.3670.48
706_E727_T1.3660.48
172_L857_V1.3630.48
197_M200_R1.3620.48
798_Q805_L1.3550.47
272_R275_Q1.3500.47
599_A711_W1.3450.47
581_S769_Q1.3440.47
600_G605_R1.3360.46
763_A829_I1.3310.46
780_Y831_I1.3290.46
453_E803_D1.3240.46
161_S164_I1.3210.45
665_E748_S1.3180.45
670_K673_H1.3180.45
701_A831_I1.3170.45
553_N627_I1.3160.45
684_P776_A1.3160.45
625_I662_E1.3140.45
505_R707_I1.3130.45
848_F852_V1.3040.45
777_P786_A1.3020.44
222_Q226_V1.3010.44
634_A649_Y1.2920.44
191_S832_Q1.2910.44
189_D545_G1.2910.44
198_P545_G1.2870.44
629_E747_E1.2860.44
389_A567_N1.2820.43
418_G737_F1.2800.43
453_E545_G1.2790.43
359_L384_G1.2730.43
547_T864_P1.2700.43
704_W713_L1.2700.43
647_W661_F1.2660.43
184_S716_N1.2630.42
547_T819_E1.2610.42
777_P810_W1.2580.42
492_E834_P1.2570.42
392_Q564_L1.2560.42
430_C450_K1.2560.42
713_L739_H1.2410.41
737_F767_N1.2400.41
496_P776_A1.2390.41
181_I262_L1.2350.41
736_A831_I1.2350.41
246_I564_L1.2270.41
611_C769_Q1.2220.40
618_E636_A1.2160.40
582_T791_T1.2150.40
187_Y254_Y1.2100.40
590_L765_W1.2090.40
605_R678_E1.2080.40
293_M784_N1.2080.40
571_L664_I1.2070.40
579_S641_T1.2070.40
399_V711_W1.2060.40
165_E786_A1.2050.39
596_G810_W1.2040.39
407_Q428_A1.1990.39
174_N725_E1.1960.39
285_E736_A1.1900.39
241_L772_A1.1860.39
440_S616_V1.1820.38
751_L754_N1.1810.38
185_K791_T1.1760.38
291_I373_S1.1750.38
788_Q805_L1.1740.38
768_L771_Y1.1740.38
791_T802_S1.1730.38
734_G782_S1.1720.38
441_L793_G1.1720.38
682_Q821_Y1.1720.38
720_I727_T1.1710.38
444_I757_V1.1700.38
473_L581_S1.1690.38
616_V751_L1.1680.38
492_E590_L1.1670.38
743_W749_G1.1640.37
431_E434_S1.1620.37
699_R706_E1.1600.37
394_A562_M1.1590.37
713_L731_D1.1580.37
401_S734_G1.1570.37
217_A294_E1.1570.37
549_E619_A1.1540.37
369_T858_R1.1530.37
241_L251_I1.1530.37
607_L707_I1.1520.37
359_L553_N1.1510.37
581_S716_N1.1510.37
590_L787_T1.1490.37
561_M754_N1.1460.37
259_L495_G1.1300.36
208_W753_A1.1300.36
359_L688_S1.1260.36
372_L718_A1.1230.36
395_F708_R1.1220.35
399_V765_W1.1170.35
835_R861_S1.1150.35
401_S590_L1.1120.35
285_E368_Y1.1120.35
492_E800_N1.1100.35
704_W765_W1.1080.35
590_L711_W1.1060.35
739_H769_Q1.1060.35
359_L427_I1.1020.35
258_H294_E1.1010.34
438_H558_A1.0970.34
704_W711_W1.0950.34
386_E614_S1.0940.34
761_T768_L1.0940.34
237_L246_I1.0940.34
588_A685_N1.0930.34
283_L509_P1.0930.34
426_P712_G1.0910.34
183_W764_Q1.0890.34
555_A739_H1.0880.34
361_L825_L1.0860.34
590_L759_P1.0840.34
716_N767_N1.0830.34
502_M636_A1.0830.34
655_E843_N1.0800.33
195_W775_V1.0770.33
386_E725_E1.0680.33
452_K732_L1.0670.33
840_R844_H1.0650.33
702_E740_N1.0590.33
563_G716_N1.0590.33
260_L705_S1.0590.33
168_D552_V1.0590.33
570_P728_Q1.0580.32
610_L813_V1.0570.32
367_T823_S1.0570.32
413_P621_L1.0570.32
368_Y825_L1.0530.32
711_W759_P1.0520.32
615_E687_Q1.0480.32
266_A610_L1.0470.32
399_V733_E1.0450.32
579_S591_D1.0420.32
359_L636_A1.0400.32
254_Y271_W1.0390.32
636_A647_W1.0380.32
184_S706_E1.0370.32
392_Q417_I1.0370.32
224_E831_I1.0360.31
832_Q864_P1.0350.31
184_S820_A1.0350.31
353_E634_A1.0350.31
399_V812_S1.0340.31
391_A664_I1.0340.31
512_A862_L1.0330.31
492_E759_P1.0330.31
580_Q797_M1.0310.31
619_A622_A1.0310.31
216_P219_S1.0300.31
579_S582_T1.0300.31
429_T789_T1.0290.31
680_L693_P1.0290.31
764_Q851_K1.0290.31
685_N693_P1.0270.31
791_T797_M1.0260.31
391_A394_A1.0250.31
491_P502_M1.0250.31
733_E846_S1.0200.31
662_E683_L1.0190.31
758_G788_Q1.0170.31
627_I633_F1.0130.30
391_A504_A1.0110.30
590_L704_W1.0090.30
504_A636_A1.0060.30
501_Q507_F1.0060.30
719_F763_A1.0060.30
715_R821_Y1.0060.30
552_V622_A1.0050.30
586_Y682_Q1.0030.30
787_T812_S1.0020.30
456_D701_A1.0010.30
492_E713_L1.0010.30
714_A775_V0.9970.30
531_L727_T0.9960.30
765_W812_S0.9960.30
433_G445_Q0.9940.30
429_T453_E0.9910.29
616_V866_G0.9910.29
843_N846_S0.9910.29
588_A767_N0.9900.29
425_V607_L0.9880.29
676_N814_M0.9860.29
182_K716_N0.9860.29
734_G784_N0.9860.29
739_H759_P0.9840.29
634_A707_I0.9830.29
579_S831_I0.9820.29
160_L517_R0.9820.29
769_Q812_S0.9820.29
729_D751_L0.9760.29
269_M277_S0.9750.29
182_K797_M0.9750.29
570_P656_A0.9740.29
361_L376_I0.9730.29
290_R703_D0.9720.29
371_R701_A0.9640.28
503_A699_R0.9620.28
687_Q720_I0.9620.28
224_E454_F0.9600.28
415_E817_D0.9580.28
177_D684_P0.9580.28
401_S704_W0.9560.28
204_F439_A0.9560.28
204_F269_M0.9540.28
587_S621_L0.9520.28
490_L715_R0.9510.28
831_I864_P0.9490.28
158_Q161_S0.9470.28
188_L550_E0.9460.28
249_S629_E0.9450.28
386_E727_T0.9440.27
165_E204_F0.9430.27
413_P841_L0.9430.27
591_D716_N0.9430.27
505_R568_I0.9430.27
417_I790_V0.9420.27
166_N294_E0.9370.27
507_F698_N0.9360.27
723_K802_S0.9360.27
672_R793_G0.9330.27
392_Q631_T0.9330.27
181_I797_M0.9310.27
513_G634_A0.9310.27
360_W661_F0.9300.27
442_P709_P0.9300.27
590_L596_G0.9290.27
224_E394_A0.9280.27
352_D571_L0.9280.27
467_K663_Q0.9260.27
387_K457_E0.9250.27
546_F610_L0.9230.27
473_L852_V0.9230.27
636_A645_L0.9230.27
600_G760_G0.9220.27
168_D648_L0.9200.27
558_A567_N0.9200.27
621_L794_L0.9200.27
359_L663_Q0.9170.26
647_W650_V0.9160.26
591_D701_A0.9110.26
558_A722_G0.9090.26
672_R676_N0.9050.26
295_W299_K0.9050.26
500_L571_L0.9040.26
232_E235_L0.9030.26
547_T572_V0.9010.26
453_E568_I0.9010.26
427_I451_I0.9010.26
202_E662_E0.9000.26
716_N839_E0.9000.26
292_S839_E0.8980.26
169_G284_T0.8970.26
286_Y771_Y0.8960.26
711_W765_W0.8960.26
844_H852_V0.8950.26
491_P734_G0.8940.25
549_E836_E0.8930.25
288_A838_V0.8920.25
507_F830_L0.8910.25
591_D598_A0.8890.25
459_V530_K0.8890.25
704_W834_P0.8880.25
200_R283_L0.8880.25
441_L562_M0.8880.25
497_W503_A0.8870.25
159_P836_E0.8860.25
756_I797_M0.8830.25
789_T802_S0.8820.25
662_E665_E0.8820.25
399_V589_A0.8790.25
200_R207_A0.8790.25
320_A571_L0.8780.25
407_Q445_Q0.8780.25
438_H598_A0.8770.25
607_L797_M0.8760.25
399_V715_R0.8730.25
240_A727_T0.8730.25
704_W731_D0.8710.25
588_A749_G0.8690.25
397_I757_V0.8680.24
187_Y562_M0.8650.24
731_D812_S0.8650.24
294_E390_L0.8650.24
208_W703_D0.8630.24
474_S656_A0.8620.24
587_S711_W0.8620.24
208_W229_W0.8620.24
713_L769_Q0.8590.24
734_G800_N0.8560.24
227_K459_V0.8550.24
739_H755_I0.8550.24
676_N680_L0.8550.24
713_L734_G0.8540.24
272_R637_E0.8540.24
603_N641_T0.8530.24
239_E295_W0.8530.24
509_P581_S0.8530.24
288_A701_A0.8510.24
243_A552_V0.8510.24
173_V177_D0.8490.24
549_E771_Y0.8480.24
599_A763_A0.8480.24
649_Y819_E0.8470.24
215_D445_Q0.8470.24
175_I426_P0.8460.24
217_A300_P0.8450.24
830_L840_R0.8440.24
269_M599_A0.8430.24
619_A729_D0.8420.23
581_S591_D0.8410.23
556_R695_A0.8390.23
715_R734_G0.8390.23
245_E390_L0.8390.23
629_E729_D0.8380.23
639_N780_Y0.8350.23
397_I763_A0.8340.23
403_P734_G0.8330.23
614_S717_A0.8320.23
233_A666_A0.8320.23
490_L496_P0.8310.23
488_L492_E0.8310.23
362_E706_E0.8290.23
749_G837_Y0.8280.23
359_L588_A0.8270.23
492_E765_W0.8260.23
716_N764_Q0.8250.23
547_T655_E0.8230.23
193_A825_L0.8230.23
722_G814_M0.8200.23
401_S492_E0.8180.23
249_S549_E0.8180.23
286_Y791_T0.8150.22
622_A666_A0.8140.22
615_E728_Q0.8100.22
267_G761_T0.8100.22
452_K658_Q0.8080.22
352_D551_K0.8070.22
582_T587_S0.8070.22
195_W198_P0.8060.22
451_I706_E0.8060.22
415_E614_S0.8060.22
635_A829_I0.8030.22
193_A771_Y0.8020.22
285_E675_V0.8020.22
364_W496_P0.8020.22
447_P653_L0.8020.22
195_W283_L0.8010.22
379_K556_R0.7990.22
320_A551_K0.7990.22
220_K707_I0.7970.22
233_A373_S0.7970.22
555_A672_R0.7970.22
384_G572_V0.7960.22
418_G767_N0.7960.22
616_V697_A0.7960.22
488_L491_P0.7950.22
414_F798_Q0.7940.22
477_F490_L0.7940.22
401_S719_F0.7930.22
401_S812_S0.7920.22
713_L834_P0.7910.22
262_L777_P0.7910.22
323_I547_T0.7890.22
420_A635_A0.7870.21
691_K854_N0.7860.21
207_A771_Y0.7850.21
451_I520_R0.7840.21
176_L354_K0.7840.21
399_V704_W0.7830.21
578_G768_L0.7820.21
438_H706_E0.7820.21
642_V671_V0.7820.21
187_Y201_E0.7810.21
696_E706_E0.7780.21
419_I561_M0.7780.21
615_E659_E0.7770.21
505_R582_T0.7760.21
567_N725_E0.7760.21
161_S806_A0.7760.21
582_T591_D0.7760.21
676_N693_P0.7750.21
184_S205_Y0.7740.21
492_E704_W0.7740.21
682_Q849_L0.7730.21
777_P793_G0.7730.21
545_G855_G0.7720.21
589_A777_P0.7720.21
274_Q829_I0.7690.21
491_P800_N0.7690.21
289_V443_I0.7680.21
428_A649_Y0.7680.21
502_M708_R0.7670.21
402_E703_D0.7670.21
759_P834_P0.7620.21
283_L453_E0.7610.21
196_T589_A0.7610.21
487_S557_Q0.7610.21
160_L220_K0.7600.21
357_K645_L0.7580.20
271_W275_Q0.7570.20
448_Q558_A0.7550.20
217_A407_Q0.7550.20
417_I564_L0.7540.20
574_I720_I0.7530.20
549_E655_E0.7520.20
216_P642_V0.7520.20
375_K558_A0.7520.20
228_G380_Q0.7510.20
581_S715_R0.7510.20
481_K704_W0.7510.20
243_A819_E0.7500.20
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212_I809_P0.5610.15
759_P812_S0.5610.15
748_S794_L0.5600.15
440_S756_I0.5600.15
633_F789_T0.5590.15
491_P590_L0.5580.15
600_G718_A0.5580.15
410_K431_E0.5580.15
193_A682_Q0.5580.15
399_V707_I0.5570.14
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607_L610_L0.5340.14
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193_A605_R0.5330.14
709_P808_L0.5330.14
412_G426_P0.5320.14
237_L755_I0.5320.14
486_S784_N0.5320.14
361_L567_N0.5300.14
338_A507_F0.5290.14
393_L788_Q0.5290.14
234_H549_E0.5280.14
483_N561_M0.5270.14
379_K385_R0.5260.14
772_A784_N0.5260.14
183_W364_W0.5250.14
696_E831_I0.5250.14
178_H838_V0.5250.14
219_S732_L0.5240.14
383_T634_A0.5230.14
715_R764_Q0.5190.14
176_L673_H0.5190.14
794_L835_R0.5180.14
564_L567_N0.5180.14
607_L821_Y0.5180.14
203_G863_D0.5170.13
208_W761_T0.5170.13
751_L855_G0.5170.13
394_A641_T0.5160.13
394_A607_L0.5160.13
172_L477_F0.5160.13
462_K518_N0.5160.13
439_A794_L0.5150.13
719_F769_Q0.5150.13
290_R605_R0.5140.13
236_A283_L0.5130.13
172_L369_T0.5130.13
426_P711_W0.5120.13
444_I739_H0.5120.13
450_K645_L0.5110.13
554_Y589_A0.5110.13
571_L809_P0.5100.13
196_T252_Q0.5100.13
528_D531_L0.5100.13
361_L680_L0.5090.13
705_S831_I0.5090.13
233_A237_L0.5080.13
176_L468_Q0.5080.13
190_D806_A0.5080.13
603_N627_I0.5070.13
429_T760_G0.5070.13
680_L778_H0.5060.13
514_R836_E0.5060.13
711_W800_N0.5060.13
175_I645_L0.5060.13
729_D854_N0.5050.13
263_P806_A0.5050.13
266_A653_L0.5050.13
226_V480_M0.5050.13
188_L361_L0.5050.13
443_I771_Y0.5040.13
657_A705_S0.5040.13
669_P720_I0.5030.13
533_L606_V0.5030.13
562_M574_I0.5030.13
750_E836_E0.5030.13
662_E843_N0.5020.13
420_A655_E0.5020.13
200_R414_F0.5020.13
507_F850_Q0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xwsA 2 0.1332 36.8 0.989 Contact Map
4m0nA 1 0.1343 27.9 0.99 Contact Map
3lyhA 2 0.1309 26.5 0.99 Contact Map
3ipzA 3 0.1183 14.5 0.991 Contact Map
3whtB 1 0.0654 14.3 0.991 Contact Map
2ct6A 1 0.101 14.2 0.991 Contact Map
3v3tA 1 0.0471 13.8 0.991 Contact Map
2ab1A 1 0.1183 13.4 0.991 Contact Map
3p0jA 1 0.1412 13.3 0.991 Contact Map
3ctgA 1 0.1091 13.2 0.991 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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