GREMLIN Database
YJKA - UPF0014 membrane protein YjkA
UniProt: O34684 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 250 (241)
Sequences: 1252 (909)
Seq/√Len: 58.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_R150_E6.2341.00
241_T245_Q5.2971.00
45_I192_L5.1571.00
13_V35_T3.4061.00
93_A230_I3.3631.00
124_M195_M3.3401.00
20_S25_A3.3091.00
65_V122_S3.1381.00
160_T163_Q3.0291.00
63_L67_L2.9091.00
139_R175_M2.8991.00
154_I159_G2.8841.00
73_A91_F2.8651.00
38_A217_V2.7671.00
136_F232_S2.6871.00
133_S227_T2.5231.00
124_M191_Q2.4641.00
138_N175_M2.3281.00
187_L217_V2.1831.00
29_K33_I2.1671.00
71_V189_L2.1241.00
18_F22_S2.1071.00
50_S205_D2.0771.00
20_S28_E2.0021.00
117_Y199_Q1.9871.00
188_G194_G1.9001.00
128_N220_T1.8511.00
199_Q212_F1.8411.00
129_S227_T1.8120.99
191_Q195_M1.7930.99
148_K152_Q1.7880.99
199_Q204_A1.7140.99
144_V165_I1.6980.99
34_A221_M1.6780.99
53_F197_T1.6660.99
61_I115_A1.6350.99
80_K83_T1.6230.99
139_R143_E1.5920.99
46_G210_V1.5830.99
161_P244_Q1.5680.98
66_L91_F1.5640.98
111_I199_Q1.5540.98
6_L215_L1.5070.98
124_M220_T1.4770.98
87_F91_F1.4770.98
34_A185_K1.4760.98
91_F95_A1.4540.97
192_L197_T1.4510.97
68_M126_I1.4490.97
7_S67_L1.4220.97
192_L210_V1.4190.97
182_E185_K1.4120.97
166_Q170_T1.4110.97
186_T191_Q1.4060.97
34_A184_Q1.3960.97
45_I189_L1.3920.97
189_L216_I1.3840.97
124_M197_T1.3750.96
76_V94_L1.3550.96
39_A214_L1.3490.96
197_T200_I1.3380.96
43_L210_V1.3350.96
216_I219_T1.3340.96
41_Q198_G1.3330.96
142_S147_R1.3320.96
190_V195_M1.3310.96
20_S31_M1.3160.95
180_T224_A1.3110.95
13_V221_M1.2980.95
186_T192_L1.2770.95
35_T218_F1.2620.94
85_G88_W1.2550.94
70_A74_Q1.2320.93
162_K236_Y1.2280.93
18_F26_G1.2100.93
151_I178_I1.2010.93
123_G194_G1.2000.93
71_V186_T1.1840.92
10_M14_L1.1770.92
44_I48_V1.1700.92
197_T201_L1.1590.91
184_Q221_M1.1510.91
196_M217_V1.1490.91
40_V44_I1.1440.91
93_A234_L1.1430.91
128_N190_V1.1390.90
59_V62_L1.1310.90
80_K137_L1.1280.90
81_K229_V1.1210.90
41_Q188_G1.1170.90
38_A214_L1.1070.89
76_V134_S1.1030.89
12_F222_A1.0960.89
153_L156_S1.0880.88
51_L130_M1.0810.88
190_V194_G1.0800.88
200_I210_V1.0690.87
161_P241_T1.0540.87
38_A187_L1.0470.86
33_I237_P1.0470.86
194_G198_G1.0440.86
17_L32_I1.0440.86
162_K233_V1.0330.86
105_L136_F1.0330.86
126_I191_Q1.0310.85
149_E153_L1.0300.85
130_M134_S1.0290.85
120_P201_L1.0290.85
91_F94_L1.0240.85
76_V172_A1.0240.85
196_M200_I1.0200.85
195_M200_I1.0200.85
68_M206_P1.0190.85
226_L229_V1.0150.85
30_D181_L1.0140.85
136_F231_L1.0120.84
136_F228_C0.9990.84
200_I211_R0.9920.83
55_G60_F0.9910.83
30_D33_I0.9910.83
135_L175_M0.9890.83
117_Y121_I0.9890.83
96_I230_I0.9780.82
41_Q194_G0.9760.82
131_V182_E0.9760.82
188_G198_G0.9750.82
44_I52_I0.9710.82
196_M210_V0.9710.82
71_V190_V0.9700.82
90_V137_L0.9690.82
125_V223_S0.9660.82
7_S11_I0.9630.81
19_L52_I0.9600.81
134_S182_E0.9580.81
48_V114_T0.9570.81
53_F115_A0.9490.80
144_V239_L0.9460.80
147_R176_S0.9440.80
47_Y51_L0.9350.79
132_L224_A0.9280.79
48_V130_M0.9240.79
49_L197_T0.9170.78
124_M216_I0.9120.78
154_I157_L0.9110.78
123_G127_G0.9090.77
103_G118_V0.9070.77
147_R168_I0.9050.77
60_F63_L0.8970.76
69_L140_L0.8870.76
44_I47_Y0.8860.76
10_M36_I0.8800.75
98_E223_S0.8730.74
66_L145_G0.8630.74
215_L218_F0.8620.74
77_I87_F0.8610.73
182_E199_Q0.8590.73
136_F176_S0.8580.73
12_F218_F0.8540.73
52_I64_M0.8530.73
197_T220_T0.8480.72
140_L144_V0.8440.72
129_S223_S0.8440.72
101_T223_S0.8380.71
81_K93_A0.8360.71
76_V137_L0.8300.71
69_L210_V0.8260.70
117_Y184_Q0.8240.70
194_G197_T0.8220.70
68_M72_A0.8210.70
132_L216_I0.8190.70
121_I187_L0.8180.70
139_R171_S0.8170.69
143_E146_V0.8130.69
42_L123_G0.8090.69
92_A234_L0.8080.69
68_M197_T0.8060.68
95_A230_I0.8050.68
150_E190_V0.8010.68
17_L24_K0.8010.68
121_I230_I0.7950.67
143_E171_S0.7870.67
65_V118_V0.7830.66
23_F233_V0.7830.66
122_S126_I0.7800.66
74_Q88_W0.7740.65
77_I90_V0.7740.65
48_V71_V0.7720.65
26_G227_T0.7720.65
50_S54_R0.7700.65
46_G121_I0.7690.65
33_I224_A0.7570.64
11_I47_Y0.7440.62
10_M215_L0.7400.62
20_S27_V0.7360.61
184_Q197_T0.7340.61
173_M233_V0.7320.61
100_V103_G0.7290.61
74_Q110_I0.7250.60
62_L66_L0.7230.60
33_I36_I0.7230.60
50_S207_I0.7230.60
239_L245_Q0.7210.60
7_S99_I0.7210.60
181_L229_V0.7200.60
36_I63_L0.7200.60
72_A186_T0.7200.60
94_L131_V0.7180.59
124_M196_M0.7150.59
75_N186_T0.7110.59
68_M194_G0.7110.59
195_M216_I0.7060.58
165_I240_F0.7040.58
97_V137_L0.7040.58
200_I224_A0.7030.58
102_Q105_L0.6950.57
144_V151_I0.6910.57
140_L172_A0.6900.56
94_L129_S0.6820.56
180_T221_M0.6790.55
141_N152_Q0.6780.55
100_V151_I0.6780.55
29_K148_K0.6770.55
182_E186_T0.6760.55
7_S216_I0.6740.55
136_F218_F0.6690.54
119_I135_L0.6690.54
142_S175_M0.6680.54
24_K172_A0.6620.53
212_F216_I0.6570.53
53_F201_L0.6560.53
43_L109_H0.6560.53
30_D217_V0.6550.53
162_K166_Q0.6530.52
138_N142_S0.6460.52
40_V102_Q0.6440.51
99_I227_T0.6430.51
82_N145_G0.6430.51
158_G164_S0.6410.51
15_I85_G0.6390.51
97_V129_S0.6380.51
86_S89_R0.6370.51
97_V154_I0.6370.51
12_F98_E0.6360.51
97_V112_P0.6350.50
216_I222_A0.6310.50
102_Q122_S0.6310.50
72_A240_F0.6290.50
85_G238_S0.6270.50
97_V152_Q0.6260.49
13_V47_Y0.6250.49
53_F119_I0.6220.49
194_G213_Q0.6210.49
76_V166_Q0.6180.49
36_I169_L0.6160.48
37_R41_Q0.6140.48
55_G107_S0.6130.48
67_L113_L0.6130.48
66_L81_K0.6110.48
63_L242_V0.6090.48
61_I130_M0.6070.47
30_D183_S0.6070.47
75_N130_M0.6060.47
177_M235_T0.6040.47
112_P199_Q0.6010.47
26_G178_I0.5970.46
25_A164_S0.5970.46
71_V219_T0.5970.46
61_I221_M0.5950.46
126_I130_M0.5950.46
120_P212_F0.5940.46
75_N192_L0.5930.46
88_W215_L0.5930.46
37_R188_G0.5930.46
53_F206_P0.5930.46
89_R93_A0.5930.46
75_N80_K0.5910.46
73_A205_D0.5890.45
156_S235_T0.5850.45
175_M227_T0.5830.45
233_V237_P0.5830.45
150_E226_L0.5820.45
220_T223_S0.5800.44
45_I211_R0.5780.44
79_R151_I0.5780.44
128_N183_S0.5770.44
195_M199_Q0.5770.44
106_L142_S0.5770.44
5_S108_L0.5750.44
135_L178_I0.5740.44
13_V77_I0.5730.44
85_G229_V0.5720.43
177_M225_A0.5720.43
91_F114_T0.5710.43
87_F125_V0.5710.43
125_V171_S0.5710.43
40_V113_L0.5700.43
44_I88_W0.5690.43
21_K65_V0.5690.43
161_P245_Q0.5680.43
135_L194_G0.5670.43
46_G192_L0.5660.43
203_G206_P0.5640.43
37_R212_F0.5630.42
14_L18_F0.5630.42
12_F170_T0.5620.42
73_A87_F0.5610.42
111_I182_E0.5580.42
74_Q78_K0.5570.42
68_M71_V0.5560.42
127_G191_Q0.5560.42
139_R142_S0.5550.42
108_L117_Y0.5550.42
47_Y174_K0.5540.41
206_P212_F0.5530.41
64_M214_L0.5500.41
17_L36_I0.5470.41
140_L168_I0.5460.41
12_F191_Q0.5440.40
154_I245_Q0.5440.40
110_I126_I0.5380.40
196_M211_R0.5380.40
114_T184_Q0.5380.40
188_G192_L0.5370.40
27_V30_D0.5370.40
36_I146_V0.5360.40
35_T48_V0.5360.40
18_F44_I0.5350.39
165_I190_V0.5330.39
45_I184_Q0.5310.39
93_A231_L0.5300.39
42_L188_G0.5300.39
72_A135_L0.5300.39
178_I205_D0.5290.39
16_A23_F0.5280.39
30_D52_I0.5270.39
55_G91_F0.5270.39
22_S103_G0.5250.38
93_A214_L0.5230.38
80_K141_N0.5210.38
146_V234_L0.5210.38
24_K95_A0.5190.38
138_N182_E0.5190.38
53_F116_R0.5190.38
93_A232_S0.5180.38
135_L224_A0.5180.38
140_L157_L0.5170.38
167_R171_S0.5160.37
18_F21_K0.5160.37
123_G190_V0.5120.37
230_I233_V0.5100.37
190_V212_F0.5090.37
89_R151_I0.5080.37
99_I102_Q0.5080.37
27_V174_K0.5080.37
133_S231_L0.5060.36
64_M119_I0.5050.36
132_L227_T0.5050.36
54_R73_A0.5040.36
5_S182_E0.5040.36
187_L216_I0.5000.36
11_I62_L0.5000.36
128_N224_A0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.82 92.1 0.93 Contact Map
3aqpA 1 0.784 76.8 0.944 Contact Map
2onkC 2 0.88 72.7 0.946 Contact Map
3tuiA 2 0.828 66.4 0.948 Contact Map
3d31C 2 0.896 63.1 0.949 Contact Map
3ne5A 3 0.804 59.4 0.95 Contact Map
4k0jA 3 0.728 57.7 0.951 Contact Map
4tquN 1 0.916 53.2 0.952 Contact Map
3w9iA 3 0.768 36.3 0.957 Contact Map
4dx5A 3 0.796 32.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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