GREMLIN Database
HIS7 - Imidazoleglycerol-phosphate dehydratase
UniProt: O34683 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (192)
Sequences: 2726 (1377)
Seq/√Len: 99.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_K14_D4.1261.00
78_L141_L3.3621.00
5_E18_A3.2841.00
103_A165_A2.8911.00
135_H157_T2.7381.00
28_D52_S2.7351.00
138_L170_L2.6701.00
151_V166_V2.5981.00
105_V169_A2.5341.00
14_D56_K2.3881.00
104_Q152_I2.3341.00
7_V16_E2.3031.00
79_L146_R2.2171.00
18_A52_S2.1971.00
129_F134_V2.1541.00
55_A70_I2.1041.00
27_A44_T2.0731.00
118_R152_I2.0651.00
72_I144_E2.0471.00
126_V163_I1.9801.00
105_V151_V1.9801.00
55_A66_T1.9121.00
104_Q154_H1.8981.00
32_D37_T1.8601.00
136_E140_K1.8041.00
109_L147_M1.8001.00
134_V163_I1.7991.00
152_I155_Y1.7911.00
95_F104_Q1.7891.00
36_M67_T1.7751.00
23_G50_D1.7561.00
119_A166_V1.7101.00
122_P159_T1.6751.00
89_K176_E1.6721.00
28_D54_N1.6521.00
89_K179_T1.6401.00
30_K54_N1.6341.00
45_K190_T1.6091.00
82_L178_T1.5861.00
141_L170_L1.5781.00
135_H139_W1.5661.00
116_E155_Y1.5501.00
86_K186_G1.5321.00
17_L53_I1.4781.00
5_E16_E1.4471.00
25_G50_D1.4451.00
89_K181_D1.4251.00
121_F163_I1.4051.00
63_D133_L1.4041.00
21_I178_T1.3740.99
34_P60_D1.3690.99
7_V14_D1.3500.99
93_S176_E1.3440.99
76_Q144_E1.3290.99
125_K128_T1.3260.99
36_M70_I1.3250.99
159_T162_M1.3110.99
109_L174_L1.3080.99
42_L91_Y1.3050.99
103_A153_V1.2970.99
71_G136_E1.2970.99
88_I109_L1.2910.99
138_L151_V1.2650.99
67_T133_L1.2480.99
17_L77_A1.2470.99
141_L147_M1.2400.99
63_D130_D1.2180.99
16_E54_N1.2010.99
71_G140_K1.1930.98
24_G50_D1.1930.98
32_D59_V1.1740.98
76_Q80_E1.1640.98
27_A41_D1.1390.98
132_E159_T1.1360.98
122_P162_M1.1310.98
3_K18_A1.1290.98
33_V63_D1.1280.98
40_L51_L1.1230.98
98_M106_V1.1220.98
175_D178_T1.1110.98
153_V162_M1.1090.97
6_R73_C1.1070.97
6_R80_E1.1030.97
11_N41_D1.0890.97
175_D179_T1.0870.97
48_Q184_V1.0870.97
79_L85_K1.0870.97
105_V170_L1.0780.97
132_E158_N1.0740.97
46_H171_G1.0740.97
71_G137_F1.0730.97
95_F154_H1.0710.97
103_A162_M1.0470.96
123_A132_E1.0450.96
119_A153_V1.0360.96
59_V63_D1.0350.96
17_L73_C1.0330.96
63_D128_T1.0300.96
113_P143_L1.0300.96
125_K130_D1.0290.96
130_D133_L1.0210.96
3_K20_T1.0210.96
67_T129_F1.0200.96
93_S106_V1.0150.96
48_Q175_D1.0120.96
2_R22_D1.0120.96
31_T37_T1.0050.95
103_A166_V0.9760.95
151_V170_L0.9640.94
30_K56_K0.9610.94
43_F171_G0.9570.94
31_T53_I0.9560.94
138_L166_V0.9500.94
97_P102_L0.9410.94
29_I41_D0.9390.94
59_V66_T0.9360.93
117_M134_V0.9320.93
96_V169_A0.9280.93
139_W143_L0.9240.93
31_T70_I0.9210.93
19_F78_L0.9180.93
78_L174_L0.9180.93
43_F174_L0.9120.93
153_V165_A0.9110.92
49_F178_T0.9100.92
123_A159_T0.9090.92
26_Q50_D0.8990.92
6_R77_A0.8990.92
121_F159_T0.8830.91
110_S148_N0.8830.91
117_M121_F0.8650.90
17_L74_L0.8640.90
34_P128_T0.8600.90
43_F47_G0.8540.90
42_L73_C0.8470.89
109_L145_A0.8410.89
115_L142_A0.8400.89
20_T50_D0.8400.89
136_E139_W0.8340.89
95_F106_V0.8310.89
36_M137_F0.8250.88
92_G173_A0.8220.88
124_A159_T0.8210.88
113_P146_R0.8180.88
33_V59_V0.8130.87
142_A149_L0.8050.87
130_D158_N0.8050.87
43_F49_F0.7930.86
156_G162_M0.7910.86
126_V159_T0.7900.86
100_E148_N0.7890.86
102_L106_V0.7750.85
63_D125_K0.7750.85
41_D60_D0.7720.85
32_D66_T0.7700.84
53_I70_I0.7670.84
104_Q155_Y0.7600.84
118_R155_Y0.7600.84
30_K37_T0.7590.84
140_K144_E0.7570.83
49_F78_L0.7420.82
133_L136_E0.7400.82
92_G176_E0.7400.82
48_Q188_P0.7390.82
119_A162_M0.7380.82
44_T51_L0.7340.82
43_F98_M0.7310.81
44_T47_G0.7300.81
82_L88_I0.7220.80
101_A156_G0.7200.80
182_P186_G0.7180.80
74_L141_L0.7170.80
109_L148_N0.7130.80
44_T49_F0.7110.79
123_A126_V0.7100.79
153_V166_V0.7040.79
101_A153_V0.7020.79
125_K132_E0.7010.78
184_V187_I0.7000.78
63_D126_V0.6960.78
34_P59_V0.6950.78
114_H139_W0.6950.78
67_T137_F0.6910.78
100_E157_T0.6830.77
101_A157_T0.6810.76
182_P185_K0.6770.76
78_L147_M0.6730.76
37_T60_D0.6730.76
34_P55_A0.6660.75
107_I149_L0.6620.74
89_K175_D0.6620.74
115_L140_K0.6610.74
149_L170_L0.6600.74
184_V188_P0.6570.74
4_A80_E0.6500.73
19_F49_F0.6460.73
83_G88_I0.6440.72
35_F39_M0.6440.72
126_V131_T0.6420.72
187_I193_M0.6410.72
103_A155_Y0.6350.71
33_V128_T0.6350.71
115_L135_H0.6300.71
37_T59_V0.6280.71
47_G171_G0.6280.71
130_D136_E0.6270.70
86_K187_I0.6270.70
63_D134_V0.6230.70
124_A130_D0.6220.70
41_D45_K0.6180.69
46_H172_R0.6180.69
29_I37_T0.6170.69
6_R76_Q0.6060.68
95_F152_I0.6050.68
7_V54_N0.6020.67
33_V129_F0.5930.66
48_Q181_D0.5930.66
36_M134_V0.5910.66
4_A73_C0.5890.66
160_H164_E0.5870.65
123_A130_D0.5870.65
94_A172_R0.5860.65
85_K88_I0.5850.65
150_H155_Y0.5840.65
123_A131_T0.5820.65
94_A176_E0.5820.65
115_L119_A0.5800.64
62_D127_G0.5800.64
70_I73_C0.5780.64
93_S104_Q0.5760.64
47_G175_D0.5680.63
117_M139_W0.5680.63
113_P144_E0.5660.63
175_D181_D0.5620.62
90_R108_D0.5610.62
49_F174_L0.5600.62
36_M71_G0.5600.62
161_H164_E0.5580.61
86_K185_K0.5550.61
124_A131_T0.5530.61
101_A165_A0.5520.61
61_I66_T0.5490.60
42_L172_R0.5480.60
39_M167_F0.5470.60
11_N61_I0.5460.60
36_M40_L0.5450.60
27_A171_G0.5440.60
102_L154_H0.5420.59
85_K111_N0.5400.59
74_L78_L0.5400.59
110_S194_L0.5390.59
181_D184_V0.5370.59
35_F38_H0.5370.59
27_A50_D0.5370.59
38_H160_H0.5350.58
78_L107_I0.5330.58
176_E179_T0.5330.58
36_M73_C0.5320.58
92_G109_L0.5320.58
11_N192_G0.5300.58
19_F51_L0.5300.58
48_Q179_T0.5290.57
42_L105_V0.5290.57
140_K143_L0.5280.57
137_F141_L0.5270.57
17_L70_I0.5260.57
107_I190_T0.5250.57
106_V190_T0.5240.57
113_P142_A0.5240.57
121_F124_A0.5220.56
105_V166_V0.5180.56
136_E157_T0.5170.56
4_A81_A0.5150.55
64_H69_D0.5140.55
131_T159_T0.5140.55
93_S154_H0.5110.55
38_H161_H0.5110.55
107_I147_M0.5100.55
28_D186_G0.5090.55
114_H135_H0.5080.54
101_A155_Y0.5060.54
121_F134_V0.5060.54
40_L53_I0.5050.54
4_A19_F0.5040.54
100_E150_H0.5030.54
175_D184_V0.5000.53
106_V152_I0.5000.53
15_I55_A0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mu3A 6 0.9536 100 -0.022 Contact Map
4gquA 6 0.9485 100 -0.016 Contact Map
2ae8A 5 0.8918 100 -0.014 Contact Map
1rhyA 4 0.9021 100 -0.009 Contact Map
4jifA 2 0.4124 38 0.957 Contact Map
3f0wA 2 0.4381 15.2 0.965 Contact Map
1aqcA 2 0.4485 12.9 0.966 Contact Map
1n3hA 1 0.4485 8.3 0.969 Contact Map
3so6A 1 0.4639 8.3 0.969 Contact Map
4q2uA 5 0.2371 7.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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