HIS7 - BACSU - GREMLIN Contacts

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HIS7 - Imidazoleglycerol-phosphate dehydratase

UniProt:	O34683	Sequences: MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFTKHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEALAQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTHHMIEAVFKALGRALDEATTIDPRVKGIPSTKGML	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	194 (192)
Sequences:	2726 (1377)
Seq/√Len:	99.4

ECOLI - HIS7
BACSU - HIS7
HALSA - HIS7
SULSO - HIS7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_K	14_D	4.126	1.00
78_L	141_L	3.362	1.00
5_E	18_A	3.284	1.00
103_A	165_A	2.891	1.00
135_H	157_T	2.738	1.00
28_D	52_S	2.735	1.00
138_L	170_L	2.670	1.00
151_V	166_V	2.598	1.00
105_V	169_A	2.534	1.00
14_D	56_K	2.388	1.00
104_Q	152_I	2.334	1.00
7_V	16_E	2.303	1.00
79_L	146_R	2.217	1.00
18_A	52_S	2.197	1.00
129_F	134_V	2.154	1.00
55_A	70_I	2.104	1.00
27_A	44_T	2.073	1.00
118_R	152_I	2.065	1.00
72_I	144_E	2.047	1.00
126_V	163_I	1.980	1.00
105_V	151_V	1.980	1.00
55_A	66_T	1.912	1.00
104_Q	154_H	1.898	1.00
32_D	37_T	1.860	1.00
136_E	140_K	1.804	1.00
109_L	147_M	1.800	1.00
134_V	163_I	1.799	1.00
152_I	155_Y	1.791	1.00
95_F	104_Q	1.789	1.00
36_M	67_T	1.775	1.00
23_G	50_D	1.756	1.00
119_A	166_V	1.710	1.00
122_P	159_T	1.675	1.00
89_K	176_E	1.672	1.00
28_D	54_N	1.652	1.00
89_K	179_T	1.640	1.00
30_K	54_N	1.634	1.00
45_K	190_T	1.609	1.00
82_L	178_T	1.586	1.00
141_L	170_L	1.578	1.00
135_H	139_W	1.566	1.00
116_E	155_Y	1.550	1.00
86_K	186_G	1.532	1.00
17_L	53_I	1.478	1.00
5_E	16_E	1.447	1.00
25_G	50_D	1.445	1.00
89_K	181_D	1.425	1.00
121_F	163_I	1.405	1.00
63_D	133_L	1.404	1.00
21_I	178_T	1.374	0.99
34_P	60_D	1.369	0.99
7_V	14_D	1.350	0.99
93_S	176_E	1.344	0.99
76_Q	144_E	1.329	0.99
125_K	128_T	1.326	0.99
36_M	70_I	1.325	0.99
159_T	162_M	1.311	0.99
109_L	174_L	1.308	0.99
42_L	91_Y	1.305	0.99
103_A	153_V	1.297	0.99
71_G	136_E	1.297	0.99
88_I	109_L	1.291	0.99
138_L	151_V	1.265	0.99
67_T	133_L	1.248	0.99
17_L	77_A	1.247	0.99
141_L	147_M	1.240	0.99
63_D	130_D	1.218	0.99
16_E	54_N	1.201	0.99
71_G	140_K	1.193	0.98
24_G	50_D	1.193	0.98
32_D	59_V	1.174	0.98
76_Q	80_E	1.164	0.98
27_A	41_D	1.139	0.98
132_E	159_T	1.136	0.98
122_P	162_M	1.131	0.98
3_K	18_A	1.129	0.98
33_V	63_D	1.128	0.98
40_L	51_L	1.123	0.98
98_M	106_V	1.122	0.98
175_D	178_T	1.111	0.98
153_V	162_M	1.109	0.97
6_R	73_C	1.107	0.97
6_R	80_E	1.103	0.97
11_N	41_D	1.089	0.97
175_D	179_T	1.087	0.97
48_Q	184_V	1.087	0.97
79_L	85_K	1.087	0.97
105_V	170_L	1.078	0.97
132_E	158_N	1.074	0.97
46_H	171_G	1.074	0.97
71_G	137_F	1.073	0.97
95_F	154_H	1.071	0.97
103_A	162_M	1.047	0.96
123_A	132_E	1.045	0.96
119_A	153_V	1.036	0.96
59_V	63_D	1.035	0.96
17_L	73_C	1.033	0.96
63_D	128_T	1.030	0.96
113_P	143_L	1.030	0.96
125_K	130_D	1.029	0.96
130_D	133_L	1.021	0.96
3_K	20_T	1.021	0.96
67_T	129_F	1.020	0.96
93_S	106_V	1.015	0.96
48_Q	175_D	1.012	0.96
2_R	22_D	1.012	0.96
31_T	37_T	1.005	0.95
103_A	166_V	0.976	0.95
151_V	170_L	0.964	0.94
30_K	56_K	0.961	0.94
43_F	171_G	0.957	0.94
31_T	53_I	0.956	0.94
138_L	166_V	0.950	0.94
97_P	102_L	0.941	0.94
29_I	41_D	0.939	0.94
59_V	66_T	0.936	0.93
117_M	134_V	0.932	0.93
96_V	169_A	0.928	0.93
139_W	143_L	0.924	0.93
31_T	70_I	0.921	0.93
19_F	78_L	0.918	0.93
78_L	174_L	0.918	0.93
43_F	174_L	0.912	0.93
153_V	165_A	0.911	0.92
49_F	178_T	0.910	0.92
123_A	159_T	0.909	0.92
26_Q	50_D	0.899	0.92
6_R	77_A	0.899	0.92
121_F	159_T	0.883	0.91
110_S	148_N	0.883	0.91
117_M	121_F	0.865	0.90
17_L	74_L	0.864	0.90
34_P	128_T	0.860	0.90
43_F	47_G	0.854	0.90
42_L	73_C	0.847	0.89
109_L	145_A	0.841	0.89
115_L	142_A	0.840	0.89
20_T	50_D	0.840	0.89
136_E	139_W	0.834	0.89
95_F	106_V	0.831	0.89
36_M	137_F	0.825	0.88
92_G	173_A	0.822	0.88
124_A	159_T	0.821	0.88
113_P	146_R	0.818	0.88
33_V	59_V	0.813	0.87
142_A	149_L	0.805	0.87
130_D	158_N	0.805	0.87
43_F	49_F	0.793	0.86
156_G	162_M	0.791	0.86
126_V	159_T	0.790	0.86
100_E	148_N	0.789	0.86
102_L	106_V	0.775	0.85
63_D	125_K	0.775	0.85
41_D	60_D	0.772	0.85
32_D	66_T	0.770	0.84
53_I	70_I	0.767	0.84
104_Q	155_Y	0.760	0.84
118_R	155_Y	0.760	0.84
30_K	37_T	0.759	0.84
140_K	144_E	0.757	0.83
49_F	78_L	0.742	0.82
133_L	136_E	0.740	0.82
92_G	176_E	0.740	0.82
48_Q	188_P	0.739	0.82
119_A	162_M	0.738	0.82
44_T	51_L	0.734	0.82
43_F	98_M	0.731	0.81
44_T	47_G	0.730	0.81
82_L	88_I	0.722	0.80
101_A	156_G	0.720	0.80
182_P	186_G	0.718	0.80
74_L	141_L	0.717	0.80
109_L	148_N	0.713	0.80
44_T	49_F	0.711	0.79
123_A	126_V	0.710	0.79
153_V	166_V	0.704	0.79
101_A	153_V	0.702	0.79
125_K	132_E	0.701	0.78
184_V	187_I	0.700	0.78
63_D	126_V	0.696	0.78
34_P	59_V	0.695	0.78
114_H	139_W	0.695	0.78
67_T	137_F	0.691	0.78
100_E	157_T	0.683	0.77
101_A	157_T	0.681	0.76
182_P	185_K	0.677	0.76
78_L	147_M	0.673	0.76
37_T	60_D	0.673	0.76
34_P	55_A	0.666	0.75
107_I	149_L	0.662	0.74
89_K	175_D	0.662	0.74
115_L	140_K	0.661	0.74
149_L	170_L	0.660	0.74
184_V	188_P	0.657	0.74
4_A	80_E	0.650	0.73
19_F	49_F	0.646	0.73
83_G	88_I	0.644	0.72
35_F	39_M	0.644	0.72
126_V	131_T	0.642	0.72
187_I	193_M	0.641	0.72
103_A	155_Y	0.635	0.71
33_V	128_T	0.635	0.71
115_L	135_H	0.630	0.71
37_T	59_V	0.628	0.71
47_G	171_G	0.628	0.71
130_D	136_E	0.627	0.70
86_K	187_I	0.627	0.70
63_D	134_V	0.623	0.70
124_A	130_D	0.622	0.70
41_D	45_K	0.618	0.69
46_H	172_R	0.618	0.69
29_I	37_T	0.617	0.69
6_R	76_Q	0.606	0.68
95_F	152_I	0.605	0.68
7_V	54_N	0.602	0.67
33_V	129_F	0.593	0.66
48_Q	181_D	0.593	0.66
36_M	134_V	0.591	0.66
4_A	73_C	0.589	0.66
160_H	164_E	0.587	0.65
123_A	130_D	0.587	0.65
94_A	172_R	0.586	0.65
85_K	88_I	0.585	0.65
150_H	155_Y	0.584	0.65
123_A	131_T	0.582	0.65
94_A	176_E	0.582	0.65
115_L	119_A	0.580	0.64
62_D	127_G	0.580	0.64
70_I	73_C	0.578	0.64
93_S	104_Q	0.576	0.64
47_G	175_D	0.568	0.63
117_M	139_W	0.568	0.63
113_P	144_E	0.566	0.63
175_D	181_D	0.562	0.62
90_R	108_D	0.561	0.62
49_F	174_L	0.560	0.62
36_M	71_G	0.560	0.62
161_H	164_E	0.558	0.61
86_K	185_K	0.555	0.61
124_A	131_T	0.553	0.61
101_A	165_A	0.552	0.61
61_I	66_T	0.549	0.60
42_L	172_R	0.548	0.60
39_M	167_F	0.547	0.60
11_N	61_I	0.546	0.60
36_M	40_L	0.545	0.60
27_A	171_G	0.544	0.60
102_L	154_H	0.542	0.59
85_K	111_N	0.540	0.59
74_L	78_L	0.540	0.59
110_S	194_L	0.539	0.59
181_D	184_V	0.537	0.59
35_F	38_H	0.537	0.59
27_A	50_D	0.537	0.59
38_H	160_H	0.535	0.58
78_L	107_I	0.533	0.58
176_E	179_T	0.533	0.58
36_M	73_C	0.532	0.58
92_G	109_L	0.532	0.58
11_N	192_G	0.530	0.58
19_F	51_L	0.530	0.58
48_Q	179_T	0.529	0.57
42_L	105_V	0.529	0.57
140_K	143_L	0.528	0.57
137_F	141_L	0.527	0.57
17_L	70_I	0.526	0.57
107_I	190_T	0.525	0.57
106_V	190_T	0.524	0.57
113_P	142_A	0.524	0.57
121_F	124_A	0.522	0.56
105_V	166_V	0.518	0.56
136_E	157_T	0.517	0.56
4_A	81_A	0.515	0.55
64_H	69_D	0.514	0.55
131_T	159_T	0.514	0.55
93_S	154_H	0.511	0.55
38_H	161_H	0.511	0.55
107_I	147_M	0.510	0.55
28_D	186_G	0.509	0.55
114_H	135_H	0.508	0.54
101_A	155_Y	0.506	0.54
121_F	134_V	0.506	0.54
40_L	53_I	0.505	0.54
4_A	19_F	0.504	0.54
100_E	150_H	0.503	0.54
175_D	184_V	0.500	0.53
106_V	152_I	0.500	0.53
15_I	55_A	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mu3A	6	0.9536	100	-0.022	Contact Map
4gquA	6	0.9485	100	-0.016	Contact Map
2ae8A	5	0.8918	100	-0.014	Contact Map
1rhyA	4	0.9021	100	-0.009	Contact Map
4jifA	2	0.4124	38	0.957	Contact Map
3f0wA	2	0.4381	15.2	0.965	Contact Map
1aqcA	2	0.4485	12.9	0.966	Contact Map
1n3hA	1	0.4485	8.3	0.969	Contact Map
3so6A	1	0.4639	8.3	0.969	Contact Map
4q2uA	5	0.2371	7.8	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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