GREMLIN Database
YLBB - Uncharacterized protein YlbB
UniProt: O34682 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (121)
Sequences: 12675 (9528)
Seq/√Len: 866.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_D23_E2.8541.00
35_A101_R2.5921.00
83_E106_K2.4001.00
81_V104_V2.3741.00
17_V71_T2.2341.00
85_A89_E2.1681.00
81_V85_A2.0541.00
79_V97_H2.0521.00
68_Q72_D1.9731.00
16_T19_D1.9581.00
24_A70_I1.9211.00
82_E85_A1.9021.00
15_C19_D1.8181.00
15_C24_A1.7981.00
15_C36_I1.7571.00
4_I90_V1.7431.00
17_V47_V1.7321.00
15_C38_V1.7131.00
83_E111_T1.7061.00
81_V90_V1.6511.00
69_K72_D1.6401.00
37_P46_L1.6261.00
100_R116_L1.6211.00
79_V99_L1.6061.00
24_A50_V1.5441.00
13_Q31_A1.4991.00
103_P110_L1.4961.00
27_K31_A1.4691.00
17_V40_D1.4381.00
90_V102_I1.4241.00
5_K83_E1.4231.00
16_T41_E1.4211.00
40_D45_T1.4021.00
26_V30_D1.3691.00
24_A36_I1.3451.00
18_L71_T1.3441.00
50_V55_L1.3371.00
20_N23_E1.3141.00
85_A93_L1.3001.00
15_C70_I1.2811.00
19_D27_K1.2741.00
93_L97_H1.2571.00
92_H96_S1.2441.00
22_Y26_V1.2361.00
52_D56_V1.2281.00
22_Y66_N1.2251.00
14_Y39_V1.2211.00
81_V102_I1.2131.00
80_S105_T1.2111.00
13_Q27_K1.1991.00
79_V93_L1.1761.00
64_K67_S1.1721.00
50_V73_A1.1531.00
23_E26_V1.1481.00
7_L87_V1.1341.00
46_L110_L1.1311.00
90_V114_V1.1281.00
40_D47_V1.1261.00
50_V70_I1.1221.00
82_E106_K1.1151.00
68_Q73_A1.1131.00
106_K109_K1.1061.00
21_V73_A1.0971.00
5_K84_D1.0901.00
35_A49_I1.0871.00
38_V74_M1.0781.00
27_K30_D1.0591.00
7_L114_V1.0541.00
86_S89_E1.0451.00
52_D100_R1.0441.00
89_E93_L1.0351.00
49_I103_P1.0291.00
39_V47_V1.0081.00
33_V36_I0.9871.00
54_D75_T0.9761.00
56_V100_R0.9761.00
25_A55_L0.9701.00
15_C27_K0.9651.00
46_L78_P0.9621.00
13_Q33_V0.9541.00
37_P110_L0.9351.00
48_G74_M0.9341.00
87_V119_L0.9311.00
34_G52_D0.9311.00
35_A100_R0.9231.00
106_K111_T0.9201.00
46_L103_P0.9051.00
101_R113_I0.8851.00
81_V93_L0.8801.00
18_L69_K0.8761.00
9_T118_D0.8661.00
65_P68_Q0.8561.00
93_L102_I0.8491.00
94_M102_I0.8491.00
24_A28_M0.8491.00
34_G100_R0.8421.00
101_R115_T0.8391.00
22_Y67_S0.8391.00
45_T109_K0.8251.00
66_N69_K0.8181.00
27_K36_I0.8141.00
37_P103_P0.8081.00
45_T108_K0.7951.00
89_E92_H0.7941.00
16_T39_V0.7881.00
70_I74_M0.7831.00
16_T40_D0.7771.00
4_I81_V0.7711.00
40_D43_G0.7641.00
100_R117_G0.7581.00
8_M104_V0.7561.00
12_L37_P0.7531.00
23_E27_K0.7511.00
95_A121_L0.7461.00
47_V74_M0.7411.00
28_M36_I0.7351.00
35_A113_I0.7241.00
53_R100_R0.7171.00
34_G116_L0.7041.00
34_G53_R0.6911.00
105_T108_K0.6861.00
39_V43_G0.6701.00
49_I78_P0.6671.00
35_A51_T0.6651.00
39_V46_L0.6511.00
120_S124_Q0.6491.00
9_T12_L0.6471.00
42_D109_K0.6461.00
71_T74_M0.6461.00
91_L119_L0.6371.00
49_I101_R0.6341.00
4_I114_V0.6331.00
108_K111_T0.6291.00
34_G101_R0.6241.00
105_T110_L0.6231.00
29_K62_I0.6221.00
101_R116_L0.6161.00
8_M111_T0.6051.00
82_E108_K0.6041.00
117_G121_L0.5971.00
49_I113_I0.5911.00
33_V37_P0.5871.00
21_V59_G0.5871.00
13_Q36_I0.5851.00
80_S108_K0.5851.00
61_A65_P0.5851.00
29_K57_L0.5841.00
11_D110_L0.5791.00
118_D121_L0.5781.00
37_P47_V0.5761.00
55_L59_G0.5741.00
33_V118_D0.5721.00
20_N69_K0.5661.00
116_L120_S0.5581.00
62_I65_P0.5541.00
94_M116_L0.5531.00
4_I7_L0.5531.00
19_D36_I0.5521.00
49_I75_T0.5521.00
17_V41_E0.5461.00
85_A90_V0.5451.00
33_V115_T0.5441.00
52_D117_G0.5431.00
75_T78_P0.5411.00
7_L122_S0.5321.00
58_R61_A0.5301.00
14_Y43_G0.5291.00
34_G37_P0.5291.00
55_L60_I0.5231.00
25_A52_D0.5231.00
5_K8_M0.5211.00
119_L123_E0.5201.00
78_P103_P0.5181.00
113_I118_D0.5171.00
103_P113_I0.5161.00
103_P111_T0.5101.00
62_I68_Q0.5081.00
22_Y65_P0.5071.00
57_L95_A0.5031.00
64_K68_Q0.5021.00
4_I8_M0.5011.00
41_E45_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o16A 2 0.8986 99.9 0.301 Contact Map
3l2bA 2 0.7838 99.9 0.314 Contact Map
3orgA 2 0.7838 99.9 0.334 Contact Map
4cooA 2 0.8446 99.9 0.337 Contact Map
3pc3A 2 0.8514 99.9 0.338 Contact Map
1y5hA 2 0.8243 99.8 0.347 Contact Map
3fhmA 2 0.8446 99.8 0.351 Contact Map
4nocA 2 0.8446 99.8 0.352 Contact Map
2rc3A 3 0.8311 99.8 0.352 Contact Map
4esyA 2 0.8446 99.8 0.356 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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