GREMLIN Database
YTBE - Uncharacterized oxidoreductase YtbE
UniProt: O34678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (255)
Sequences: 32311 (20800)
Seq/√Len: 1302.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_T244_K3.2371.00
99_E138_R2.9001.00
30_G66_E2.7621.00
214_Y258_D2.7531.00
255_T258_D2.5631.00
95_L132_T2.4771.00
39_T43_H2.3801.00
98_F133_L2.3791.00
95_L136_E2.3151.00
69_E106_G2.3121.00
131_E135_K2.1191.00
109_Y140_K2.1091.00
213_T261_R2.1071.00
228_Q259_M2.0951.00
182_Y186_Q2.0751.00
39_T240_E2.0501.00
240_E244_K2.0461.00
100_T104_K2.0451.00
132_T136_E2.0441.00
183_C190_M1.9681.00
213_T258_D1.9551.00
208_A212_Q1.9431.00
21_G47_S1.8851.00
256_Q260_N1.8531.00
43_H244_K1.8511.00
91_Y132_T1.8451.00
74_S77_D1.8371.00
209_D261_R1.8161.00
153_E182_Y1.7161.00
216_K252_F1.6981.00
229_H263_D1.6921.00
40_A45_Y1.6851.00
153_E157_T1.6781.00
34_V38_K1.6751.00
114_L165_I1.6711.00
39_T42_V1.6611.00
132_T135_K1.6451.00
189_Q232_I1.6441.00
84_V113_Y1.6421.00
91_Y95_L1.6401.00
43_H247_A1.6361.00
34_V66_E1.6301.00
95_L99_E1.6301.00
217_S245_E1.5991.00
58_A62_E1.5981.00
129_A132_T1.5891.00
260_N264_A1.5821.00
82_S110_L1.5811.00
82_S101_S1.5781.00
30_G34_V1.5771.00
9_A16_E1.5761.00
248_S251_D1.5671.00
206_V209_D1.5561.00
80_I107_L1.5521.00
224_R252_F1.5391.00
98_F113_Y1.5381.00
131_E161_I1.5321.00
84_V94_T1.5161.00
156_M186_Q1.4861.00
10_T16_E1.4851.00
41_I78_L1.4771.00
96_A100_T1.4771.00
24_V48_I1.4561.00
15_V141_A1.4561.00
81_T114_L1.4521.00
148_Q151_H1.4341.00
184_Q230_G1.4311.00
99_E103_S1.4271.00
181_R185_N1.4261.00
134_Y161_I1.4191.00
52_A97_A1.4141.00
32_E35_N1.3951.00
216_K220_Q1.3861.00
35_N39_T1.3831.00
168_V190_M1.3821.00
178_E181_R1.3801.00
29_E32_E1.3731.00
114_L191_E1.3561.00
224_R228_Q1.3471.00
65_R106_G1.3261.00
38_K42_V1.3251.00
110_L139_I1.3061.00
91_Y128_R1.3021.00
244_K248_S1.3011.00
180_I184_Q1.2901.00
206_V261_R1.2891.00
216_K221_I1.2831.00
141_A164_M1.2821.00
100_T103_S1.2811.00
90_G93_E1.2801.00
124_K158_A1.2661.00
149_I182_Y1.2561.00
15_V79_F1.2561.00
105_L110_L1.2541.00
95_L129_A1.2531.00
208_A218_V1.2521.00
156_M182_Y1.2501.00
261_R264_A1.2501.00
133_L139_I1.2381.00
209_D213_T1.2311.00
237_S242_R1.2271.00
237_S243_I1.2131.00
170_F229_H1.2111.00
34_V67_G1.2051.00
79_F112_L1.1961.00
217_S220_Q1.1931.00
118_P151_H1.1741.00
139_I142_I1.1731.00
47_S81_T1.1701.00
91_Y129_A1.1691.00
93_E96_A1.1691.00
125_E128_R1.1541.00
31_S35_N1.1531.00
92_E96_A1.1391.00
153_E186_Q1.1321.00
75_R107_L1.1311.00
37_V67_G1.1301.00
134_Y164_M1.1091.00
61_G65_R1.1071.00
131_E134_Y1.1061.00
112_L165_I1.0941.00
35_N240_E1.0921.00
65_R69_E1.0901.00
135_K160_E1.0841.00
226_D233_T1.0791.00
241_H244_K1.0791.00
133_L138_R1.0751.00
169_E174_L1.0741.00
47_S191_E1.0721.00
99_E136_E1.0671.00
130_L142_I1.0621.00
75_R109_Y1.0471.00
46_R79_F1.0381.00
115_I130_L1.0371.00
210_I221_I1.0361.00
149_I153_E1.0351.00
153_E185_N1.0351.00
220_Q248_S1.0271.00
175_T266_N1.0261.00
154_D158_A1.0251.00
48_I64_I1.0201.00
209_D212_Q1.0191.00
66_E106_G1.0181.00
13_N141_A1.0001.00
207_L218_V0.9971.00
89_L115_I0.9931.00
9_A14_G0.9881.00
36_A243_I0.9701.00
12_H164_M0.9701.00
98_F110_L0.9681.00
165_I191_E0.9651.00
19_W250_F0.9641.00
19_W227_L0.9611.00
181_R184_Q0.9611.00
220_Q245_E0.9611.00
18_P46_R0.9601.00
177_K181_R0.9431.00
227_L249_V0.9411.00
144_V163_P0.9391.00
111_D140_K0.9331.00
57_E61_G0.9321.00
35_N38_K0.9271.00
88_D93_E0.9271.00
95_L98_F0.9271.00
128_R132_T0.9191.00
182_Y185_N0.9151.00
239_K242_R0.9151.00
133_L136_E0.9131.00
96_A99_E0.9121.00
129_A133_L0.9101.00
58_A104_K0.9061.00
172_P222_I0.9011.00
172_P262_I0.9001.00
62_E66_E0.8971.00
245_E248_S0.8951.00
37_V48_I0.8931.00
124_K154_D0.8921.00
24_V64_I0.8901.00
144_V152_L0.8841.00
62_E104_K0.8771.00
128_R131_E0.8751.00
241_H245_E0.8741.00
228_Q253_E0.8731.00
18_P45_Y0.8671.00
257_D261_R0.8651.00
91_Y125_E0.8651.00
191_E232_I0.8631.00
52_A100_T0.8631.00
95_L133_L0.8621.00
243_I247_A0.8611.00
152_L188_I0.8541.00
52_A93_E0.8541.00
200_Q203_D0.8541.00
260_N263_D0.8491.00
142_I163_P0.8441.00
52_A88_D0.8411.00
210_I214_Y0.8401.00
81_T112_L0.8331.00
52_A104_K0.8311.00
22_L40_A0.8291.00
13_N164_M0.8231.00
229_H259_M0.8161.00
131_E160_E0.8151.00
166_N183_C0.8101.00
81_T191_E0.8101.00
154_D157_T0.8051.00
131_E142_I0.8051.00
68_I78_L0.8001.00
222_I226_D0.7931.00
206_V265_L0.7901.00
173_R204_H0.7871.00
41_I74_S0.7871.00
175_T263_D0.7841.00
156_M162_K0.7841.00
38_K67_G0.7791.00
39_T243_I0.7781.00
257_D260_N0.7721.00
170_F180_I0.7701.00
43_H248_S0.7701.00
214_Y255_T0.7661.00
223_L249_V0.7641.00
179_L183_C0.7641.00
149_I179_L0.7631.00
213_T255_T0.7621.00
45_Y247_A0.7491.00
180_I190_M0.7451.00
238_T242_R0.7451.00
13_N134_Y0.7401.00
41_I48_I0.7391.00
219_A245_E0.7351.00
34_V63_G0.7341.00
224_R249_V0.7301.00
149_I178_E0.7251.00
228_Q256_Q0.7241.00
180_I229_H0.7221.00
34_V62_E0.7201.00
102_L138_R0.7171.00
98_F138_R0.7101.00
102_L107_L0.7101.00
97_A100_T0.7081.00
203_D208_A0.7071.00
82_S113_Y0.7051.00
89_L126_A0.7031.00
24_V60_V0.7001.00
38_K72_G0.6991.00
192_A195_P0.6981.00
94_T133_L0.6971.00
101_S113_Y0.6951.00
31_S34_V0.6951.00
20_F227_L0.6951.00
127_W142_I0.6941.00
146_N193_W0.6901.00
114_L143_G0.6861.00
30_G63_G0.6841.00
38_K74_S0.6831.00
144_V147_F0.6831.00
57_E104_K0.6811.00
202_L205_P0.6801.00
50_T64_I0.6791.00
38_K73_I0.6791.00
225_W263_D0.6781.00
195_P235_P0.6771.00
61_G101_S0.6751.00
10_T13_N0.6731.00
192_A233_T0.6721.00
64_I68_I0.6671.00
117_W146_N0.6661.00
9_A19_W0.6661.00
127_W155_L0.6661.00
183_C188_I0.6631.00
46_R77_D0.6621.00
170_F226_D0.6591.00
211_A221_I0.6591.00
17_M232_I0.6581.00
36_A240_E0.6561.00
212_Q215_N0.6521.00
126_A129_A0.6521.00
41_I67_G0.6491.00
69_E73_I0.6491.00
210_I258_D0.6481.00
30_G58_A0.6411.00
41_I77_D0.6401.00
214_Y221_I0.6361.00
94_T126_A0.6361.00
127_W163_P0.6331.00
195_P226_D0.6331.00
76_E109_Y0.6301.00
9_A189_Q0.6281.00
110_L113_Y0.6271.00
21_G235_P0.6261.00
43_H243_I0.6251.00
26_Q198_Q0.6241.00
153_E156_M0.6231.00
131_E159_A0.6231.00
254_L259_M0.6191.00
73_I78_L0.6171.00
27_V33_L0.6161.00
226_D231_I0.6151.00
134_Y139_I0.6151.00
242_R245_E0.6151.00
15_V140_K0.6141.00
221_I254_L0.6141.00
57_E60_V0.6141.00
124_K128_R0.6141.00
12_H187_G0.6141.00
94_T129_A0.6131.00
144_V166_N0.6121.00
22_L27_V0.6111.00
170_F231_I0.6111.00
42_V240_E0.6091.00
216_K248_S0.6081.00
207_L222_I0.6041.00
170_F190_M0.5981.00
194_S198_Q0.5981.00
102_L109_Y0.5971.00
41_I46_R0.5961.00
123_Y158_A0.5951.00
207_L262_I0.5941.00
170_F175_T0.5941.00
258_D261_R0.5941.00
216_K251_D0.5901.00
123_Y126_A0.5881.00
201_L222_I0.5841.00
221_I262_I0.5841.00
32_E240_E0.5841.00
95_L138_R0.5841.00
90_G126_A0.5841.00
130_L134_Y0.5791.00
53_I85_W0.5771.00
58_A63_G0.5751.00
220_Q252_F0.5711.00
49_D167_Q0.5711.00
151_H154_D0.5701.00
211_A214_Y0.5681.00
135_K161_I0.5681.00
113_Y139_I0.5651.00
37_V64_I0.5631.00
189_Q231_I0.5631.00
237_S246_N0.5611.00
33_L63_G0.5601.00
221_I258_D0.5601.00
22_L36_A0.5591.00
102_L110_L0.5591.00
211_A218_V0.5581.00
12_H162_K0.5571.00
62_E103_S0.5561.00
227_L233_T0.5561.00
25_F194_S0.5541.00
102_L108_D0.5541.00
123_Y151_H0.5521.00
36_A237_S0.5501.00
173_R200_Q0.5491.00
98_F102_L0.5481.00
91_Y94_T0.5471.00
37_V41_I0.5431.00
221_I252_F0.5431.00
134_Y141_A0.5411.00
74_S78_L0.5371.00
84_V97_A0.5361.00
259_M263_D0.5351.00
115_I126_A0.5341.00
210_I261_R0.5341.00
254_L258_D0.5301.00
123_Y154_D0.5291.00
144_V155_L0.5251.00
28_E60_V0.5241.00
207_L211_A0.5231.00
142_I161_I0.5231.00
54_Y116_H0.5201.00
192_A226_D0.5191.00
84_V89_L0.5181.00
27_V36_A0.5171.00
156_M188_I0.5161.00
67_G72_G0.5121.00
101_S104_K0.5111.00
68_I74_S0.5101.00
20_F250_F0.5081.00
113_Y130_L0.5061.00
150_H153_E0.5041.00
112_L141_A0.5041.00
40_A48_I0.5021.00
224_R253_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b3dA 1 0.9786 100 0.116 Contact Map
3f7jA 1 0.9821 100 0.117 Contact Map
4f40A 1 0.9643 100 0.125 Contact Map
3v0sA 1 0.9 100 0.125 Contact Map
4otkA 1 0.975 100 0.126 Contact Map
2wzmA 1 0.9679 100 0.126 Contact Map
1pyfA 1 0.925 100 0.129 Contact Map
4r9oA 5 0.9464 100 0.13 Contact Map
3wbwA 1 0.9571 100 0.13 Contact Map
4q3mA 2 0.9607 100 0.13 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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