GREMLIN Database
KAMA - L-lysine 2,3-aminomutase
UniProt: O34676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 471 (370)
Sequences: 696 (415)
Seq/√Len: 21.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_D256_K6.2381.00
210_T236_L5.4021.00
191_E231_Y5.0811.00
191_E195_K4.8391.00
167_R196_E4.5801.00
39_T42_D4.3551.00
278_V323_G3.7851.00
140_Y241_N3.3861.00
195_K231_Y3.3511.00
191_E227_I3.3421.00
272_A276_D3.3171.00
166_I203_L3.1321.00
77_D80_N3.1011.00
191_E230_K3.0871.00
44_K54_E2.9530.99
229_K259_N2.9040.99
73_A76_M2.8550.99
126_V172_I2.8370.99
160_D164_A2.8230.99
276_D316_K2.8150.99
198_R206_I2.8080.99
281_M285_M2.7780.99
25_K28_D2.7690.99
130_V185_I2.7030.99
76_M83_C2.6240.99
164_A168_E2.4230.97
22_P25_K2.4150.97
37_V43_L2.3720.97
316_K319_E2.3510.97
268_A285_M2.3450.97
170_P201_P2.3240.97
127_L178_S2.2780.96
227_I232_H2.2270.96
287_D290_K2.2110.96
89_S140_Y2.1990.95
83_C244_I2.1360.95
254_C291_I2.0940.94
314_V338_V2.0400.93
88_Q211_R2.0290.93
160_D192_Y2.0250.93
41_D58_R2.0060.93
266_N293_V1.9610.92
252_E256_K1.9500.91
183_L224_L1.9500.91
195_K227_I1.9450.91
254_C293_V1.9280.91
53_E56_G1.9180.91
238_T266_N1.8920.90
46_V73_A1.8700.90
190_L208_I1.8440.89
50_T53_E1.8280.88
167_R199_S1.8210.88
159_L193_I1.8110.88
43_L90_V1.8090.88
190_L227_I1.7980.88
166_I172_I1.7820.87
168_E171_E1.7240.85
252_E255_E1.7200.85
55_E58_R1.7120.85
213_P250_S1.7090.85
289_V331_Y1.7080.85
183_L236_L1.6780.84
240_F250_S1.6530.83
142_T302_D1.6360.82
325_R335_T1.6290.82
126_V175_C1.6130.81
65_P144_R1.6060.81
241_N271_L1.5890.80
18_W46_V1.5880.80
86_R218_Q1.5360.78
105_D109_E1.5180.77
226_E256_K1.5080.76
246_M291_I1.4990.76
214_V240_F1.4950.76
235_W289_V1.4860.75
222_D226_E1.4820.75
18_W21_V1.4630.74
282_K286_H1.4570.74
172_I175_C1.4310.72
118_L172_I1.4300.72
237_N331_Y1.4270.72
23_E27_N1.3970.71
322_E365_R1.3940.70
127_L302_D1.3910.70
198_R231_Y1.3760.69
302_D339_D1.3700.69
258_V264_V1.3700.69
163_I167_R1.3620.69
85_V266_N1.3590.68
142_T339_D1.3550.68
347_I364_L1.3360.67
304_S307_I1.3240.66
43_L66_L1.3070.65
127_L339_D1.3020.65
198_R232_H1.3010.65
182_G185_I1.2780.64
120_H127_L1.2690.63
65_P151_G1.2610.63
314_V362_V1.2550.62
36_T67_N1.2450.61
73_A90_V1.2430.61
241_N266_N1.2400.61
183_L190_L1.2370.61
186_N189_I1.2360.61
178_S339_D1.2340.61
107_L339_D1.2310.61
120_H302_D1.2270.60
25_K34_T1.2230.60
77_D244_I1.2150.60
212_A239_H1.2130.59
277_S280_I1.2120.59
206_I239_H1.2100.59
281_M298_I1.2090.59
40_L54_E1.2080.59
196_E199_S1.2060.59
118_L246_M1.1940.58
48_N79_D1.1930.58
214_V266_N1.1900.58
71_Y247_T1.1810.57
168_E256_K1.1700.57
218_Q222_D1.1650.56
299_Y337_V1.1620.56
34_T189_I1.1590.56
182_G208_I1.1560.56
187_D221_T1.1550.56
172_I201_P1.1510.55
284_L293_V1.1480.55
225_C257_L1.1430.55
151_G240_F1.1330.54
140_Y144_R1.1310.54
85_V241_N1.1300.54
140_Y238_T1.1290.54
68_I252_E1.1290.54
49_L274_I1.1220.53
178_S302_D1.0980.52
175_C204_E1.0960.52
53_E86_R1.0880.51
228_L234_V1.0840.51
164_A167_R1.0830.51
160_D196_E1.0750.50
51_E55_E1.0740.50
136_M144_R1.0610.49
120_H142_T1.0550.49
72_Y215_V1.0510.49
34_T155_P1.0500.49
133_Q184_L1.0490.48
108_H135_S1.0430.48
237_N265_G1.0410.48
105_D343_G1.0370.48
161_A164_A1.0360.48
183_L249_E1.0350.48
120_H339_D1.0320.47
87_M94_E1.0300.47
321_I325_R1.0270.47
194_L234_V1.0250.47
107_L178_S1.0250.47
142_T178_S1.0240.47
205_V237_N1.0200.47
218_Q249_E1.0180.46
381_I384_Q1.0170.46
228_L257_L1.0130.46
183_L227_I1.0070.46
47_I73_A1.0040.45
139_R306_G1.0010.45
185_I336_F1.0000.45
78_P81_P0.9980.45
56_G64_I0.9970.45
243_S280_I0.9900.45
107_L302_D0.9890.44
162_A177_I0.9880.44
101_Y104_E0.9860.44
69_T301_C0.9830.44
76_M244_I0.9810.44
18_W132_N0.9770.44
88_Q241_N0.9750.44
131_T154_V0.9720.43
95_E139_R0.9670.43
107_L142_T0.9670.43
163_I200_I0.9640.43
76_M86_R0.9610.43
311_R339_D0.9560.42
16_E19_K0.9560.42
214_V238_T0.9510.42
204_E290_K0.9510.42
185_I210_T0.9470.42
211_R214_V0.9430.41
316_K323_G0.9430.41
170_P202_H0.9410.41
335_T340_A0.9400.41
266_N284_L0.9370.41
172_I206_I0.9330.41
163_I203_L0.9270.40
213_P293_V0.9260.40
364_L371_I0.9250.40
127_L142_T0.9250.40
87_M190_L0.9240.40
86_R90_V0.9130.39
24_E229_K0.9110.39
125_R324_L0.9110.39
37_V42_D0.9080.39
361_K373_S0.9070.39
63_T96_M0.9010.39
232_H239_H0.9000.39
221_T292_R0.8990.39
354_V358_S0.8990.39
259_N292_R0.8980.39
286_H328_T0.8940.38
289_V332_A0.8890.38
57_V272_A0.8890.38
97_H157_K0.8830.38
115_V337_V0.8830.38
187_D224_L0.8810.37
34_T182_G0.8790.37
137_Y314_V0.8790.37
263_P319_E0.8790.37
48_N90_V0.8760.37
250_S318_L0.8760.37
73_A83_C0.8690.37
116_P161_A0.8670.37
72_Y214_V0.8590.36
173_R332_A0.8550.36
307_I311_R0.8550.36
219_R224_L0.8520.36
50_T76_M0.8510.36
232_H258_V0.8510.36
299_Y303_L0.8470.35
163_I231_Y0.8470.35
51_E54_E0.8460.35
284_L288_L0.8440.35
130_V193_I0.8400.35
43_L57_V0.8340.35
174_D265_G0.8310.34
129_L146_F0.8300.34
281_M320_I0.8270.34
163_I197_L0.8270.34
16_E25_K0.8260.34
174_D257_L0.8260.34
226_E229_K0.8230.34
96_M223_H0.8220.34
25_K33_L0.8210.34
118_L128_F0.8200.34
126_V178_S0.8180.34
129_L142_T0.8180.34
205_V329_S0.8170.33
318_L349_L0.8160.33
119_T238_T0.8150.33
246_M287_D0.8150.33
140_Y239_H0.8150.33
241_N274_I0.8130.33
136_M215_V0.8070.33
212_A220_I0.8070.33
272_A316_K0.8040.33
160_D163_I0.8040.33
129_L178_S0.8020.33
147_S151_G0.8010.33
129_L132_N0.7980.32
211_R266_N0.7960.32
315_S319_E0.7940.32
50_T244_I0.7910.32
28_D31_W0.7910.32
299_Y331_Y0.7860.32
110_D329_S0.7860.32
42_D272_A0.7860.32
88_Q266_N0.7840.32
31_W70_P0.7840.32
270_V312_A0.7810.31
66_L90_V0.7790.31
34_T188_Q0.7780.31
218_Q280_I0.7770.31
223_H227_I0.7750.31
144_R151_G0.7700.31
27_N252_E0.7630.30
129_L302_D0.7630.30
264_V340_A0.7630.30
68_I73_A0.7620.30
65_P147_S0.7590.30
126_V176_L0.7590.30
109_E114_P0.7590.30
188_Q226_E0.7570.30
62_K210_T0.7570.30
382_P385_A0.7560.30
76_M89_S0.7550.30
211_R241_N0.7540.30
55_E189_I0.7530.30
84_P96_M0.7510.30
107_L127_L0.7500.30
128_F162_A0.7490.30
183_L284_L0.7480.29
194_L316_K0.7470.29
142_T366_N0.7450.29
89_S238_T0.7430.29
52_D167_R0.7410.29
176_L209_G0.7350.29
178_S303_L0.7350.29
67_N274_I0.7350.29
25_K360_D0.7310.29
120_H129_L0.7300.28
265_G292_R0.7290.28
21_V274_I0.7290.28
107_L120_H0.7290.28
110_D316_K0.7270.28
223_H226_E0.7240.28
293_V348_A0.7230.28
120_H178_S0.7210.28
41_D252_E0.7180.28
271_L306_G0.7180.28
70_P284_L0.7180.28
82_R87_M0.7170.28
126_V304_S0.7170.28
104_E170_P0.7150.28
140_Y271_L0.7130.28
144_R211_R0.7120.28
257_L260_A0.7120.28
164_A170_P0.7070.27
37_V61_T0.7060.27
189_I255_E0.7050.27
21_V35_H0.7050.27
339_D344_G0.7040.27
119_T302_D0.7040.27
121_R302_D0.7040.27
233_P292_R0.7030.27
121_R142_T0.7020.27
164_A256_K0.7020.27
41_D78_P0.7010.27
77_D206_I0.6990.27
142_T344_G0.6970.27
228_L262_V0.6940.27
159_L186_N0.6940.27
38_R223_H0.6890.26
159_L211_R0.6860.26
286_H291_I0.6840.26
128_F193_I0.6830.26
244_I274_I0.6810.26
248_E251_V0.6810.26
66_L178_S0.6810.26
208_I337_V0.6800.26
183_L212_A0.6790.26
95_E306_G0.6790.26
119_T136_M0.6780.26
175_C197_L0.6780.26
198_R239_H0.6760.26
70_P74_S0.6750.26
298_I347_I0.6750.26
306_G369_G0.6720.25
314_V327_H0.6720.25
90_V218_Q0.6690.25
369_G374_Y0.6670.25
166_I215_V0.6650.25
97_H349_L0.6630.25
49_L315_S0.6600.25
136_M140_Y0.6590.25
365_R376_E0.6590.25
268_A281_M0.6560.25
187_D219_R0.6550.25
257_L262_V0.6550.25
89_S136_M0.6550.25
147_S307_I0.6500.24
348_A353_Y0.6490.24
181_D296_Y0.6450.24
98_K305_E0.6440.24
52_D58_R0.6440.24
211_R237_N0.6440.24
51_E199_S0.6430.24
172_I200_I0.6420.24
246_M250_S0.6400.24
163_I206_I0.6380.24
56_G93_S0.6370.24
266_N288_L0.6370.24
140_Y266_N0.6360.24
311_R344_G0.6360.24
165_Y310_F0.6350.24
101_Y168_E0.6350.24
198_R233_P0.6340.24
279_P283_K0.6330.23
121_R341_P0.6330.23
221_T349_L0.6310.23
125_R351_P0.6310.23
68_I90_V0.6310.23
85_V116_P0.6300.23
55_E168_E0.6280.23
189_I193_I0.6260.23
116_P210_T0.6260.23
231_Y234_V0.6240.23
104_E305_E0.6240.23
22_P81_P0.6240.23
256_K259_N0.6230.23
172_I283_K0.6230.23
286_H332_A0.6220.23
105_D288_L0.6220.23
63_T305_E0.6210.23
336_F367_F0.6210.23
83_C274_I0.6200.23
18_W73_A0.6200.23
22_P42_D0.6180.23
194_L228_L0.6180.23
340_A364_L0.6170.23
154_V158_Q0.6170.23
94_E100_K0.6160.23
153_G184_L0.6140.23
136_M238_T0.6140.23
54_E290_K0.6130.23
230_K361_K0.6130.23
105_D118_L0.6110.22
113_S116_P0.6100.22
135_S215_V0.6100.22
283_K287_D0.6070.22
57_V234_V0.6070.22
160_D199_S0.6060.22
90_V304_S0.6060.22
325_R348_A0.6050.22
136_M214_V0.6040.22
188_Q357_Q0.6040.22
94_E223_H0.6020.22
47_I82_R0.5970.22
324_L329_S0.5960.22
268_A303_L0.5960.22
163_I230_K0.5960.22
65_P310_F0.5950.22
56_G60_S0.5910.22
135_S184_L0.5910.22
222_D229_K0.5900.21
51_E160_D0.5900.21
119_T144_R0.5900.21
61_T318_L0.5890.21
72_Y238_T0.5890.21
184_L212_A0.5890.21
115_V161_A0.5890.21
283_K291_I0.5890.21
104_E259_N0.5870.21
174_D326_G0.5870.21
34_T133_Q0.5870.21
343_G365_R0.5850.21
241_N268_A0.5850.21
225_C260_A0.5850.21
315_S359_P0.5830.21
173_R353_Y0.5820.21
135_S212_A0.5800.21
42_D46_V0.5800.21
227_I262_V0.5800.21
25_K94_E0.5800.21
201_P290_K0.5780.21
107_L121_R0.5770.21
128_F159_L0.5770.21
25_K212_A0.5770.21
238_T241_N0.5760.21
84_P88_Q0.5760.21
192_Y196_E0.5750.21
140_Y322_E0.5740.21
136_M240_F0.5740.21
225_C256_K0.5740.21
41_D293_V0.5720.21
57_V73_A0.5710.21
268_A301_C0.5710.21
56_G59_I0.5710.21
241_N306_G0.5700.21
121_R339_D0.5700.21
41_D82_R0.5690.21
194_L231_Y0.5670.20
279_P323_G0.5670.20
52_D222_D0.5660.20
187_D227_I0.5640.20
142_T301_C0.5630.20
156_K189_I0.5620.20
49_L53_E0.5620.20
26_W69_T0.5620.20
138_C141_C0.5610.20
134_C141_C0.5610.20
134_C138_C0.5610.20
78_P100_K0.5610.20
129_L144_R0.5610.20
142_T299_Y0.5600.20
42_D111_E0.5600.20
210_T373_S0.5590.20
300_Q313_P0.5590.20
139_R325_R0.5580.20
311_R374_Y0.5570.20
308_G311_R0.5570.20
63_T98_K0.5570.20
95_E125_R0.5570.20
148_G211_R0.5560.20
379_N384_Q0.5560.20
304_S370_V0.5560.20
16_E363_I0.5540.20
192_Y234_V0.5510.20
101_Y298_I0.5500.20
286_H290_K0.5490.20
193_I227_I0.5480.20
313_P359_P0.5480.20
251_V287_D0.5460.20
81_P160_D0.5440.19
306_G326_G0.5420.19
213_P355_L0.5420.19
44_K160_D0.5410.19
194_L210_T0.5410.19
128_F339_D0.5400.19
121_R368_E0.5390.19
173_R247_T0.5390.19
43_L87_M0.5380.19
136_M368_E0.5380.19
50_T274_I0.5370.19
301_C309_H0.5360.19
112_D119_T0.5360.19
235_W331_Y0.5320.19
372_T375_P0.5320.19
81_P252_E0.5320.19
344_G369_G0.5310.19
145_R317_G0.5310.19
41_D45_K0.5300.19
325_R343_G0.5300.19
51_E135_S0.5290.19
64_I300_Q0.5280.19
191_E223_H0.5280.19
135_S259_N0.5280.19
245_E346_K0.5280.19
183_L208_I0.5280.19
30_L225_C0.5270.19
248_E252_E0.5270.19
119_T361_K0.5250.19
74_S83_C0.5240.19
322_E353_Y0.5240.19
24_E234_V0.5240.19
137_Y303_L0.5230.19
20_D33_L0.5230.19
267_Q330_G0.5230.19
273_G278_V0.5220.19
16_E21_V0.5210.18
164_A201_P0.5200.18
106_P125_R0.5180.18
264_V314_V0.5150.18
84_P241_N0.5140.18
85_V238_T0.5130.18
132_N147_S0.5130.18
277_S373_S0.5130.18
30_L256_K0.5120.18
33_L133_Q0.5120.18
81_P118_L0.5120.18
159_L189_I0.5110.18
227_I231_Y0.5100.18
233_P353_Y0.5100.18
89_S250_S0.5090.18
116_P272_A0.5080.18
265_G328_T0.5070.18
35_H46_V0.5070.18
326_G334_P0.5060.18
120_H366_N0.5050.18
114_P185_I0.5050.18
39_T48_N0.5040.18
53_E81_P0.5040.18
97_H195_K0.5040.18
173_R309_H0.5020.18
30_L67_N0.5020.18
285_M289_V0.5020.18
107_L335_T0.5020.18
245_E345_G0.5000.18
106_P187_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a5hA 4 0.8705 100 0.503 Contact Map
3rfaA 1 0.6709 100 0.857 Contact Map
3c8fA 1 0.4628 99.6 0.915 Contact Map
1tv8A 2 0.6221 99.6 0.916 Contact Map
1r30A 2 0.6136 99.4 0.925 Contact Map
2qgqA 1 0.518 99.4 0.925 Contact Map
4jc0A 1 0.7134 99.3 0.931 Contact Map
2yx0A 1 0.5796 99.2 0.931 Contact Map
1oltA 1 0.758 99.2 0.933 Contact Map
3iixA 1 0.6794 99.1 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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