GREMLIN Database
GLNM - Probable glutamine ABC transporter permease protein GlnM
UniProt: O34671 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (204)
Sequences: 17740 (10668)
Seq/√Len: 746.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_G205_V3.2531.00
30_G94_T3.2431.00
182_V185_D3.1311.00
89_G161_L2.9041.00
120_A130_A2.8861.00
173_A190_V2.7271.00
18_Y22_L2.6791.00
126_T129_Q2.5671.00
41_M53_G2.5471.00
38_V102_A2.4121.00
116_Q138_Q2.2521.00
117_M130_A2.1811.00
63_I68_I2.1301.00
128_S132_L2.1071.00
121_R130_A2.0971.00
38_V98_S2.0781.00
203_I207_Y2.0711.00
48_P52_L2.0561.00
171_Y175_L1.9591.00
42_R54_T1.9551.00
117_M121_R1.9211.00
48_P51_W1.8701.00
34_L98_S1.8631.00
177_S183_V1.8181.00
19_H22_L1.7851.00
47_K51_W1.7801.00
24_S155_V1.7651.00
26_I90_T1.7531.00
84_D87_Q1.7251.00
14_M18_Y1.7111.00
39_A105_I1.6931.00
173_A186_V1.6921.00
22_L86_F1.6911.00
111_S142_I1.6881.00
108_G143_V1.6811.00
43_I110_Q1.6501.00
17_F197_L1.6391.00
23_A161_L1.6131.00
207_Y210_K1.6091.00
57_V102_A1.6071.00
126_T130_A1.6011.00
199_I203_I1.5931.00
72_F92_A1.5921.00
195_L199_I1.5841.00
203_I206_N1.5721.00
15_D18_Y1.5321.00
31_S97_T1.5321.00
19_H166_G1.4871.00
28_L151_F1.4791.00
103_E106_R1.4761.00
38_V53_G1.4651.00
127_Y131_M1.4521.00
101_I147_L1.4481.00
129_Q133_H1.4261.00
12_M15_D1.3921.00
36_V105_I1.3541.00
24_S158_S1.3411.00
129_Q132_L1.3201.00
125_F129_Q1.2991.00
204_G207_Y1.2981.00
47_K50_Q1.2581.00
10_F14_M1.2511.00
68_I96_Y1.2501.00
37_A41_M1.2471.00
46_F51_W1.2411.00
69_T92_A1.2401.00
121_R127_Y1.2301.00
172_Q175_L1.2291.00
86_F90_T1.2291.00
105_I143_V1.2241.00
60_I95_I1.2121.00
51_W55_A1.2121.00
26_I94_T1.2091.00
50_Q54_T1.2081.00
101_I150_Q1.1911.00
30_G90_T1.1721.00
12_M172_Q1.1611.00
167_L171_Y1.1471.00
117_M135_I1.1471.00
42_R103_E1.1361.00
63_I96_Y1.1301.00
15_D19_H1.1221.00
46_F49_L1.1201.00
33_V37_A1.1191.00
177_S187_Y1.1161.00
207_Y211_R1.1131.00
22_L26_I1.1061.00
35_G101_I1.1011.00
171_Y174_D1.0991.00
109_I135_I1.0981.00
120_A134_I1.0931.00
106_R110_Q1.0901.00
104_A150_Q1.0861.00
52_L55_A1.0831.00
155_V197_L1.0811.00
58_E199_I1.0781.00
90_T94_T1.0621.00
43_I109_I1.0611.00
68_I72_F1.0551.00
53_G102_A1.0501.00
52_L56_Y1.0321.00
87_Q90_T1.0281.00
72_F88_A1.0221.00
11_S15_D1.0211.00
69_T161_L1.0161.00
127_Y130_A1.0121.00
174_D177_S1.0101.00
41_M44_T1.0071.00
60_I99_A1.0061.00
104_A146_P1.0051.00
85_G165_A1.0021.00
56_Y98_S0.9931.00
131_M136_L0.9851.00
175_L179_S0.9731.00
206_N210_K0.9701.00
176_V186_V0.9621.00
55_A58_E0.9621.00
41_M49_L0.9561.00
86_F166_G0.9461.00
161_L168_D0.9461.00
24_S151_F0.9411.00
58_E195_L0.9371.00
185_D188_I0.9371.00
112_V139_A0.9351.00
28_L154_L0.9341.00
204_G208_L0.9211.00
125_F133_H0.9141.00
46_F52_L0.9131.00
70_F74_F0.9021.00
153_N157_N0.8991.00
45_V50_Q0.8941.00
69_T160_I0.8911.00
206_N209_E0.8841.00
73_Y164_V0.8831.00
17_F193_F0.8831.00
20_T155_V0.8801.00
27_A94_T0.8731.00
87_Q91_V0.8671.00
32_F147_L0.8671.00
155_V201_L0.8631.00
39_A43_I0.8591.00
65_L157_N0.8591.00
56_Y60_I0.8541.00
112_V142_I0.8501.00
65_L96_Y0.8491.00
51_W54_T0.8441.00
26_I30_G0.8371.00
39_A109_I0.8361.00
75_G79_A0.8321.00
115_G119_A0.8301.00
29_A33_V0.8291.00
163_V167_L0.8291.00
159_S194_Y0.8231.00
93_L158_S0.8191.00
27_A154_L0.8181.00
71_V75_G0.8141.00
97_T150_Q0.8071.00
155_V198_T0.8061.00
17_F169_L0.8061.00
16_G172_Q0.8021.00
114_K118_E0.8011.00
73_Y88_A0.7971.00
131_M135_I0.7971.00
44_T53_G0.7911.00
11_S14_M0.7881.00
117_M127_Y0.7871.00
200_P204_G0.7801.00
161_L166_G0.7801.00
188_I192_L0.7771.00
56_Y99_A0.7731.00
179_S182_V0.7731.00
169_L193_F0.7701.00
31_S101_I0.7681.00
44_T127_Y0.7661.00
40_V131_M0.7661.00
25_V29_A0.7651.00
36_V136_L0.7631.00
142_I146_P0.7601.00
196_V200_P0.7521.00
173_A177_S0.7521.00
97_T157_N0.7501.00
85_G166_G0.7481.00
21_L25_V0.7481.00
69_T164_V0.7471.00
54_T58_E0.7441.00
184_F188_I0.7441.00
89_G164_V0.7401.00
71_V188_I0.7371.00
180_T183_V0.7361.00
23_A166_G0.7331.00
27_A93_L0.7331.00
34_L38_V0.7311.00
73_Y83_L0.7281.00
20_T24_S0.7261.00
66_L163_V0.7221.00
167_L172_Q0.7201.00
19_H168_D0.7191.00
34_L94_T0.7181.00
114_K117_M0.7181.00
23_A89_G0.7141.00
170_M187_Y0.7141.00
83_L87_Q0.7131.00
109_I139_A0.6991.00
46_F50_Q0.6971.00
42_R57_V0.6971.00
20_T194_Y0.6951.00
68_I92_A0.6921.00
26_I86_F0.6841.00
162_G171_Y0.6821.00
93_L154_L0.6821.00
101_I105_I0.6811.00
42_R50_Q0.6751.00
38_V41_M0.6661.00
26_I29_A0.6631.00
19_H86_F0.6621.00
159_S162_G0.6621.00
192_L196_V0.6611.00
177_S186_V0.6531.00
105_I109_I0.6481.00
41_M52_L0.6481.00
170_M194_Y0.6451.00
23_A27_A0.6441.00
145_P209_E0.6431.00
187_Y190_V0.6431.00
208_L212_L0.6361.00
97_T154_L0.6301.00
49_L52_L0.6281.00
189_F193_F0.6281.00
108_G142_I0.6271.00
159_S170_M0.6271.00
60_I68_I0.6251.00
97_T101_I0.6241.00
170_M190_V0.6201.00
144_I212_L0.6141.00
115_G118_E0.6121.00
144_I208_L0.6121.00
30_G33_V0.6111.00
94_T98_S0.6101.00
109_I131_M0.6101.00
202_S206_N0.6081.00
16_G19_H0.6081.00
59_F63_I0.6071.00
201_L205_V0.6051.00
36_V140_I0.6001.00
114_K121_R0.5991.00
23_A158_S0.5971.00
112_V135_I0.5941.00
162_G165_A0.5941.00
22_L87_Q0.5891.00
120_A125_F0.5891.00
190_V193_F0.5881.00
42_R102_A0.5821.00
38_V56_Y0.5791.00
108_G146_P0.5781.00
32_F105_I0.5761.00
42_R45_V0.5761.00
141_K212_L0.5761.00
33_V94_T0.5761.00
14_M17_F0.5741.00
146_P149_N0.5731.00
118_E133_H0.5681.00
126_T133_H0.5681.00
66_L70_F0.5681.00
55_A59_F0.5671.00
89_G166_G0.5661.00
73_Y85_G0.5641.00
13_Y193_F0.5601.00
150_Q153_N0.5561.00
200_P207_Y0.5531.00
96_Y157_N0.5531.00
54_T57_V0.5531.00
135_I138_Q0.5511.00
12_M16_G0.5441.00
30_G34_L0.5441.00
13_Y173_A0.5441.00
33_V36_V0.5421.00
93_L161_L0.5421.00
34_L37_A0.5421.00
35_G39_A0.5411.00
18_Y21_L0.5411.00
151_F201_L0.5401.00
152_L201_L0.5341.00
75_G78_N0.5301.00
66_L160_I0.5301.00
28_L32_F0.5291.00
35_G102_A0.5271.00
41_M46_F0.5261.00
152_L198_T0.5231.00
85_G164_V0.5181.00
200_P203_I0.5151.00
32_F101_I0.5151.00
61_R103_E0.5141.00
205_V208_L0.5131.00
15_D172_Q0.5101.00
32_F151_F0.5101.00
14_M193_F0.5091.00
140_I212_L0.5081.00
45_V127_Y0.5071.00
24_S28_L0.5051.00
96_Y150_Q0.5051.00
13_Y176_V0.5041.00
12_M175_L0.5031.00
15_D22_L0.5031.00
130_A135_I0.5031.00
113_S142_I0.5011.00
195_L198_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9861 100 0.491 Contact Map
3tuiA 2 0.9676 99.9 0.558 Contact Map
2onkC 2 0.963 99.9 0.59 Contact Map
3rlfF 1 0.9398 99.9 0.592 Contact Map
3d31C 2 0.9444 99.9 0.598 Contact Map
4tquM 1 0.9861 99.9 0.622 Contact Map
3rlfG 1 0.9954 99.8 0.63 Contact Map
4tquN 1 0.9676 99.7 0.669 Contact Map
4ltoA 3 0.4676 7.2 0.956 Contact Map
3mktA 1 0.9167 6.9 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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