GREMLIN Database
YOCH - Cell wall-binding protein YocH
UniProt: O34669 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (261)
Sequences: 656 (602)
Seq/√Len: 37.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_I252_A5.3321.00
198_T278_V4.5271.00
228_I241_V4.4001.00
147_E150_Q4.1291.00
154_P158_A3.5721.00
158_A161_Q3.5451.00
269_S272_D3.4031.00
154_P157_E3.2551.00
197_V283_V3.0541.00
168_K173_T2.7511.00
206_D209_I2.6621.00
158_A171_A2.6501.00
246_Y249_A2.6491.00
149_V152_E2.5671.00
161_Q173_T2.4771.00
198_T262_K2.3341.00
232_P235_I2.2420.99
158_A173_T2.1990.99
156_Q161_Q2.1810.99
242_Y284_K2.1000.99
160_Q168_K2.0950.99
265_V276_W2.0470.99
77_T82_I1.9790.98
194_E284_K1.9530.98
161_Q167_T1.9460.98
205_N220_N1.9430.98
148_A152_E1.9260.98
270_K274_S1.9110.98
148_A151_K1.9090.98
161_Q171_A1.9090.98
256_G278_V1.8750.98
234_V261_N1.8710.98
220_N266_F1.8430.98
80_Y83_K1.7770.97
214_A254_T1.7570.97
105_W121_V1.7470.97
231_D260_G1.7050.96
265_V279_K1.6860.96
276_W281_V1.6850.96
228_I243_V1.6840.96
206_D210_S1.6590.95
214_A256_G1.6510.95
80_Y95_F1.6300.95
173_T177_T1.6250.95
199_A202_Y1.5930.94
161_Q168_K1.5730.94
28_I39_I1.5570.94
252_A276_W1.5450.93
155_K168_K1.5420.93
85_G91_I1.5410.93
156_Q172_E1.5270.93
225_A252_A1.5230.93
147_E152_E1.5160.93
87_T113_I1.4810.92
157_E172_E1.4420.91
77_T83_K1.4270.90
203_T209_I1.4130.90
192_S195_L1.3980.89
168_K171_A1.3730.88
197_V228_I1.3630.88
166_E171_A1.3570.88
120_S193_K1.3550.88
173_T176_N1.3430.87
191_A284_K1.3260.86
156_Q173_T1.3090.86
246_Y281_V1.3010.85
158_A166_E1.2930.85
154_P167_T1.2690.84
75_T83_K1.2620.84
282_S285_V1.2610.84
199_A267_V1.2430.83
144_P147_E1.2330.82
208_G211_G1.2290.82
119_L194_E1.2260.82
217_I227_V1.2180.81
168_K172_E1.2160.81
189_Q192_S1.2070.81
161_Q172_E1.2040.81
158_A167_T1.2040.81
158_A170_E1.1990.80
249_A281_V1.1990.80
257_A262_K1.1980.80
267_V273_A1.1720.79
196_T199_A1.1600.78
166_E170_E1.1590.78
105_W109_S1.1530.78
229_A232_P1.1500.77
214_A257_A1.1490.77
154_P173_T1.1490.77
204_A219_L1.1490.77
41_Q44_G1.1440.77
169_A172_E1.1420.77
85_G89_S1.1420.77
97_T267_V1.1420.77
155_K158_A1.1410.77
258_I262_K1.1390.77
76_T81_T1.1390.77
127_A130_T1.1370.77
39_I43_N1.1350.76
167_T171_A1.1340.76
194_E282_S1.1280.76
231_D237_L1.1200.75
75_T82_I1.1180.75
39_I65_E1.1130.75
158_A168_K1.1090.75
161_Q170_E1.1060.75
144_P150_Q1.1000.74
239_S285_V1.0980.74
197_V281_V1.0830.73
221_K226_K1.0740.72
76_T83_K1.0640.72
126_T285_V1.0640.72
262_K278_V1.0590.71
231_D234_V1.0580.71
174_S177_T1.0550.71
155_K161_Q1.0530.71
154_P161_Q1.0400.70
193_K199_A1.0370.70
230_V251_A1.0360.70
163_P168_K1.0330.69
240_K286_L1.0310.69
214_A237_L1.0270.69
166_E173_T1.0260.69
246_Y265_V1.0260.69
199_A246_Y1.0250.69
145_K150_Q1.0220.69
137_T147_E1.0160.68
199_A281_V1.0150.68
228_I265_V1.0150.68
256_G273_A1.0080.67
282_S286_L1.0080.67
145_K152_E1.0040.67
270_K273_A1.0020.67
157_E164_K1.0000.67
157_E163_P0.9990.67
162_Q166_E0.9960.67
231_D245_G0.9920.66
194_E197_V0.9870.66
161_Q169_A0.9830.65
240_K249_A0.9780.65
92_A103_K0.9750.65
167_T173_T0.9740.65
172_E177_T0.9660.64
199_A243_V0.9650.64
228_I263_I0.9620.64
219_L266_F0.9590.64
39_I61_I0.9390.62
204_A266_F0.9380.62
170_E173_T0.9360.62
217_I225_A0.9260.61
218_D268_P0.9250.61
208_G221_K0.9150.60
82_I119_L0.9100.59
160_Q163_P0.8950.58
36_L65_E0.8940.58
80_Y86_D0.8930.58
226_K284_K0.8920.58
164_K167_T0.8890.58
34_D61_I0.8850.57
232_P239_S0.8850.57
263_I273_A0.8800.57
42_K66_K0.8780.57
208_G273_A0.8720.56
196_T282_S0.8640.55
196_T202_Y0.8610.55
40_S57_T0.8590.55
217_I250_T0.8590.55
154_P172_E0.8590.55
199_A265_V0.8530.54
154_P170_E0.8530.54
165_Q168_K0.8520.54
245_G260_G0.8510.54
204_A211_G0.8500.54
82_I91_I0.8470.54
231_D258_I0.8460.54
227_V252_A0.8390.53
232_P236_P0.8360.53
39_I116_G0.8320.53
275_N282_S0.8290.52
180_K185_N0.8270.52
91_I94_K0.8130.51
209_I219_L0.8130.51
160_Q167_T0.8120.51
197_V203_T0.8100.51
30_V34_D0.8070.50
159_V165_Q0.8070.50
160_Q171_A0.8060.50
203_T270_K0.8050.50
165_Q170_E0.8050.50
155_K163_P0.8050.50
186_T189_Q0.8040.50
119_L133_E0.8010.50
84_A280_T0.8010.50
195_L283_V0.7990.50
37_W67_L0.7950.49
232_P251_A0.7900.49
40_S46_N0.7880.49
39_I50_L0.7860.49
227_V266_F0.7860.49
176_N181_A0.7840.48
225_A266_F0.7830.48
239_S250_T0.7830.48
213_T236_P0.7820.48
64_G275_N0.7800.48
154_P160_Q0.7780.48
211_G227_V0.7750.48
271_S274_S0.7700.47
159_V172_E0.7690.47
54_N269_S0.7670.47
221_K276_W0.7620.46
35_T38_G0.7600.46
247_G251_A0.7590.46
171_A174_S0.7580.46
115_A118_T0.7580.46
276_W279_K0.7580.46
37_W58_S0.7560.46
136_Q172_E0.7550.46
73_E86_D0.7540.46
157_E161_Q0.7530.46
276_W280_T0.7520.46
221_K227_V0.7520.46
167_T174_S0.7520.46
88_L103_K0.7480.45
121_V157_E0.7470.45
160_Q173_T0.7470.45
209_I268_P0.7450.45
160_Q172_E0.7410.45
225_A276_W0.7380.44
206_D226_K0.7380.44
248_E286_L0.7380.44
237_L260_G0.7360.44
164_K173_T0.7360.44
172_E176_N0.7350.44
197_V237_L0.7340.44
157_E162_Q0.7330.44
260_G283_V0.7310.44
199_A249_A0.7260.43
99_V104_V0.7250.43
230_V236_P0.7200.43
206_D219_L0.7150.42
240_K248_E0.7130.42
158_A175_V0.7120.42
244_E259_K0.7110.42
121_V127_A0.7110.42
144_P149_V0.7110.42
146_Q149_V0.7100.42
227_V231_D0.7090.42
243_V246_Y0.7040.41
203_T210_S0.7020.41
73_E117_S0.7000.41
215_T232_P0.6990.41
243_V276_W0.6960.41
259_K266_F0.6940.41
55_K121_V0.6930.40
160_Q164_K0.6910.40
40_S103_K0.6860.40
272_D279_K0.6860.40
162_Q285_V0.6860.40
106_N122_K0.6850.40
146_Q150_Q0.6830.40
106_N208_G0.6800.39
212_V262_K0.6790.39
230_V235_I0.6780.39
102_L106_N0.6730.39
129_N133_E0.6730.39
237_L246_Y0.6710.39
50_L54_N0.6700.38
96_G113_I0.6690.38
229_A235_I0.6670.38
231_D236_P0.6640.38
220_N227_V0.6630.38
37_W41_Q0.6610.38
91_I95_F0.6600.38
259_K283_V0.6570.37
216_G230_V0.6530.37
170_E177_T0.6500.37
40_S45_V0.6500.37
152_E155_K0.6480.37
33_G56_L0.6460.37
40_S54_N0.6460.37
169_A173_T0.6380.36
64_G182_V0.6370.36
215_T235_I0.6360.36
85_G94_K0.6350.36
231_D235_I0.6290.35
221_K266_F0.6280.35
113_I205_N0.6260.35
226_K241_V0.6250.35
156_Q168_K0.6220.35
165_Q173_T0.6200.34
241_V249_A0.6200.34
159_V162_Q0.6190.34
239_S249_A0.6190.34
227_V248_E0.6190.34
142_A151_K0.6170.34
36_L241_V0.6170.34
262_K282_S0.6160.34
42_K285_V0.6150.34
121_V263_I0.6130.34
26_K200_T0.6120.34
158_A172_E0.6120.34
157_E169_A0.6090.34
34_D56_L0.6090.34
162_Q167_T0.6090.34
165_Q171_A0.6070.33
261_N275_N0.6060.33
235_I263_I0.6060.33
113_I117_S0.6020.33
76_T80_Y0.6010.33
64_G118_T0.6000.33
28_I65_E0.6000.33
107_N119_L0.5960.33
138_N171_A0.5920.32
45_V224_N0.5910.32
67_L89_S0.5910.32
178_E183_Q0.5910.32
192_S198_T0.5910.32
77_T81_T0.5900.32
170_E174_S0.5880.32
234_V237_L0.5820.31
123_G126_T0.5820.31
229_A236_P0.5790.31
203_T206_D0.5780.31
259_K279_K0.5780.31
38_G121_V0.5770.31
86_D113_I0.5760.31
164_K170_E0.5750.31
137_T150_Q0.5750.31
206_D211_G0.5750.31
86_D91_I0.5750.31
229_A242_Y0.5730.31
196_T280_T0.5720.31
53_W69_I0.5720.31
52_E93_Q0.5680.30
159_V168_K0.5670.30
99_V110_S0.5670.30
33_G36_L0.5660.30
153_Q158_A0.5650.30
66_K114_Y0.5630.30
183_Q187_N0.5630.30
243_V252_A0.5630.30
108_L117_S0.5620.30
266_F284_K0.5610.30
176_N184_S0.5570.30
235_I239_S0.5570.30
103_K124_Q0.5560.29
45_V234_V0.5550.29
61_I96_G0.5550.29
221_K272_D0.5530.29
228_I276_W0.5450.29
223_P235_I0.5440.29
113_I149_V0.5430.29
164_K168_K0.5420.28
270_K286_L0.5400.28
113_I185_N0.5390.28
44_G97_T0.5390.28
204_A210_S0.5380.28
162_Q173_T0.5370.28
225_A240_K0.5370.28
116_G278_V0.5360.28
33_G122_K0.5350.28
258_I261_N0.5340.28
202_Y247_G0.5340.28
199_A276_W0.5340.28
27_E30_V0.5330.28
36_L60_K0.5330.28
157_E174_S0.5320.28
236_P239_S0.5320.28
156_Q167_T0.5310.28
40_S48_K0.5310.28
234_V251_A0.5290.28
83_K132_T0.5260.27
225_A267_V0.5230.27
163_P167_T0.5220.27
176_N185_N0.5200.27
227_V238_G0.5200.27
237_L241_V0.5200.27
261_N280_T0.5180.27
207_G270_K0.5180.27
162_Q165_Q0.5160.27
218_D221_K0.5160.27
49_D53_W0.5160.27
50_L82_I0.5150.27
173_T181_A0.5140.26
231_D238_G0.5120.26
260_G273_A0.5070.26
271_S275_N0.5030.26
51_K72_E0.5030.26
79_Q121_V0.5020.26
36_L113_I0.5010.26
85_G106_N0.5000.26
208_G226_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wjtA 2 0.3624 100 0.621 Contact Map
2ae0X 1 0.6969 99.8 0.743 Contact Map
2gu1A 1 0.8118 99.8 0.744 Contact Map
4uz3A 1 0.3449 99.8 0.755 Contact Map
2g5dA 1 0.662 99.8 0.756 Contact Map
4b8vA 2 0.4495 99.8 0.758 Contact Map
3czbA 2 0.7038 99.7 0.76 Contact Map
2pnwA 1 0.6655 99.7 0.763 Contact Map
4xcmA 2 0.7143 99.7 0.77 Contact Map
4ebyA 1 0.4634 99.6 0.789 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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