GREMLIN Database
LUXS - S-ribosylhomocysteine lyase
UniProt: O34667 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (141)
Sequences: 966 (376)
Seq/√Len: 31.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_Q131_L3.6841.00
38_I144_W3.3111.00
50_P131_L3.2111.00
67_H107_D3.0341.00
42_Q45_K2.8421.00
10_D13_A2.7871.00
21_H34_N2.4971.00
51_D131_L2.3560.99
19_V105_L2.3000.99
41_C140_L2.2200.99
122_N125_Q2.1820.99
116_T138_K2.1090.98
48_M140_L2.0810.98
50_P85_Q2.0470.98
56_L141_M2.0280.98
18_Y22_C2.0140.98
12_N123_E1.9170.97
49_K52_T1.8340.96
55_T132_H1.8190.96
76_I92_V1.7970.95
56_L112_A1.7790.95
97_T100_E1.7500.95
15_V42_Q1.7310.94
110_K114_E1.7270.94
142_R146_S1.7170.94
33_V91_V1.7140.94
10_D124_K1.6540.93
53_I88_Y1.5910.91
82_M89_Y1.5900.91
60_L108_T1.5650.91
60_L64_I1.5560.90
143_F147_Q1.5500.90
52_T136_G1.5400.90
106_E110_K1.5170.89
118_I132_H1.4760.88
4_V120_A1.4590.87
25_H95_E1.4550.87
48_M53_I1.4350.86
76_I90_L1.3840.84
17_P42_Q1.3440.82
32_V95_E1.3430.82
3_S125_Q1.3180.81
36_F94_G1.2970.80
28_G31_G1.2960.80
55_T118_I1.2230.76
79_I144_W1.2210.76
97_T103_D1.1940.74
90_L101_I1.1820.73
98_S102_V1.1770.73
68_A104_L1.1480.71
52_T133_D1.1460.71
139_R143_F1.1440.71
64_I76_I1.1360.70
46_Q143_F1.1340.70
22_C35_K1.1260.69
112_A141_M1.1220.69
106_E145_L1.1220.69
17_P41_C1.1180.69
102_V106_E1.1160.69
64_I90_L1.1030.68
52_T140_L1.1000.68
27_V30_D1.0890.67
60_L105_L1.0820.66
17_P140_L1.0720.66
113_V142_R1.0600.65
14_V20_R1.0230.62
60_L79_I1.0160.61
107_D110_K1.0160.61
67_H111_E1.0070.61
110_K142_R1.0060.61
28_G77_I1.0040.60
136_G139_R1.0040.60
47_A133_D0.9840.59
63_T67_H0.9830.59
113_V138_K0.9730.58
64_I104_L0.9680.58
14_V42_Q0.9580.57
2_P5_E0.9560.57
41_C143_F0.9410.55
133_D136_G0.9340.55
21_H98_S0.9240.54
18_Y23_G0.9160.53
96_P100_E0.9030.52
56_L109_M0.9010.52
79_I88_Y0.8930.52
5_E9_L0.8910.51
3_S8_E0.8890.51
35_K82_M0.8880.51
139_R142_R0.8830.51
103_D107_D0.8800.50
135_E142_R0.8740.50
108_T112_A0.8660.49
27_V33_V0.8580.49
77_I91_V0.8510.48
19_V140_L0.8460.48
56_L79_I0.8380.47
17_P20_R0.8340.47
36_F98_S0.8320.47
35_K89_Y0.8230.46
22_C80_S0.8120.45
12_N124_K0.8040.44
137_A141_M0.7980.44
27_V31_G0.7970.44
101_I105_L0.7950.44
40_F45_K0.7920.43
68_A101_I0.7900.43
40_F118_I0.7870.43
92_V104_L0.7860.43
14_V18_Y0.7810.42
128_Q131_L0.7800.42
9_L14_V0.7790.42
110_K113_V0.7780.42
36_F96_P0.7780.42
55_T130_K0.7780.42
117_E125_Q0.7680.41
14_V35_K0.7640.41
10_D123_E0.7500.40
49_K136_G0.7480.40
85_Q129_A0.7460.40
38_I104_L0.7360.39
22_C82_M0.7340.39
35_K120_A0.7280.38
18_Y21_H0.7240.38
20_R80_S0.7240.38
1_M66_S0.7210.38
13_A124_K0.7190.38
9_L42_Q0.7170.37
24_V29_T0.7030.36
35_K78_D0.6960.36
7_F61_A0.6890.35
101_I146_S0.6870.35
8_E62_F0.6850.35
41_C53_I0.6850.35
59_L63_T0.6840.35
63_T115_I0.6820.35
61_A65_R0.6820.35
47_A128_Q0.6780.35
64_I105_L0.6770.34
92_V95_E0.6770.34
115_I138_K0.6750.34
24_V32_V0.6720.34
22_C89_Y0.6640.33
3_S9_L0.6620.33
109_M141_M0.6620.33
79_I85_Q0.6550.33
109_M113_V0.6530.33
101_I135_E0.6490.32
23_G104_L0.6470.32
40_F48_M0.6470.32
121_A132_H0.6460.32
40_F53_I0.6420.32
62_F66_S0.6400.32
17_P147_Q0.6380.32
33_V77_I0.6360.31
75_D96_P0.6340.31
4_V35_K0.6300.31
66_S104_L0.6280.31
32_V97_T0.6220.30
20_R78_D0.6170.30
101_I104_L0.6150.30
92_V141_M0.6100.30
27_V48_M0.6090.30
9_L18_Y0.6080.30
40_F109_M0.6060.29
116_T142_R0.6010.29
69_E107_D0.5980.29
63_T107_D0.5970.29
4_V91_V0.5970.29
15_V147_Q0.5900.28
61_A120_A0.5860.28
59_L109_M0.5860.28
133_D139_R0.5830.28
55_T131_L0.5820.28
47_A131_L0.5800.28
31_G77_I0.5770.27
36_F102_V0.5720.27
18_Y53_I0.5670.27
9_L105_L0.5640.27
34_N94_G0.5630.27
110_K146_S0.5570.26
2_P66_S0.5570.26
99_A103_D0.5570.26
45_K123_E0.5570.26
32_V91_V0.5550.26
92_V101_I0.5550.26
40_F113_V0.5540.26
14_V80_S0.5530.26
135_E139_R0.5520.26
34_N92_V0.5520.26
59_L115_I0.5510.26
49_K139_R0.5490.26
60_L109_M0.5450.25
85_Q128_Q0.5440.25
59_L119_P0.5430.25
41_C46_Q0.5400.25
19_V144_W0.5370.25
36_F101_I0.5360.25
12_N132_H0.5330.25
109_M145_L0.5320.25
113_V116_T0.5290.24
92_V96_P0.5240.24
4_V18_Y0.5230.24
99_A102_V0.5220.24
29_T77_I0.5150.24
25_H32_V0.5100.23
15_V143_F0.5090.23
32_V93_S0.5080.23
9_L132_H0.5050.23
20_R23_G0.5040.23
110_K145_L0.5030.23
100_E103_D0.5020.23
21_H36_F0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j98A 2 0.9745 100 0.059 Contact Map
1vjeA 2 0.9363 100 0.08 Contact Map
1j6xA 2 0.9554 100 0.085 Contact Map
1j6wA 2 0.9682 100 0.087 Contact Map
4xchA 4 0.9045 100 0.095 Contact Map
2kvoA 1 0.5924 36 0.952 Contact Map
1ihkA 2 0.5605 16.2 0.96 Contact Map
2q7aA 2 0.4777 15.5 0.96 Contact Map
3bw6A 1 0.5541 12.4 0.962 Contact Map
3emuA 1 0.7389 12.2 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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