GREMLIN Database
CTPA - Carboxy-terminal processing protease CtpA
UniProt: O34666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 466 (377)
Sequences: 4887 (3661)
Seq/√Len: 188.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
291_V319_T7.0191.00
306_L312_V6.4141.00
239_G292_N5.9891.00
166_K182_S4.2001.00
141_K170_E4.1791.00
307_H350_E3.7111.00
166_K184_K3.6951.00
195_S221_A3.1721.00
130_K186_D3.1461.00
207_I214_T3.0721.00
197_M230_A3.0491.00
92_A336_T2.9161.00
207_I251_M2.8571.00
230_A233_Y2.8181.00
133_I171_L2.7691.00
224_S228_K2.7601.00
293_D317_E2.7351.00
168_K180_D2.7211.00
201_N231_K2.6681.00
235_L302_M2.6341.00
303_A314_L2.6151.00
168_K182_S2.5881.00
171_L181_L2.5201.00
203_G225_L2.4311.00
163_K186_D2.4251.00
318_T358_K2.3961.00
119_I133_I2.3781.00
202_I232_G2.2701.00
221_A224_S2.2241.00
145_K158_L2.2171.00
63_D66_K2.1981.00
252_S302_M2.1721.00
124_K129_E2.1261.00
173_R179_I2.1201.00
380_Y383_G2.0871.00
291_V314_L2.0671.00
295_T299_A2.0131.00
215_A250_T2.0041.00
118_L138_Q2.0021.00
251_M302_M1.9981.00
232_G286_P1.9571.00
116_E138_Q1.9361.00
117_I155_A1.8701.00
141_K144_G1.8481.00
380_Y384_D1.8191.00
235_L287_T1.8151.00
104_E163_K1.8101.00
375_D381_K1.8081.00
378_K381_K1.7941.00
288_V315_I1.7571.00
85_T338_K1.7451.00
170_E180_D1.7181.00
375_D378_K1.7081.00
218_L255_F1.6821.00
317_E364_E1.6741.00
315_I361_V1.6741.00
226_E285_K1.6701.00
256_I309_S1.6651.00
266_E272_K1.6561.00
49_K332_D1.6441.00
304_A357_I1.6401.00
253_N262_I1.6111.00
216_K220_D1.6081.00
84_S339_L1.6051.00
358_K362_K1.5951.00
102_S187_T1.5731.00
192_T214_T1.5721.00
138_Q172_N1.5591.00
113_K118_L1.5471.00
165_T185_R1.5001.00
379_T382_S1.4981.00
217_E220_D1.4981.00
266_E345_L1.4731.00
88_D91_Q1.4681.00
137_D173_R1.4621.00
213_T216_K1.4531.00
219_T223_D1.4521.00
382_S385_T1.4371.00
241_P295_T1.4361.00
222_I233_Y1.4331.00
388_N392_A1.4301.00
142_V147_V1.4281.00
327_T341_V1.4201.00
161_G185_R1.4201.00
324_T353_H1.4181.00
203_G233_Y1.4011.00
304_A346_T1.3991.00
69_D86_Y1.3931.00
378_K382_S1.3911.00
195_S224_S1.3811.00
377_D381_K1.3731.00
150_M158_L1.3701.00
215_A247_Q1.3561.00
169_L183_I1.3471.00
51_Y55_K1.3341.00
373_Y379_T1.3341.00
87_M95_F1.3321.00
209_S241_P1.3111.00
94_S97_E1.2931.00
267_Y271_S1.2921.00
381_K385_T1.2901.00
86_Y335_S1.2871.00
267_Y270_G1.2791.00
248_A302_M1.2781.00
381_K384_D1.2681.00
60_Q343_K1.2661.00
379_T383_G1.2651.00
307_H360_Q1.2411.00
225_L230_A1.2381.00
253_N279_K1.2381.00
302_M306_L1.2361.00
99_I244_L1.2281.00
252_S262_I1.2251.00
103_F123_I1.2251.00
104_E187_T1.2251.00
151_N154_E1.2241.00
140_I172_N1.2171.00
207_I235_L1.2141.00
249_I262_I1.2141.00
375_D379_T1.2041.00
70_G78_S1.2011.00
27_G30_S1.2001.00
70_G74_G1.1941.00
325_V342_A1.1941.00
163_K187_T1.1891.00
76_I337_V1.1891.00
379_T385_T1.1811.00
214_T251_M1.1761.00
161_G165_T1.1711.00
50_A337_V1.1611.00
379_T386_G1.1591.00
246_E250_T1.1541.00
219_T254_L1.1501.00
205_I218_L1.1401.00
222_I283_V1.1381.00
155_A159_I1.1331.00
111_E120_V1.1311.00
377_D382_S1.1271.00
18_A22_T1.1251.00
55_K64_D1.1241.00
133_I181_L1.1241.00
29_S32_L1.1231.00
18_A21_L1.1181.00
253_N277_A1.1171.00
308_E348_D1.1151.00
218_L251_M1.1101.00
140_I170_E1.1101.00
247_Q250_T1.1071.00
373_Y376_A1.0951.00
144_G168_K1.0921.00
264_Q272_K1.0891.00
252_S256_I1.0861.00
176_V179_I1.0771.00
95_F338_K1.0761.00
89_Q335_S1.0641.00
314_L357_I1.0591.00
141_K146_S1.0551.00
245_M301_I1.0511.00
377_D380_Y1.0511.00
287_T312_V1.0461.00
21_L24_F1.0421.00
142_V167_V1.0411.00
343_K351_W1.0401.00
215_A251_M1.0401.00
328_A336_T1.0351.00
172_N175_G1.0351.00
380_Y386_G1.0321.00
237_L302_M1.0241.00
386_G389_V1.0211.00
376_A379_T1.0201.00
326_Q340_T1.0191.00
46_K69_D1.0191.00
141_K180_D1.0161.00
109_Q121_S1.0101.00
83_Y353_H1.0061.00
203_G230_A1.0020.99
154_E157_A1.0000.99
235_L289_V0.9990.99
313_P361_V0.9970.99
121_S294_G0.9960.99
92_A96_D0.9910.99
112_E117_I0.9890.99
233_Y285_K0.9880.99
110_V152_V0.9820.99
249_I263_M0.9800.99
375_D385_T0.9790.99
191_E217_E0.9780.99
256_I262_I0.9740.99
375_D382_S0.9740.99
384_D387_T0.9710.99
304_A308_E0.9690.99
207_I218_L0.9670.99
127_P131_A0.9670.99
229_G232_G0.9650.99
54_I339_L0.9590.99
147_V150_M0.9590.99
346_T357_I0.9540.99
54_I84_S0.9520.99
389_V392_A0.9500.99
109_Q123_I0.9490.99
197_M228_K0.9480.99
385_T388_N0.9450.99
54_I79_L0.9430.99
367_D371_L0.9350.99
124_K194_Y0.9330.99
249_I275_M0.9320.99
117_I139_I0.9310.99
308_E346_T0.9260.99
183_I186_D0.9250.99
108_A119_I0.9250.99
218_L254_L0.9220.99
125_G130_K0.9180.99
83_Y324_T0.9160.99
159_I169_L0.9140.99
26_T31_I0.9110.99
93_K97_E0.9090.99
67_L74_G0.9060.99
81_D84_S0.9050.99
131_A181_L0.9040.99
343_K353_H0.9000.99
46_K335_S0.9000.99
200_N231_K0.9000.99
376_A382_S0.8970.99
71_A75_M0.8970.99
225_L233_Y0.8970.99
201_N228_K0.8960.99
345_L351_W0.8940.99
381_K388_N0.8940.99
113_K116_E0.8930.99
53_Q57_D0.8910.99
248_A252_S0.8870.99
162_K165_T0.8860.99
143_N168_K0.8850.99
218_L235_L0.8840.99
69_D89_Q0.8830.99
109_Q120_V0.8830.99
112_E115_G0.8800.99
22_T25_I0.8790.99
169_L181_L0.8740.99
375_D386_G0.8670.99
197_M229_G0.8660.99
161_G164_G0.8640.98
322_K326_Q0.8620.98
47_L68_V0.8570.98
232_G288_V0.8560.98
68_V72_I0.8550.98
51_Y64_D0.8540.98
205_I221_A0.8540.98
287_T306_L0.8530.98
296_A320_F0.8460.98
119_I139_I0.8440.98
122_P135_P0.8430.98
314_L319_T0.8420.98
377_D385_T0.8410.98
377_D384_D0.8340.98
117_I147_V0.8330.98
260_K309_S0.8300.98
71_A74_G0.8290.98
198_K201_N0.8260.98
24_F27_G0.8220.98
378_K385_T0.8210.98
110_V156_V0.8190.98
244_L247_Q0.8180.98
28_N31_I0.8170.98
220_D224_S0.8170.98
304_A350_E0.8160.98
368_Y371_L0.8130.98
262_I277_A0.8120.98
289_V306_L0.8110.98
143_N158_L0.8110.98
104_E126_S0.8110.98
377_D383_G0.8100.98
288_V313_P0.8090.98
175_G178_N0.8090.98
19_S22_T0.8050.98
373_Y380_Y0.8040.98
102_S162_K0.8030.98
103_F190_V0.8020.98
313_P360_Q0.7930.97
62_T67_L0.7930.97
213_T247_Q0.7920.97
17_V20_A0.7910.97
379_T388_N0.7820.97
46_K86_Y0.7820.97
385_T389_V0.7790.97
308_E350_E0.7780.97
47_L51_Y0.7780.97
64_D67_L0.7770.97
382_S388_N0.7740.97
173_R176_V0.7720.97
195_S203_G0.7700.97
139_I147_V0.7650.97
102_S213_T0.7650.97
233_Y287_T0.7630.97
49_K53_Q0.7600.97
164_G186_D0.7590.97
381_K386_G0.7580.97
46_K333_D0.7570.97
215_A219_T0.7560.96
97_E103_F0.7520.96
239_G294_G0.7490.96
304_A347_A0.7480.96
375_D380_Y0.7450.96
368_Y372_P0.7430.96
171_L179_I0.7380.96
88_D335_S0.7370.96
98_T209_S0.7370.96
73_K91_Q0.7360.96
289_V312_V0.7350.96
76_I84_S0.7340.96
253_N278_E0.7330.96
315_I363_A0.7330.96
150_M154_E0.7310.96
199_D202_I0.7310.96
106_I159_I0.7300.96
144_G180_D0.7300.96
25_I28_N0.7290.96
355_K358_K0.7290.96
69_D88_D0.7290.96
374_L378_K0.7270.96
156_V160_R0.7260.96
383_G386_G0.7260.96
142_V158_L0.7210.95
226_E284_T0.7200.95
257_D277_A0.7190.95
234_I288_V0.7180.95
72_I76_I0.7180.95
386_G390_K0.7160.95
325_V352_I0.7160.95
90_E157_A0.7150.95
195_S225_L0.7130.95
212_E244_L0.7130.95
61_K268_K0.7120.95
221_A225_L0.7110.95
223_D227_K0.7110.95
39_T42_S0.7100.95
26_T29_S0.7040.95
112_E149_G0.7020.95
320_F353_H0.6990.95
388_N391_V0.6990.95
381_K387_T0.6980.95
72_I75_M0.6960.94
264_Q349_G0.6960.94
122_P294_G0.6960.94
124_K206_Q0.6960.94
390_K393_Q0.6960.94
267_Y272_K0.6940.94
375_D388_N0.6940.94
384_D388_N0.6930.94
20_A23_L0.6920.94
380_Y388_N0.6920.94
269_N272_K0.6900.94
222_I282_K0.6870.94
202_I382_S0.6860.94
43_K51_Y0.6850.94
391_V395_M0.6850.94
215_A254_L0.6850.94
240_N243_G0.6840.94
133_I179_I0.6840.94
97_E160_R0.6830.94
19_S23_L0.6820.94
245_M325_V0.6820.94
22_T26_T0.6790.94
240_N297_S0.6790.94
375_D384_D0.6770.94
242_G297_S0.6720.93
65_D69_D0.6710.93
308_E311_N0.6710.93
264_Q274_V0.6700.93
369_A372_P0.6700.93
322_K340_T0.6680.93
30_S33_G0.6670.93
210_F302_M0.6660.93
21_L25_I0.6650.93
210_F240_N0.6640.93
224_S227_K0.6630.93
373_Y382_S0.6630.93
96_D100_S0.6620.93
303_A307_H0.6610.93
106_I167_V0.6590.93
197_M203_G0.6590.93
73_K88_D0.6580.93
252_S305_A0.6560.93
290_L315_I0.6560.93
23_L26_T0.6560.93
260_K274_V0.6540.92
378_K386_G0.6530.92
226_E283_V0.6450.92
51_Y75_M0.6450.92
201_N232_G0.6410.92
387_T390_K0.6410.92
133_I183_I0.6410.92
167_V185_R0.6410.92
197_M225_L0.6400.92
327_T342_A0.6380.91
324_T351_W0.6380.91
323_G326_Q0.6380.91
20_A24_F0.6370.91
131_A183_I0.6360.91
289_V303_A0.6350.91
44_F48_N0.6350.91
57_D329_K0.6350.91
28_N35_K0.6340.91
380_Y385_T0.6330.91
124_K208_T0.6320.91
289_V301_I0.6300.91
47_L75_M0.6280.91
108_A133_I0.6220.90
263_M301_I0.6200.90
373_Y377_D0.6200.90
237_L299_A0.6190.90
82_P322_K0.6170.90
53_Q337_V0.6170.90
328_A338_K0.6150.90
376_A380_Y0.6150.90
373_Y378_K0.6140.90
230_A285_K0.6130.90
383_G387_T0.6120.90
375_D392_A0.6100.90
210_F299_A0.6080.89
257_D260_K0.6020.89
112_E152_V0.6020.89
82_P353_H0.6000.89
387_T391_V0.6000.89
90_E94_S0.5990.89
69_D73_K0.5970.89
379_T384_D0.5950.88
303_A357_I0.5940.88
193_V221_A0.5890.88
201_N229_G0.5870.88
172_N177_G0.5860.88
22_T27_G0.5850.88
103_F160_R0.5840.87
89_Q93_K0.5840.87
257_D280_E0.5830.87
258_K280_E0.5830.87
125_G129_E0.5820.87
248_A255_F0.5820.87
350_E355_K0.5820.87
384_D389_V0.5810.87
219_T282_K0.5800.87
120_V135_P0.5790.87
42_S45_D0.5780.87
21_L29_S0.5760.87
377_D388_N0.5760.87
87_M338_K0.5750.87
214_T218_L0.5740.87
54_I62_T0.5740.87
296_A322_K0.5740.87
317_E362_K0.5730.86
59_Y324_T0.5730.86
143_N167_V0.5720.86
125_G191_E0.5710.86
48_N51_Y0.5700.86
222_I255_F0.5700.86
23_L28_N0.5700.86
95_F328_A0.5690.86
161_G167_V0.5690.86
79_L84_S0.5680.86
54_I58_Y0.5680.86
376_A381_K0.5660.86
344_W352_I0.5650.86
252_S306_L0.5640.86
210_F298_A0.5640.86
174_A177_G0.5640.86
226_E233_Y0.5640.86
104_E159_I0.5620.85
329_K339_L0.5620.85
27_G31_I0.5610.85
272_K277_A0.5600.85
106_I185_R0.5580.85
152_V156_V0.5570.85
63_D74_G0.5570.85
192_T207_I0.5550.85
323_G340_T0.5550.85
218_L222_I0.5550.85
207_I302_M0.5540.85
106_I183_I0.5540.85
260_K264_Q0.5520.84
220_D223_D0.5510.84
66_K70_G0.5500.84
48_N52_E0.5500.84
173_R181_L0.5500.84
68_V75_M0.5490.84
330_E336_T0.5490.84
17_V21_L0.5490.84
226_E229_G0.5480.84
194_Y208_T0.5480.84
59_Y343_K0.5470.84
23_L27_G0.5470.84
366_P369_A0.5470.84
253_N257_D0.5460.84
147_V158_L0.5450.84
47_L71_A0.5440.84
123_I126_S0.5420.83
249_I252_S0.5420.83
172_N178_N0.5420.83
26_T32_L0.5410.83
392_A395_M0.5400.83
273_E276_K0.5390.83
382_S386_G0.5390.83
291_V295_T0.5380.83
110_V155_A0.5380.83
185_R188_I0.5370.83
378_K388_N0.5370.83
134_K173_R0.5350.83
25_I31_I0.5350.83
310_S348_D0.5340.82
121_S135_P0.5340.82
18_A25_I0.5330.82
210_F322_K0.5320.82
374_L377_D0.5310.82
40_G55_K0.5310.82
27_G32_L0.5310.82
214_T235_L0.5300.82
307_H357_I0.5300.82
345_L353_H0.5300.82
59_Y345_L0.5290.82
29_S33_G0.5290.82
172_N176_V0.5290.82
90_E153_N0.5280.82
67_L75_M0.5280.82
104_E162_K0.5270.82
210_F295_T0.5270.82
128_A131_A0.5260.82
240_N322_K0.5250.81
122_P133_I0.5240.81
99_I328_A0.5210.81
83_Y351_W0.5210.81
18_A23_L0.5200.81
274_V277_A0.5190.81
20_A26_T0.5190.81
57_D269_N0.5190.81
374_L382_S0.5180.81
28_N32_L0.5170.80
298_A322_K0.5170.80
192_T211_S0.5160.80
213_T217_E0.5160.80
50_A72_I0.5160.80
260_K276_K0.5160.80
380_Y389_V0.5150.80
386_G391_V0.5140.80
60_Q268_K0.5140.80
277_A281_R0.5140.80
122_P131_A0.5130.80
174_A178_N0.5120.80
106_I110_V0.5120.80
378_K384_D0.5110.80
32_L36_S0.5110.80
69_D335_S0.5100.80
303_A324_T0.5100.80
295_T325_V0.5090.79
304_A344_W0.5080.79
345_L349_G0.5080.79
253_N281_R0.5070.79
391_V394_K0.5070.79
234_I358_K0.5060.79
386_G392_A0.5050.79
46_K49_K0.5050.79
67_L71_A0.5030.79
17_V23_L0.5030.79
25_I30_S0.5030.79
194_Y197_M0.5020.78
132_G181_L0.5020.78
44_F47_L0.5020.78
245_M249_I0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c2eA 2 0.9185 100 0.228 Contact Map
4ql6A 2 0.6953 100 0.294 Contact Map
1fc6A 1 0.7468 100 0.313 Contact Map
3k50A 1 0.7189 100 0.353 Contact Map
4ghnA 1 0.7361 100 0.41 Contact Map
1k32A 5 0.8047 100 0.41 Contact Map
4lurA 1 0.6223 100 0.468 Contact Map
3dorA 2 0.7232 100 0.474 Contact Map
1j7xA 1 0.6137 100 0.489 Contact Map
4l8kA 3 0.6116 100 0.518 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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