GREMLIN Database
YODT - Uncharacterized aminotransferase YodT
UniProt: O34662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (380)
Sequences: 20888 (12348)
Seq/√Len: 633.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_K61_D4.3601.00
226_S230_R3.8841.00
391_R432_E3.7331.00
24_Y32_K3.5031.00
335_V424_E3.1711.00
184_A224_R3.0611.00
19_Y26_Y3.0281.00
82_L318_R2.9741.00
335_V420_D2.8291.00
250_R256_H2.8161.00
324_G327_K2.7041.00
328_Q332_K2.6841.00
419_S422_E2.6131.00
51_D322_K2.5621.00
346_Q431_S2.4911.00
54_E58_E2.4631.00
36_G426_L2.4091.00
82_L321_L2.3671.00
315_E318_R2.3411.00
51_D319_Y2.3301.00
24_Y422_E2.2771.00
224_R227_E2.2661.00
387_E436_A2.2451.00
339_K427_I2.2111.00
391_R436_A2.2021.00
18_S28_Q2.1971.00
227_E231_T2.1881.00
49_V319_Y2.1511.00
26_Y32_K2.1161.00
51_D315_E2.0771.00
387_E390_K2.0721.00
82_L314_L2.0721.00
339_K424_E2.0711.00
331_K420_D2.0581.00
188_D231_T2.0091.00
125_I198_F1.9791.00
164_S186_E1.9571.00
425_E429_I1.9421.00
79_L313_A1.9411.00
53_T57_K1.9331.00
337_K341_D1.8961.00
347_S431_S1.8451.00
27_D31_K1.8261.00
387_E391_R1.8221.00
93_W284_D1.8201.00
92_N284_D1.8121.00
31_K392_G1.8061.00
334_A338_K1.8011.00
393_L429_I1.7961.00
351_G365_V1.7701.00
284_D288_E1.7631.00
319_Y323_H1.7541.00
125_I161_P1.7431.00
337_K355_G1.7321.00
24_Y425_E1.7301.00
18_S62_Q1.7301.00
339_K342_E1.7191.00
74_E78_Q1.7171.00
203_V237_I1.7001.00
97_V278_A1.6861.00
347_S435_A1.6591.00
81_A85_Q1.6251.00
187_L225_L1.6241.00
188_D192_K1.6151.00
130_W164_S1.5991.00
104_I265_V1.5951.00
78_Q314_L1.5941.00
337_K360_L1.5821.00
56_L60_L1.5811.00
86_E321_L1.5711.00
56_L312_A1.5701.00
250_R330_E1.5671.00
82_L85_Q1.5631.00
387_E433_T1.5481.00
21_K50_R1.5421.00
204_A225_L1.5171.00
23_S422_E1.5151.00
332_K335_V1.5041.00
271_G277_I1.4991.00
185_D189_T1.4881.00
191_I234_V1.4811.00
202_F229_C1.4811.00
431_S435_A1.4801.00
58_E62_Q1.4751.00
266_L279_A1.4741.00
238_A254_T1.4731.00
220_G223_E1.4551.00
343_A431_S1.4501.00
332_K423_M1.4501.00
127_L199_I1.4331.00
106_T280_A1.4261.00
114_Y286_I1.4231.00
32_K425_E1.4191.00
275_A309_S1.4171.00
188_D224_R1.4151.00
266_L281_V1.4121.00
23_S417_T1.4051.00
226_S229_C1.3991.00
189_T193_R1.3981.00
50_R54_E1.3861.00
126_F201_G1.3831.00
328_Q331_K1.3801.00
166_P218_P1.3801.00
87_L281_V1.3781.00
192_K232_H1.3781.00
84_A94_S1.3731.00
226_S236_F1.3721.00
128_S162_A1.3571.00
80_A96_F1.3561.00
251_M255_E1.3561.00
114_Y289_T1.3541.00
94_S281_V1.3541.00
314_L318_R1.3501.00
388_A395_V1.3481.00
332_K420_D1.3441.00
256_H356_K1.3291.00
108_M126_F1.3261.00
315_E319_Y1.3211.00
391_R433_T1.3181.00
54_E57_K1.3151.00
129_R221_Y1.3101.00
250_R255_E1.3051.00
341_D344_A1.2961.00
335_V339_K1.2901.00
339_K428_S1.2871.00
327_K331_K1.2811.00
204_A222_Y1.2791.00
277_I310_A1.2781.00
21_K48_G1.2711.00
343_A427_I1.2671.00
27_D33_Y1.2641.00
85_Q321_L1.2631.00
107_A265_V1.2511.00
339_K431_S1.2501.00
254_T264_A1.2481.00
111_A237_I1.2421.00
202_F225_L1.2401.00
260_V283_S1.2351.00
55_K315_E1.2341.00
104_I203_V1.2341.00
418_I423_M1.2311.00
48_G53_T1.2221.00
263_I282_V1.2211.00
93_W288_E1.2191.00
19_Y62_Q1.2161.00
185_D188_D1.2161.00
53_T61_D1.2131.00
422_E425_E1.2121.00
45_I319_Y1.2111.00
257_W356_K1.2051.00
188_D228_V1.2041.00
49_V323_H1.1961.00
17_V25_V1.1961.00
78_Q318_R1.1951.00
53_T60_L1.1901.00
223_E227_E1.1891.00
270_L277_I1.1881.00
330_E334_A1.1871.00
318_R322_K1.1851.00
277_I313_A1.1781.00
220_G257_W1.1581.00
184_A228_V1.1301.00
428_S432_E1.1271.00
143_L160_Y1.1271.00
56_L308_Y1.1261.00
235_L286_I1.1251.00
97_V280_A1.1251.00
57_K60_L1.1191.00
341_D345_S1.1171.00
246_G326_I1.1141.00
223_E258_D1.1141.00
96_F310_A1.1101.00
163_I190_M1.1071.00
252_L266_L1.1041.00
391_R429_I1.0921.00
16_V28_Q1.0891.00
319_Y322_K1.0831.00
388_A433_T1.0831.00
90_D260_V1.0801.00
270_L279_A1.0801.00
238_A259_T1.0711.00
143_L203_V1.0711.00
425_E428_S1.0641.00
393_L426_L1.0631.00
23_S34_L1.0601.00
263_I280_A1.0581.00
388_A429_I1.0571.00
24_Y34_L1.0531.00
186_E189_T1.0471.00
18_S74_E1.0461.00
18_S26_Y1.0361.00
420_D424_E1.0341.00
103_A265_V1.0311.00
51_D318_R1.0251.00
91_V281_V1.0251.00
338_K342_E1.0191.00
424_E428_S1.0111.00
229_C234_V1.0071.00
21_K32_K0.9991.00
123_K233_D0.9961.00
124_S198_F0.9901.00
101_S140_A0.9881.00
86_E251_M0.9851.00
21_K26_Y0.9841.00
82_L86_E0.9841.00
18_S30_G0.9801.00
388_A393_L0.9791.00
79_L314_L0.9791.00
219_P223_E0.9761.00
188_D227_E0.9741.00
272_A316_V0.9741.00
110_I280_A0.9731.00
201_G237_I0.9681.00
227_E230_R0.9591.00
54_E61_D0.9581.00
249_G255_E0.9571.00
383_L387_E0.9551.00
351_G363_E0.9531.00
344_A350_I0.9511.00
386_S390_K0.9501.00
125_I194_I0.9501.00
188_D232_H0.9461.00
327_K330_E0.9431.00
206_P238_A0.9431.00
58_E311_K0.9431.00
363_E408_D0.9421.00
245_L320_V0.9341.00
34_L422_E0.9321.00
326_I329_S0.9301.00
16_V77_E0.9291.00
216_T356_K0.9251.00
220_G224_R0.9251.00
51_D54_E0.9231.00
108_M143_L0.9231.00
333_G337_K0.9191.00
45_I316_V0.9171.00
222_Y257_W0.9161.00
107_A237_I0.9071.00
110_I282_V0.9061.00
342_E346_Q0.9061.00
128_S203_V0.9031.00
207_I356_K0.8991.00
45_I52_V0.8951.00
44_N269_G0.8921.00
421_G424_E0.8921.00
34_L425_E0.8901.00
225_L236_F0.8881.00
328_Q420_D0.8731.00
311_K315_E0.8721.00
114_Y235_L0.8721.00
129_R217_P0.8701.00
86_E317_L0.8691.00
338_K341_D0.8691.00
256_H330_E0.8671.00
190_M193_R0.8641.00
361_G409_A0.8611.00
142_S157_I0.8601.00
320_V325_L0.8601.00
52_V312_A0.8541.00
124_S159_R0.8511.00
320_V326_I0.8481.00
28_Q74_E0.8471.00
111_A201_G0.8461.00
164_S167_H0.8451.00
228_V232_H0.8431.00
36_G418_I0.8391.00
58_E61_D0.8361.00
75_P311_K0.8351.00
191_I199_I0.8341.00
251_M326_I0.8301.00
43_C272_A0.8281.00
165_A217_P0.8281.00
101_S137_T0.8271.00
23_S419_S0.8241.00
230_R260_V0.8191.00
129_R165_A0.8151.00
325_L329_S0.8131.00
342_E431_S0.8131.00
326_I330_E0.8111.00
125_I199_I0.8111.00
418_I426_L0.8101.00
352_E363_E0.8081.00
75_P314_L0.8081.00
243_T359_L0.8031.00
51_D55_K0.8001.00
83_L281_V0.8001.00
78_Q82_L0.7971.00
122_Q198_F0.7951.00
161_P190_M0.7941.00
432_E436_A0.7941.00
111_A235_L0.7941.00
346_Q435_A0.7931.00
89_G264_A0.7931.00
88_P254_T0.7881.00
34_L426_L0.7881.00
412_I430_F0.7861.00
382_Q386_S0.7861.00
335_V338_K0.7791.00
195_G232_H0.7771.00
358_L418_I0.7751.00
229_C236_F0.7731.00
359_L413_A0.7721.00
331_K335_V0.7721.00
125_I192_K0.7721.00
75_P78_Q0.7691.00
353_V360_L0.7671.00
113_Q294_S0.7621.00
224_R228_V0.7601.00
84_A91_V0.7581.00
285_S288_E0.7561.00
206_P222_Y0.7541.00
342_E345_S0.7541.00
97_V103_A0.7531.00
254_T259_T0.7521.00
183_A186_E0.7521.00
385_V397_P0.7511.00
139_G157_I0.7511.00
252_L264_A0.7501.00
245_L317_L0.7491.00
202_F234_V0.7451.00
245_L266_L0.7431.00
339_K423_M0.7431.00
354_R363_E0.7421.00
22_G417_T0.7401.00
79_L310_A0.7381.00
186_E190_M0.7381.00
275_A308_Y0.7311.00
355_G360_L0.7291.00
41_V413_A0.7291.00
107_A263_I0.7281.00
199_I234_V0.7281.00
291_K294_S0.7281.00
384_I430_F0.7281.00
94_S279_A0.7271.00
332_K358_L0.7211.00
72_T77_E0.7181.00
251_M321_L0.7181.00
226_S259_T0.7171.00
75_P310_A0.7161.00
194_I198_F0.7151.00
190_M194_I0.7151.00
331_K334_A0.7151.00
108_M203_V0.7101.00
204_A236_F0.7091.00
111_A263_I0.7091.00
189_T192_K0.7061.00
191_I228_V0.7061.00
223_E257_W0.7051.00
233_D285_S0.7031.00
163_I166_P0.7031.00
110_I290_I0.7021.00
23_S415_P0.7021.00
301_H304_S0.7001.00
283_S286_I0.6991.00
383_L386_S0.6971.00
34_L393_L0.6961.00
248_T256_H0.6941.00
246_G320_V0.6911.00
187_L202_F0.6901.00
55_K312_A0.6861.00
73_S76_A0.6841.00
245_L251_M0.6831.00
343_A347_S0.6801.00
36_G393_L0.6781.00
384_I433_T0.6761.00
62_Q74_E0.6761.00
421_G425_E0.6731.00
254_T261_P0.6731.00
62_Q75_P0.6661.00
163_I187_L0.6661.00
364_F384_I0.6661.00
91_V264_A0.6651.00
104_I140_A0.6641.00
216_T355_G0.6631.00
364_F434_V0.6631.00
76_A80_A0.6631.00
384_I388_A0.6631.00
329_S333_G0.6631.00
59_Q62_Q0.6611.00
245_L270_L0.6611.00
335_V423_M0.6581.00
388_A430_F0.6581.00
347_S434_V0.6571.00
77_E81_A0.6571.00
16_V72_T0.6571.00
363_E409_A0.6561.00
418_I422_E0.6561.00
209_G242_M0.6551.00
236_F259_T0.6531.00
334_A337_K0.6511.00
328_Q419_S0.6491.00
23_S418_I0.6481.00
52_V272_A0.6481.00
228_V231_T0.6471.00
333_G355_G0.6461.00
219_P257_W0.6451.00
31_K390_K0.6441.00
266_L270_L0.6431.00
59_Q75_P0.6421.00
86_E252_L0.6421.00
37_S396_Y0.6411.00
365_V368_Q0.6401.00
349_I365_V0.6401.00
75_P79_L0.6381.00
98_N102_E0.6381.00
99_S102_E0.6361.00
426_L429_I0.6341.00
90_D283_S0.6341.00
222_Y238_A0.6331.00
82_L317_L0.6321.00
219_P356_K0.6311.00
217_P220_G0.6291.00
209_G359_L0.6291.00
207_I248_T0.6281.00
339_K343_A0.6281.00
163_I167_H0.6241.00
100_G241_V0.6241.00
17_V20_A0.6231.00
50_R61_D0.6221.00
241_V265_V0.6211.00
191_I232_H0.6211.00
114_Y285_S0.6211.00
282_V287_I0.6201.00
286_I289_T0.6191.00
110_I263_I0.6191.00
130_W162_A0.6181.00
60_L308_Y0.6151.00
237_I263_I0.6151.00
230_R236_F0.6141.00
184_A188_D0.6121.00
38_S413_A0.6111.00
125_I159_R0.6101.00
87_L252_L0.6101.00
433_T436_A0.6091.00
79_L96_F0.6091.00
55_K58_E0.6081.00
427_I431_S0.6081.00
208_I359_L0.6071.00
412_I426_L0.6071.00
86_E250_R0.6061.00
288_E292_Q0.6041.00
55_K318_R0.6031.00
384_I410_V0.6021.00
84_A92_N0.6011.00
45_I325_L0.6011.00
32_K429_I0.6001.00
267_G278_A0.6001.00
25_V394_I0.5991.00
429_I433_T0.5991.00
87_L264_A0.5991.00
20_A63_V0.5981.00
88_P255_E0.5951.00
386_S389_K0.5941.00
353_V362_I0.5941.00
393_L425_E0.5931.00
38_S415_P0.5921.00
89_G92_N0.5921.00
48_G60_L0.5921.00
112_I155_H0.5921.00
127_L187_L0.5911.00
185_D224_R0.5891.00
336_L427_I0.5881.00
312_A315_E0.5881.00
429_I432_E0.5871.00
206_P243_T0.5861.00
17_V71_F0.5841.00
21_K24_Y0.5841.00
329_S358_L0.5831.00
329_S416_F0.5801.00
88_P91_V0.5791.00
60_L64_S0.5781.00
108_M139_G0.5781.00
20_A25_V0.5771.00
109_K299_S0.5771.00
112_I138_L0.5761.00
123_K234_V0.5761.00
332_K418_I0.5751.00
410_V430_F0.5751.00
208_I211_A0.5741.00
336_L423_M0.5741.00
362_I430_F0.5731.00
223_E226_S0.5721.00
129_R163_I0.5711.00
16_V74_E0.5651.00
127_L190_M0.5641.00
123_K198_F0.5641.00
163_I186_E0.5641.00
161_P164_S0.5631.00
129_R204_A0.5631.00
44_N416_F0.5631.00
350_I434_V0.5621.00
187_L228_V0.5621.00
330_E333_G0.5611.00
187_L191_I0.5611.00
145_G162_A0.5601.00
58_E315_E0.5601.00
263_I286_I0.5591.00
63_V66_A0.5581.00
288_E291_K0.5561.00
79_L277_I0.5561.00
97_V102_E0.5551.00
89_G260_V0.5551.00
336_L360_L0.5551.00
106_T299_S0.5551.00
78_Q81_A0.5541.00
34_L418_I0.5541.00
15_P18_S0.5541.00
37_S394_I0.5521.00
245_L252_L0.5511.00
344_A353_V0.5511.00
44_N320_V0.5501.00
89_G254_T0.5471.00
332_K419_S0.5461.00
60_L312_A0.5461.00
335_V427_I0.5451.00
354_R409_A0.5441.00
306_H309_S0.5410.99
424_E427_I0.5390.99
366_A369_K0.5370.99
192_K198_F0.5370.99
364_F380_I0.5370.99
59_Q63_V0.5360.99
128_S160_Y0.5360.99
184_A187_L0.5350.99
230_R285_S0.5340.99
127_L163_I0.5340.99
354_R361_G0.5330.99
84_A281_V0.5330.99
343_A428_S0.5310.99
225_L234_V0.5310.99
133_Y136_I0.5300.99
147_Y151_Y0.5300.99
423_M426_L0.5290.99
17_V63_V0.5280.99
204_A238_A0.5280.99
323_H328_Q0.5270.99
385_V389_K0.5270.99
390_K436_A0.5240.99
197_Q232_H0.5220.99
321_L324_G0.5210.99
430_F434_V0.5200.99
423_M427_I0.5190.99
392_G429_I0.5190.99
235_L263_I0.5190.99
264_A281_V0.5190.99
18_S21_K0.5170.99
187_L224_R0.5160.99
349_I380_I0.5160.99
217_P222_Y0.5160.99
155_H159_R0.5150.99
221_Y225_L0.5140.99
52_V316_V0.5130.99
325_L416_F0.5090.99
15_P389_K0.5090.99
219_P258_D0.5090.99
242_M359_L0.5080.99
226_S260_V0.5070.99
362_I412_I0.5060.99
261_P264_A0.5060.99
426_L430_F0.5060.99
415_P418_I0.5050.99
192_K231_T0.5050.99
87_L266_L0.5040.99
251_M317_L0.5040.99
121_T200_A0.5040.99
150_R154_T0.5020.99
71_F394_I0.5020.99
129_R225_L0.5020.99
151_Y154_T0.5010.99
251_M320_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e3qA 3 0.9707 100 0.38 Contact Map
3hmuA 2 0.9707 100 0.386 Contact Map
4atqA 7 0.9324 100 0.387 Contact Map
4uoxA 3 0.9099 100 0.388 Contact Map
3oksA 2 0.9347 100 0.392 Contact Map
4a0gA 2 0.9347 100 0.396 Contact Map
4ffcA 4 0.9347 100 0.398 Contact Map
3i4jA 2 0.8671 100 0.401 Contact Map
1z7dA 2 0.8311 100 0.401 Contact Map
3i5tA 2 0.9662 100 0.403 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0118 seconds.