GREMLIN Database
PANE - Probable 2-dehydropantoate 2-reductase
UniProt: O34661 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (289)
Sequences: 5007 (3912)
Seq/√Len: 230.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_R252_I4.5961.00
271_S281_E4.5551.00
270_A277_A3.8801.00
224_E273_Q3.5301.00
16_A27_V3.0131.00
4_G66_F2.9951.00
2_K24_D2.9431.00
190_T245_S2.8591.00
213_V283_L2.8261.00
220_I277_A2.7821.00
263_I280_L2.5771.00
36_A40_S2.5431.00
267_L281_E2.5281.00
269_E272_L2.4801.00
78_L97_Q2.3421.00
260_D288_K2.3191.00
194_Q252_I2.2671.00
70_V94_L2.2541.00
248_L252_I2.2451.00
224_E269_E2.2181.00
144_A150_P2.1861.00
68_L94_L2.1631.00
277_A281_E2.1341.00
244_R248_L2.1261.00
144_A152_R2.1171.00
46_Y131_A2.0701.00
196_K199_E1.9171.00
3_I158_Q1.8951.00
177_T221_L1.8811.00
6_I81_V1.8621.00
183_N187_N1.8591.00
8_G27_V1.8541.00
127_K133_D1.8331.00
35_A39_Q1.8181.00
212_L279_H1.7581.00
213_V279_H1.7371.00
171_D174_R1.7121.00
33_E36_A1.7111.00
143_S172_W1.6701.00
79_Q105_D1.6611.00
181_I217_A1.6601.00
3_I68_L1.6271.00
194_Q248_L1.6231.00
37_A41_E1.6181.00
83_S109_W1.6161.00
139_A167_Y1.6051.00
96_L118_G1.6011.00
86_E109_W1.6001.00
141_K169_E1.5811.00
184_A217_A1.5701.00
156_L160_N1.5701.00
13_L132_V1.5411.00
267_L277_A1.5341.00
276_D281_E1.5341.00
68_L155_I1.5211.00
192_L286_S1.5151.00
269_E273_Q1.5031.00
29_T35_A1.5001.00
116_Y153_L1.4971.00
191_A251_V1.4911.00
47_K134_H1.4901.00
284_Y288_K1.4831.00
198_G241_K1.4761.00
169_E175_L1.4761.00
257_T287_I1.4541.00
263_I284_Y1.4311.00
259_A287_I1.4261.00
88_I91_T1.4161.00
223_L275_L1.4151.00
260_D284_Y1.4031.00
209_F282_F1.3801.00
78_L102_H1.3771.00
207_L211_K1.3721.00
23_H161_H1.3641.00
220_I266_L1.3541.00
53_R56_C1.3491.00
194_Q290_L1.3441.00
103_I176_L1.3401.00
15_C96_L1.3181.00
188_P247_M1.3161.00
44_R51_E1.3091.00
47_K50_E1.3061.00
111_V114_S1.3021.00
54_A57_S1.3011.00
14_L124_A1.2961.00
267_L284_Y1.2951.00
251_V257_T1.2851.00
79_Q108_D1.2851.00
36_A39_Q1.2841.00
31_R35_A1.2701.00
83_S86_E1.2671.00
288_K291_E1.2661.00
128_S131_A1.2591.00
34_Q38_I1.2571.00
260_D268_K1.2411.00
79_Q83_S1.2221.00
46_Y51_E1.2211.00
281_E285_G1.2181.00
195_V199_E1.2131.00
101_G104_H1.2051.00
29_T38_I1.2031.00
154_N157_F1.2031.00
211_K215_Q1.2011.00
237_C240_T1.2011.00
59_D62_I1.1911.00
95_F106_L1.1871.00
217_A266_L1.1811.00
26_T66_F1.1651.00
157_F160_N1.1651.00
5_I70_V1.1611.00
44_R131_A1.1521.00
151_D154_N1.1501.00
80_S83_S1.1481.00
80_S84_S1.1471.00
75_Q261_A1.1471.00
46_Y133_D1.1401.00
93_I110_H1.1381.00
4_G69_L1.1221.00
207_L238_G1.1151.00
282_F286_S1.1131.00
120_V140_I1.1111.00
11_V72_T1.1061.00
100_M265_Y1.1061.00
107_K112_G1.1011.00
213_V280_L1.0971.00
235_A239_Q1.0941.00
211_K230_W1.0931.00
268_K272_L1.0911.00
157_F161_H1.0911.00
119_I176_L1.0901.00
223_L273_Q1.0731.00
265_Y268_K1.0661.00
224_E272_L1.0611.00
277_A280_L1.0601.00
122_H134_H1.0571.00
257_T291_E1.0561.00
226_E229_A1.0541.00
94_L118_G1.0531.00
187_N247_M1.0521.00
127_K131_A1.0471.00
265_Y269_E1.0441.00
153_L168_Y1.0441.00
270_A275_L1.0361.00
92_N152_R1.0361.00
275_L278_V1.0301.00
209_F279_H1.0301.00
235_A238_G1.0291.00
150_P154_N1.0231.00
59_D63_N1.0211.00
3_I23_H1.0171.00
144_A153_L1.0161.00
188_P263_I1.0141.00
60_T63_N1.0121.00
4_G28_V1.0121.00
92_N116_Y1.0081.00
192_L290_L1.0001.00
179_K246_S0.9901.00
78_L95_F0.9871.00
156_L168_Y0.9761.00
231_E235_A0.9761.00
6_I69_L0.9721.00
144_A147_D0.9601.00
174_R178_G0.9451.00
196_K242_E0.9451.00
279_H282_F0.9441.00
11_V120_V0.9431.00
63_N66_F0.9261.00
68_L92_N0.9211.00
98_N179_K0.9151.00
52_F55_D0.9040.99
53_R58_A0.9030.99
34_Q129_D0.9010.99
190_T200_L0.9000.99
231_E234_Q0.9000.99
13_L43_I0.8980.99
65_D91_T0.8930.99
194_Q251_V0.8910.99
193_L286_S0.8890.99
53_R57_S0.8880.99
55_D58_A0.8870.99
125_V135_T0.8850.99
8_G16_A0.8850.99
15_C120_V0.8830.99
9_G12_G0.8810.99
76_H256_Q0.8790.99
111_V115_I0.8780.99
180_L262_I0.8750.99
83_S87_R0.8750.99
220_I270_A0.8700.99
54_A58_A0.8700.99
142_W156_L0.8700.99
8_G13_L0.8680.99
77_Q80_S0.8680.99
189_L200_L0.8670.99
207_L234_Q0.8650.99
160_N166_I0.8650.99
74_K179_K0.8620.99
141_K175_L0.8610.99
197_N243_N0.8560.99
212_L281_E0.8540.99
187_N246_S0.8500.99
270_A276_D0.8490.99
263_I266_L0.8490.99
38_I130_T0.8470.99
101_G268_K0.8470.99
125_V133_D0.8440.99
103_I117_V0.8440.99
2_K64_S0.8430.99
187_N191_A0.8420.99
34_Q126_R0.8410.99
208_A212_L0.8410.99
92_N114_S0.8390.99
250_D258_E0.8370.99
249_V253_G0.8360.99
69_L91_T0.8320.99
69_L88_I0.8260.99
5_I16_A0.8240.99
155_I159_H0.8180.99
71_V93_I0.8170.99
185_C214_F0.8120.99
82_F109_W0.8110.99
14_L122_H0.8090.99
219_R222_K0.8070.99
75_Q102_H0.8070.99
124_A132_V0.8060.99
193_L209_F0.8060.99
125_V249_V0.8050.99
74_K250_D0.8050.99
92_N155_I0.8040.99
118_G140_I0.8020.99
264_G284_Y0.8020.99
234_Q238_G0.8010.99
74_K258_E0.8000.99
17_Y45_L0.7980.99
264_G268_K0.7970.99
215_Q230_W0.7920.99
217_A220_I0.7880.99
107_K111_V0.7830.99
81_V84_S0.7810.98
208_A211_K0.7780.98
282_F285_G0.7740.98
123_G135_T0.7710.98
260_D264_G0.7690.98
256_Q291_E0.7690.98
6_I73_V0.7660.98
95_F102_H0.7660.98
101_G265_Y0.7660.98
218_C222_K0.7610.98
204_P208_A0.7600.98
183_N262_I0.7600.98
23_H158_Q0.7590.98
268_K271_S0.7590.98
104_H108_D0.7580.98
70_V96_L0.7570.98
141_K167_Y0.7550.98
189_L210_M0.7540.98
180_L266_L0.7520.98
215_Q219_R0.7500.98
230_W234_Q0.7480.98
97_Q102_H0.7390.98
5_I25_V0.7360.98
266_L280_L0.7360.98
286_S290_L0.7320.98
178_G232_R0.7300.98
66_F69_L0.7300.98
244_R249_V0.7280.98
219_R223_L0.7280.98
71_V95_F0.7270.98
4_G26_T0.7240.98
271_S277_A0.7230.98
188_P283_L0.7220.97
182_V186_I0.7170.97
2_K65_D0.7170.97
200_L237_C0.7140.97
74_K246_S0.7110.97
21_L162_S0.7080.97
184_A280_L0.7050.97
107_K145_F0.7040.97
267_L280_L0.7030.97
82_F106_L0.7000.97
160_N165_P0.6990.97
186_I243_N0.6980.97
232_R235_A0.6960.97
240_T243_N0.6950.97
69_L93_I0.6950.97
270_A278_V0.6930.97
187_N249_V0.6890.97
17_Y20_S0.6860.97
250_D255_R0.6850.97
139_A165_P0.6830.97
34_Q43_I0.6800.96
94_L116_Y0.6790.96
106_L115_I0.6780.96
41_E131_A0.6770.96
206_Y289_A0.6770.96
33_E37_A0.6720.96
15_C140_I0.6710.96
46_Y127_K0.6700.96
246_S250_D0.6690.96
211_K231_E0.6640.96
142_W166_I0.6580.96
187_N262_I0.6560.96
169_E172_W0.6540.96
195_V200_L0.6520.95
81_V85_L0.6500.95
220_I275_L0.6490.95
103_I107_K0.6480.95
189_L213_V0.6420.95
73_V78_L0.6410.95
15_C70_V0.6400.95
201_L238_G0.6380.95
41_E44_R0.6350.95
20_S27_V0.6340.95
117_V176_L0.6340.95
147_D150_P0.6340.95
186_I197_N0.6340.95
197_N240_T0.6340.95
180_L183_N0.6300.95
263_I267_L0.6290.95
251_V290_L0.6250.94
183_N246_S0.6250.94
203_T206_Y0.6250.94
71_V106_L0.6240.94
29_T34_Q0.6240.94
209_F286_S0.6240.94
202_T241_K0.6220.94
236_V240_T0.6210.94
228_K231_E0.6210.94
212_L285_G0.6200.94
219_R275_L0.6180.94
188_P191_A0.6170.94
233_V237_C0.6160.94
184_A262_I0.6130.94
224_E275_L0.6130.94
65_D90_K0.6120.94
214_F230_W0.6110.94
38_I42_G0.6100.94
271_S276_D0.6100.94
229_A232_R0.6090.94
179_K187_N0.6080.93
149_E154_N0.6080.93
230_W239_Q0.6050.93
181_I229_A0.6040.93
6_I28_V0.6020.93
98_N246_S0.6020.93
102_H176_L0.5990.93
15_C18_Y0.5920.93
230_W233_V0.5880.92
74_K98_N0.5870.92
179_K250_D0.5860.92
191_A195_V0.5860.92
236_V239_Q0.5860.92
183_N249_V0.5860.92
105_D108_D0.5850.92
104_H269_E0.5850.92
100_M180_L0.5830.92
191_A257_T0.5820.92
233_V240_T0.5810.92
95_F103_I0.5800.92
18_Y162_S0.5780.92
246_S258_E0.5780.92
98_N183_N0.5750.91
234_Q237_C0.5730.91
39_Q58_A0.5730.91
120_V138_G0.5730.91
43_I47_K0.5700.91
173_Y224_E0.5690.91
126_R132_V0.5680.91
116_Y144_A0.5680.91
2_K67_D0.5670.91
24_D57_S0.5670.91
153_L156_L0.5660.91
69_L85_L0.5660.91
73_V77_Q0.5650.91
14_L134_H0.5620.91
145_F173_Y0.5610.90
119_I175_L0.5580.90
117_V145_F0.5580.90
96_L120_V0.5580.90
198_G202_T0.5570.90
186_I236_V0.5560.90
266_L277_A0.5550.90
247_M257_T0.5530.90
227_E231_E0.5520.90
186_I240_T0.5510.90
247_M250_D0.5490.89
14_L18_Y0.5480.89
15_C72_T0.5460.89
117_V172_W0.5460.89
173_Y176_L0.5450.89
122_H138_G0.5450.89
6_I84_S0.5450.89
181_I218_C0.5440.89
229_A240_T0.5440.89
198_G242_E0.5440.89
88_I113_H0.5430.89
196_K244_R0.5420.89
34_Q37_A0.5400.89
98_N258_E0.5390.89
65_D89_G0.5380.89
214_F233_V0.5380.89
77_Q256_Q0.5370.88
19_L70_V0.5350.88
182_V236_V0.5350.88
45_L52_F0.5330.88
191_A248_L0.5330.88
201_L237_C0.5320.88
37_A129_D0.5320.88
156_L166_I0.5310.88
31_R36_A0.5300.88
31_R34_Q0.5290.88
142_W168_Y0.5260.87
2_K26_T0.5260.87
185_C188_P0.5260.87
287_I291_E0.5250.87
30_R77_Q0.5240.87
219_R276_D0.5220.87
138_G243_N0.5220.87
178_G228_K0.5200.87
28_V103_I0.5200.87
150_P153_L0.5170.87
229_A233_V0.5160.86
44_R53_R0.5130.86
19_L162_S0.5130.86
9_G98_N0.5080.86
52_F58_A0.5070.85
24_D55_D0.5060.85
264_G280_L0.5050.85
99_G179_K0.5030.85
206_Y209_F0.5030.85
233_V236_V0.5020.85
123_G243_N0.5020.85
13_L27_V0.5010.85
10_S259_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3egoA 2 0.9765 100 0.35 Contact Map
3wfiA 2 0.9966 100 0.359 Contact Map
2ew2A 2 0.9966 100 0.37 Contact Map
3ghyA 2 0.9933 100 0.397 Contact Map
3i83A 2 0.9899 100 0.406 Contact Map
3hn2A 2 0.9765 100 0.407 Contact Map
3hwrA 2 0.9732 100 0.416 Contact Map
2qytA 1 0.8926 100 0.418 Contact Map
1ks9A 1 0.943 100 0.437 Contact Map
4ol9A 2 0.9564 100 0.438 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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