GREMLIN Database
ALDH4 - Putative aldehyde dehydrogenase DhaS
UniProt: O34660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 495 (456)
Sequences: 36403 (21719)
Seq/√Len: 1017.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
310_K409_E5.0261.00
254_S258_K3.9681.00
310_K407_P3.1651.00
282_K319_E3.1211.00
313_Y407_P2.9521.00
38_D50_T2.8221.00
370_S380_A2.7941.00
67_R236_A2.7921.00
277_P309_H2.7411.00
388_E391_M2.6701.00
345_K349_E2.6411.00
357_K392_T2.5951.00
286_P323_Y2.5801.00
202_Y205_E2.5471.00
356_Q360_D2.5251.00
317_V405_A2.5161.00
277_P311_D2.4551.00
97_H100_E2.4141.00
95_E129_R2.4021.00
38_D47_T2.3461.00
431_T437_A2.3451.00
67_R238_D2.2321.00
355_I379_V2.2241.00
208_D214_A2.2091.00
55_Q58_D2.1901.00
98_K122_P2.1721.00
352_L356_Q2.1521.00
90_L207_I2.1421.00
93_L209_Q2.1071.00
411_V436_Q2.0651.00
422_E468_Q2.0261.00
156_E487_K2.0101.00
364_K386_N2.0091.00
195_Q344_S1.9961.00
352_L371_C1.9751.00
357_K361_E1.9651.00
233_N255_T1.9451.00
321_A325_E1.9371.00
342_L351_V1.9361.00
273_N288_A1.9311.00
229_E233_N1.9251.00
439_Y443_R1.9161.00
155_H481_D1.9121.00
100_E202_Y1.9081.00
352_L379_V1.9071.00
315_E319_E1.9051.00
366_V385_A1.8951.00
86_L212_F1.8761.00
251_K254_S1.8371.00
359_K365_A1.8321.00
278_D436_Q1.7951.00
250_K468_Q1.7921.00
64_K236_A1.7901.00
99_T118_N1.7721.00
93_L96_E1.7691.00
97_H209_Q1.7601.00
307_F417_R1.7561.00
93_L210_A1.7471.00
445_Q467_K1.7401.00
60_D230_A1.7331.00
394_A406_I1.7331.00
155_H484_T1.7301.00
411_V439_Y1.7261.00
71_D74_E1.6981.00
60_D64_K1.6961.00
384_F393_I1.6901.00
389_D417_R1.6641.00
47_T50_T1.6641.00
364_K385_A1.6561.00
309_H408_Y1.6551.00
321_A366_V1.6531.00
324_A383_V1.6431.00
204_A219_I1.6391.00
307_F414_V1.6331.00
93_L206_L1.6281.00
104_L202_Y1.6261.00
88_Y129_R1.6241.00
413_E416_E1.6071.00
409_E413_E1.5961.00
288_A316_V1.5841.00
95_E125_I1.5681.00
313_Y317_V1.5681.00
70_F76_R1.5661.00
318_D322_S1.5641.00
79_S82_S1.5641.00
293_M324_A1.5591.00
128_M179_G1.5591.00
92_D96_E1.5471.00
392_T396_E1.5441.00
353_S392_T1.5391.00
187_T216_V1.5291.00
281_L319_E1.5171.00
319_E322_S1.5121.00
89_K92_D1.5001.00
345_K377_Y1.4961.00
223_F226_D1.4901.00
60_D234_H1.4871.00
314_D407_P1.4821.00
285_I319_E1.4821.00
306_V403_L1.4731.00
36_T50_T1.4701.00
82_S85_R1.4701.00
365_A384_F1.4401.00
88_Y136_T1.4381.00
205_E209_Q1.4351.00
77_T443_R1.4341.00
276_L436_Q1.4331.00
287_G430_W1.4301.00
307_F408_Y1.4291.00
45_G375_A1.4241.00
46_E375_A1.4231.00
313_Y385_A1.4161.00
103_Q107_L1.4151.00
99_T103_Q1.4131.00
412_D443_R1.4101.00
323_Y326_S1.4091.00
427_A446_A1.4031.00
78_M82_S1.3971.00
91_A129_R1.3941.00
315_E318_D1.3941.00
288_A306_V1.3921.00
277_P436_Q1.3921.00
92_D129_R1.3751.00
134_W137_K1.3751.00
413_E417_R1.3751.00
154_R442_D1.3701.00
308_I316_V1.3691.00
40_P47_T1.3661.00
356_Q359_K1.3571.00
128_M175_M1.3571.00
163_Q188_I1.3561.00
58_D61_K1.3531.00
97_H202_Y1.3501.00
328_R336_D1.3391.00
106_T116_T1.3381.00
351_V400_G1.3331.00
35_A53_E1.3321.00
103_Q333_L1.3291.00
253_M471_L1.3201.00
348_H352_L1.3191.00
354_Y398_I1.3031.00
239_K264_T1.3001.00
348_H371_C1.2951.00
349_E353_S1.2891.00
276_L408_Y1.2851.00
174_A190_L1.2841.00
348_H379_V1.2831.00
70_F187_T1.2821.00
408_Y417_R1.2801.00
314_D318_D1.2741.00
41_N44_T1.2721.00
361_E392_T1.2711.00
204_A217_I1.2711.00
322_S325_E1.2611.00
276_L440_I1.2531.00
325_E367_T1.2521.00
317_V321_A1.2401.00
113_I118_N1.2371.00
415_I440_I1.2331.00
345_K348_H1.2321.00
141_Q477_S1.2321.00
91_A95_E1.2281.00
309_H410_T1.2131.00
274_I414_V1.2091.00
309_H312_Q1.1981.00
410_T413_E1.1981.00
328_R338_Q1.1971.00
312_Q315_E1.1931.00
478_Y481_D1.1931.00
390_E395_K1.1911.00
64_K68_K1.1841.00
53_E223_F1.1801.00
155_H486_V1.1801.00
152_Y438_H1.1781.00
103_Q113_I1.1751.00
101_L202_Y1.1731.00
353_S357_K1.1721.00
63_V234_H1.1711.00
229_E255_T1.1691.00
330_G337_T1.1651.00
319_E323_Y1.1631.00
207_I217_I1.1621.00
63_V236_A1.1551.00
477_S481_D1.1541.00
320_M403_L1.1531.00
78_M86_L1.1481.00
389_D420_H1.1391.00
427_A449_V1.1381.00
233_N258_K1.1351.00
317_V385_A1.1341.00
63_V237_V1.1331.00
316_V320_M1.1301.00
441_A489_V1.1271.00
363_A384_F1.1241.00
322_S326_S1.1231.00
106_T332_G1.1191.00
229_E251_K1.1191.00
59_V227_A1.1181.00
437_A451_V1.1171.00
251_K255_T1.1131.00
358_G384_F1.1101.00
89_K93_L1.1091.00
412_D439_Y1.1071.00
215_G218_N1.1071.00
317_V366_V1.1021.00
248_I251_K1.1011.00
395_K422_E1.0981.00
194_E223_F1.0951.00
178_M217_I1.0941.00
90_L212_F1.0931.00
158_V239_K1.0921.00
90_L206_L1.0921.00
56_A230_A1.0921.00
37_F53_E1.0911.00
201_L221_P1.0851.00
41_N331_A1.0841.00
247_E251_K1.0811.00
395_K420_H1.0811.00
464_G473_R1.0751.00
473_R485_E1.0741.00
88_Y133_G1.0731.00
98_K118_N1.0721.00
194_E225_E1.0711.00
65_A218_N1.0701.00
412_D416_E1.0681.00
273_N303_G1.0661.00
163_Q241_A1.0651.00
253_M263_V1.0641.00
49_M198_L1.0641.00
274_I440_I1.0611.00
280_N432_E1.0601.00
325_E380_A1.0591.00
90_L128_M1.0551.00
230_A234_H1.0541.00
327_L339_I1.0501.00
478_Y486_V1.0491.00
141_Q478_Y1.0471.00
321_A367_T1.0461.00
411_V440_I1.0411.00
415_I443_R1.0401.00
178_M188_I1.0371.00
53_E226_D1.0341.00
162_G237_V1.0321.00
101_L206_L1.0211.00
433_N436_Q1.0151.00
361_E391_M1.0121.00
274_I418_A1.0051.00
169_F299_V1.0031.00
69_A187_T1.0011.00
74_E78_M0.9991.00
250_K260_I0.9931.00
348_H377_Y0.9901.00
43_A332_G0.9861.00
280_N283_K0.9851.00
84_S136_T0.9851.00
45_G377_Y0.9841.00
124_A175_M0.9831.00
96_E209_Q0.9821.00
97_H206_L0.9811.00
194_E224_G0.9811.00
408_Y414_V0.9781.00
270_K304_S0.9771.00
201_L219_I0.9721.00
71_D416_E0.9691.00
154_R489_V0.9661.00
160_V187_T0.9661.00
331_A334_H0.9651.00
67_R71_D0.9581.00
71_D445_Q0.9571.00
162_G231_L0.9551.00
466_Y485_E0.9511.00
135_C183_A0.9491.00
205_E208_D0.9491.00
56_A226_D0.9491.00
289_L323_Y0.9471.00
88_Y132_A0.9421.00
158_V262_R0.9421.00
97_H205_E0.9411.00
354_Y357_K0.9411.00
416_E420_H0.9361.00
283_K287_G0.9361.00
107_L333_L0.9341.00
357_K360_D0.9321.00
282_K315_E0.9301.00
272_P427_A0.9301.00
100_E103_Q0.9301.00
351_V402_V0.9291.00
368_G382_T0.9271.00
428_G454_Y0.9251.00
387_V391_M0.9241.00
253_M257_A0.9221.00
291_G303_G0.9211.00
56_A60_D0.9161.00
368_G380_A0.9101.00
156_E442_D0.9081.00
41_N107_L0.9081.00
353_S356_Q0.9011.00
314_D317_V0.9011.00
93_L97_H0.9001.00
292_V304_S0.8971.00
151_N461_S0.8961.00
161_V239_K0.8951.00
85_R89_K0.8941.00
238_D445_Q0.8921.00
111_K120_D0.8891.00
109_N196_T0.8871.00
80_P84_S0.8841.00
84_S88_Y0.8821.00
160_V237_V0.8821.00
281_L285_I0.8801.00
76_R445_Q0.8801.00
41_N46_E0.8781.00
59_V162_G0.8761.00
349_E352_L0.8761.00
354_Y392_T0.8751.00
273_N430_W0.8741.00
276_L411_V0.8731.00
156_E466_Y0.8731.00
313_Y405_A0.8721.00
91_A132_A0.8721.00
253_M256_A0.8711.00
71_D77_T0.8701.00
124_A171_L0.8701.00
250_K254_S0.8691.00
351_V398_I0.8681.00
406_I417_R0.8671.00
276_L431_T0.8651.00
285_I320_M0.8641.00
195_Q346_E0.8631.00
94_M124_A0.8621.00
40_P377_Y0.8591.00
77_T442_D0.8591.00
61_K65_A0.8571.00
285_I323_Y0.8571.00
362_G391_M0.8561.00
245_S248_I0.8531.00
438_H442_D0.8511.00
84_S132_A0.8491.00
204_A208_D0.8471.00
359_K384_F0.8431.00
389_D406_I0.8431.00
262_R485_E0.8411.00
427_A444_L0.8331.00
429_L440_I0.8211.00
284_A288_A0.8201.00
184_T484_T0.8191.00
461_S488_S0.8191.00
74_E77_T0.8191.00
190_L200_A0.8191.00
414_V417_R0.8191.00
57_A61_K0.8181.00
240_I256_A0.8171.00
69_A216_V0.8151.00
434_V437_A0.8151.00
415_I419_N0.8131.00
369_G382_T0.8131.00
31_S58_D0.8131.00
37_F223_F0.8121.00
275_L316_V0.8121.00
158_V485_E0.8121.00
43_A378_F0.8111.00
61_K64_K0.8111.00
253_M260_I0.8101.00
75_W216_V0.8091.00
408_Y413_E0.8081.00
177_K474_E0.8081.00
65_A215_G0.8061.00
285_I316_V0.8061.00
158_V186_C0.8051.00
363_A391_M0.8051.00
57_A60_D0.8001.00
201_L205_E0.7961.00
174_A178_M0.7941.00
141_Q144_P0.7941.00
358_G398_I0.7941.00
181_A188_I0.7941.00
240_I252_I0.7941.00
318_D321_A0.7931.00
180_A479_A0.7931.00
66_A218_N0.7871.00
385_A407_P0.7841.00
88_Y92_D0.7801.00
355_I402_V0.7801.00
192_P221_P0.7781.00
249_G267_L0.7751.00
48_L107_L0.7741.00
109_N343_V0.7721.00
106_T113_I0.7681.00
87_M183_A0.7671.00
446_A449_V0.7661.00
81_A136_T0.7661.00
175_M203_L0.7631.00
68_K71_D0.7581.00
54_A58_D0.7581.00
114_N338_Q0.7551.00
320_M383_V0.7551.00
31_S52_Y0.7531.00
162_G240_I0.7531.00
346_E349_E0.7521.00
95_E98_K0.7521.00
246_T468_Q0.7481.00
31_S36_T0.7481.00
86_L210_A0.7481.00
95_E122_P0.7471.00
232_T252_I0.7471.00
212_F217_I0.7471.00
94_M125_I0.7471.00
249_G265_L0.7461.00
242_F248_I0.7461.00
271_S304_S0.7451.00
222_G227_A0.7431.00
313_Y386_N0.7421.00
225_E229_E0.7421.00
272_P418_A0.7411.00
163_Q177_K0.7401.00
107_L198_L0.7391.00
256_A263_V0.7371.00
102_A113_I0.7361.00
250_K258_K0.7361.00
281_L312_Q0.7361.00
351_V379_V0.7341.00
309_H411_V0.7311.00
372_P380_A0.7311.00
284_A316_V0.7261.00
54_A62_A0.7261.00
102_A106_T0.7251.00
212_F216_V0.7241.00
89_K210_A0.7241.00
285_I289_L0.7241.00
113_I333_L0.7241.00
324_A367_T0.7231.00
171_L199_S0.7221.00
174_A200_A0.7211.00
327_L338_Q0.7191.00
232_T255_T0.7191.00
228_G232_T0.7151.00
102_A118_N0.7141.00
354_Y396_E0.7131.00
71_D76_R0.7121.00
308_I312_Q0.7091.00
282_K323_Y0.7081.00
195_Q343_V0.7061.00
334_H337_T0.7041.00
289_L320_M0.7041.00
40_P45_G0.7021.00
227_A230_A0.7021.00
99_T113_I0.7001.00
118_N122_P0.6981.00
75_W86_L0.6951.00
190_L217_I0.6951.00
359_K370_S0.6921.00
66_A187_T0.6911.00
158_V238_D0.6901.00
69_A74_E0.6901.00
321_A324_A0.6891.00
350_R353_S0.6881.00
60_D236_A0.6881.00
165_I174_A0.6871.00
276_L309_H0.6871.00
432_E435_K0.6841.00
151_N488_S0.6821.00
104_L198_L0.6801.00
75_W182_L0.6771.00
67_R70_F0.6771.00
324_A327_L0.6761.00
347_Q350_R0.6761.00
278_D431_T0.6751.00
255_T258_K0.6751.00
162_G228_G0.6741.00
226_D229_E0.6741.00
186_C484_T0.6741.00
389_D394_A0.6731.00
307_F389_D0.6711.00
76_R443_R0.6691.00
59_V63_V0.6681.00
410_T416_E0.6681.00
434_V438_H0.6681.00
45_G345_K0.6681.00
254_S257_A0.6671.00
344_S347_Q0.6661.00
35_A226_D0.6661.00
306_V316_V0.6651.00
105_E108_D0.6641.00
59_V230_A0.6631.00
345_K371_C0.6621.00
307_F394_A0.6621.00
100_E205_E0.6581.00
262_R482_N0.6571.00
174_A203_L0.6551.00
80_P135_C0.6541.00
288_A320_M0.6541.00
441_A451_V0.6541.00
296_Q339_I0.6531.00
289_L327_L0.6501.00
224_G228_G0.6501.00
154_R487_K0.6501.00
417_R420_H0.6491.00
207_I212_F0.6491.00
275_L284_A0.6481.00
76_R157_P0.6481.00
379_V382_T0.6471.00
411_V415_I0.6461.00
92_D95_E0.6451.00
138_I484_T0.6441.00
150_F438_H0.6421.00
445_Q466_Y0.6401.00
41_N333_L0.6401.00
106_T333_L0.6391.00
329_Q339_I0.6391.00
355_I384_F0.6391.00
76_R156_E0.6381.00
281_L315_E0.6381.00
320_M405_A0.6371.00
481_D484_T0.6361.00
151_N490_W0.6361.00
91_A125_I0.6351.00
331_A337_T0.6351.00
481_D486_V0.6321.00
71_D443_R0.6311.00
361_E390_E0.6311.00
36_T52_Y0.6301.00
346_E350_R0.6301.00
111_K115_E0.6291.00
387_V394_A0.6291.00
111_K169_F0.6281.00
367_T383_V0.6261.00
194_E350_R0.6231.00
152_Y489_V0.6221.00
264_T482_N0.6211.00
283_K286_P0.6211.00
283_K432_E0.6181.00
189_V218_N0.6181.00
82_S86_L0.6161.00
232_T240_I0.6161.00
222_G228_G0.6141.00
352_L355_I0.6131.00
177_K241_A0.6131.00
202_Y206_L0.6121.00
98_K102_A0.6121.00
101_L171_L0.6121.00
431_T436_Q0.6121.00
253_M265_L0.6101.00
437_A441_A0.6091.00
54_A220_I0.6081.00
387_V393_I0.6061.00
365_A382_T0.6061.00
121_I125_I0.6061.00
56_A229_E0.6061.00
39_T49_M0.6031.00
194_E251_K0.6031.00
105_E199_S0.6011.00
52_Y221_P0.6001.00
278_D432_E0.6001.00
171_L203_L0.6001.00
308_I313_Y0.5991.00
103_Q106_T0.5991.00
65_A214_A0.5981.00
64_K67_R0.5961.00
178_M190_L0.5961.00
384_F387_V0.5961.00
80_P183_A0.5961.00
342_L347_Q0.5951.00
51_L197_P0.5931.00
39_T108_D0.5921.00
225_E251_K0.5921.00
429_L437_A0.5911.00
415_I439_Y0.5911.00
369_G380_A0.5901.00
105_E116_T0.5901.00
435_K438_H0.5901.00
278_D433_N0.5891.00
329_Q338_Q0.5871.00
62_A220_I0.5871.00
187_T218_N0.5871.00
398_I402_V0.5851.00
389_D416_E0.5851.00
94_M203_L0.5841.00
161_V186_C0.5821.00
94_M128_M0.5821.00
48_L198_L0.5821.00
273_N306_V0.5781.00
291_G454_Y0.5771.00
56_A233_N0.5761.00
435_K439_Y0.5731.00
105_E120_D0.5721.00
94_M171_L0.5711.00
371_C380_A0.5691.00
239_K482_N0.5681.00
321_A383_V0.5671.00
429_L451_V0.5661.00
138_I480_L0.5661.00
246_T250_K0.5641.00
386_N407_P0.5641.00
184_T480_L0.5641.00
203_L207_I0.5631.00
91_A128_M0.5631.00
121_I171_L0.5611.00
308_I405_A0.5601.00
415_I444_L0.5581.00
273_N428_G0.5561.00
299_V302_A0.5561.00
372_P375_A0.5551.00
281_L316_V0.5531.00
292_V403_L0.5531.00
418_A444_L0.5521.00
229_E232_T0.5521.00
102_A121_I0.5511.00
282_K322_S0.5501.00
277_P408_Y0.5501.00
393_I398_I0.5501.00
414_V418_A0.5481.00
67_R160_V0.5471.00
411_V443_R0.5471.00
65_A69_A0.5421.00
39_T197_P0.5421.00
66_A189_V0.5421.00
450_W453_C0.5411.00
352_L359_K0.5411.00
86_L90_L0.5411.00
355_I382_T0.5401.00
90_L93_L0.5401.00
279_A284_A0.5401.00
449_V487_K0.5401.00
301_C456_V0.5391.00
130_Y134_W0.5391.00
232_T259_S0.5371.00
101_L121_I0.5371.00
68_K74_E0.5361.00
163_Q178_M0.5361.00
118_N335_K0.5351.00
440_I444_L0.5351.00
160_V238_D0.5341.00
271_S426_A0.5331.00
81_A85_R0.5331.00
161_V188_I0.5321.00
141_Q145_V0.5321.00
328_R334_H0.5321.00
306_V405_A0.5321.00
281_L284_A0.5321.00
131_Y180_A0.5321.00
172_L176_W0.5301.00
31_S34_G0.5291.00
85_R88_Y0.5281.00
445_Q485_E0.5271.00
303_G428_G0.5261.00
35_A55_Q0.5261.00
182_L217_I0.5261.00
361_E388_E0.5251.00
122_P125_I0.5251.00
263_V471_L0.5251.00
98_K125_I0.5251.00
66_A160_V0.5251.00
134_W477_S0.5241.00
310_K313_Y0.5231.00
226_D230_A0.5221.00
51_L198_L0.5221.00
247_E346_E0.5221.00
94_M101_L0.5221.00
30_P52_Y0.5221.00
342_L379_V0.5211.00
80_P139_T0.5201.00
123_L172_L0.5191.00
241_A483_Y0.5191.00
62_A218_N0.5181.00
156_E445_Q0.5181.00
366_V386_N0.5181.00
74_E187_T0.5181.00
176_W475_M0.5171.00
318_D325_E0.5171.00
293_M327_L0.5161.00
120_D169_F0.5151.00
194_E247_E0.5131.00
109_N295_N0.5131.00
208_D215_G0.5121.00
350_R354_Y0.5111.00
133_G136_T0.5101.00
285_I312_Q0.5091.00
62_A189_V0.5091.00
182_L212_F0.5081.00
39_T48_L0.5041.00
330_G334_H0.5041.00
162_G189_V0.5031.00
426_A450_W0.5011.00
102_A116_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lihA 5 0.9879 100 0.04 Contact Map
1a4sA 4 0.9919 100 0.04 Contact Map
4yweA 5 0.9515 100 0.041 Contact Map
4o5hA 4 0.998 100 0.042 Contact Map
4wj9A 4 0.9838 100 0.044 Contact Map
4qf6A 4 0.9879 100 0.045 Contact Map
4pxlA 4 0.9697 100 0.046 Contact Map
4pz2A 4 0.9798 100 0.046 Contact Map
2o2pA 5 0.9919 100 0.047 Contact Map
4qtoA 4 0.9717 100 0.051 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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