COTI - BACSU - GREMLIN Contacts

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COTI - Spore coat protein I

UniProt:	O34656	Sequences: MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQAEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGILPNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGVPIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLLQSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIPLLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSALPKEELESAFEYERIKANALRQLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	357 (283)
Sequences:	3770 (3041)
Seq/√Len:	180.7

ECOLI - RDOA
BACSU - COTI COTS YSXE YUTH YERI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
104_N	111_S	4.118	1.00
145_A	299_R	3.564	1.00
142_K	298_S	3.422	1.00
78_E	112_K	2.846	1.00
71_L	120_V	2.831	1.00
138_E	294_N	2.705	1.00
70_C	123_W	2.675	1.00
42_D	105_K	2.646	1.00
63_H	68_A	2.620	1.00
144_L	240_Y	2.559	1.00
61_K	68_A	2.544	1.00
141_M	295_A	2.540	1.00
138_E	295_A	2.532	1.00
61_K	123_W	2.477	1.00
100_G	122_D	2.463	1.00
90_Y	154_Y	2.435	1.00
236_C	264_D	2.352	1.00
297_E	307_K	2.248	1.00
89_D	103_P	2.246	1.00
90_Y	153_G	2.100	1.00
206_F	209_D	2.096	1.00
134_K	291_V	2.093	1.00
92_A	100_G	1.995	1.00
103_P	109_L	1.991	1.00
124_I	254_W	1.983	1.00
183_W	186_M	1.971	1.00
62_V	120_V	1.953	1.00
139_F	142_K	1.911	1.00
215_D	219_Q	1.889	1.00
138_E	298_S	1.886	1.00
149_T	300_A	1.864	1.00
81_A	84_S	1.864	1.00
49_D	61_K	1.843	1.00
177_C	181_E	1.832	1.00
246_L	256_I	1.831	1.00
87_A	261_V	1.799	1.00
44_Q	65_D	1.798	1.00
43_V	120_V	1.792	1.00
206_F	210_G	1.773	1.00
209_D	212_R	1.768	1.00
297_E	301_P	1.746	1.00
51_I	70_C	1.736	1.00
47_K	63_H	1.723	1.00
171_N	175_K	1.699	1.00
211_L	215_D	1.690	1.00
146_D	299_R	1.677	1.00
138_E	142_K	1.673	1.00
94_K	153_G	1.664	1.00
149_T	299_R	1.648	1.00
239_D	257_D	1.644	1.00
270_L	292_M	1.638	1.00
152_V	300_A	1.625	1.00
78_E	117_L	1.619	1.00
88_Q	258_L	1.609	1.00
230_K	305_E	1.602	1.00
35_E	39_Q	1.593	1.00
248_G	252_Q	1.582	1.00
86_F	154_Y	1.581	1.00
234_N	266_P	1.567	1.00
104_N	108_S	1.567	1.00
291_V	295_A	1.562	1.00
68_A	125_E	1.562	1.00
82_L	86_F	1.560	1.00
213_I	216_R	1.535	1.00
183_W	187_A	1.521	1.00
213_I	217_L	1.510	1.00
240_Y	255_V	1.504	1.00
210_G	213_I	1.500	1.00
180_M	183_W	1.487	1.00
102_L	122_D	1.483	1.00
273_M	292_M	1.479	1.00
40_G	104_N	1.469	1.00
244_N	257_D	1.447	1.00
145_A	300_A	1.434	1.00
133_V	136_D	1.426	1.00
270_L	293_L	1.418	1.00
69_V	120_V	1.412	1.00
214_K	217_L	1.405	1.00
322_D	325_R	1.398	1.00
144_L	148_H	1.382	1.00
175_K	178_K	1.378	1.00
38_L	41_W	1.369	1.00
143_G	255_V	1.366	1.00
172_H	176_R	1.359	1.00
64_T	67_G	1.359	1.00
64_T	69_V	1.334	1.00
216_R	219_Q	1.318	1.00
184_K	187_A	1.312	1.00
290_N	294_N	1.308	1.00
176_R	179_Q	1.307	1.00
207_I	211_L	1.305	1.00
73_R	118_F	1.295	1.00
176_R	180_M	1.292	1.00
77_P	80_K	1.290	1.00
206_F	214_K	1.288	1.00
112_K	115_S	1.287	1.00
175_K	179_Q	1.269	1.00
179_Q	182_T	1.266	1.00
148_H	296_Y	1.259	1.00
232_S	266_P	1.259	1.00
323_V	326_E	1.254	1.00
85_I	109_L	1.239	1.00
295_A	298_S	1.226	1.00
145_A	149_T	1.220	1.00
147_F	255_V	1.212	1.00
87_A	151_S	1.206	1.00
138_E	291_V	1.205	1.00
331_K	334_L	1.203	1.00
329_V	332_S	1.195	1.00
179_Q	183_W	1.191	1.00
73_R	116_F	1.181	1.00
96_M	147_F	1.168	1.00
148_H	269_D	1.168	1.00
178_K	185_L	1.166	1.00
78_E	82_L	1.158	1.00
212_R	216_R	1.146	1.00
72_K	84_S	1.142	1.00
181_E	184_K	1.138	1.00
323_V	327_K	1.136	1.00
89_D	109_L	1.132	1.00
178_K	181_E	1.124	1.00
243_G	276_P	1.119	1.00
142_K	299_R	1.114	1.00
142_K	146_D	1.100	1.00
46_E	65_D	1.094	1.00
41_W	111_S	1.093	1.00
203_I	207_I	1.086	1.00
304_E	308_Q	1.086	1.00
180_M	187_A	1.086	1.00
50_V	58_L	1.084	1.00
39_Q	105_K	1.073	1.00
210_G	217_L	1.072	1.00
239_D	244_N	1.069	1.00
247_L	253_I	1.068	1.00
204_D	208_E	1.063	1.00
143_G	146_D	1.057	1.00
144_L	269_D	1.052	1.00
178_K	186_M	1.043	1.00
209_D	213_I	1.035	1.00
48_I	62_V	1.035	1.00
242_T	276_P	1.034	1.00
77_P	81_A	1.027	1.00
232_S	306_Q	1.026	0.99
113_H	118_F	1.021	0.99
141_M	145_A	1.017	0.99
85_I	119_V	1.016	0.99
180_M	184_K	1.016	0.99
318_Y	321_Y	1.013	0.99
69_V	122_D	1.007	0.99
57_A	259_D	1.006	0.99
61_K	70_C	1.002	0.99
212_R	215_D	1.001	0.99
176_R	183_W	0.998	0.99
232_S	300_A	0.983	0.99
72_K	271_R	0.971	0.99
140_I	245_T	0.968	0.99
302_L	307_K	0.968	0.99
184_K	188_E	0.961	0.99
174_T	178_K	0.958	0.99
272_K	275_I	0.957	0.99
180_M	188_E	0.952	0.99
208_E	211_L	0.951	0.99
41_W	104_N	0.943	0.99
77_P	84_S	0.939	0.99
325_R	329_V	0.933	0.99
204_D	207_I	0.933	0.99
32_E	35_E	0.928	0.99
49_D	63_H	0.926	0.99
208_E	212_R	0.924	0.99
167_G	172_H	0.915	0.99
40_G	111_S	0.914	0.99
127_R	246_L	0.911	0.99
140_I	255_V	0.910	0.99
180_M	186_M	0.910	0.99
58_L	73_R	0.908	0.99
90_Y	150_A	0.906	0.99
89_D	93_K	0.905	0.99
162_I	166_L	0.902	0.99
217_L	220_S	0.897	0.99
59_V	70_C	0.894	0.99
179_Q	184_K	0.889	0.99
176_R	181_E	0.888	0.99
112_K	117_L	0.883	0.98
169_W	172_H	0.882	0.98
170_P	173_Y	0.880	0.98
178_K	183_W	0.879	0.98
142_K	295_A	0.877	0.98
43_V	69_V	0.876	0.98
55_Q	276_P	0.874	0.98
68_A	123_W	0.865	0.98
179_Q	187_A	0.856	0.98
87_A	235_L	0.853	0.98
59_V	259_D	0.852	0.98
237_H	244_N	0.851	0.98
238_Q	268_R	0.847	0.98
209_D	217_L	0.842	0.98
38_L	44_Q	0.842	0.98
74_I	119_V	0.841	0.98
269_D	296_Y	0.835	0.98
101_I	122_D	0.835	0.98
174_T	177_C	0.834	0.98
303_T	306_Q	0.832	0.98
314_M	317_P	0.830	0.98
205_G	209_D	0.829	0.98
181_E	185_L	0.825	0.98
71_L	118_F	0.825	0.98
137_L	291_V	0.823	0.98
266_P	300_A	0.821	0.98
179_Q	186_M	0.817	0.97
110_Y	117_L	0.814	0.97
84_S	88_Q	0.811	0.97
318_Y	322_D	0.808	0.97
124_I	246_L	0.806	0.97
97_N	146_D	0.805	0.97
166_L	169_W	0.803	0.97
241_G	276_P	0.802	0.97
267_I	309_V	0.801	0.97
284_W	287_E	0.800	0.97
171_N	174_T	0.799	0.97
271_R	314_M	0.796	0.97
129_F	245_T	0.795	0.97
89_D	101_I	0.793	0.97
173_Y	177_C	0.788	0.97
163_F	166_L	0.787	0.97
202_E	206_F	0.785	0.97
169_W	175_K	0.783	0.97
90_Y	93_K	0.781	0.97
244_N	259_D	0.775	0.97
77_P	83_F	0.772	0.96
57_A	72_K	0.767	0.96
175_K	180_M	0.766	0.96
320_L	323_V	0.766	0.96
332_S	335_P	0.764	0.96
181_E	186_M	0.764	0.96
212_R	217_L	0.764	0.96
207_I	218_L	0.763	0.96
137_L	288_T	0.762	0.96
140_I	273_M	0.762	0.96
141_M	292_M	0.762	0.96
294_N	297_E	0.757	0.96
210_G	214_K	0.757	0.96
135_Q	138_E	0.756	0.96
99_P	122_D	0.755	0.96
216_R	312_I	0.746	0.96
172_H	179_Q	0.745	0.96
88_Q	101_I	0.738	0.95
233_P	263_F	0.738	0.95
147_F	258_L	0.731	0.95
86_F	89_D	0.726	0.95
260_T	317_P	0.723	0.95
140_I	240_Y	0.723	0.95
136_D	264_D	0.722	0.95
155_Q	158_N	0.718	0.95
104_N	110_Y	0.716	0.95
203_I	210_G	0.716	0.95
151_S	234_N	0.714	0.95
333_A	336_K	0.709	0.94
59_V	241_G	0.709	0.94
37_V	41_W	0.708	0.94
206_F	213_I	0.708	0.94
91_L	147_F	0.707	0.94
173_Y	188_E	0.706	0.94
249_E	252_Q	0.701	0.94
280_T	283_V	0.701	0.94
35_E	40_G	0.699	0.94
134_K	287_E	0.697	0.94
126_G	249_E	0.696	0.94
305_E	308_Q	0.690	0.94
99_P	124_I	0.689	0.93
270_L	302_L	0.689	0.93
295_A	299_R	0.687	0.93
81_A	85_I	0.686	0.93
205_G	208_E	0.681	0.93
274_I	289_F	0.678	0.93
265_L	309_V	0.674	0.93
267_I	306_Q	0.672	0.93
177_C	211_L	0.672	0.93
126_G	246_L	0.672	0.93
319_E	334_L	0.672	0.93
36_N	40_G	0.671	0.93
125_E	248_G	0.671	0.93
173_Y	176_R	0.670	0.93
238_Q	262_S	0.669	0.92
322_D	326_E	0.663	0.92
202_E	205_G	0.657	0.92
270_L	310_M	0.657	0.92
152_V	232_S	0.657	0.92
323_V	331_K	0.655	0.92
216_R	220_S	0.654	0.92
82_L	109_L	0.650	0.91
182_T	185_L	0.646	0.91
208_E	213_I	0.644	0.91
82_L	108_S	0.643	0.91
34_A	37_V	0.642	0.91
56_M	259_D	0.642	0.91
145_A	148_H	0.641	0.91
323_V	329_V	0.641	0.91
33_L	38_L	0.640	0.91
34_A	48_I	0.640	0.91
89_D	100_G	0.637	0.91
329_V	333_A	0.636	0.90
33_L	36_N	0.636	0.90
57_A	70_C	0.633	0.90
319_E	322_D	0.633	0.90
134_K	138_E	0.632	0.90
332_S	336_K	0.632	0.90
207_I	216_R	0.632	0.90
214_K	218_L	0.631	0.90
149_T	152_V	0.630	0.90
95_G	146_D	0.630	0.90
62_V	71_L	0.628	0.90
172_H	178_K	0.625	0.90
178_K	182_T	0.623	0.90
166_L	171_N	0.622	0.89
37_V	111_S	0.621	0.89
241_G	259_D	0.620	0.89
274_I	314_M	0.612	0.89
325_R	328_Y	0.611	0.89
175_K	184_K	0.611	0.89
128_P	242_T	0.610	0.89
57_A	243_G	0.610	0.89
268_R	313_D	0.608	0.88
144_L	238_Q	0.607	0.88
324_I	329_V	0.606	0.88
41_W	120_V	0.605	0.88
126_G	239_D	0.605	0.88
55_Q	72_K	0.604	0.88
169_W	173_Y	0.601	0.88
183_W	188_E	0.600	0.88
331_K	335_P	0.597	0.87
53_G	267_I	0.597	0.87
99_P	254_W	0.596	0.87
159_G	235_L	0.593	0.87
78_E	84_S	0.590	0.87
40_G	43_V	0.589	0.87
89_D	92_A	0.589	0.87
33_L	114_G	0.588	0.87
74_I	84_S	0.588	0.87
324_I	331_K	0.587	0.87
145_A	298_S	0.587	0.87
74_I	81_A	0.582	0.86
70_C	99_P	0.582	0.86
40_G	106_K	0.580	0.86
57_A	84_S	0.578	0.86
72_K	241_G	0.577	0.86
274_I	310_M	0.576	0.86
76_R	84_S	0.572	0.85
43_V	64_T	0.572	0.85
238_Q	264_D	0.570	0.85
260_T	272_K	0.570	0.85
69_V	123_W	0.567	0.85
53_G	58_L	0.566	0.85
59_V	72_K	0.566	0.85
328_Y	331_K	0.566	0.85
178_K	184_K	0.565	0.85
307_K	311_F	0.565	0.85
287_E	290_N	0.563	0.84
185_L	188_E	0.558	0.84
177_C	180_M	0.556	0.84
309_V	312_I	0.555	0.83
44_Q	305_E	0.555	0.83
320_L	324_I	0.552	0.83
147_F	269_D	0.552	0.83
146_D	298_S	0.552	0.83
243_G	268_R	0.551	0.83
136_D	141_M	0.550	0.83
171_N	176_R	0.550	0.83
104_N	107_G	0.550	0.83
148_H	151_S	0.549	0.83
144_L	255_V	0.549	0.83
310_M	314_M	0.548	0.83
56_M	260_T	0.547	0.83
236_C	273_M	0.547	0.83
294_N	298_S	0.545	0.82
38_L	71_L	0.544	0.82
170_P	218_L	0.543	0.82
321_Y	324_I	0.543	0.82
323_V	330_R	0.542	0.82
150_A	154_Y	0.542	0.82
204_D	210_G	0.540	0.82
72_K	75_H	0.539	0.82
208_E	215_D	0.539	0.82
322_D	330_R	0.538	0.82
145_A	262_S	0.536	0.81
227_E	308_Q	0.535	0.81
267_I	313_D	0.534	0.81
205_G	210_G	0.534	0.81
234_N	300_A	0.533	0.81
42_D	65_D	0.532	0.81
70_C	121_Y	0.532	0.81
57_A	239_D	0.532	0.81
37_V	120_V	0.531	0.81
177_C	186_M	0.530	0.81
319_E	323_V	0.526	0.80
75_H	259_D	0.524	0.80
313_D	317_P	0.523	0.80
327_K	330_R	0.523	0.80
138_E	141_M	0.522	0.80
148_H	236_C	0.522	0.80
59_V	257_D	0.522	0.80
266_P	306_Q	0.520	0.79
115_S	118_F	0.519	0.79
326_E	330_R	0.518	0.79
46_E	120_V	0.517	0.79
271_R	313_D	0.515	0.79
241_G	275_I	0.514	0.79
207_I	210_G	0.514	0.79
210_G	220_S	0.513	0.78
259_D	272_K	0.513	0.78
38_L	45_A	0.512	0.78
127_R	136_D	0.512	0.78
155_Q	263_F	0.511	0.78
267_I	302_L	0.510	0.78
215_D	228_Q	0.510	0.78
137_L	277_L	0.509	0.78
72_K	259_D	0.508	0.78
236_C	317_P	0.508	0.78
56_M	75_H	0.508	0.78
235_L	263_F	0.508	0.78
53_G	243_G	0.506	0.77
293_L	297_E	0.505	0.77
73_R	260_T	0.505	0.77
65_D	68_A	0.501	0.77
37_V	40_G	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2q83A	1	0.9328	100	0.323	Contact Map
4pdyA	1	0.902	100	0.382	Contact Map
2ppqA	2	0.8347	100	0.475	Contact Map
4ocvA	1	0.8796	100	0.495	Contact Map
1zylA	1	0.8543	100	0.551	Contact Map
3i1aA	1	0.8908	100	0.556	Contact Map
3jr1A	1	0.7983	100	0.604	Contact Map
3mesA	2	0.8375	100	0.611	Contact Map
3atsA	1	0.8207	100	0.613	Contact Map
3dxpA	2	0.8123	100	0.617	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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