GREMLIN Database
COTI - Spore coat protein I
UniProt: O34656 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (283)
Sequences: 3770 (3041)
Seq/√Len: 180.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_N111_S4.1181.00
145_A299_R3.5641.00
142_K298_S3.4221.00
78_E112_K2.8461.00
71_L120_V2.8311.00
138_E294_N2.7051.00
70_C123_W2.6751.00
42_D105_K2.6461.00
63_H68_A2.6201.00
144_L240_Y2.5591.00
61_K68_A2.5441.00
141_M295_A2.5401.00
138_E295_A2.5321.00
61_K123_W2.4771.00
100_G122_D2.4631.00
90_Y154_Y2.4351.00
236_C264_D2.3521.00
297_E307_K2.2481.00
89_D103_P2.2461.00
90_Y153_G2.1001.00
206_F209_D2.0961.00
134_K291_V2.0931.00
92_A100_G1.9951.00
103_P109_L1.9911.00
124_I254_W1.9831.00
183_W186_M1.9711.00
62_V120_V1.9531.00
139_F142_K1.9111.00
215_D219_Q1.8891.00
138_E298_S1.8861.00
149_T300_A1.8641.00
81_A84_S1.8641.00
49_D61_K1.8431.00
177_C181_E1.8321.00
246_L256_I1.8311.00
87_A261_V1.7991.00
44_Q65_D1.7981.00
43_V120_V1.7921.00
206_F210_G1.7731.00
209_D212_R1.7681.00
297_E301_P1.7461.00
51_I70_C1.7361.00
47_K63_H1.7231.00
171_N175_K1.6991.00
211_L215_D1.6901.00
146_D299_R1.6771.00
138_E142_K1.6731.00
94_K153_G1.6641.00
149_T299_R1.6481.00
239_D257_D1.6441.00
270_L292_M1.6381.00
152_V300_A1.6251.00
78_E117_L1.6191.00
88_Q258_L1.6091.00
230_K305_E1.6021.00
35_E39_Q1.5931.00
248_G252_Q1.5821.00
86_F154_Y1.5811.00
234_N266_P1.5671.00
104_N108_S1.5671.00
291_V295_A1.5621.00
68_A125_E1.5621.00
82_L86_F1.5601.00
213_I216_R1.5351.00
183_W187_A1.5211.00
213_I217_L1.5101.00
240_Y255_V1.5041.00
210_G213_I1.5001.00
180_M183_W1.4871.00
102_L122_D1.4831.00
273_M292_M1.4791.00
40_G104_N1.4691.00
244_N257_D1.4471.00
145_A300_A1.4341.00
133_V136_D1.4261.00
270_L293_L1.4181.00
69_V120_V1.4121.00
214_K217_L1.4051.00
322_D325_R1.3981.00
144_L148_H1.3821.00
175_K178_K1.3781.00
38_L41_W1.3691.00
143_G255_V1.3661.00
172_H176_R1.3591.00
64_T67_G1.3591.00
64_T69_V1.3341.00
216_R219_Q1.3181.00
184_K187_A1.3121.00
290_N294_N1.3081.00
176_R179_Q1.3071.00
207_I211_L1.3051.00
73_R118_F1.2951.00
176_R180_M1.2921.00
77_P80_K1.2901.00
206_F214_K1.2881.00
112_K115_S1.2871.00
175_K179_Q1.2691.00
179_Q182_T1.2661.00
148_H296_Y1.2591.00
232_S266_P1.2591.00
323_V326_E1.2541.00
85_I109_L1.2391.00
295_A298_S1.2261.00
145_A149_T1.2201.00
147_F255_V1.2121.00
87_A151_S1.2061.00
138_E291_V1.2051.00
331_K334_L1.2031.00
329_V332_S1.1951.00
179_Q183_W1.1911.00
73_R116_F1.1811.00
96_M147_F1.1681.00
148_H269_D1.1681.00
178_K185_L1.1661.00
78_E82_L1.1581.00
212_R216_R1.1461.00
72_K84_S1.1421.00
181_E184_K1.1381.00
323_V327_K1.1361.00
89_D109_L1.1321.00
178_K181_E1.1241.00
243_G276_P1.1191.00
142_K299_R1.1141.00
142_K146_D1.1001.00
46_E65_D1.0941.00
41_W111_S1.0931.00
203_I207_I1.0861.00
304_E308_Q1.0861.00
180_M187_A1.0861.00
50_V58_L1.0841.00
39_Q105_K1.0731.00
210_G217_L1.0721.00
239_D244_N1.0691.00
247_L253_I1.0681.00
204_D208_E1.0631.00
143_G146_D1.0571.00
144_L269_D1.0521.00
178_K186_M1.0431.00
209_D213_I1.0351.00
48_I62_V1.0351.00
242_T276_P1.0341.00
77_P81_A1.0271.00
232_S306_Q1.0260.99
113_H118_F1.0210.99
141_M145_A1.0170.99
85_I119_V1.0160.99
180_M184_K1.0160.99
318_Y321_Y1.0130.99
69_V122_D1.0070.99
57_A259_D1.0060.99
61_K70_C1.0020.99
212_R215_D1.0010.99
176_R183_W0.9980.99
232_S300_A0.9830.99
72_K271_R0.9710.99
140_I245_T0.9680.99
302_L307_K0.9680.99
184_K188_E0.9610.99
174_T178_K0.9580.99
272_K275_I0.9570.99
180_M188_E0.9520.99
208_E211_L0.9510.99
41_W104_N0.9430.99
77_P84_S0.9390.99
325_R329_V0.9330.99
204_D207_I0.9330.99
32_E35_E0.9280.99
49_D63_H0.9260.99
208_E212_R0.9240.99
167_G172_H0.9150.99
40_G111_S0.9140.99
127_R246_L0.9110.99
140_I255_V0.9100.99
180_M186_M0.9100.99
58_L73_R0.9080.99
90_Y150_A0.9060.99
89_D93_K0.9050.99
162_I166_L0.9020.99
217_L220_S0.8970.99
59_V70_C0.8940.99
179_Q184_K0.8890.99
176_R181_E0.8880.99
112_K117_L0.8830.98
169_W172_H0.8820.98
170_P173_Y0.8800.98
178_K183_W0.8790.98
142_K295_A0.8770.98
43_V69_V0.8760.98
55_Q276_P0.8740.98
68_A123_W0.8650.98
179_Q187_A0.8560.98
87_A235_L0.8530.98
59_V259_D0.8520.98
237_H244_N0.8510.98
238_Q268_R0.8470.98
209_D217_L0.8420.98
38_L44_Q0.8420.98
74_I119_V0.8410.98
269_D296_Y0.8350.98
101_I122_D0.8350.98
174_T177_C0.8340.98
303_T306_Q0.8320.98
314_M317_P0.8300.98
205_G209_D0.8290.98
181_E185_L0.8250.98
71_L118_F0.8250.98
137_L291_V0.8230.98
266_P300_A0.8210.98
179_Q186_M0.8170.97
110_Y117_L0.8140.97
84_S88_Q0.8110.97
318_Y322_D0.8080.97
124_I246_L0.8060.97
97_N146_D0.8050.97
166_L169_W0.8030.97
241_G276_P0.8020.97
267_I309_V0.8010.97
284_W287_E0.8000.97
171_N174_T0.7990.97
271_R314_M0.7960.97
129_F245_T0.7950.97
89_D101_I0.7930.97
173_Y177_C0.7880.97
163_F166_L0.7870.97
202_E206_F0.7850.97
169_W175_K0.7830.97
90_Y93_K0.7810.97
244_N259_D0.7750.97
77_P83_F0.7720.96
57_A72_K0.7670.96
175_K180_M0.7660.96
320_L323_V0.7660.96
332_S335_P0.7640.96
181_E186_M0.7640.96
212_R217_L0.7640.96
207_I218_L0.7630.96
137_L288_T0.7620.96
140_I273_M0.7620.96
141_M292_M0.7620.96
294_N297_E0.7570.96
210_G214_K0.7570.96
135_Q138_E0.7560.96
99_P122_D0.7550.96
216_R312_I0.7460.96
172_H179_Q0.7450.96
88_Q101_I0.7380.95
233_P263_F0.7380.95
147_F258_L0.7310.95
86_F89_D0.7260.95
260_T317_P0.7230.95
140_I240_Y0.7230.95
136_D264_D0.7220.95
155_Q158_N0.7180.95
104_N110_Y0.7160.95
203_I210_G0.7160.95
151_S234_N0.7140.95
333_A336_K0.7090.94
59_V241_G0.7090.94
37_V41_W0.7080.94
206_F213_I0.7080.94
91_L147_F0.7070.94
173_Y188_E0.7060.94
249_E252_Q0.7010.94
280_T283_V0.7010.94
35_E40_G0.6990.94
134_K287_E0.6970.94
126_G249_E0.6960.94
305_E308_Q0.6900.94
99_P124_I0.6890.93
270_L302_L0.6890.93
295_A299_R0.6870.93
81_A85_I0.6860.93
205_G208_E0.6810.93
274_I289_F0.6780.93
265_L309_V0.6740.93
267_I306_Q0.6720.93
177_C211_L0.6720.93
126_G246_L0.6720.93
319_E334_L0.6720.93
36_N40_G0.6710.93
125_E248_G0.6710.93
173_Y176_R0.6700.93
238_Q262_S0.6690.92
322_D326_E0.6630.92
202_E205_G0.6570.92
270_L310_M0.6570.92
152_V232_S0.6570.92
323_V331_K0.6550.92
216_R220_S0.6540.92
82_L109_L0.6500.91
182_T185_L0.6460.91
208_E213_I0.6440.91
82_L108_S0.6430.91
34_A37_V0.6420.91
56_M259_D0.6420.91
145_A148_H0.6410.91
323_V329_V0.6410.91
33_L38_L0.6400.91
34_A48_I0.6400.91
89_D100_G0.6370.91
329_V333_A0.6360.90
33_L36_N0.6360.90
57_A70_C0.6330.90
319_E322_D0.6330.90
134_K138_E0.6320.90
332_S336_K0.6320.90
207_I216_R0.6320.90
214_K218_L0.6310.90
149_T152_V0.6300.90
95_G146_D0.6300.90
62_V71_L0.6280.90
172_H178_K0.6250.90
178_K182_T0.6230.90
166_L171_N0.6220.89
37_V111_S0.6210.89
241_G259_D0.6200.89
274_I314_M0.6120.89
325_R328_Y0.6110.89
175_K184_K0.6110.89
128_P242_T0.6100.89
57_A243_G0.6100.89
268_R313_D0.6080.88
144_L238_Q0.6070.88
324_I329_V0.6060.88
41_W120_V0.6050.88
126_G239_D0.6050.88
55_Q72_K0.6040.88
169_W173_Y0.6010.88
183_W188_E0.6000.88
331_K335_P0.5970.87
53_G267_I0.5970.87
99_P254_W0.5960.87
159_G235_L0.5930.87
78_E84_S0.5900.87
40_G43_V0.5890.87
89_D92_A0.5890.87
33_L114_G0.5880.87
74_I84_S0.5880.87
324_I331_K0.5870.87
145_A298_S0.5870.87
74_I81_A0.5820.86
70_C99_P0.5820.86
40_G106_K0.5800.86
57_A84_S0.5780.86
72_K241_G0.5770.86
274_I310_M0.5760.86
76_R84_S0.5720.85
43_V64_T0.5720.85
238_Q264_D0.5700.85
260_T272_K0.5700.85
69_V123_W0.5670.85
53_G58_L0.5660.85
59_V72_K0.5660.85
328_Y331_K0.5660.85
178_K184_K0.5650.85
307_K311_F0.5650.85
287_E290_N0.5630.84
185_L188_E0.5580.84
177_C180_M0.5560.84
309_V312_I0.5550.83
44_Q305_E0.5550.83
320_L324_I0.5520.83
147_F269_D0.5520.83
146_D298_S0.5520.83
243_G268_R0.5510.83
136_D141_M0.5500.83
171_N176_R0.5500.83
104_N107_G0.5500.83
148_H151_S0.5490.83
144_L255_V0.5490.83
310_M314_M0.5480.83
56_M260_T0.5470.83
236_C273_M0.5470.83
294_N298_S0.5450.82
38_L71_L0.5440.82
170_P218_L0.5430.82
321_Y324_I0.5430.82
323_V330_R0.5420.82
150_A154_Y0.5420.82
204_D210_G0.5400.82
72_K75_H0.5390.82
208_E215_D0.5390.82
322_D330_R0.5380.82
145_A262_S0.5360.81
227_E308_Q0.5350.81
267_I313_D0.5340.81
205_G210_G0.5340.81
234_N300_A0.5330.81
42_D65_D0.5320.81
70_C121_Y0.5320.81
57_A239_D0.5320.81
37_V120_V0.5310.81
177_C186_M0.5300.81
319_E323_V0.5260.80
75_H259_D0.5240.80
313_D317_P0.5230.80
327_K330_R0.5230.80
138_E141_M0.5220.80
148_H236_C0.5220.80
59_V257_D0.5220.80
266_P306_Q0.5200.79
115_S118_F0.5190.79
326_E330_R0.5180.79
46_E120_V0.5170.79
271_R313_D0.5150.79
241_G275_I0.5140.79
207_I210_G0.5140.79
210_G220_S0.5130.78
259_D272_K0.5130.78
38_L45_A0.5120.78
127_R136_D0.5120.78
155_Q263_F0.5110.78
267_I302_L0.5100.78
215_D228_Q0.5100.78
137_L277_L0.5090.78
72_K259_D0.5080.78
236_C317_P0.5080.78
56_M75_H0.5080.78
235_L263_F0.5080.78
53_G243_G0.5060.77
293_L297_E0.5050.77
73_R260_T0.5050.77
65_D68_A0.5010.77
37_V40_G0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q83A 1 0.9328 100 0.323 Contact Map
4pdyA 1 0.902 100 0.382 Contact Map
2ppqA 2 0.8347 100 0.475 Contact Map
4ocvA 1 0.8796 100 0.495 Contact Map
1zylA 1 0.8543 100 0.551 Contact Map
3i1aA 1 0.8908 100 0.556 Contact Map
3jr1A 1 0.7983 100 0.604 Contact Map
3mesA 2 0.8375 100 0.611 Contact Map
3atsA 1 0.8207 100 0.613 Contact Map
3dxpA 2 0.8123 100 0.617 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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