GREMLIN Database
DES - Fatty acid desaturase
UniProt: O34653 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (300)
Sequences: 4307 (2938)
Seq/√Len: 169.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_A219_I4.0551.00
287_K290_V3.8131.00
13_L16_Q2.9011.00
283_V291_A2.5311.00
88_R92_I2.5081.00
10_Q14_T2.4831.00
12_Q16_Q2.4741.00
189_T192_A2.4061.00
9_K13_L2.3491.00
152_Y156_F2.3051.00
78_C83_F2.2671.00
185_N189_T2.2541.00
195_A199_A2.1571.00
9_K12_Q2.1341.00
182_E185_N2.1291.00
84_F93_L2.1181.00
10_Q16_Q2.0981.00
15_K19_A2.0911.00
86_Q89_Y2.0601.00
163_P167_F2.0461.00
296_E300_N2.0321.00
193_I196_L2.0061.00
174_N177_G1.9991.00
94_G105_Y1.9881.00
164_I167_F1.9871.00
163_P166_V1.9611.00
257_F276_V1.9491.00
19_A290_V1.9421.00
46_A60_L1.9071.00
205_G208_S1.8811.00
26_K30_I1.8781.00
189_T193_I1.8711.00
134_T137_E1.8151.00
190_N194_V1.8031.00
193_I197_A1.7931.00
12_Q17_V1.7741.00
309_S312_S1.7591.00
308_T312_S1.7401.00
29_L33_L1.7211.00
84_F89_Y1.7211.00
143_R146_K1.6981.00
289_E293_E1.6961.00
150_R156_F1.6951.00
198_A202_L1.6861.00
191_L195_A1.6721.00
44_F48_L1.6431.00
28_S31_Q1.6401.00
195_A198_A1.6391.00
10_Q13_L1.6131.00
121_N124_K1.5711.00
198_A201_C1.5661.00
190_N193_I1.5611.00
133_L141_A1.5561.00
187_Y191_L1.5561.00
185_N192_A1.5541.00
10_Q17_V1.5511.00
31_Q34_N1.5511.00
42_L63_I1.5501.00
38_P42_L1.5331.00
197_A201_C1.5071.00
168_L173_F1.4931.00
168_L171_N1.4831.00
261_P264_L1.4741.00
153_R156_F1.4731.00
134_T139_K1.4631.00
19_A294_H1.4531.00
308_T313_L1.4411.00
45_L48_L1.4381.00
158_M162_G1.4371.00
37_I41_G1.4261.00
32_L35_T1.4221.00
20_F294_H1.4151.00
135_V138_Y1.4061.00
308_T311_Q1.4011.00
189_T197_A1.3881.00
179_R182_E1.3881.00
183_R187_Y1.3871.00
12_Q301_V1.3751.00
293_E296_E1.3741.00
11_K14_T1.3741.00
84_F90_N1.3741.00
196_L199_A1.3491.00
178_A189_T1.3441.00
9_K17_V1.3421.00
134_T140_A1.3421.00
185_N190_N1.3311.00
142_S145_T1.3211.00
136_N139_K1.3201.00
91_H109_Q1.3201.00
183_R186_T1.3181.00
55_L59_A1.3171.00
194_V197_A1.3101.00
294_H297_P1.3031.00
270_N289_E1.2981.00
246_S249_Q1.2931.00
265_Q272_G1.2831.00
276_V295_H1.2731.00
188_L192_A1.2701.00
262_K265_Q1.2641.00
27_N287_K1.2621.00
18_A22_Q1.2601.00
43_W46_A1.2571.00
40_F44_F1.2551.00
168_L172_R1.2441.00
157_I161_L1.2431.00
227_L268_T1.2391.00
24_E27_N1.2381.00
210_L214_G1.2361.00
309_S313_L1.2331.00
191_L194_V1.2281.00
14_T18_A1.2261.00
182_E189_T1.2141.00
207_Q211_L1.2131.00
33_L37_I1.2091.00
152_Y155_P1.2051.00
133_L138_Y1.2051.00
135_V139_K1.2041.00
42_L46_A1.2011.00
112_H116_H1.1971.00
135_V140_A1.1951.00
74_I97_T1.1941.00
186_T189_T1.1861.00
71_I97_T1.1851.00
25_T29_L1.1791.00
42_L67_F1.1781.00
170_T173_F1.1781.00
86_Q92_I1.1751.00
199_A203_I1.1701.00
192_A196_L1.1651.00
192_A199_A1.1641.00
234_F256_S1.1551.00
28_S35_T1.1531.00
133_L137_E1.1421.00
20_F291_A1.1401.00
74_I78_C1.1361.00
192_A195_A1.1281.00
180_R184_V1.1201.00
298_L302_P1.1201.00
16_Q301_V1.1141.00
189_T196_L1.1131.00
182_E186_T1.1101.00
42_L60_L1.1081.00
78_C93_L1.1081.00
164_I168_L1.1071.00
92_I96_L1.0981.00
92_I95_F1.0961.00
167_F170_T1.0941.00
79_C113_S1.0861.00
31_Q35_T1.0841.00
62_V219_I1.0761.00
206_W210_L1.0711.00
178_A182_E1.0701.00
193_I199_A1.0701.00
106_L109_Q1.0641.00
153_R157_I1.0600.99
163_P168_L1.0580.99
184_V187_Y1.0530.99
271_I274_H1.0530.99
143_R147_L1.0490.99
43_W47_Y1.0460.99
134_T138_Y1.0450.99
154_N157_I1.0390.99
29_L35_T1.0390.99
265_Q270_N1.0330.99
189_T198_A1.0290.99
39_F43_W1.0280.99
293_E297_P1.0230.99
73_I285_N1.0190.99
144_R147_L1.0150.99
299_K302_P1.0070.99
25_T89_Y1.0030.99
250_A254_G0.9970.99
58_L61_T0.9940.99
31_Q285_N0.9910.99
35_T42_L0.9860.99
34_N38_P0.9850.99
208_S211_L0.9830.99
179_R190_N0.9820.99
23_P85_K0.9810.99
297_P301_V0.9790.99
28_S32_L0.9750.99
181_K185_N0.9740.99
55_L58_L0.9730.99
252_V299_K0.9700.99
32_L36_F0.9700.99
59_A63_I0.9690.99
44_F47_Y0.9620.99
22_Q85_K0.9610.99
77_D288_L0.9600.99
21_A283_V0.9570.99
38_P67_F0.9560.99
276_V292_H0.9540.99
189_T194_V0.9510.99
180_R183_R0.9500.99
167_F171_N0.9500.99
179_R186_T0.9460.99
211_L215_P0.9410.99
16_Q297_P0.9390.99
124_K242_D0.9390.99
186_T190_N0.9330.99
128_G132_M0.9170.99
46_A49_S0.9160.99
24_E287_K0.9100.98
207_Q210_L0.9080.98
145_T148_A0.9070.98
140_A143_R0.9010.98
150_R154_N0.8940.98
169_I173_F0.8900.98
195_A200_C0.8880.98
35_T39_F0.8870.98
184_V188_L0.8840.98
69_T227_L0.8830.98
155_P158_M0.8790.98
112_H115_H0.8780.98
150_R153_R0.8780.98
194_V198_A0.8770.98
9_K16_Q0.8760.98
81_Q91_H0.8740.98
187_Y190_N0.8740.98
35_T38_P0.8740.98
69_T224_G0.8700.98
297_P300_N0.8700.98
27_N30_I0.8620.98
290_V293_E0.8560.98
188_L191_L0.8560.98
170_T174_N0.8550.98
35_T47_Y0.8510.98
298_L301_V0.8490.98
206_W209_F0.8460.98
152_Y157_I0.8450.98
30_I34_N0.8430.97
91_H105_Y0.8420.97
129_D132_M0.8340.97
134_T141_A0.8300.97
36_F39_F0.8290.97
161_L164_I0.8280.97
14_T17_V0.8230.97
77_D269_G0.8210.97
260_L272_G0.8170.97
260_L265_Q0.8140.97
29_L32_L0.8130.97
299_K305_T0.8100.97
32_L83_F0.8090.97
16_Q19_A0.8080.97
32_L74_I0.8060.97
161_L165_Y0.8030.97
167_F172_R0.7970.96
26_K29_L0.7970.96
141_A145_T0.7960.96
118_T121_N0.7960.96
151_L155_P0.7940.96
157_I162_G0.7910.96
39_F42_L0.7900.96
139_K145_T0.7880.96
180_R188_L0.7830.96
182_E190_N0.7820.96
96_L99_V0.7810.96
188_L195_A0.7810.96
158_M161_L0.7780.96
118_T124_K0.7780.96
57_T215_P0.7720.96
40_F43_W0.7710.96
142_S146_K0.7670.96
9_K14_T0.7670.96
139_K143_R0.7640.96
262_K289_E0.7620.95
264_L267_L0.7600.95
32_L93_L0.7600.95
41_G45_L0.7580.95
96_L100_L0.7530.95
197_A200_C0.7530.95
154_N158_M0.7520.95
229_Y232_H0.7500.95
224_G228_F0.7450.95
75_F79_C0.7440.95
162_G166_V0.7400.95
180_R186_T0.7320.94
265_Q289_E0.7300.94
221_G224_G0.7290.94
166_V170_T0.7270.94
11_K17_V0.7270.94
300_N303_T0.7260.94
45_L49_S0.7240.94
185_N193_I0.7190.94
29_L89_Y0.7150.94
294_H298_L0.7140.94
86_Q90_N0.7140.94
303_T308_T0.7140.94
87_K91_H0.7130.94
192_A197_A0.7070.93
151_L156_F0.7050.93
36_F100_L0.7020.93
162_G165_Y0.7000.93
147_L151_L0.7000.93
17_V20_F0.6990.93
40_F65_A0.6980.93
73_I78_C0.6950.93
140_A146_K0.6930.93
88_R91_H0.6910.92
14_T19_A0.6910.92
81_Q87_K0.6910.92
136_N140_A0.6900.92
39_F71_I0.6900.92
54_Y211_L0.6880.92
25_T28_S0.6820.92
181_K190_N0.6770.92
151_L157_I0.6730.91
73_I271_I0.6700.91
290_V294_H0.6700.91
299_K304_I0.6690.91
78_C94_G0.6690.91
182_E192_A0.6690.91
186_T195_A0.6660.91
43_W48_L0.6660.91
73_I269_G0.6650.91
178_A186_T0.6650.91
179_R185_N0.6640.91
91_H106_L0.6620.91
288_L292_H0.6620.91
150_R157_I0.6610.91
35_T70_R0.6600.91
185_N188_L0.6590.91
137_E141_A0.6590.91
299_K306_L0.6580.91
242_D246_S0.6570.90
259_K262_K0.6560.90
10_Q18_A0.6550.90
138_Y141_A0.6540.90
179_R189_T0.6530.90
199_A202_L0.6500.90
136_N141_A0.6500.90
68_L220_S0.6490.90
98_G105_Y0.6460.90
42_L64_A0.6440.90
280_S283_V0.6410.89
209_F213_Q0.6400.89
211_L214_G0.6390.89
227_L231_Q0.6390.89
191_L202_L0.6380.89
184_V190_N0.6370.89
13_L17_V0.6330.89
188_L194_V0.6300.89
180_R191_L0.6290.88
84_F91_H0.6280.88
178_A190_N0.6250.88
181_K188_L0.6220.88
181_K194_V0.6210.88
194_V199_A0.6210.88
178_A185_N0.6210.88
261_P265_Q0.6200.88
158_M163_P0.6200.88
194_V202_L0.6170.88
69_T223_I0.6150.87
197_A202_L0.6140.87
259_K273_Y0.6120.87
53_S57_T0.6100.87
81_Q90_N0.6100.87
111_S167_F0.6090.87
75_F98_G0.6090.87
165_Y168_L0.6070.87
157_I165_Y0.6050.86
178_A184_V0.6040.86
95_F106_L0.6030.86
61_T219_I0.6020.86
29_L44_F0.6020.86
22_Q25_T0.6010.86
52_V56_L0.6000.86
41_G44_F0.5970.86
182_E197_A0.5970.86
270_N285_N0.5950.86
258_Y268_T0.5950.86
293_E303_T0.5950.86
69_T73_I0.5940.85
259_K265_Q0.5940.85
92_I97_T0.5910.85
157_I163_P0.5910.85
257_F275_H0.5890.85
77_D285_N0.5870.85
166_V171_N0.5860.85
179_R183_R0.5850.85
186_T192_A0.5850.85
151_L158_M0.5840.85
231_Q255_S0.5820.84
32_L109_Q0.5820.84
160_I163_P0.5810.84
161_L172_R0.5780.84
178_A181_K0.5760.84
46_A57_T0.5720.83
15_K18_A0.5710.83
279_L295_H0.5690.83
273_Y276_V0.5650.83
79_C101_T0.5640.82
75_F97_T0.5640.82
56_L59_A0.5630.82
178_A191_L0.5630.82
120_S127_T0.5610.82
303_T311_Q0.5610.82
60_L64_A0.5600.82
108_W231_Q0.5570.82
53_S56_L0.5570.82
95_F99_V0.5550.81
76_H277_H0.5530.81
156_F162_G0.5510.81
200_C203_I0.5490.81
40_F47_Y0.5480.81
258_Y309_S0.5460.80
188_L203_I0.5460.80
155_P160_I0.5450.80
228_F274_H0.5430.80
70_R266_W0.5410.80
76_H80_H0.5400.80
38_P41_G0.5360.79
17_V21_A0.5360.79
69_T220_S0.5340.79
39_F46_A0.5330.79
81_Q109_Q0.5330.79
73_I83_F0.5330.79
160_I164_I0.5320.79
162_G169_I0.5320.79
218_L222_S0.5310.79
247_Y269_G0.5310.79
100_L196_L0.5300.78
159_F163_P0.5290.78
188_L193_I0.5270.78
156_F163_P0.5260.78
9_K18_A0.5260.78
157_I164_I0.5240.78
110_H114_I0.5240.78
273_Y289_E0.5220.77
264_L268_T0.5220.77
155_P161_L0.5210.77
147_L152_Y0.5190.77
284_P287_K0.5160.77
217_F221_G0.5140.76
196_L201_C0.5130.76
273_Y292_H0.5130.76
231_Q274_H0.5130.76
221_G225_V0.5130.76
204_F209_F0.5110.76
122_L126_G0.5080.75
75_F103_F0.5050.75
192_A198_A0.5050.75
110_H171_N0.5040.75
54_Y58_L0.5040.75
11_K16_Q0.5040.75
151_L159_F0.5040.75
61_T215_P0.5020.75
38_P46_A0.5010.74
231_Q271_I0.5010.74
229_Y233_T0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymkA 1 0.8182 99.2 0.827 Contact Map
2mmuA 1 0.142 22.5 0.96 Contact Map
3cqbA 4 0.2443 11 0.965 Contact Map
4yz6A 1 0.1847 9.8 0.966 Contact Map
1qs0A 2 0.1705 9.4 0.966 Contact Map
1w85A 2 0.1705 8.6 0.967 Contact Map
3fewX 1 0.2727 8.5 0.967 Contact Map
3hl2A 3 0.0653 8.2 0.967 Contact Map
1q42A 1 0.1818 7.2 0.968 Contact Map
2wr1A 3 0.1335 6.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.