GREMLIN Database
HISX - Histidinol dehydrogenase
UniProt: O34651 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 427 (411)
Sequences: 3824 (2140)
Seq/√Len: 105.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D39_N4.1501.00
49_A55_E4.1391.00
39_N46_S3.5751.00
60_L177_D3.3001.00
119_S149_R3.1591.00
33_I188_A3.1431.00
128_T258_K3.0941.00
153_V190_L3.0711.00
289_R293_E2.9741.00
244_S278_E2.9381.00
329_S332_A2.8351.00
236_L315_V2.7851.00
88_I136_L2.7711.00
122_V139_V2.7301.00
89_R93_E2.7091.00
331_E389_S2.5751.00
149_R177_D2.5411.00
83_Q401_S2.5401.00
309_V336_S2.5031.00
72_S164_P2.5001.00
269_M273_E2.4901.00
306_E310_E2.4851.00
35_D47_Y2.4571.00
278_E281_K2.3291.00
407_R419_E2.3231.00
70_Y171_A2.3141.00
118_D338_K2.2701.00
143_L176_K2.2551.00
82_R172_E2.1481.00
305_A311_A2.1441.00
66_F178_I2.1261.00
272_A302_I2.1021.00
239_E268_S2.0731.00
272_A304_V2.0721.00
85_I89_R2.0481.00
293_E297_R2.0421.00
46_S50_K2.0391.00
41_D194_T2.0361.00
399_A422_E2.0241.00
407_R412_E2.0091.00
403_A419_E2.0031.00
234_V315_V2.0011.00
213_L217_E1.9821.00
39_N42_Q1.9641.00
85_I140_I1.9541.00
35_D46_S1.9511.00
312_I337_I1.9461.00
201_D371_R1.9381.00
257_D260_S1.9241.00
139_V175_I1.9211.00
28_T210_Y1.9181.00
276_S302_I1.9161.00
31_S35_D1.9121.00
148_E338_K1.9111.00
236_L311_A1.8721.00
67_E171_A1.8721.00
233_I252_S1.8601.00
34_E38_A1.8601.00
67_E71_T1.8471.00
270_A274_T1.8041.00
240_T328_Q1.7851.00
283_L292_A1.7611.00
266_T272_A1.7551.00
118_D339_H1.7531.00
416_R419_E1.7451.00
78_L82_R1.7411.00
287_P412_E1.7331.00
60_L179_Y1.7121.00
118_D148_E1.7111.00
352_P417_S1.6981.00
89_R143_L1.6851.00
392_Q396_E1.6831.00
312_I333_L1.6431.00
353_V402_I1.6361.00
30_R217_E1.6331.00
62_T65_E1.6301.00
63_K67_E1.6251.00
117_L202_K1.6181.00
192_Y221_D1.6161.00
65_E180_K1.5961.00
239_E267_D1.5821.00
325_I337_I1.5601.00
307_T310_E1.5571.00
45_R59_P1.5511.00
152_L170_A1.5251.00
330_P345_L1.5151.00
248_A282_Q1.5151.00
78_L168_V1.5061.00
115_T385_S1.4971.00
267_D305_A1.4841.00
68_E72_S1.4781.00
212_A227_I1.4741.00
77_L408_L1.4641.00
101_F109_M1.4551.00
41_D196_T1.4481.00
70_Y168_V1.4451.00
179_Y198_E1.4431.00
181_M197_I1.4231.00
278_E282_Q1.4171.00
403_A407_R1.4061.00
264_F275_V1.4031.00
85_I136_L1.3911.00
80_V405_F1.3851.00
121_G190_L1.3821.00
136_L140_I1.3751.00
286_L292_A1.3611.00
327_T333_L1.3601.00
75_S79_Q1.3571.00
154_T162_L1.3521.00
97_Q379_T1.3500.99
157_G161_L1.3500.99
239_E328_Q1.3480.99
358_A388_I1.3450.99
244_S281_K1.3310.99
403_A415_A1.3190.99
120_A202_K1.3160.99
135_V152_L1.3120.99
379_T384_K1.3060.99
153_V186_A1.2950.99
26_R30_R1.2910.99
81_I172_E1.2890.99
80_V404_A1.2890.99
64_E68_E1.2880.99
151_V177_D1.2850.99
63_K171_A1.2840.99
274_T277_A1.2840.99
348_Y392_Q1.2810.99
343_I385_S1.2780.99
69_A167_L1.2760.99
168_V171_A1.2740.99
191_A218_V1.2690.99
258_K294_A1.2620.99
326_I347_R1.2590.99
36_V188_A1.2570.99
339_H383_K1.2540.99
294_A297_R1.2500.99
407_R415_A1.2460.99
169_A173_L1.2440.99
26_R217_E1.2390.99
280_N293_E1.2380.99
151_V190_L1.2360.99
192_Y218_V1.2360.99
33_I221_D1.2330.99
234_V265_V1.2290.99
85_I172_E1.2230.99
73_L78_L1.2080.99
236_L265_V1.2020.99
271_L275_V1.2010.99
77_L165_G1.1990.99
240_T347_R1.1980.99
134_S138_N1.1900.99
395_F418_I1.1900.99
209_I213_L1.1820.99
150_I176_K1.1740.99
415_A419_E1.1730.99
128_T288_R1.1690.99
242_I245_E1.1690.99
68_E161_L1.1550.98
61_V167_L1.1520.98
97_Q382_Q1.1470.98
42_Q195_E1.1440.98
284_E289_R1.1430.98
63_K176_K1.1380.98
44_V181_M1.1370.98
202_K380_D1.1370.98
315_V320_P1.1330.98
153_V181_M1.1280.98
30_R34_E1.1270.98
343_I387_I1.1190.98
282_Q416_R1.1100.98
236_L325_I1.1080.98
265_V314_T1.1070.98
33_I218_V1.0970.98
294_A298_D1.0940.98
246_I275_V1.0880.98
265_V305_A1.0860.98
266_T302_I1.0780.98
218_V222_V1.0780.98
241_A246_I1.0770.98
61_V180_K1.0730.97
138_N363_V1.0720.97
251_L292_A1.0700.97
357_F402_I1.0630.97
327_T330_P1.0620.97
115_T383_K1.0620.97
25_Q213_L1.0600.97
244_S420_A1.0520.97
81_I405_F1.0510.97
109_M389_S1.0500.97
27_K31_S1.0480.97
319_A370_A1.0460.97
32_I184_A1.0460.97
357_F401_S1.0440.97
237_A271_L1.0400.97
117_L120_A1.0380.97
122_V150_I1.0380.97
47_Y51_F1.0270.97
243_P274_T1.0270.97
97_Q114_V1.0260.97
269_M304_V1.0220.97
143_L173_L1.0190.97
48_T185_Q1.0110.96
305_A314_T1.0080.96
70_Y78_L1.0040.96
369_T372_F1.0040.96
377_N384_K1.0020.96
236_L312_I0.9900.96
277_A281_K0.9860.96
235_V250_L0.9850.96
93_E144_V0.9730.95
251_L413_A0.9730.95
103_H106_D0.9690.95
61_V69_A0.9690.95
266_T304_V0.9640.95
59_P181_M0.9600.95
117_L223_D0.9600.95
265_V315_V0.9590.95
252_S352_P0.9540.95
353_V390_Y0.9530.95
134_S363_V0.9500.95
233_I324_E0.9490.95
242_I347_R0.9480.95
363_V376_L0.9450.95
94_R102_Y0.9440.95
138_N204_T0.9390.94
37_K221_D0.9360.94
308_M333_L0.9360.94
350_P417_S0.9350.94
81_I169_A0.9330.94
281_K285_T0.9330.94
325_I345_L0.9310.94
33_I37_K0.9270.94
276_S280_N0.9270.94
250_L264_F0.9250.94
33_I192_Y0.9240.94
26_R213_L0.9220.94
79_Q82_R0.9200.94
237_A241_A0.9190.94
28_T31_S0.9120.94
390_Y398_H0.9120.94
32_I36_V0.9110.94
334_L345_L0.9100.94
86_E89_R0.9100.94
29_V213_L0.9090.93
267_D311_A0.9080.93
416_R420_A0.9070.93
402_I418_I0.9050.93
284_E293_E0.9020.93
35_D50_K0.8990.93
395_F399_A0.8980.93
74_D77_L0.8980.93
236_L308_M0.8920.93
96_L382_Q0.8910.93
37_K192_Y0.8910.93
66_F70_Y0.8890.93
248_A420_A0.8890.93
139_V173_L0.8890.93
104_R108_T0.8890.93
42_Q46_S0.8880.93
36_V184_A0.8860.93
246_I271_L0.8850.93
334_L387_I0.8800.92
66_F171_A0.8770.92
67_E70_Y0.8760.92
48_T56_I0.8680.92
39_N50_K0.8670.92
82_R168_V0.8640.92
308_M311_A0.8630.92
77_L404_A0.8610.92
90_E94_R0.8560.91
124_V152_L0.8540.91
100_W112_Q0.8530.91
189_A197_I0.8530.91
76_R404_A0.8470.91
266_T271_L0.8460.91
280_N284_E0.8430.91
342_A388_I0.8420.91
353_V398_H0.8410.91
310_E313_E0.8410.91
284_E287_P0.8400.90
86_E90_E0.8400.90
245_E347_R0.8400.90
80_V401_S0.8390.90
44_V184_A0.8380.90
53_C159_D0.8380.90
118_D201_D0.8370.90
282_Q420_A0.8350.90
290_E293_E0.8330.90
149_R179_Y0.8330.90
213_L216_R0.8310.90
267_D308_M0.8300.90
23_E30_R0.8300.90
23_E27_K0.8290.90
89_R140_I0.8240.90
44_V189_A0.8220.90
375_P386_S0.8210.89
177_D198_E0.8180.89
342_A386_S0.8130.89
337_I343_I0.8130.89
65_E161_L0.8120.89
243_P275_V0.8100.89
100_W111_G0.8060.89
151_V198_E0.8060.89
32_I47_Y0.8060.89
379_T382_Q0.8010.88
135_V169_A0.8000.88
342_A387_I0.7980.88
313_E316_N0.7970.88
44_V194_T0.7950.88
84_A88_I0.7940.88
122_V138_N0.7940.88
393_S396_E0.7930.88
201_D339_H0.7900.88
132_P405_F0.7900.88
334_L343_I0.7890.88
273_E276_S0.7890.88
316_N336_S0.7870.87
92_H95_Q0.7840.87
95_Q361_N0.7840.87
244_S282_Q0.7810.87
396_E422_E0.7800.87
54_I156_P0.7790.87
96_L144_V0.7790.87
45_R49_A0.7780.87
91_Y360_P0.7770.87
244_S423_R0.7740.87
312_I336_S0.7740.87
265_V311_A0.7710.86
151_V179_Y0.7710.86
90_E93_E0.7700.86
250_L279_V0.7640.86
235_V246_I0.7640.86
350_P395_F0.7640.86
87_N357_F0.7620.86
168_V172_E0.7590.85
39_N43_A0.7590.85
41_D195_E0.7570.85
377_N382_Q0.7560.85
406_A415_A0.7560.85
106_D397_E0.7560.85
138_N376_L0.7560.85
179_Y197_I0.7540.85
33_I217_E0.7520.85
130_A410_G0.7510.85
412_E416_R0.7500.85
223_D372_F0.7490.85
203_I218_V0.7460.84
25_Q209_I0.7460.84
156_P162_L0.7410.84
199_P368_G0.7400.84
233_I262_C0.7400.84
84_A357_F0.7380.84
234_V318_L0.7380.84
241_A271_L0.7360.84
62_T180_K0.7350.84
189_A194_T0.7350.84
28_T50_K0.7350.84
342_A358_A0.7350.84
93_E96_L0.7340.83
288_R291_I0.7340.83
60_L149_R0.7340.83
404_A408_L0.7330.83
251_L283_L0.7330.83
24_E27_K0.7320.83
135_V175_I0.7320.83
31_S34_E0.7290.83
31_S50_K0.7280.83
360_P388_I0.7270.83
357_F398_H0.7270.83
376_L380_D0.7260.83
353_V395_F0.7250.83
143_L175_I0.7250.83
328_Q347_R0.7230.83
273_E277_A0.7220.82
390_Y394_A0.7220.82
44_V48_T0.7200.82
149_R198_E0.7190.82
70_Y172_E0.7190.82
312_I327_T0.7170.82
252_S417_S0.7160.82
47_Y185_Q0.7160.82
112_Q377_N0.7160.82
90_E102_Y0.7130.82
209_I259_L0.7100.81
45_R56_I0.7090.81
35_D38_A0.7040.81
194_T197_I0.7030.81
122_V204_T0.7020.81
290_E294_A0.7020.81
45_R58_S0.7010.81
45_R57_D0.7010.81
374_S384_K0.6990.80
239_E270_A0.6980.80
138_N361_N0.6980.80
245_E326_I0.6970.80
49_A54_I0.6960.80
188_A218_V0.6960.80
115_T338_K0.6940.80
203_I222_V0.6940.80
28_T47_Y0.6940.80
114_V382_Q0.6930.80
223_D373_S0.6900.80
399_A403_A0.6890.79
85_I173_L0.6890.79
136_L169_A0.6880.79
82_R86_E0.6880.79
277_A280_N0.6880.79
39_N47_Y0.6870.79
83_Q357_F0.6870.79
86_E93_E0.6840.79
395_F402_I0.6820.79
171_A178_I0.6820.79
60_L63_K0.6820.79
332_A335_G0.6810.79
349_S390_Y0.6810.79
45_R55_E0.6810.79
76_R400_E0.6780.78
25_Q29_V0.6780.78
262_C300_G0.6780.78
129_A411_L0.6760.78
14_L17_S0.6740.78
279_V296_V0.6740.78
286_L416_R0.6730.78
286_L413_A0.6710.78
344_F354_G0.6710.78
407_R416_R0.6700.78
42_Q45_R0.6670.77
241_A347_R0.6670.77
218_V221_D0.6670.77
270_A273_E0.6670.77
48_T53_C0.6650.77
216_R220_G0.6630.77
24_E28_T0.6620.77
121_G153_V0.6600.76
400_E404_A0.6580.76
96_L99_S0.6550.76
243_P271_L0.6540.76
70_Y167_L0.6540.76
271_L274_T0.6530.76
308_M312_I0.6520.76
70_Y82_R0.6520.76
49_A56_I0.6490.75
101_F331_E0.6490.75
251_L286_L0.6470.75
85_I88_I0.6460.75
308_M315_V0.6440.75
27_K30_R0.6440.75
311_A315_V0.6430.75
68_E71_T0.6420.75
330_P334_L0.6420.75
316_N338_K0.6410.74
308_M327_T0.6410.74
252_S413_A0.6390.74
316_N334_L0.6370.74
73_L168_V0.6350.74
60_L151_V0.6330.73
44_V47_Y0.6330.73
340_A343_I0.6330.73
87_N402_I0.6320.73
83_Q86_E0.6310.73
281_K284_E0.6300.73
119_S201_D0.6280.73
236_L327_T0.6220.72
276_S279_V0.6220.72
292_A296_V0.6210.72
130_A163_S0.6210.72
286_L412_E0.6190.72
113_K335_G0.6180.72
65_E68_E0.6170.72
61_V65_E0.6160.71
179_Y196_T0.6150.71
43_A47_Y0.6150.71
283_L293_E0.6150.71
117_L147_V0.6140.71
228_A361_N0.6130.71
267_D307_T0.6130.71
181_M189_A0.6130.71
315_V337_I0.6130.71
99_S114_V0.6120.71
165_G408_L0.6120.71
412_E419_E0.6120.71
220_G372_F0.6110.71
64_E67_E0.6110.71
241_A326_I0.6090.71
200_V222_V0.6080.70
63_K66_F0.6060.70
227_I373_S0.6040.70
320_P323_L0.6030.70
282_Q286_L0.6010.70
122_V175_I0.6000.69
61_V178_I0.5990.69
199_P221_D0.5970.69
72_S161_L0.5960.69
45_R196_T0.5960.69
202_K223_D0.5930.69
128_T226_M0.5930.69
245_E348_Y0.5880.68
309_V313_E0.5870.68
330_P389_S0.5860.68
349_S388_I0.5850.68
122_V152_L0.5840.67
138_N152_L0.5830.67
79_Q83_Q0.5830.67
129_A288_R0.5820.67
21_G24_E0.5820.67
44_V59_P0.5810.67
135_V173_L0.5810.67
312_I343_I0.5810.67
66_F168_V0.5780.67
285_T416_R0.5780.67
101_F387_I0.5770.66
109_M391_S0.5760.66
395_F422_E0.5740.66
245_E420_A0.5720.66
355_D362_H0.5700.66
91_Y386_S0.5690.65
81_I165_G0.5670.65
89_R144_V0.5670.65
15_K18_I0.5670.65
84_A405_F0.5660.65
95_Q112_Q0.5660.65
204_T363_V0.5650.65
61_V156_P0.5620.64
288_R410_G0.5610.64
100_W113_K0.5600.64
81_I168_V0.5600.64
44_V197_I0.5590.64
254_A262_C0.5590.64
253_Q355_D0.5590.64
33_I44_V0.5550.64
344_F351_E0.5550.64
119_S200_V0.5550.64
246_I326_I0.5550.64
119_S151_V0.5540.63
101_F111_G0.5530.63
87_N104_R0.5530.63
317_T371_R0.5520.63
272_A276_S0.5500.63
287_P292_A0.5480.63
156_P181_M0.5470.62
36_V54_I0.5460.62
152_L175_I0.5440.62
32_I51_F0.5440.62
251_L296_V0.5430.62
279_V284_E0.5430.62
33_I191_A0.5420.62
337_I385_S0.5400.61
313_E317_T0.5400.61
324_E361_N0.5390.61
79_Q401_S0.5390.61
391_S394_A0.5390.61
342_A360_P0.5380.61
28_T36_V0.5370.61
131_Y411_L0.5360.61
110_L342_A0.5360.61
69_A168_V0.5350.61
115_T387_I0.5350.61
99_S113_K0.5340.61
117_L380_D0.5340.61
234_V314_T0.5340.61
250_L262_C0.5330.60
46_S49_A0.5310.60
267_D271_L0.5310.60
261_S318_L0.5310.60
295_S300_G0.5310.60
73_L172_E0.5300.60
78_L172_E0.5300.60
394_A398_H0.5300.60
238_D241_A0.5290.60
113_K385_S0.5290.60
154_T157_G0.5280.60
153_V156_P0.5280.60
167_L178_I0.5280.60
204_T376_L0.5270.60
398_H401_S0.5270.60
41_D189_A0.5250.59
216_R219_F0.5250.59
114_V384_K0.5250.59
120_A204_T0.5240.59
278_E418_I0.5240.59
169_A405_F0.5240.59
287_P407_R0.5220.59
167_L381_F0.5210.59
23_E34_E0.5200.59
157_G160_G0.5200.59
126_G129_A0.5180.58
76_R80_V0.5180.58
118_D316_N0.5180.58
403_A422_E0.5160.58
53_C185_Q0.5150.58
230_P259_L0.5140.58
21_G25_Q0.5140.58
36_V153_V0.5140.58
149_R176_K0.5130.58
113_K387_I0.5130.58
112_Q384_K0.5130.58
14_L301_C0.5120.57
216_R372_F0.5120.57
352_P418_I0.5100.57
268_S271_L0.5090.57
94_R100_W0.5090.57
87_N105_K0.5080.57
219_F373_S0.5080.57
77_L405_F0.5070.57
131_Y212_A0.5060.57
350_P399_A0.5060.57
226_M342_A0.5050.56
303_Y314_T0.5050.56
29_V217_E0.5040.56
78_L171_A0.5040.56
266_T275_V0.5030.56
393_S397_E0.5030.56
153_V179_Y0.5020.56
395_F420_A0.5010.56
239_E274_T0.5010.56
29_V33_I0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g09A 2 0.9859 100 0.017 Contact Map
1kaeA 2 0.9883 100 0.033 Contact Map
4gicA 2 0.8689 100 0.05 Contact Map
3my7A 2 0.7447 98 0.948 Contact Map
4itaA 2 0.7728 98 0.948 Contact Map
4ghkA 3 0.7869 97.9 0.949 Contact Map
4jbeA 2 0.7799 97.7 0.951 Contact Map
1euhA 4 0.7986 97.7 0.951 Contact Map
1o20A 3 0.808 97.7 0.952 Contact Map
4qtoA 4 0.808 97.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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