GREMLIN Database
YVLD - Uncharacterized membrane protein YvlD
UniProt: O34648 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (110)
Sequences: 1506 (1125)
Seq/√Len: 107.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_T67_L3.7301.00
72_A95_I2.9471.00
75_L101_L2.8991.00
18_I101_L2.7091.00
43_L78_T2.4991.00
68_F95_I2.3411.00
22_I93_T2.3051.00
75_L97_A2.2881.00
52_I67_L2.2801.00
53_I56_L2.2081.00
18_I100_I2.1981.00
91_F95_I2.0771.00
48_K52_I2.0131.00
43_L74_T1.9861.00
15_L36_A1.9421.00
73_I76_M1.9401.00
82_M85_S1.9141.00
25_I97_A1.8641.00
16_I33_A1.6551.00
72_A91_F1.6411.00
14_L108_I1.5751.00
26_H89_D1.5651.00
55_T67_L1.5211.00
40_L78_T1.4941.00
4_W38_L1.4891.00
22_I100_I1.4791.00
52_I55_T1.4361.00
92_G96_W1.4141.00
75_L88_I1.4121.00
15_L101_L1.3911.00
10_V108_I1.2980.99
82_M86_F1.2960.99
52_I70_I1.2680.99
93_T97_A1.1850.99
15_L97_A1.1690.99
91_F94_A1.1620.99
104_F108_I1.1610.99
4_W8_I1.1580.99
51_L74_T1.1480.98
24_S89_D1.1390.98
32_A82_M1.1380.98
100_I104_F1.0970.98
98_S102_S1.0800.98
71_N102_S1.0790.98
97_A101_L1.0640.97
12_A34_I1.0600.97
56_L59_T1.0590.97
16_I20_G1.0500.97
65_L69_V1.0410.97
66_F69_V1.0400.97
39_I82_M1.0250.97
8_I38_L1.0070.96
79_A88_I1.0020.96
77_M80_S1.0000.96
59_T66_F0.9980.96
14_L18_I0.9950.96
12_A47_I0.9880.96
79_A87_Q0.9860.96
14_L104_F0.9760.96
36_A86_F0.9670.96
27_I33_A0.9630.95
90_G93_T0.9570.95
88_I97_A0.9380.95
55_T66_F0.9380.95
28_S32_A0.9300.94
25_I79_A0.9280.94
52_I56_L0.9230.94
56_L60_M0.8940.93
59_T70_I0.8900.93
7_S109_Q0.8860.93
22_I96_W0.8860.93
30_I33_A0.8850.93
17_V104_F0.8800.93
43_L47_I0.8680.92
8_I37_S0.8680.92
41_S105_H0.8650.92
25_I75_L0.8550.92
75_L79_A0.8480.91
55_T74_T0.8260.90
8_I11_N0.8130.89
39_I78_T0.8110.89
16_I27_I0.8100.89
25_I86_F0.8010.89
48_K102_S0.7970.88
106_L110_K0.7940.88
48_K67_L0.7850.88
89_D93_T0.7770.87
39_I81_I0.7720.87
68_F71_N0.7700.87
92_G95_I0.7700.87
30_I34_I0.7690.87
76_M80_S0.7650.86
3_K7_S0.7540.86
29_S33_A0.7510.85
22_I97_A0.7500.85
39_I43_L0.7500.85
72_A76_M0.7490.85
5_A9_L0.7430.85
17_V20_G0.7350.84
65_L95_I0.7260.83
69_V95_I0.7260.83
17_V108_I0.7250.83
95_I98_S0.7190.83
38_L45_V0.7180.83
105_H109_Q0.7170.83
38_L42_I0.7140.82
46_L52_I0.7090.82
17_V21_Y0.7010.81
58_V67_L0.6970.81
33_A86_F0.6930.80
50_L80_S0.6930.80
53_I60_M0.6870.80
14_L17_V0.6860.80
18_I22_I0.6810.79
73_I90_G0.6690.78
67_L109_Q0.6670.78
25_I101_L0.6580.77
4_W7_S0.6550.77
75_L85_S0.6530.76
19_D86_F0.6370.75
63_L110_K0.6330.74
76_M94_A0.6300.74
15_L105_H0.6240.73
17_V81_I0.6220.73
15_L27_I0.6160.72
26_H70_I0.6110.71
37_S73_I0.6010.70
53_I61_V0.6000.70
2_V103_V0.5920.69
47_I74_T0.5880.69
18_I93_T0.5870.68
52_I59_T0.5820.68
20_G108_I0.5760.67
40_L82_M0.5750.67
32_A37_S0.5740.67
37_S85_S0.5710.66
32_A78_T0.5680.66
79_A82_M0.5680.66
43_L106_L0.5670.66
49_P66_F0.5650.65
4_W11_N0.5640.65
15_L86_F0.5600.65
31_G103_V0.5590.65
63_L109_Q0.5580.65
6_V16_I0.5560.64
73_I77_M0.5500.63
55_T59_T0.5480.63
9_L16_I0.5450.63
41_S45_V0.5420.62
62_T70_I0.5370.62
58_V70_I0.5360.61
38_L82_M0.5360.61
40_L48_K0.5350.61
7_S17_V0.5350.61
10_V14_L0.5240.60
23_D28_S0.5210.59
6_V10_V0.5140.58
20_G30_I0.5130.58
108_I112_I0.5120.58
22_I36_A0.5090.58
47_I67_L0.5080.57
8_I42_I0.5070.57
101_L106_L0.5040.57
99_V103_V0.5020.57
14_L21_Y0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.9748 12 0.93 Contact Map
2kv5A 1 0.2689 9.6 0.933 Contact Map
4b19A 1 0.2521 6.9 0.937 Contact Map
4czbA 2 0.9832 6.1 0.939 Contact Map
4oh3A 2 0.9748 4.5 0.943 Contact Map
4cz8A 2 0.958 4.1 0.944 Contact Map
3wajA 1 0.9496 2.8 0.948 Contact Map
4rp9A 2 0.8319 2.3 0.95 Contact Map
3wdoA 1 0.9664 2.3 0.95 Contact Map
2ksfA 1 0.8403 2.1 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.