GREMLIN Database
YOTB - SPBc2 prophage-derived uncharacterized protein YotB
UniProt: O34642 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (225)
Sequences: 1475 (1142)
Seq/√Len: 76.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_E236_S3.9001.00
45_V188_V3.5831.00
178_T181_N3.3561.00
5_Y220_V3.2171.00
125_V183_Q2.5571.00
221_C230_F2.3871.00
176_Y180_E2.3821.00
151_S165_V2.3661.00
129_D172_S2.2711.00
227_Q241_C2.2301.00
166_R170_K2.1181.00
123_G184_V2.0181.00
201_F204_N2.0071.00
70_K112_T1.9961.00
118_T178_T1.9751.00
114_L128_G1.9621.00
189_S219_W1.9411.00
46_I50_F1.9411.00
185_D216_A1.9171.00
125_V185_D1.8491.00
75_Y113_P1.7981.00
95_L115_I1.7951.00
218_H236_S1.7691.00
58_L62_D1.7511.00
206_C209_V1.7211.00
180_E214_I1.6991.00
230_F237_F1.6991.00
203_P209_V1.6761.00
198_Y204_N1.6591.00
195_H198_Y1.6441.00
160_N165_V1.6371.00
49_D225_H1.6351.00
131_M211_V1.5910.99
126_F186_V1.5760.99
43_V126_F1.5680.99
198_Y201_F1.5520.99
164_G167_A1.5520.99
221_C224_D1.5490.99
126_F188_V1.5420.99
218_H238_H1.5410.99
200_P203_P1.5390.99
200_P205_T1.5210.99
75_Y98_L1.5210.99
45_V220_V1.5160.99
200_P204_N1.5130.99
116_K172_S1.5120.99
49_D77_N1.5070.99
194_V212_P1.5050.99
127_A175_W1.4990.99
4_D41_G1.4970.99
72_Y126_F1.4970.99
221_C237_F1.4810.99
156_L160_N1.4780.99
201_F206_C1.4610.99
201_F209_V1.4540.99
78_H225_H1.4370.99
135_P151_S1.4370.99
45_V72_Y1.4180.99
120_T125_V1.4180.99
198_Y207_Y1.4170.99
150_D154_I1.4170.99
192_P221_C1.3990.99
58_L108_M1.3920.99
201_F208_M1.3720.98
148_S154_I1.3650.98
49_D223_H1.3590.98
75_Y115_I1.3370.98
3_I45_V1.3340.98
203_P206_C1.3320.98
49_D78_H1.3310.98
127_A185_D1.3280.98
204_N210_D1.3260.98
129_D175_W1.3240.98
198_Y202_E1.3130.98
77_N225_H1.3080.98
11_I51_T1.3060.98
205_T209_V1.2870.98
132_W191_V1.2670.97
72_Y188_V1.2600.97
192_P208_M1.2540.97
77_N223_H1.2520.97
224_D228_A1.2450.97
167_A171_E1.2260.97
140_G144_F1.2090.97
120_T183_Q1.2090.97
62_D66_K1.2040.96
144_F203_P1.1990.96
209_V212_P1.1970.96
81_Y154_I1.1930.96
202_E205_T1.1930.96
205_T208_M1.1900.96
194_V232_K1.1890.96
45_V126_F1.1690.96
60_V64_A1.1530.95
195_H203_P1.1510.95
187_F219_W1.1480.95
148_S152_N1.1450.95
192_P237_F1.1430.95
115_I172_S1.1400.95
151_S154_I1.1380.95
185_D215_N1.1290.95
149_N153_Y1.1290.95
47_A188_V1.1270.95
210_D213_F1.1200.95
184_V217_K1.1150.95
199_S203_P1.1120.95
203_P210_D1.1080.94
204_N207_Y1.0990.94
65_A110_N1.0990.94
199_S204_N1.0930.94
156_L159_Y1.0830.94
199_S202_E1.0820.94
81_Y150_D1.0820.94
202_E206_C1.0820.94
201_F205_T1.0730.93
78_H223_H1.0710.93
47_A220_V1.0600.93
4_D39_G1.0590.93
158_G161_K1.0560.93
193_P219_W1.0540.93
12_N79_D1.0450.92
75_Y80_L1.0450.92
221_C241_C1.0250.92
138_I205_T1.0220.92
231_D234_G1.0190.92
135_P165_V1.0170.91
162_V165_V1.0120.91
196_N199_S1.0070.91
201_F207_Y1.0050.91
190_H223_H1.0010.91
208_M212_P0.9990.91
149_N152_N0.9780.90
198_Y203_P0.9770.90
203_P213_F0.9750.90
12_N46_I0.9690.89
124_K184_V0.9680.89
174_D177_E0.9610.89
148_S207_Y0.9570.89
141_W144_F0.9510.88
163_D167_A0.9480.88
6_V44_L0.9430.88
121_Y126_F0.9400.88
201_F212_P0.9370.88
154_I158_G0.9340.88
10_H223_H0.9320.87
179_L187_F0.9290.87
143_F146_G0.9240.87
204_N213_F0.9230.87
116_K175_W0.9110.86
10_H225_H0.9040.86
199_S210_D0.9040.86
192_P224_D0.9040.86
130_V191_V0.8980.85
195_H199_S0.8980.85
208_M213_F0.8970.85
72_Y119_E0.8960.85
147_V150_D0.8960.85
202_E207_Y0.8940.85
147_V203_P0.8940.85
90_K93_D0.8920.85
191_V219_W0.8800.84
173_M176_Y0.8750.84
199_S205_T0.8720.84
194_V230_F0.8710.84
168_M172_S0.8710.84
58_L105_A0.8670.83
74_T128_G0.8660.83
163_D170_K0.8660.83
74_T188_V0.8640.83
150_D153_Y0.8520.82
112_T119_E0.8480.82
177_E181_N0.8420.81
11_I60_V0.8410.81
202_E208_M0.8380.81
44_L61_L0.8380.81
105_A111_V0.8380.81
49_D190_H0.8300.81
204_N209_V0.8300.81
131_M169_W0.8260.80
56_Q73_F0.8200.80
202_E209_V0.8200.80
224_D227_Q0.8200.80
3_I186_V0.8190.80
248_Y251_Y0.8170.79
4_D44_L0.8170.79
12_N52_E0.8070.79
169_W209_V0.8050.78
200_P208_M0.8020.78
206_C212_P0.7960.78
145_K148_S0.7960.78
141_W149_N0.7890.77
125_V184_V0.7810.76
204_N208_M0.7800.76
44_L69_E0.7790.76
206_C210_D0.7780.76
247_D251_Y0.7770.76
80_L130_V0.7750.76
229_E238_H0.7750.76
193_P221_C0.7750.76
199_S208_M0.7690.75
207_Y212_P0.7610.74
190_H225_H0.7570.74
200_P211_V0.7460.73
205_T210_D0.7460.73
3_I198_Y0.7420.73
78_H190_H0.7400.72
209_V213_F0.7330.72
10_H49_D0.7330.72
77_N190_H0.7220.71
221_C239_M0.7210.70
197_P205_T0.7210.70
195_H208_M0.7210.70
199_S209_V0.7200.70
131_M191_V0.7180.70
195_H204_N0.7170.70
177_E180_E0.7160.70
183_Q215_N0.7150.70
93_D96_G0.7150.70
176_Y214_I0.7110.69
220_V238_H0.7070.69
54_N79_D0.7060.69
12_N51_T0.7010.68
196_N204_N0.6980.68
10_H77_N0.6970.68
54_N57_T0.6960.68
44_L68_Y0.6900.67
195_H202_E0.6890.67
88_K152_N0.6860.67
13_H81_Y0.6850.67
70_K108_M0.6780.66
232_K238_H0.6690.65
10_H78_H0.6670.64
70_K231_D0.6660.64
171_E174_D0.6620.64
216_A235_T0.6620.64
207_Y241_C0.6600.64
141_W145_K0.6590.64
37_S67_Q0.6580.63
56_Q59_W0.6560.63
142_D145_K0.6540.63
127_A178_T0.6530.63
13_H52_E0.6520.63
205_T211_V0.6520.63
124_K186_V0.6520.63
13_H245_P0.6470.62
154_I191_V0.6450.62
157_N160_N0.6450.62
221_C228_A0.6450.62
189_S194_V0.6430.62
57_T60_V0.6400.61
40_N68_Y0.6400.61
157_N161_K0.6400.61
200_P206_C0.6360.61
78_H244_Y0.6350.61
65_A68_Y0.6330.60
88_K91_Y0.6320.60
186_V218_H0.6300.60
143_F147_V0.6270.60
103_Q108_M0.6260.60
142_D152_N0.6260.60
118_T127_A0.6230.59
66_K96_G0.6200.59
94_S97_R0.6140.58
134_L179_L0.6120.58
241_C244_Y0.6090.57
16_P128_G0.6070.57
167_A177_E0.6020.57
95_L98_L0.6020.57
41_G44_L0.6010.56
125_V229_E0.6000.56
57_T105_A0.5990.56
200_P207_Y0.5990.56
164_G191_V0.5970.56
144_F148_S0.5940.56
81_Y148_S0.5870.55
118_T125_V0.5860.55
124_K217_K0.5830.54
179_L214_I0.5820.54
9_L46_I0.5820.54
81_Y244_Y0.5800.54
4_D14_W0.5790.54
15_I249_D0.5790.54
61_L106_A0.5780.54
231_D236_S0.5780.54
198_Y205_T0.5750.53
64_A71_V0.5750.53
167_A170_K0.5750.53
165_V168_M0.5730.53
201_F210_D0.5720.53
169_W173_M0.5690.52
4_D38_N0.5690.52
106_A109_K0.5690.52
167_A174_D0.5650.52
136_K166_R0.5640.52
200_P210_D0.5640.52
18_N242_I0.5600.51
123_G183_Q0.5600.51
64_A67_Q0.5600.51
227_Q247_D0.5590.51
51_T57_T0.5570.51
76_G222_G0.5530.50
94_S98_L0.5520.50
12_N219_W0.5510.50
196_N201_F0.5510.50
165_V169_W0.5500.50
203_P207_Y0.5490.50
148_S153_Y0.5470.50
43_V72_Y0.5450.49
44_L168_M0.5440.49
205_T213_F0.5410.49
74_T113_P0.5410.49
177_E215_N0.5390.49
196_N203_P0.5380.49
219_W237_F0.5340.48
114_L189_S0.5340.48
198_Y206_C0.5320.48
140_G205_T0.5310.48
175_W237_F0.5290.47
230_F238_H0.5290.47
72_Y115_I0.5250.47
132_W193_P0.5230.47
65_A174_D0.5230.47
195_H210_D0.5220.47
122_K183_Q0.5190.46
133_Y169_W0.5180.46
154_I160_N0.5150.46
198_Y208_M0.5150.46
116_K127_A0.5130.45
62_D108_M0.5120.45
176_Y216_A0.5110.45
199_S213_F0.5100.45
110_N117_T0.5090.45
41_G68_Y0.5040.44
6_V46_I0.5030.44
48_G76_G0.5020.44
75_Y79_D0.5010.44
60_V63_E0.5000.44
134_L239_M0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4peiA 2 0.8509 99.9 0.667 Contact Map
3rl5A 1 0.7636 99.9 0.685 Contact Map
1uf3A 6 0.7709 99.9 0.706 Contact Map
2yvtA 1 0.7927 99.9 0.711 Contact Map
2nxfA 1 0.9127 99.9 0.714 Contact Map
3d03A 5 0.8618 99.8 0.721 Contact Map
1xm7A 1 0.6436 99.8 0.73 Contact Map
3ib7A 2 0.84 99.8 0.733 Contact Map
3tghA 1 0.8582 99.8 0.738 Contact Map
3qfmA 2 0.7418 99.8 0.738 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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