GREMLIN Database
YERI - Uncharacterized protein YerI
UniProt: O34640 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (275)
Sequences: 7362 (5696)
Seq/√Len: 343.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_E51_P3.5591.00
86_K113_E3.5351.00
88_L113_E3.0241.00
46_M51_P2.9371.00
131_Y267_G2.9361.00
44_E114_K2.8481.00
134_G267_G2.8071.00
127_E263_H2.6661.00
132_E135_R2.5831.00
135_R267_G2.5591.00
188_E192_L2.4961.00
54_L111_V2.4881.00
135_R270_E2.4541.00
139_S271_E2.4191.00
138_G271_E2.3841.00
144_T149_L2.3561.00
53_I114_K2.2751.00
33_R44_E2.2651.00
202_V229_N2.2221.00
135_R271_E2.2111.00
31_Q46_M2.2031.00
51_P114_K2.1991.00
137_T206_L2.1981.00
238_L264_F2.0921.00
212_N221_F2.0691.00
74_L87_P2.0501.00
200_G231_F1.9811.00
133_L211_F1.9721.00
78_A86_K1.9701.00
147_Y150_S1.9591.00
142_S272_N1.9571.00
187_N191_R1.9281.00
136_Y220_A1.9251.00
51_P116_P1.8721.00
131_Y266_K1.8491.00
75_R89_P1.8441.00
131_Y270_E1.8371.00
214_D217_K1.7831.00
18_L22_A1.7691.00
144_T150_S1.7661.00
206_L220_A1.7591.00
144_T147_Y1.7271.00
181_Q184_S1.7251.00
134_G264_F1.7221.00
267_G270_E1.7101.00
45_C111_V1.6751.00
299_Q303_L1.6611.00
115_A219_T1.6471.00
127_E131_Y1.6161.00
269_W279_L1.6141.00
47_K50_Q1.6111.00
183_D187_N1.5881.00
71_M87_P1.5791.00
52_Y88_L1.5181.00
131_Y135_R1.5101.00
142_S271_E1.4971.00
119_K212_N1.4941.00
81_G139_S1.4941.00
68_M72_E1.4941.00
16_Q19_A1.4761.00
33_R46_M1.4721.00
64_S108_L1.4701.00
144_T148_K1.4601.00
135_R139_S1.4561.00
158_E161_E1.4431.00
26_G91_L1.4421.00
138_G272_N1.4351.00
76_H147_Y1.4311.00
262_T266_K1.4281.00
73_W226_I1.4251.00
235_I265_M1.4001.00
145_K149_L1.3901.00
132_E218_I1.3901.00
266_K270_E1.3581.00
175_Q179_F1.3471.00
35_L53_I1.3461.00
141_H268_Y1.3391.00
50_Q113_E1.3281.00
80_G146_S1.3181.00
19_A23_A1.3121.00
163_E166_K1.3091.00
182_A186_M1.2961.00
260_F263_H1.2911.00
145_K148_K1.2901.00
32_V45_C1.2891.00
74_L223_F1.2881.00
235_I264_F1.2751.00
275_D278_W1.2741.00
185_L189_L1.2731.00
89_P95_D1.2691.00
236_S286_L1.2551.00
132_E217_K1.2511.00
76_H146_S1.2421.00
168_R186_M1.2401.00
180_Q184_S1.2351.00
148_K151_N1.2281.00
74_L85_A1.2211.00
263_H267_G1.2071.00
179_F183_D1.1961.00
136_Y139_S1.1951.00
161_E165_L1.1881.00
116_P214_D1.1871.00
153_A156_R1.1851.00
165_L168_R1.1591.00
132_E136_Y1.1561.00
214_D219_T1.1551.00
90_S94_K1.1541.00
145_K150_S1.1501.00
67_M70_E1.1491.00
187_N190_R1.1481.00
184_S187_N1.1441.00
126_N129_L1.1401.00
185_L188_E1.1311.00
186_M190_R1.1301.00
133_L238_L1.1181.00
174_D178_V1.1111.00
131_Y134_G1.1021.00
178_V182_A1.1001.00
175_Q178_V1.1001.00
174_D177_K1.0941.00
198_N278_W1.0921.00
267_G271_E1.0791.00
75_R87_P1.0731.00
140_M220_A1.0661.00
146_S151_N1.0601.00
134_G138_G1.0461.00
90_S93_G1.0401.00
184_S188_E1.0391.00
21_A111_V1.0381.00
56_I109_L1.0361.00
269_W273_E1.0361.00
91_L96_V1.0361.00
20_E89_P1.0311.00
213_W218_I1.0301.00
266_K269_W1.0231.00
128_T131_Y1.0211.00
72_E75_R1.0161.00
293_I297_L1.0121.00
21_A25_Y1.0081.00
52_Y111_V1.0081.00
168_R172_P1.0041.00
131_Y263_H1.0021.00
205_D210_N0.9991.00
17_V22_A0.9931.00
141_H234_D0.9921.00
54_L109_L0.9911.00
145_K272_N0.9811.00
17_V20_E0.9771.00
76_H143_L0.9771.00
156_R160_D0.9761.00
239_L261_M0.9711.00
71_M95_D0.9701.00
115_A212_N0.9701.00
163_E167_L0.9691.00
265_M269_W0.9671.00
71_M110_R0.9631.00
55_K70_E0.9591.00
166_K169_K0.9581.00
75_R79_I0.9561.00
167_L171_V0.9551.00
188_E284_D0.9551.00
263_H266_K0.9541.00
297_L300_M0.9541.00
169_K172_P0.9531.00
82_I140_M0.9431.00
78_A87_P0.9421.00
196_Q277_A0.9411.00
39_E224_D0.9351.00
290_H293_I0.9321.00
40_N224_D0.9271.00
144_T151_N0.9241.00
147_Y151_N0.9211.00
24_R90_S0.9181.00
72_E147_Y0.9121.00
22_A25_Y0.9111.00
42_V53_I0.9051.00
44_E53_I0.9011.00
22_A28_S0.8941.00
156_R159_W0.8931.00
29_K48_D0.8891.00
63_S66_Y0.8891.00
210_N222_D0.8841.00
182_A185_L0.8841.00
296_L300_M0.8811.00
73_W144_T0.8801.00
205_D222_D0.8801.00
198_N231_F0.8801.00
146_S149_L0.8791.00
17_V21_A0.8781.00
133_L206_L0.8771.00
64_S68_M0.8761.00
261_M283_P0.8751.00
198_N272_N0.8741.00
199_Y228_Y0.8701.00
121_D209_G0.8671.00
298_H302_D0.8641.00
30_D48_D0.8631.00
159_W162_E0.8571.00
76_H80_G0.8561.00
231_F272_N0.8331.00
76_H79_I0.8321.00
157_Q162_E0.8281.00
137_T234_D0.8251.00
40_N55_K0.8221.00
156_R162_E0.8201.00
70_E74_L0.8161.00
137_T141_H0.8121.00
30_D45_C0.8091.00
75_R86_K0.8071.00
165_L169_K0.8041.00
176_I180_Q0.8021.00
68_M90_S0.8001.00
27_F111_V0.8001.00
129_L213_W0.7981.00
157_Q160_D0.7911.00
154_F157_Q0.7871.00
41_Y56_I0.7841.00
75_R78_A0.7831.00
136_Y218_I0.7811.00
176_I179_F0.7801.00
20_E24_R0.7801.00
297_L301_F0.7791.00
128_T132_E0.7771.00
165_L190_R0.7771.00
82_I136_Y0.7771.00
130_F259_E0.7751.00
297_L305_T0.7731.00
168_R190_R0.7701.00
139_S142_S0.7691.00
189_L192_L0.7681.00
157_Q161_E0.7651.00
174_D182_A0.7641.00
56_I101_D0.7631.00
175_Q182_A0.7601.00
34_F41_Y0.7591.00
138_G142_S0.7521.00
243_L261_M0.7461.00
237_I240_Y0.7431.00
204_A227_G0.7411.00
153_A157_Q0.7390.99
207_H240_Y0.7390.99
65_D68_M0.7380.99
276_P280_M0.7370.99
163_E170_Y0.7350.99
21_A24_R0.7290.99
232_V274_L0.7280.99
265_M279_L0.7250.99
20_E23_A0.7240.99
166_K170_Y0.7220.99
134_G271_E0.7220.99
154_F160_D0.7220.99
18_L21_A0.7210.99
186_M288_L0.7190.99
198_N274_L0.7180.99
210_N224_D0.7150.99
37_D42_V0.7150.99
280_M283_P0.7140.99
25_Y89_P0.7110.99
167_L170_Y0.7080.99
68_M94_K0.7070.99
156_R161_E0.7050.99
71_M90_S0.7010.99
23_A91_L0.6970.99
128_T216_G0.6960.99
83_S139_S0.6920.99
277_A280_M0.6900.99
75_R95_D0.6900.99
138_G267_G0.6890.99
46_M50_Q0.6890.99
275_D279_L0.6890.99
236_S285_F0.6880.99
71_M75_R0.6880.99
293_I296_L0.6870.99
130_F260_F0.6870.99
99_V109_L0.6850.99
80_G143_L0.6820.99
290_H294_Y0.6810.99
204_A233_N0.6770.99
256_F259_E0.6750.99
294_Y297_L0.6700.99
155_K158_E0.6680.99
154_F159_W0.6670.99
129_L132_E0.6660.99
73_W201_L0.6650.99
190_R193_P0.6640.99
90_S108_L0.6610.99
166_K172_P0.6560.99
203_H206_L0.6550.99
168_R183_D0.6540.99
62_R65_D0.6520.99
42_V55_K0.6480.99
165_L171_V0.6470.99
146_S150_S0.6470.99
39_E58_H0.6430.99
178_V181_Q0.6400.99
274_L279_L0.6390.99
178_V186_M0.6380.99
42_V207_H0.6370.99
127_E130_F0.6360.98
158_E162_E0.6360.98
82_I143_L0.6340.98
153_A226_I0.6340.98
63_S70_E0.6340.98
182_A291_M0.6330.98
87_P90_S0.6310.98
19_A22_A0.6310.98
136_Y206_L0.6290.98
289_R293_I0.6290.98
283_P287_R0.6280.98
35_L44_E0.6270.98
38_A241_N0.6270.98
295_G298_H0.6260.98
16_Q22_A0.6250.98
174_D179_F0.6250.98
120_V211_F0.6230.98
188_E191_R0.6220.98
70_E224_D0.6200.98
285_F289_R0.6170.98
212_N219_T0.6160.98
225_D289_R0.6100.98
200_G272_N0.6080.98
91_L94_K0.6070.98
227_G233_N0.6050.98
96_V108_L0.6050.98
47_K52_Y0.6040.98
164_Q171_V0.6030.98
173_E178_V0.6030.98
301_F305_T0.5990.98
140_M223_F0.5980.98
183_D186_M0.5980.98
87_P113_E0.5950.98
85_A113_E0.5950.98
130_F263_H0.5940.98
239_L283_P0.5940.98
83_S136_Y0.5920.98
94_K108_L0.5890.98
259_E263_H0.5890.98
197_D230_W0.5880.97
145_K151_N0.5860.97
241_N290_H0.5860.97
207_H241_N0.5850.97
62_R221_F0.5830.97
155_K160_D0.5830.97
85_A115_A0.5810.97
57_T67_M0.5800.97
165_L172_P0.5800.97
177_K180_Q0.5780.97
294_Y298_H0.5760.97
53_I85_A0.5750.97
93_G96_V0.5740.97
133_L137_T0.5730.97
177_K295_G0.5690.97
127_E259_E0.5690.97
239_L282_I0.5640.97
90_S96_V0.5630.97
195_S198_N0.5600.97
206_L211_F0.5570.97
25_Y90_S0.5570.97
160_D163_E0.5520.96
28_S48_D0.5490.96
164_Q168_R0.5490.96
257_T260_F0.5470.96
289_R300_M0.5470.96
155_K159_W0.5470.96
137_T204_A0.5420.96
274_L278_W0.5370.96
261_M265_M0.5360.96
57_T70_E0.5350.96
129_L216_G0.5350.96
130_F242_V0.5340.96
189_L194_K0.5330.96
134_G238_L0.5330.96
299_Q302_D0.5330.96
292_L296_L0.5290.95
279_L283_P0.5280.95
197_D278_W0.5280.95
42_V296_L0.5270.95
269_W276_P0.5250.95
281_I285_F0.5210.95
62_R70_E0.5200.95
40_N70_E0.5200.95
82_I139_S0.5190.95
163_E168_R0.5180.95
143_L147_Y0.5180.95
150_S157_Q0.5170.95
153_A161_E0.5170.95
301_F304_N0.5170.95
169_K173_E0.5170.95
213_W219_T0.5160.95
112_Y221_F0.5150.95
134_G272_N0.5150.95
74_L112_Y0.5140.95
236_S283_P0.5140.95
239_L265_M0.5130.95
292_L295_G0.5130.95
225_D237_I0.5120.95
201_L228_Y0.5120.95
39_E42_V0.5080.94
176_I183_D0.5080.94
69_G226_I0.5070.94
192_L278_W0.5060.94
110_R224_D0.5060.94
119_K221_F0.5050.94
132_E216_G0.5040.94
189_L193_P0.5040.94
204_A229_N0.5030.94
199_Y202_V0.5030.94
53_I112_Y0.5030.94
182_A189_L0.5020.94
66_Y70_E0.5020.94
55_K224_D0.5000.94
144_T201_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ppqA 2 0.8958 100 0.385 Contact Map
2q83A 1 0.8869 100 0.403 Contact Map
4pdyA 1 0.8869 100 0.409 Contact Map
1zylA 1 0.9256 100 0.416 Contact Map
4ocvA 1 0.9464 100 0.422 Contact Map
3i1aA 1 0.8929 100 0.461 Contact Map
3dxpA 2 0.9137 100 0.474 Contact Map
3atsA 1 0.9107 100 0.492 Contact Map
3jr1A 1 0.8244 100 0.511 Contact Map
1nw1A 2 0.9137 100 0.522 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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