GREMLIN Database
YKOH - Sensor histidine kinase YkoH
UniProt: O34638 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 454 (431)
Sequences: 49802 (43201)
Seq/√Len: 2080.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
380_R441_A4.1701.00
374_R445_Q3.9411.00
381_D385_G3.7851.00
420_K424_D3.6641.00
306_I340_A3.5121.00
431_S443_T3.4911.00
378_S441_A3.3351.00
254_S275_I3.0321.00
367_S378_S3.0161.00
360_S382_E2.9631.00
378_S443_T2.9201.00
376_F445_Q2.9171.00
391_I434_S2.8851.00
371_R376_F2.8641.00
330_E365_E2.7981.00
369_G376_F2.7811.00
376_F443_T2.7571.00
305_T339_K2.6851.00
258_K276_H2.6761.00
387_P390_H2.5931.00
365_E380_R2.5821.00
432_V442_V2.5701.00
433_K443_T2.5541.00
332_D367_S2.5011.00
433_K441_A2.4721.00
258_K273_E2.4631.00
369_G378_S2.4541.00
435_K438_Q2.4501.00
340_A426_H2.4441.00
251_E280_V2.4311.00
348_L423_A2.4261.00
305_T337_L2.4251.00
367_S380_R2.3891.00
419_A430_L2.3791.00
307_D310_K2.3261.00
390_H393_H2.2861.00
423_A428_I2.2591.00
395_F430_L2.2421.00
386_I394_L2.2341.00
391_I432_V2.2071.00
429_E445_Q2.1881.00
314_A346_K2.1721.00
209_D212_Y2.1351.00
265_P268_L2.0991.00
251_E279_A2.0911.00
304_K342_E2.0891.00
319_L350_T2.0681.00
332_D365_E2.0341.00
434_S440_T2.0131.00
303_L339_K1.9781.00
393_H396_E1.9551.00
423_A444_M1.9461.00
388_E391_I1.9381.00
251_E283_K1.9261.00
431_S445_Q1.9051.00
207_S212_Y1.8681.00
222_A225_L1.8671.00
24_T28_L1.8471.00
348_L419_A1.8281.00
283_K287_N1.8241.00
348_L422_I1.7931.00
234_Q238_D1.7771.00
208_N212_Y1.7761.00
340_A345_I1.7681.00
264_K268_L1.7631.00
393_H399_Y1.7591.00
390_H399_Y1.7371.00
354_D358_K1.7061.00
386_I390_H1.7001.00
349_L377_L1.6581.00
226_K230_D1.6561.00
422_I426_H1.6531.00
341_D344_R1.6411.00
255_S276_H1.6351.00
254_S276_H1.6331.00
386_I440_T1.6311.00
424_D429_E1.6291.00
322_V357_I1.6051.00
309_I313_R1.6041.00
365_E382_E1.5861.00
186_M213_Q1.5801.00
191_D196_K1.5781.00
390_H401_A1.5701.00
258_K269_E1.5461.00
351_I419_A1.5321.00
264_K267_V1.5211.00
253_Y271_S1.5041.00
360_S364_I1.4971.00
232_Q236_V1.4871.00
314_A342_E1.4791.00
189_M192_I1.4591.00
81_N85_K1.4541.00
309_I368_A1.4511.00
381_D439_G1.4481.00
318_T346_K1.4471.00
276_H280_V1.4471.00
215_G219_N1.4431.00
377_L444_M1.4421.00
211_L215_G1.4401.00
227_E231_K1.4321.00
257_M272_I1.4271.00
395_F432_V1.4261.00
230_D234_Q1.4241.00
250_I279_A1.4241.00
396_E399_Y1.4221.00
391_I395_F1.4141.00
348_L444_M1.4121.00
423_A430_L1.4021.00
307_D337_L1.3991.00
371_R445_Q1.3971.00
249_I253_Y1.3911.00
434_S437_G1.3891.00
434_S438_Q1.3881.00
320_Q323_Y1.3791.00
196_K199_K1.3741.00
171_G175_A1.3681.00
186_M190_K1.3671.00
344_R425_E1.3641.00
344_R347_Q1.3631.00
387_P436_P1.3531.00
207_S215_G1.3511.00
250_I275_I1.3371.00
307_D335_S1.3321.00
316_M331_T1.3311.00
260_W268_L1.3281.00
226_K229_Y1.3211.00
218_F221_M1.3141.00
251_E276_H1.3131.00
342_E346_K1.3121.00
222_A226_K1.2971.00
360_S363_P1.2921.00
207_S211_L1.2921.00
374_R429_E1.2861.00
421_Q424_D1.2861.00
228_H231_K1.2851.00
242_E347_Q1.2791.00
221_M225_L1.2751.00
301_V341_D1.2521.00
191_D199_K1.2461.00
359_Y400_R1.2391.00
25_A29_I1.2261.00
257_M268_L1.2201.00
183_R186_M1.2041.00
313_R331_T1.2031.00
254_S258_K1.2001.00
235_F239_A1.2001.00
344_R422_I1.1831.00
249_I278_E1.1791.00
402_D405_R1.1741.00
371_R374_R1.1731.00
428_I446_F1.1731.00
311_A315_V1.1711.00
253_Y274_A1.1701.00
31_S35_T1.1691.00
273_E277_S1.1651.00
254_S279_A1.1591.00
211_L214_M1.1571.00
284_K343_E1.1511.00
176_R180_N1.1491.00
249_I252_S1.1481.00
208_N211_L1.1411.00
192_I222_A1.1361.00
142_L146_E1.1341.00
229_Y232_Q1.1231.00
388_E434_S1.1181.00
217_T220_E1.1151.00
315_V350_T1.1131.00
269_E273_E1.1101.00
394_L432_V1.1101.00
395_F420_K1.1091.00
154_I158_A1.1061.00
238_D397_R1.1041.00
39_A43_A1.0981.00
380_R435_K1.0961.00
432_V440_T1.0931.00
252_S256_L1.0901.00
46_T50_A1.0871.00
315_V346_K1.0851.00
265_P269_E1.0831.00
122_A125_P1.0781.00
351_I354_D1.0781.00
200_T223_M1.0761.00
395_F442_V1.0731.00
312_A368_A1.0711.00
287_N291_A1.0711.00
251_E255_S1.0691.00
356_A364_I1.0581.00
189_M218_F1.0541.00
336_L375_P1.0531.00
290_L293_A1.0451.00
219_N222_A1.0411.00
175_A179_I1.0401.00
188_T201_I1.0271.00
189_M193_Q1.0231.00
309_I335_S1.0231.00
150_F154_I1.0201.00
316_M320_Q1.0191.00
212_Y216_L1.0191.00
278_E281_H1.0181.00
386_I391_I1.0161.00
315_V319_L1.0151.00
212_Y215_G1.0151.00
43_A47_D1.0151.00
185_L189_M1.0121.00
397_R421_Q1.0071.00
301_V344_R1.0011.00
386_I432_V1.0011.00
23_H27_Y0.9981.00
189_M217_T0.9931.00
303_L426_H0.9911.00
200_T219_N0.9911.00
352_L430_L0.9901.00
234_Q397_R0.9891.00
27_Y153_K0.9871.00
186_M189_M0.9871.00
190_K213_Q0.9841.00
381_D440_T0.9831.00
80_V86_A0.9801.00
45_E48_N0.9771.00
186_M217_T0.9751.00
63_L66_M0.9681.00
270_E274_A0.9651.00
169_F173_L0.9641.00
306_I311_A0.9641.00
178_I181_P0.9641.00
345_I426_H0.9621.00
310_K314_A0.9601.00
173_L177_R0.9571.00
50_A54_R0.9521.00
244_K287_N0.9521.00
284_K288_Q0.9511.00
319_L353_L0.9471.00
35_T39_A0.9471.00
352_L442_V0.9451.00
346_K350_T0.9441.00
405_R410_G0.9391.00
363_P382_E0.9361.00
311_A340_A0.9351.00
28_L32_S0.9331.00
134_V138_L0.9301.00
336_L370_T0.9261.00
352_L419_A0.9251.00
6_K209_D0.9251.00
172_S176_R0.9241.00
350_T354_D0.9201.00
349_L353_L0.9171.00
273_E276_H0.9161.00
261_G268_L0.9071.00
214_M218_F0.9061.00
254_S272_I0.9061.00
28_L31_S0.9031.00
193_Q220_E0.9031.00
288_Q344_R0.8981.00
349_L379_V0.8971.00
313_R317_Q0.8951.00
203_L216_L0.8931.00
46_T49_I0.8911.00
42_L46_T0.8911.00
121_E124_V0.8911.00
37_K41_R0.8891.00
318_T350_T0.8891.00
266_E269_E0.8871.00
280_V283_K0.8861.00
303_L427_G0.8851.00
242_E351_I0.8771.00
64_Q68_Q0.8771.00
168_F172_S0.8691.00
59_E62_A0.8681.00
307_D336_L0.8671.00
352_L444_M0.8621.00
359_Y384_I0.8611.00
192_I221_M0.8591.00
414_L418_I0.8581.00
343_E346_K0.8571.00
220_E224_M0.8551.00
386_I392_P0.8511.00
224_M227_E0.8491.00
203_L207_S0.8481.00
38_D41_R0.8471.00
275_I279_A0.8431.00
308_L377_L0.8411.00
319_L354_D0.8381.00
423_A446_F0.8381.00
135_S139_V0.8371.00
353_L366_M0.8351.00
202_S219_N0.8341.00
324_Q327_I0.8331.00
327_I360_S0.8331.00
41_R44_D0.8331.00
274_A278_E0.8321.00
394_L442_V0.8291.00
229_Y233_Q0.8291.00
279_A283_K0.8231.00
421_Q425_E0.8211.00
215_G218_F0.8181.00
328_L331_T0.8181.00
270_E273_E0.8171.00
315_V353_L0.8161.00
188_T199_K0.8161.00
245_T249_I0.8151.00
119_F123_A0.8101.00
333_K336_L0.8101.00
428_I444_M0.8091.00
385_G440_T0.8091.00
256_L260_W0.8031.00
326_D362_K0.8021.00
150_F153_K0.8021.00
78_R137_Q0.8011.00
277_S314_A0.8001.00
37_K40_A0.7981.00
188_T191_D0.7981.00
38_D42_L0.7971.00
242_E246_P0.7931.00
40_A43_A0.7931.00
177_R180_N0.7931.00
63_L67_L0.7921.00
419_A423_A0.7911.00
268_L271_S0.7891.00
420_K429_E0.7891.00
86_A89_T0.7871.00
291_A347_Q0.7861.00
187_I191_D0.7861.00
41_R45_E0.7851.00
306_I342_E0.7841.00
227_E230_D0.7841.00
374_R447_S0.7821.00
213_Q216_L0.7781.00
244_K283_K0.7781.00
120_A123_A0.7771.00
35_T38_D0.7751.00
327_I331_T0.7741.00
241_H245_T0.7741.00
190_K217_T0.7711.00
183_R187_I0.7691.00
196_K200_T0.7691.00
317_Q320_Q0.7681.00
213_Q217_T0.7671.00
366_M379_V0.7661.00
177_R181_P0.7611.00
125_P135_S0.7591.00
40_A44_D0.7581.00
151_L155_I0.7581.00
314_A318_T0.7581.00
36_S39_A0.7571.00
388_E392_P0.7541.00
189_M221_M0.7541.00
181_P185_L0.7531.00
209_D213_Q0.7521.00
14_S18_L0.7501.00
301_V425_E0.7481.00
347_Q422_I0.7481.00
33_A37_K0.7401.00
312_A349_L0.7391.00
253_Y275_I0.7391.00
312_A366_M0.7381.00
153_K157_I0.7381.00
146_E150_F0.7371.00
313_R316_M0.7351.00
378_S433_K0.7351.00
303_L340_A0.7341.00
391_I433_K0.7341.00
189_M214_M0.7321.00
175_A178_I0.7321.00
239_A289_L0.7291.00
255_S259_R0.7291.00
89_T92_K0.7271.00
418_I422_I0.7271.00
208_N215_G0.7271.00
78_R86_A0.7271.00
51_E55_A0.7271.00
400_R411_G0.7221.00
42_L45_E0.7211.00
250_I254_S0.7211.00
253_Y278_E0.7211.00
116_G119_F0.7171.00
316_M329_L0.7151.00
292_L417_S0.7131.00
190_K194_R0.7121.00
282_M286_T0.7111.00
60_G64_Q0.7111.00
123_A135_S0.7091.00
381_D384_I0.7091.00
201_I219_N0.7051.00
214_M217_T0.7041.00
335_S338_V0.7041.00
281_H346_K0.7041.00
352_L423_A0.7021.00
149_L153_K0.7021.00
32_S36_S0.7011.00
302_D341_D0.7001.00
258_K272_I0.6991.00
274_A277_S0.6961.00
20_I24_T0.6951.00
308_L338_V0.6941.00
290_L294_K0.6941.00
32_S35_T0.6931.00
322_V364_I0.6931.00
276_H279_A0.6921.00
261_G265_P0.6921.00
386_I434_S0.6921.00
66_M70_Y0.6911.00
145_T149_L0.6901.00
34_L37_K0.6901.00
348_L426_H0.6891.00
223_M227_E0.6891.00
344_R426_H0.6881.00
47_D50_A0.6881.00
323_Y326_D0.6871.00
217_T221_M0.6791.00
157_I161_A0.6791.00
154_I157_I0.6791.00
255_S258_K0.6771.00
44_D47_D0.6771.00
309_I336_L0.6761.00
92_K95_A0.6761.00
368_A375_P0.6731.00
236_V239_A0.6721.00
306_I339_K0.6721.00
241_H351_I0.6711.00
308_L375_P0.6711.00
388_E435_K0.6681.00
27_Y31_S0.6681.00
199_K203_L0.6641.00
310_K342_E0.6641.00
80_V137_Q0.6611.00
10_Y14_S0.6611.00
182_I185_L0.6611.00
68_Q71_L0.6601.00
390_H403_E0.6601.00
216_L219_N0.6601.00
395_F398_F0.6581.00
364_I379_V0.6581.00
317_Q321_S0.6581.00
216_L220_E0.6581.00
376_F431_S0.6571.00
195_D199_K0.6571.00
288_Q347_Q0.6571.00
334_E370_T0.6561.00
386_I442_V0.6561.00
51_E54_R0.6561.00
260_W271_S0.6541.00
39_A42_L0.6541.00
207_S214_M0.6541.00
201_I215_G0.6541.00
214_M219_N0.6531.00
199_K202_S0.6521.00
119_F122_A0.6521.00
13_I16_L0.6521.00
67_L70_Y0.6511.00
21_L25_A0.6501.00
401_A405_R0.6501.00
233_Q296_H0.6501.00
24_T27_Y0.6501.00
370_T375_P0.6461.00
117_K121_E0.6451.00
49_I52_A0.6431.00
198_F226_K0.6431.00
61_V64_Q0.6421.00
39_A120_A0.6421.00
291_A344_R0.6421.00
347_Q350_T0.6401.00
29_I32_S0.6401.00
47_D51_E0.6401.00
327_I357_I0.6391.00
207_S210_E0.6391.00
272_I276_H0.6381.00
322_V329_L0.6361.00
91_T94_K0.6361.00
167_S171_G0.6341.00
197_E200_T0.6341.00
321_S324_Q0.6331.00
271_S275_I0.6331.00
184_R187_I0.6311.00
419_A422_I0.6301.00
185_L215_G0.6301.00
243_L246_P0.6301.00
387_P401_A0.6291.00
368_A377_L0.6291.00
356_A379_V0.6291.00
243_L282_M0.6261.00
394_L417_S0.6231.00
358_K411_G0.6231.00
235_F242_E0.6231.00
271_S274_A0.6211.00
289_L293_A0.6211.00
52_A55_A0.6211.00
391_I442_V0.6201.00
400_R410_G0.6171.00
283_K286_T0.6171.00
299_L344_R0.6161.00
36_S40_A0.6161.00
219_N223_M0.6161.00
325_R360_S0.6151.00
184_R188_T0.6151.00
266_E270_E0.6131.00
145_T148_S0.6111.00
253_Y257_M0.6111.00
430_L442_V0.6111.00
247_L286_T0.6111.00
396_E420_K0.6111.00
33_A36_S0.6101.00
11_T171_G0.6071.00
428_I447_S0.6061.00
108_T112_R0.6061.00
344_R348_L0.6051.00
29_I33_A0.6041.00
310_K313_R0.6041.00
417_S421_Q0.6041.00
63_L70_Y0.6021.00
353_L364_I0.6011.00
325_R357_I0.6011.00
267_V271_S0.6001.00
380_R437_G0.6001.00
309_I334_E0.5991.00
248_T252_S0.5981.00
65_D68_Q0.5971.00
114_P117_K0.5961.00
81_N87_V0.5941.00
118_L121_E0.5941.00
121_E139_V0.5921.00
311_A345_I0.5921.00
75_G78_R0.5921.00
260_W267_V0.5901.00
322_V327_I0.5901.00
256_L271_S0.5901.00
60_G63_L0.5891.00
62_A65_D0.5891.00
245_T252_S0.5871.00
25_A28_L0.5861.00
224_M228_H0.5861.00
315_V318_T0.5841.00
248_T251_E0.5841.00
58_T61_V0.5831.00
280_V284_K0.5821.00
103_F111_V0.5811.00
256_L261_G0.5811.00
161_A165_I0.5811.00
319_L357_I0.5801.00
267_V270_E0.5791.00
130_D134_V0.5791.00
309_I333_K0.5761.00
76_M89_T0.5761.00
193_Q196_K0.5751.00
332_D369_G0.5751.00
184_R202_S0.5751.00
296_H397_R0.5731.00
53_L57_E0.5721.00
185_L188_T0.5691.00
228_H232_Q0.5681.00
195_D200_T0.5671.00
258_K261_G0.5661.00
322_V326_D0.5661.00
151_L154_I0.5661.00
243_L247_L0.5651.00
293_A296_H0.5641.00
208_N214_M0.5641.00
278_E318_T0.5641.00
252_S279_A0.5641.00
392_P396_E0.5621.00
249_I274_A0.5601.00
338_V341_D0.5601.00
143_E146_E0.5601.00
182_I186_M0.5591.00
180_N184_R0.5571.00
195_D198_F0.5571.00
131_G134_V0.5561.00
158_A162_A0.5561.00
191_D194_R0.5541.00
230_D233_Q0.5541.00
242_E418_I0.5531.00
292_L421_Q0.5521.00
221_M224_M0.5511.00
356_A360_S0.5501.00
44_D48_N0.5491.00
311_A346_K0.5491.00
130_D133_V0.5491.00
30_F33_A0.5481.00
257_M271_S0.5481.00
187_I190_K0.5481.00
52_A56_A0.5471.00
115_D119_F0.5471.00
193_Q224_M0.5461.00
277_S280_V0.5461.00
316_M366_M0.5451.00
238_D242_E0.5451.00
314_A317_Q0.5451.00
123_A126_V0.5451.00
431_S444_M0.5451.00
46_T138_L0.5451.00
200_T222_A0.5441.00
113_K117_K0.5431.00
142_L145_T0.5411.00
253_Y256_L0.5401.00
391_I440_T0.5391.00
53_L56_A0.5391.00
365_E368_A0.5391.00
203_L215_G0.5381.00
293_A297_Q0.5371.00
68_Q72_P0.5371.00
370_T374_R0.5361.00
261_G264_K0.5361.00
45_E49_I0.5351.00
242_E285_L0.5341.00
90_I93_E0.5341.00
49_I53_L0.5331.00
241_H246_P0.5331.00
361_E382_E0.5331.00
218_F222_A0.5321.00
345_I446_F0.5321.00
13_I20_I0.5321.00
304_K343_E0.5311.00
91_T95_A0.5311.00
322_V325_R0.5301.00
144_N147_E0.5301.00
31_S34_L0.5301.00
81_N84_Q0.5301.00
253_Y279_A0.5281.00
353_L357_I0.5281.00
380_R438_Q0.5281.00
325_R362_K0.5281.00
120_A124_V0.5281.00
16_L20_I0.5251.00
394_L399_Y0.5241.00
155_I158_A0.5231.00
236_V240_S0.5211.00
193_Q197_E0.5201.00
26_V30_F0.5191.00
123_A137_Q0.5181.00
301_V426_H0.5181.00
387_P391_I0.5161.00
248_T253_Y0.5151.00
181_P207_S0.5141.00
169_F172_S0.5101.00
312_A315_V0.5101.00
309_I331_T0.5081.00
311_A314_A0.5071.00
334_E337_L0.5071.00
288_Q343_E0.5071.00
260_W265_P0.5061.00
282_M290_L0.5061.00
62_A66_M0.5051.00
292_L397_R0.5051.00
147_E151_L0.5041.00
404_A410_G0.5031.00
74_N77_V0.5021.00
240_S245_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5903 100 0.354 Contact Map
4bixA 2 0.4978 100 0.371 Contact Map
4ctiA 2 0.5044 100 0.396 Contact Map
4q20A 2 0.4956 100 0.479 Contact Map
4gczA 2 0.7841 100 0.483 Contact Map
4mpcA 2 0.652 100 0.484 Contact Map
2e0aA 2 0.6762 100 0.49 Contact Map
2q8gA 2 0.6608 100 0.491 Contact Map
3jz3A 2 0.348 100 0.494 Contact Map
2c2aA 2 0.5044 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0138 seconds.