GREMLIN Database
YOCA - Uncharacterized membrane protein YocA
UniProt: O34636 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (194)
Sequences: 252 (197)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_Y156_H5.0151.00
59_V76_L4.4241.00
56_K60_E3.6250.99
87_G90_P3.3560.99
79_M90_P2.9030.97
79_M87_G2.8800.97
153_G160_L2.7520.96
96_S117_Q2.5680.94
165_S170_K2.4810.92
164_Y191_Y2.4740.92
81_Q193_D2.3860.91
158_E194_Y2.2190.87
134_T146_I2.1490.85
65_S112_K2.1490.85
53_T56_K2.1040.84
55_Y107_P2.0940.84
63_L75_I2.0270.82
149_V160_L2.0110.81
144_G164_Y1.9960.81
99_L103_E1.9290.78
69_S157_T1.9270.78
169_V194_Y1.8820.77
98_G103_E1.8340.75
59_V79_M1.8330.75
100_K103_E1.8210.74
74_L106_D1.7760.72
113_Q117_Q1.7490.71
133_D201_K1.7410.71
117_Q121_M1.7190.70
168_Q191_Y1.7190.70
149_V153_G1.7060.69
16_M51_R1.6990.69
25_F28_V1.6980.69
136_I201_K1.6560.67
122_Y135_I1.6500.66
178_C199_K1.6360.66
80_Y203_K1.6260.65
70_N152_H1.6000.64
66_Q119_T1.5980.64
96_S113_Q1.5850.63
78_M136_I1.5840.63
165_S169_V1.5720.62
174_D188_P1.5620.62
44_T48_V1.5380.61
62_E65_S1.4950.58
104_I107_P1.4580.56
95_E102_N1.4550.56
55_Y90_P1.4470.56
49_L80_Y1.3820.52
22_I26_L1.3580.51
16_M28_V1.3520.51
51_R86_K1.3410.50
188_P193_D1.3100.48
58_L108_Q1.3030.48
66_Q71_Y1.2830.47
173_P176_Y1.2680.46
24_S32_F1.2410.45
178_C181_N1.2310.44
199_K202_E1.2140.43
53_T73_S1.2130.43
22_I43_D1.2090.43
155_T160_L1.2090.43
91_M118_F1.2050.43
133_D136_I1.2030.43
22_I36_L1.1930.42
180_G184_N1.1840.42
62_E68_L1.1830.41
149_V155_T1.1820.41
27_L31_F1.1790.41
188_P191_Y1.1760.41
101_R157_T1.1610.40
21_V30_L1.1580.40
193_D199_K1.1570.40
52_L80_Y1.1570.40
81_Q202_E1.1340.39
121_M143_A1.1260.38
26_L30_L1.1230.38
168_Q171_K1.1220.38
178_C193_D1.1200.38
169_V187_Y1.1120.38
186_R195_T1.1120.38
50_E64_E1.0910.37
144_G191_Y1.0860.36
99_L109_L1.0600.35
42_I70_N1.0560.35
68_L118_F1.0500.35
185_F195_T1.0470.35
29_L36_L1.0440.34
135_I141_M1.0420.34
54_D80_Y1.0380.34
56_K73_S1.0360.34
24_S27_L1.0270.34
181_N186_R1.0190.33
51_R80_Y1.0120.33
71_Y122_Y1.0100.33
177_T180_G1.0070.33
153_G157_T0.9800.31
169_V191_Y0.9640.31
49_L108_Q0.9580.30
55_Y79_M0.9570.30
20_F26_L0.9560.30
119_T123_K0.9540.30
106_D109_L0.9460.30
79_M86_K0.9420.30
15_M30_L0.9310.29
162_K199_K0.9290.29
93_S129_G0.9280.29
180_G186_R0.9280.29
173_P178_C0.9260.29
68_L119_T0.9150.28
185_F194_Y0.9130.28
165_S190_C0.9110.28
174_D178_C0.9050.28
189_Y199_K0.8990.28
149_V154_G0.8950.27
90_P107_P0.8950.27
141_M200_V0.8920.27
138_S155_T0.8850.27
23_A28_V0.8830.27
69_S151_E0.8820.27
52_L154_G0.8790.27
47_I93_S0.8720.26
164_Y168_Q0.8710.26
93_S122_Y0.8690.26
165_S187_Y0.8670.26
62_E108_Q0.8600.26
98_G102_N0.8560.26
116_K119_T0.8560.26
115_I130_V0.8490.25
48_V182_A0.8470.25
29_L150_A0.8470.25
62_E156_H0.8470.25
96_S109_L0.8390.25
56_K76_L0.8370.25
85_G111_V0.8320.25
23_A39_K0.8230.24
157_T208_E0.8200.24
195_T199_K0.8180.24
25_F152_H0.8170.24
184_N189_Y0.8160.24
158_E193_D0.8060.24
81_Q199_K0.8030.24
18_F64_E0.7990.23
185_F188_P0.7980.23
78_M118_F0.7980.23
90_P165_S0.7940.23
21_V24_S0.7910.23
99_L102_N0.7900.23
193_D202_E0.7830.23
28_V39_K0.7800.23
81_Q158_E0.7780.23
28_V41_P0.7760.23
169_V185_F0.7690.22
61_E108_Q0.7640.22
94_S161_A0.7620.22
96_S103_E0.7600.22
104_I115_I0.7580.22
51_R61_E0.7570.22
165_S171_K0.7560.22
90_P204_T0.7520.22
97_L138_S0.7500.22
148_F163_Q0.7500.22
134_T156_H0.7470.21
186_R189_Y0.7470.21
96_S127_E0.7430.21
81_Q195_T0.7430.21
160_L163_Q0.7430.21
35_D138_S0.7420.21
75_I118_F0.7360.21
84_K197_A0.7310.21
27_L32_F0.7300.21
179_G193_D0.7280.21
145_Y152_H0.7240.21
51_R64_E0.7240.21
24_S40_L0.7240.21
176_Y193_D0.7180.20
64_E86_K0.7170.20
109_L127_E0.7170.20
68_L115_I0.7140.20
23_A31_F0.7110.20
67_G119_T0.7080.20
18_F22_I0.7030.20
67_G145_Y0.7030.20
176_Y180_G0.7010.20
96_S99_L0.7000.20
194_Y199_K0.7000.20
81_Q178_C0.6980.20
175_L178_C0.6940.20
20_F34_R0.6930.20
25_F29_L0.6900.19
168_Q188_P0.6890.19
94_S117_Q0.6870.19
80_Y86_K0.6870.19
188_P195_T0.6870.19
186_R190_C0.6860.19
28_V163_Q0.6860.19
178_C202_E0.6780.19
81_Q134_T0.6780.19
74_L136_I0.6750.19
109_L113_Q0.6670.19
23_A30_L0.6660.19
158_E195_T0.6640.19
162_K194_Y0.6620.19
177_T181_N0.6580.18
32_F206_T0.6510.18
176_Y184_N0.6510.18
148_F160_L0.6460.18
52_L83_S0.6450.18
97_L117_Q0.6450.18
41_P157_T0.6430.18
68_L202_E0.6420.18
171_K178_C0.6420.18
76_L84_K0.6410.18
81_Q137_Q0.6390.18
60_E69_S0.6390.18
134_T149_V0.6360.18
86_K126_K0.6350.18
188_P194_Y0.6350.18
176_Y181_N0.6340.18
33_N79_M0.6340.18
190_C193_D0.6300.17
81_Q188_P0.6290.17
74_L132_L0.6280.17
49_L61_E0.6190.17
36_L93_S0.6100.17
163_Q167_Q0.6070.17
66_Q112_K0.6060.17
52_L64_E0.6020.17
58_L112_K0.6010.17
48_V58_L0.6000.17
63_L68_L0.5940.16
18_F30_L0.5930.16
30_L44_T0.5900.16
66_Q79_M0.5880.16
152_H198_E0.5860.16
98_G117_Q0.5850.16
63_L72_T0.5840.16
181_N199_K0.5840.16
180_G193_D0.5820.16
15_M34_R0.5700.16
105_T116_K0.5700.16
164_Y170_K0.5700.16
34_R37_I0.5700.16
26_L32_F0.5700.16
90_P103_E0.5680.16
48_V93_S0.5680.16
148_F153_G0.5680.16
38_K151_E0.5660.16
15_M18_F0.5650.16
19_V29_L0.5650.16
23_A117_Q0.5600.15
181_N193_D0.5600.15
174_D193_D0.5550.15
128_K146_I0.5530.15
174_D194_Y0.5520.15
176_Y179_G0.5520.15
47_I50_E0.5500.15
100_K204_T0.5490.15
162_K166_E0.5480.15
188_P199_K0.5470.15
34_R39_K0.5450.15
17_I30_L0.5430.15
145_Y160_L0.5390.15
24_S28_V0.5350.15
157_T173_P0.5340.15
99_L106_D0.5340.15
50_E54_D0.5330.15
30_L33_N0.5300.15
74_L201_K0.5290.15
63_L130_V0.5270.14
106_D164_Y0.5270.14
134_T137_Q0.5270.14
162_K187_Y0.5260.14
181_N184_N0.5260.14
189_Y194_Y0.5230.14
107_P118_F0.5230.14
75_I156_H0.5220.14
196_Y200_V0.5170.14
22_I27_L0.5140.14
104_I193_D0.5130.14
90_P97_L0.5120.14
19_V25_F0.5100.14
99_L113_Q0.5100.14
145_Y182_A0.5090.14
38_K70_N0.5080.14
21_V148_F0.5080.14
49_L62_E0.5070.14
176_Y199_K0.5060.14
18_F206_T0.5030.14
26_L33_N0.5000.14
31_F34_R0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fdyA 1 0.8 100 0.588 Contact Map
4hpeA 1 0.7822 100 0.6 Contact Map
4p0gA 1 0.8933 99.4 0.828 Contact Map
4hjzA 1 0.68 99.3 0.843 Contact Map
4cfpA 1 0.8267 99.1 0.852 Contact Map
3gxrA 1 0.6978 99.1 0.855 Contact Map
1gbsA 1 0.7422 99.1 0.856 Contact Map
4g9sA 1 0.72 99 0.857 Contact Map
3w6bA 1 0.6133 99 0.858 Contact Map
1qsaA 1 0.8222 98.8 0.87 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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