GREMLIN Database
SDHAB - Probable L-serine dehydratase, beta chain
UniProt: O34635 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (196)
Sequences: 2233 (1598)
Seq/√Len: 114.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_R112_S4.0351.00
169_K205_E3.9071.00
42_R91_D3.2441.00
44_I93_E3.1981.00
194_V198_I3.1591.00
41_E114_E2.9241.00
204_D207_S2.9221.00
175_G181_R2.6061.00
134_E137_G2.5161.00
44_I110_T2.4861.00
65_I92_I2.4801.00
26_A66_G2.4761.00
112_S117_E2.4111.00
161_A164_A2.3341.00
44_I95_R2.2541.00
161_A168_A2.2261.00
200_D204_D2.1741.00
32_A111_I2.1351.00
108_K121_T2.0931.00
46_S110_T2.0811.00
131_E141_R2.0361.00
121_T134_E1.9731.00
170_F205_E1.9621.00
84_I88_K1.9351.00
163_V190_M1.9021.00
65_I82_I1.8881.00
181_R195_D1.8741.00
64_I109_I1.8491.00
38_R115_K1.8141.00
43_I68_L1.7741.00
82_I92_I1.7661.00
179_V190_M1.7311.00
155_D188_A1.7161.00
28_I109_I1.6961.00
80_T83_Q1.6531.00
110_T117_E1.6381.00
106_T121_T1.6151.00
71_F84_I1.5801.00
36_F118_L1.5721.00
26_A78_I1.5711.00
149_I194_V1.4961.00
165_N169_K1.4951.00
204_D208_K1.4841.00
181_R188_A1.4821.00
187_L213_I1.4631.00
160_I179_V1.3951.00
44_I112_S1.3791.00
118_L136_N1.3671.00
47_F64_I1.3581.00
43_I65_I1.3571.00
170_F202_I1.3401.00
182_K187_L1.3201.00
38_R114_E1.3181.00
181_R185_G1.3171.00
83_Q87_A1.3121.00
106_T133_T1.3001.00
162_G211_N1.2981.00
25_A107_A1.2940.99
39_E88_K1.2910.99
205_E208_K1.2880.99
155_D181_R1.2810.99
30_R70_D1.2790.99
110_T119_E1.2720.99
43_I111_I1.2680.99
45_V68_L1.2430.99
46_S97_E1.2370.99
38_R113_D1.2080.99
155_D158_G1.1920.99
119_E137_G1.1900.99
198_I202_I1.1710.99
41_E113_D1.1670.99
175_G195_D1.1510.99
203_L207_S1.1500.99
136_N152_V1.1490.99
200_D217_K1.1480.99
154_N213_I1.1360.99
160_I177_M1.1340.99
175_G185_G1.1270.99
36_F111_I1.1200.99
31_V130_I1.1170.98
36_F113_D1.1160.98
158_G164_A1.0860.98
45_V64_I1.0820.98
173_N195_D1.0770.98
134_E139_E1.0710.98
39_E114_E1.0670.98
151_V212_I1.0670.98
108_K119_E1.0640.98
47_F94_F1.0460.98
28_I122_G1.0380.98
153_H179_V1.0340.97
177_M190_M1.0310.97
47_F60_T1.0230.97
77_R80_T1.0170.97
162_G209_L1.0130.97
201_H204_D1.0060.97
154_N211_N1.0050.97
66_G70_D1.0030.97
122_G132_I1.0000.97
48_Y99_A0.9980.97
42_R93_E0.9940.97
158_G188_A0.9920.97
151_V190_M0.9890.97
150_L191_T0.9780.96
188_A195_D0.9720.96
138_F189_L0.9710.96
57_G60_T0.9680.96
85_A92_I0.9590.96
162_G165_N0.9580.96
25_A59_G0.9540.96
108_K134_E0.9520.96
50_S105_N0.9370.96
66_G78_I0.9340.95
79_K164_A0.9260.95
46_S95_R0.9210.95
106_T123_I0.9160.95
48_Y97_E0.9140.95
149_I167_L0.9130.95
158_G173_N0.9110.95
209_L212_I0.9100.95
28_I50_S0.9090.95
41_E112_S0.8990.94
46_S108_K0.8890.94
152_V187_L0.8840.94
24_G122_G0.8770.94
25_A64_I0.8750.94
51_F54_T0.8740.94
152_V214_Q0.8620.93
81_A85_A0.8510.93
201_H205_E0.8410.92
153_H190_M0.8400.92
123_I133_T0.8360.92
52_A218_I0.8340.92
30_R34_S0.8300.92
199_D202_I0.8230.91
138_F179_V0.8220.91
64_I107_A0.8200.91
23_A27_R0.8180.91
155_D173_N0.8160.91
48_Y102_V0.8150.91
160_I190_M0.8120.91
84_I87_A0.8060.90
170_F199_D0.8050.90
32_A36_F0.7980.90
123_I131_E0.7940.90
81_A92_I0.7900.90
68_L90_I0.7880.89
45_V107_A0.7870.89
155_D175_G0.7850.89
157_F171_S0.7790.89
153_H177_M0.7780.89
206_L215_V0.7740.89
29_G67_G0.7710.88
53_E96_V0.7690.88
147_P217_K0.7670.88
24_G28_I0.7660.88
156_K211_N0.7640.88
104_P124_S0.7600.88
134_E140_L0.7570.87
207_S214_Q0.7570.87
83_Q86_E0.7520.87
203_L215_V0.7500.87
153_H212_I0.7440.87
29_G45_V0.7410.86
162_G169_K0.7390.86
133_T142_L0.7340.86
49_G123_I0.7320.86
147_P197_N0.7310.86
69_L73_T0.7310.86
47_F56_K0.7290.85
54_T57_G0.7220.85
120_L132_I0.7210.85
166_V206_L0.7190.85
173_N181_R0.7180.85
28_I120_L0.7120.84
36_F116_G0.7110.84
207_S215_V0.7080.84
28_I132_I0.7060.84
180_A189_L0.7000.83
36_F40_P0.7000.83
71_F77_R0.6980.83
119_E134_E0.6950.83
77_R88_K0.6930.82
51_F105_N0.6910.82
138_F180_A0.6890.82
62_V78_I0.6850.82
125_I131_E0.6840.82
153_H176_H0.6830.82
169_K208_K0.6820.81
28_I59_G0.6810.81
25_A67_G0.6760.81
161_A165_N0.6740.81
53_E98_D0.6690.80
38_R116_G0.6610.79
41_E116_G0.6600.79
48_Y100_V0.6590.79
31_V35_L0.6530.79
167_L199_D0.6510.78
68_L111_I0.6490.78
160_I174_V0.6480.78
173_N188_A0.6450.78
166_V205_E0.6410.77
167_L202_I0.6380.77
175_G188_A0.6380.77
51_F55_Y0.6380.77
113_D116_G0.6380.77
62_V79_K0.6360.77
65_I85_A0.6350.77
125_I129_K0.6340.77
170_F201_H0.6340.77
25_A29_G0.6330.76
159_T176_H0.6330.76
149_I198_I0.6320.76
92_I165_N0.6320.76
87_A95_R0.6300.76
43_I64_I0.6260.76
65_I81_A0.6240.75
152_V198_I0.6220.75
162_G210_P0.6190.75
63_A67_G0.6150.74
37_G216_T0.6140.74
32_A52_A0.6110.74
47_F107_A0.6090.74
126_G130_I0.6090.74
54_T58_H0.6090.74
48_Y123_I0.6050.73
158_G181_R0.6030.73
156_K165_N0.5980.72
68_L109_I0.5980.72
82_I86_E0.5960.72
60_T107_A0.5920.72
171_S208_K0.5870.71
155_D195_D0.5860.71
133_T141_R0.5860.71
172_I194_V0.5850.71
124_S128_G0.5840.71
159_T211_N0.5830.70
32_A120_L0.5830.70
185_G188_A0.5800.70
202_I205_E0.5790.70
175_G193_E0.5770.70
138_F177_M0.5700.69
190_M211_N0.5700.69
166_V209_L0.5670.68
51_F63_A0.5660.68
22_T124_S0.5630.68
141_R190_M0.5630.68
179_V188_A0.5620.68
161_A173_N0.5600.67
106_T124_S0.5590.67
69_L90_I0.5570.67
172_I205_E0.5570.67
75_D105_N0.5560.67
132_I144_G0.5550.67
78_I82_I0.5530.66
142_L148_A0.5520.66
104_P144_G0.5500.66
57_G105_N0.5460.65
167_L179_V0.5430.65
51_F57_G0.5410.65
40_P90_I0.5390.64
117_E201_H0.5310.63
54_T105_N0.5310.63
34_S216_T0.5310.63
73_T88_K0.5300.63
162_G166_V0.5300.63
157_F168_A0.5300.63
48_Y101_P0.5290.63
182_K189_L0.5250.62
97_E122_G0.5250.62
156_K192_I0.5230.62
150_L163_V0.5230.62
103_H128_G0.5200.62
141_R178_E0.5190.62
146_H176_H0.5190.62
149_I184_I0.5190.62
62_V176_H0.5170.61
50_S104_P0.5170.61
153_H209_L0.5140.61
166_V202_I0.5140.61
159_T209_L0.5140.61
135_L213_I0.5120.60
168_A192_I0.5110.60
49_G198_I0.5100.60
157_F190_M0.5100.60
140_L180_A0.5080.60
55_Y59_G0.5060.60
158_G174_V0.5040.59
164_A168_A0.5030.59
122_G135_L0.5030.59
86_E92_I0.5020.59
102_V123_I0.5020.59
33_R37_G0.5000.59
200_D207_S0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ygyA 4 0.9955 100 0.315 Contact Map
4rqoA 2 0.8818 99.9 0.626 Contact Map
2iafA 1 0.5227 99.7 0.739 Contact Map
1y7pA 5 0.3545 99.1 0.818 Contact Map
3k5pA 3 0.8045 98.6 0.847 Contact Map
2pc6A 2 0.35 98.4 0.855 Contact Map
2f1fA 4 0.3455 98.4 0.855 Contact Map
1sc6A 4 0.7864 98.4 0.857 Contact Map
2ko1A 2 0.35 98.3 0.858 Contact Map
2fgcA 2 0.35 98.3 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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