SDHAB - BACSU - GREMLIN Contacts

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SDHAB - Probable L-serine dehydratase, beta chain

UniProt:	O34635	Sequences: MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERIIVSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPVHPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTIAGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKIAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	220 (196)
Sequences:	2233 (1598)
Seq/√Len:	114.2

BACSU - SDHAB SERA
HALSA - Q9HMR0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_R	112_S	4.035	1.00
169_K	205_E	3.907	1.00
42_R	91_D	3.244	1.00
44_I	93_E	3.198	1.00
194_V	198_I	3.159	1.00
41_E	114_E	2.924	1.00
204_D	207_S	2.922	1.00
175_G	181_R	2.606	1.00
134_E	137_G	2.516	1.00
44_I	110_T	2.486	1.00
65_I	92_I	2.480	1.00
26_A	66_G	2.476	1.00
112_S	117_E	2.411	1.00
161_A	164_A	2.334	1.00
44_I	95_R	2.254	1.00
161_A	168_A	2.226	1.00
200_D	204_D	2.174	1.00
32_A	111_I	2.135	1.00
108_K	121_T	2.093	1.00
46_S	110_T	2.081	1.00
131_E	141_R	2.036	1.00
121_T	134_E	1.973	1.00
170_F	205_E	1.962	1.00
84_I	88_K	1.935	1.00
163_V	190_M	1.902	1.00
65_I	82_I	1.888	1.00
181_R	195_D	1.874	1.00
64_I	109_I	1.849	1.00
38_R	115_K	1.814	1.00
43_I	68_L	1.774	1.00
82_I	92_I	1.766	1.00
179_V	190_M	1.731	1.00
155_D	188_A	1.716	1.00
28_I	109_I	1.696	1.00
80_T	83_Q	1.653	1.00
110_T	117_E	1.638	1.00
106_T	121_T	1.615	1.00
71_F	84_I	1.580	1.00
36_F	118_L	1.572	1.00
26_A	78_I	1.571	1.00
149_I	194_V	1.496	1.00
165_N	169_K	1.495	1.00
204_D	208_K	1.484	1.00
181_R	188_A	1.482	1.00
187_L	213_I	1.463	1.00
160_I	179_V	1.395	1.00
44_I	112_S	1.379	1.00
118_L	136_N	1.367	1.00
47_F	64_I	1.358	1.00
43_I	65_I	1.357	1.00
170_F	202_I	1.340	1.00
182_K	187_L	1.320	1.00
38_R	114_E	1.318	1.00
181_R	185_G	1.317	1.00
83_Q	87_A	1.312	1.00
106_T	133_T	1.300	1.00
162_G	211_N	1.298	1.00
25_A	107_A	1.294	0.99
39_E	88_K	1.291	0.99
205_E	208_K	1.288	0.99
155_D	181_R	1.281	0.99
30_R	70_D	1.279	0.99
110_T	119_E	1.272	0.99
43_I	111_I	1.268	0.99
45_V	68_L	1.243	0.99
46_S	97_E	1.237	0.99
38_R	113_D	1.208	0.99
155_D	158_G	1.192	0.99
119_E	137_G	1.190	0.99
198_I	202_I	1.171	0.99
41_E	113_D	1.167	0.99
175_G	195_D	1.151	0.99
203_L	207_S	1.150	0.99
136_N	152_V	1.149	0.99
200_D	217_K	1.148	0.99
154_N	213_I	1.136	0.99
160_I	177_M	1.134	0.99
175_G	185_G	1.127	0.99
36_F	111_I	1.120	0.99
31_V	130_I	1.117	0.98
36_F	113_D	1.116	0.98
158_G	164_A	1.086	0.98
45_V	64_I	1.082	0.98
173_N	195_D	1.077	0.98
134_E	139_E	1.071	0.98
39_E	114_E	1.067	0.98
151_V	212_I	1.067	0.98
108_K	119_E	1.064	0.98
47_F	94_F	1.046	0.98
28_I	122_G	1.038	0.98
153_H	179_V	1.034	0.97
177_M	190_M	1.031	0.97
47_F	60_T	1.023	0.97
77_R	80_T	1.017	0.97
162_G	209_L	1.013	0.97
201_H	204_D	1.006	0.97
154_N	211_N	1.005	0.97
66_G	70_D	1.003	0.97
122_G	132_I	1.000	0.97
48_Y	99_A	0.998	0.97
42_R	93_E	0.994	0.97
158_G	188_A	0.992	0.97
151_V	190_M	0.989	0.97
150_L	191_T	0.978	0.96
188_A	195_D	0.972	0.96
138_F	189_L	0.971	0.96
57_G	60_T	0.968	0.96
85_A	92_I	0.959	0.96
162_G	165_N	0.958	0.96
25_A	59_G	0.954	0.96
108_K	134_E	0.952	0.96
50_S	105_N	0.937	0.96
66_G	78_I	0.934	0.95
79_K	164_A	0.926	0.95
46_S	95_R	0.921	0.95
106_T	123_I	0.916	0.95
48_Y	97_E	0.914	0.95
149_I	167_L	0.913	0.95
158_G	173_N	0.911	0.95
209_L	212_I	0.910	0.95
28_I	50_S	0.909	0.95
41_E	112_S	0.899	0.94
46_S	108_K	0.889	0.94
152_V	187_L	0.884	0.94
24_G	122_G	0.877	0.94
25_A	64_I	0.875	0.94
51_F	54_T	0.874	0.94
152_V	214_Q	0.862	0.93
81_A	85_A	0.851	0.93
201_H	205_E	0.841	0.92
153_H	190_M	0.840	0.92
123_I	133_T	0.836	0.92
52_A	218_I	0.834	0.92
30_R	34_S	0.830	0.92
199_D	202_I	0.823	0.91
138_F	179_V	0.822	0.91
64_I	107_A	0.820	0.91
23_A	27_R	0.818	0.91
155_D	173_N	0.816	0.91
48_Y	102_V	0.815	0.91
160_I	190_M	0.812	0.91
84_I	87_A	0.806	0.90
170_F	199_D	0.805	0.90
32_A	36_F	0.798	0.90
123_I	131_E	0.794	0.90
81_A	92_I	0.790	0.90
68_L	90_I	0.788	0.89
45_V	107_A	0.787	0.89
155_D	175_G	0.785	0.89
157_F	171_S	0.779	0.89
153_H	177_M	0.778	0.89
206_L	215_V	0.774	0.89
29_G	67_G	0.771	0.88
53_E	96_V	0.769	0.88
147_P	217_K	0.767	0.88
24_G	28_I	0.766	0.88
156_K	211_N	0.764	0.88
104_P	124_S	0.760	0.88
134_E	140_L	0.757	0.87
207_S	214_Q	0.757	0.87
83_Q	86_E	0.752	0.87
203_L	215_V	0.750	0.87
153_H	212_I	0.744	0.87
29_G	45_V	0.741	0.86
162_G	169_K	0.739	0.86
133_T	142_L	0.734	0.86
49_G	123_I	0.732	0.86
147_P	197_N	0.731	0.86
69_L	73_T	0.731	0.86
47_F	56_K	0.729	0.85
54_T	57_G	0.722	0.85
120_L	132_I	0.721	0.85
166_V	206_L	0.719	0.85
173_N	181_R	0.718	0.85
28_I	120_L	0.712	0.84
36_F	116_G	0.711	0.84
207_S	215_V	0.708	0.84
28_I	132_I	0.706	0.84
180_A	189_L	0.700	0.83
36_F	40_P	0.700	0.83
71_F	77_R	0.698	0.83
119_E	134_E	0.695	0.83
77_R	88_K	0.693	0.82
51_F	105_N	0.691	0.82
138_F	180_A	0.689	0.82
62_V	78_I	0.685	0.82
125_I	131_E	0.684	0.82
153_H	176_H	0.683	0.82
169_K	208_K	0.682	0.81
28_I	59_G	0.681	0.81
25_A	67_G	0.676	0.81
161_A	165_N	0.674	0.81
53_E	98_D	0.669	0.80
38_R	116_G	0.661	0.79
41_E	116_G	0.660	0.79
48_Y	100_V	0.659	0.79
31_V	35_L	0.653	0.79
167_L	199_D	0.651	0.78
68_L	111_I	0.649	0.78
160_I	174_V	0.648	0.78
173_N	188_A	0.645	0.78
166_V	205_E	0.641	0.77
167_L	202_I	0.638	0.77
175_G	188_A	0.638	0.77
51_F	55_Y	0.638	0.77
113_D	116_G	0.638	0.77
62_V	79_K	0.636	0.77
65_I	85_A	0.635	0.77
125_I	129_K	0.634	0.77
170_F	201_H	0.634	0.77
25_A	29_G	0.633	0.76
159_T	176_H	0.633	0.76
149_I	198_I	0.632	0.76
92_I	165_N	0.632	0.76
87_A	95_R	0.630	0.76
43_I	64_I	0.626	0.76
65_I	81_A	0.624	0.75
152_V	198_I	0.622	0.75
162_G	210_P	0.619	0.75
63_A	67_G	0.615	0.74
37_G	216_T	0.614	0.74
32_A	52_A	0.611	0.74
47_F	107_A	0.609	0.74
126_G	130_I	0.609	0.74
54_T	58_H	0.609	0.74
48_Y	123_I	0.605	0.73
158_G	181_R	0.603	0.73
156_K	165_N	0.598	0.72
68_L	109_I	0.598	0.72
82_I	86_E	0.596	0.72
60_T	107_A	0.592	0.72
171_S	208_K	0.587	0.71
155_D	195_D	0.586	0.71
133_T	141_R	0.586	0.71
172_I	194_V	0.585	0.71
124_S	128_G	0.584	0.71
159_T	211_N	0.583	0.70
32_A	120_L	0.583	0.70
185_G	188_A	0.580	0.70
202_I	205_E	0.579	0.70
175_G	193_E	0.577	0.70
138_F	177_M	0.570	0.69
190_M	211_N	0.570	0.69
166_V	209_L	0.567	0.68
51_F	63_A	0.566	0.68
22_T	124_S	0.563	0.68
141_R	190_M	0.563	0.68
179_V	188_A	0.562	0.68
161_A	173_N	0.560	0.67
106_T	124_S	0.559	0.67
69_L	90_I	0.557	0.67
172_I	205_E	0.557	0.67
75_D	105_N	0.556	0.67
132_I	144_G	0.555	0.67
78_I	82_I	0.553	0.66
142_L	148_A	0.552	0.66
104_P	144_G	0.550	0.66
57_G	105_N	0.546	0.65
167_L	179_V	0.543	0.65
51_F	57_G	0.541	0.65
40_P	90_I	0.539	0.64
117_E	201_H	0.531	0.63
54_T	105_N	0.531	0.63
34_S	216_T	0.531	0.63
73_T	88_K	0.530	0.63
162_G	166_V	0.530	0.63
157_F	168_A	0.530	0.63
48_Y	101_P	0.529	0.63
182_K	189_L	0.525	0.62
97_E	122_G	0.525	0.62
156_K	192_I	0.523	0.62
150_L	163_V	0.523	0.62
103_H	128_G	0.520	0.62
141_R	178_E	0.519	0.62
146_H	176_H	0.519	0.62
149_I	184_I	0.519	0.62
62_V	176_H	0.517	0.61
50_S	104_P	0.517	0.61
153_H	209_L	0.514	0.61
166_V	202_I	0.514	0.61
159_T	209_L	0.514	0.61
135_L	213_I	0.512	0.60
168_A	192_I	0.511	0.60
49_G	198_I	0.510	0.60
157_F	190_M	0.510	0.60
140_L	180_A	0.508	0.60
55_Y	59_G	0.506	0.60
158_G	174_V	0.504	0.59
164_A	168_A	0.503	0.59
122_G	135_L	0.503	0.59
86_E	92_I	0.502	0.59
102_V	123_I	0.502	0.59
33_R	37_G	0.500	0.59
200_D	207_S	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ygyA	4	0.9955	100	0.315	Contact Map
4rqoA	2	0.8818	99.9	0.626	Contact Map
2iafA	1	0.5227	99.7	0.739	Contact Map
1y7pA	5	0.3545	99.1	0.818	Contact Map
3k5pA	3	0.8045	98.6	0.847	Contact Map
2pc6A	2	0.35	98.4	0.855	Contact Map
2f1fA	4	0.3455	98.4	0.855	Contact Map
1sc6A	4	0.7864	98.4	0.857	Contact Map
2ko1A	2	0.35	98.3	0.858	Contact Map
2fgcA	2	0.35	98.3	0.862	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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