GREMLIN Database
RUVX - Putative Holliday junction resolvase
UniProt: O34634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (132)
Sequences: 3573 (2289)
Seq/√Len: 199.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_Q135_D3.2481.00
29_E44_R3.1441.00
69_V77_Q3.1141.00
80_A93_L3.1061.00
56_K92_V2.9841.00
65_M98_L2.2081.00
94_W132_G2.2011.00
70_G73_G2.1761.00
46_S87_Y2.0261.00
46_S86_T1.9621.00
64_N68_T1.9501.00
3_I56_K1.9081.00
49_I57_I1.9031.00
59_L80_A1.8841.00
10_T75_A1.8801.00
44_R47_E1.8791.00
61_F77_Q1.7811.00
69_V73_G1.7121.00
30_T123_K1.6881.00
56_K90_P1.6541.00
99_T128_M1.6431.00
6_L15_V1.6131.00
104_E121_I1.5811.00
17_L28_I1.5171.00
8_L59_L1.5161.00
15_V48_L1.5161.00
65_M97_R1.4951.00
72_R75_A1.4951.00
49_I87_Y1.4941.00
80_A84_E1.4931.00
61_F93_L1.4881.00
13_L33_I1.4801.00
46_S50_K1.4801.00
108_I114_R1.4541.00
47_E51_D1.4481.00
94_W136_S1.4061.00
81_K84_E1.3941.00
21_M24_T1.3591.00
57_I89_V1.3461.00
28_I52_Y1.3381.00
17_L52_Y1.3321.00
8_L79_F1.3221.00
4_L54_I1.3211.00
10_T72_R1.3111.00
102_A128_M1.3101.00
61_F69_V1.3031.00
12_T32_K1.2851.00
92_V133_Y1.2811.00
76_S80_A1.2591.00
42_L82_V1.2441.00
64_N70_G1.2141.00
124_M127_V1.2101.00
17_L54_I1.1901.00
3_I133_Y1.1841.00
72_R76_S1.1701.00
77_Q93_L1.1671.00
107_L120_V1.1451.00
105_K109_A1.1431.00
42_L86_T1.1411.00
15_V29_E1.1101.00
98_L101_M1.0991.00
13_L79_F1.0811.00
25_A131_Q1.0701.00
27_G123_K1.0601.00
18_S22_G1.0571.00
99_T102_A1.0521.00
57_I87_Y1.0351.00
104_E117_R1.0301.00
31_I44_R1.0121.00
18_S134_L0.9941.00
120_V123_K0.9921.00
29_E123_K0.9901.00
71_P74_E0.9861.00
106_M124_M0.9650.99
8_L72_R0.9300.99
74_E78_T0.9140.99
4_L48_L0.9060.99
73_G93_L0.8970.99
108_I117_R0.8950.99
81_K85_T0.8930.99
59_L83_L0.8910.99
34_N38_G0.8820.99
61_F73_G0.8640.99
107_L124_M0.8610.99
16_A126_A0.8540.99
64_N71_P0.8490.99
108_I111_D0.8470.99
102_A132_G0.8430.99
43_S86_T0.8340.98
22_G55_D0.8320.98
108_I113_S0.8310.98
57_I83_L0.8300.98
104_E107_L0.8170.98
113_S116_K0.8160.98
71_P75_A0.8110.98
106_M131_Q0.8100.98
12_T121_I0.8060.98
43_S47_E0.8010.98
28_I48_L0.7930.98
3_I58_V0.7920.98
5_G58_V0.7870.98
63_K67_G0.7860.98
18_S23_W0.7760.97
36_A82_V0.7750.97
114_R117_R0.7730.97
101_M105_K0.7690.97
103_A124_M0.7660.97
112_V117_R0.7660.97
76_S93_L0.7650.97
48_L52_Y0.7600.97
102_A106_M0.7600.97
36_A39_D0.7590.97
77_Q80_A0.7580.97
4_L15_V0.7580.97
27_G127_V0.7520.97
128_M132_G0.7450.97
72_R100_T0.7440.97
43_S46_S0.7400.97
45_L79_F0.7390.97
44_R48_L0.7390.97
63_K69_V0.7380.97
58_V92_V0.7210.96
58_V129_I0.7200.96
33_I39_D0.7170.96
59_L76_S0.7150.96
103_A121_I0.7130.96
21_M26_Q0.7120.96
34_N39_D0.7020.95
84_E88_N0.7010.95
69_V74_E0.7010.95
49_I89_V0.6970.95
103_A128_M0.6920.95
59_L91_V0.6840.95
12_T30_T0.6840.95
77_Q81_K0.6820.95
104_E108_I0.6810.95
78_T85_T0.6800.95
59_L93_L0.6770.94
13_L39_D0.6770.94
35_E38_G0.6770.94
112_V116_K0.6760.94
82_V85_T0.6700.94
12_T122_D0.6650.94
5_G130_L0.6580.94
92_V136_S0.6570.94
3_I55_D0.6530.93
79_F83_L0.6490.93
132_G136_S0.6390.93
100_T104_E0.6340.92
78_T82_V0.6330.92
106_M128_M0.6330.92
100_T121_I0.6300.92
45_L83_L0.6280.92
63_K70_G0.6270.92
107_L112_V0.6160.91
58_V94_W0.6140.91
82_V86_T0.6080.91
112_V120_V0.6040.90
4_L49_I0.6020.90
132_G135_D0.6020.90
106_M110_A0.5960.90
19_D22_G0.5900.89
15_V31_I0.5900.89
49_I54_I0.5890.89
111_D114_R0.5880.89
19_D23_W0.5870.89
42_L87_Y0.5860.89
6_L12_T0.5820.89
26_Q52_Y0.5810.89
6_L59_L0.5790.88
46_S49_I0.5780.88
62_P97_R0.5780.88
55_D90_P0.5770.88
20_E53_T0.5700.88
10_T100_T0.5690.88
84_E91_V0.5650.87
98_L102_A0.5650.87
120_V124_M0.5590.87
64_N72_R0.5580.87
43_S50_K0.5580.87
50_K53_T0.5550.86
58_V133_Y0.5550.86
50_K87_Y0.5530.86
4_L28_I0.5460.85
73_G76_S0.5400.85
6_L57_I0.5390.85
116_K120_V0.5370.84
9_G14_G0.5330.84
56_K133_Y0.5280.83
3_I130_L0.5130.82
33_I38_G0.5110.81
78_T81_K0.5100.81
116_K119_K0.5080.81
8_L39_D0.5070.81
35_E39_D0.5040.81
101_M106_M0.5040.81
5_G16_A0.5030.80
4_L57_I0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 1 100 0.204 Contact Map
1nu0A 1 0.9348 100 0.221 Contact Map
1iv0A 1 0.7101 99.9 0.444 Contact Map
4ep4A 2 0.9565 98.9 0.742 Contact Map
1hjrA 2 0.971 98.1 0.797 Contact Map
3bzcA 1 0.9275 97.1 0.835 Contact Map
3psfA 1 0.9058 96.4 0.849 Contact Map
3psiA 1 0.9058 96.3 0.851 Contact Map
2gupA 2 0.9348 95.4 0.861 Contact Map
2aa4A 2 0.9565 94.4 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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