GREMLIN Database
YVRA - Uncharacterized ABC transporter ATP-binding protein YvrA
UniProt: O34631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (365)
Sequences: 903 (787)
Seq/√Len: 41.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_G18_N7.0431.00
30_G205_C5.4461.00
234_V238_D3.9491.00
238_D242_L3.8131.00
2_K22_T3.7481.00
122_M131_A3.4741.00
5_G20_S3.4541.00
17_N215_T3.1251.00
238_D241_A2.9961.00
234_V237_T2.8771.00
123_E128_A2.7811.00
234_V241_A2.7791.00
234_V242_L2.7641.00
124_Q182_R2.6421.00
220_Q224_Y2.6061.00
278_D285_I2.5711.00
235_Y242_L2.5491.00
235_Y238_D2.5201.00
237_T241_A2.4011.00
56_R63_L2.3881.00
4_E56_R2.3321.00
282_Q285_I2.3221.00
234_V239_V2.3151.00
236_D239_V2.2901.00
241_A244_H2.2841.00
120_E124_Q2.2381.00
281_L288_R2.2051.00
241_A245_Q2.1720.99
233_A237_T2.1690.99
281_L285_I2.1390.99
210_F218_P2.0770.99
239_V242_L2.0330.99
116_A120_E2.0310.99
153_A158_I2.0180.99
235_Y239_V1.9740.99
242_L245_Q1.9710.99
338_A342_R1.9490.99
236_D241_A1.8720.98
234_V240_T1.8710.98
119_Q131_A1.8320.98
235_Y241_A1.8230.98
238_D245_Q1.7990.98
278_D281_L1.7850.98
8_G45_L1.7830.98
285_I288_R1.7740.98
341_E344_D1.7540.98
92_E131_A1.7450.98
278_D287_L1.7450.98
277_D281_L1.7430.97
292_S295_I1.7300.97
282_Q288_R1.7300.97
14_R17_N1.7300.97
91_V138_L1.7160.97
23_V192_V1.7160.97
270_A274_A1.6950.97
234_V245_Q1.6890.97
27_E207_G1.6840.97
278_D282_Q1.6630.97
240_T245_Q1.6630.97
239_V244_H1.6580.97
244_H248_P1.6550.97
274_A278_D1.6430.96
236_D240_T1.6340.96
237_T242_L1.6060.96
282_Q287_L1.6030.96
280_L285_I1.6000.96
77_A156_P1.5970.96
239_V245_Q1.5870.96
257_E261_V1.5860.96
238_D244_H1.5730.95
178_D182_R1.5490.95
281_L286_P1.5450.95
232_K236_D1.5450.95
245_Q248_P1.5430.95
90_T93_E1.5400.95
7_S18_N1.5350.95
4_E58_Y1.5290.95
237_T240_T1.5270.95
242_L250_P1.5200.94
254_I258_K1.5090.94
233_A238_D1.5050.94
277_D284_E1.4990.94
258_K261_V1.4770.94
195_F201_A1.4640.93
274_A281_L1.4630.93
75_I157_R1.4570.93
307_H310_L1.4400.93
236_D242_L1.4190.92
235_Y245_Q1.4150.92
280_L286_P1.4110.92
233_A241_A1.4020.92
255_Q260_S1.3870.91
274_A285_I1.3820.91
370_I376_A1.3800.91
236_D244_H1.3770.91
60_A157_R1.3660.90
242_L246_S1.3630.90
177_L200_T1.3610.90
180_I184_T1.3540.90
241_A246_S1.3360.89
282_Q286_P1.3210.89
272_L275_G1.3200.89
375_Y378_D1.3000.88
235_Y243_V1.2960.88
258_K262_K1.2690.87
256_P259_D1.2600.87
371_L376_A1.2570.86
274_A286_P1.2560.86
173_Q200_T1.2550.86
273_Q288_R1.2450.86
273_Q280_L1.2430.86
279_I287_L1.2420.86
159_L189_L1.2370.85
271_L278_D1.2340.85
274_A282_Q1.2320.85
253_V258_K1.2220.85
233_A236_D1.2200.85
255_Q258_K1.2200.85
277_D282_Q1.2090.84
253_V257_E1.2080.84
94_T150_Q1.2050.84
114_G118_V1.2000.84
273_Q286_P1.1980.84
281_L287_L1.1940.83
113_K155_Q1.1880.83
277_D285_I1.1810.83
16_I45_L1.1800.83
6_L45_L1.1680.82
218_P225_A1.1660.82
94_T144_Q1.1650.82
232_K240_T1.1650.82
238_D243_V1.1590.82
173_Q197_D1.1550.81
40_T78_V1.1530.81
173_Q177_L1.1510.81
322_A328_G1.1480.81
278_D288_R1.1470.81
254_I261_V1.1460.81
274_A287_L1.1440.81
124_Q187_S1.1410.80
29_L190_A1.1360.80
65_A68_K1.1300.80
163_E196_H1.1210.79
290_L294_P1.1170.79
273_Q278_D1.1160.79
43_L194_V1.1160.79
119_Q123_E1.1110.79
291_S294_P1.1070.78
270_A273_Q1.1070.78
309_R312_D1.1030.78
121_A152_L1.0990.78
273_Q276_R1.0950.78
109_Q126_G1.0830.77
280_L287_L1.0710.76
237_T243_V1.0670.76
270_A282_Q1.0660.76
275_G279_I1.0630.76
3_A21_L1.0610.75
79_L150_Q1.0590.75
340_S343_L1.0530.75
270_A281_L1.0470.74
125_T149_A1.0310.73
25_K157_R1.0300.73
353_D356_L1.0260.73
305_L310_L1.0250.73
241_A250_P1.0230.73
273_Q281_L1.0170.72
274_A279_I1.0170.72
302_S309_R1.0130.72
272_L277_D1.0110.72
279_I285_I1.0090.72
237_T245_Q1.0080.72
232_K238_D1.0080.72
236_D243_V1.0070.71
232_K239_V1.0060.71
270_A277_D1.0050.71
290_L295_I1.0030.71
237_T244_H1.0010.71
252_I257_E0.9980.71
83_M144_Q0.9950.71
278_D286_P0.9940.70
276_R287_L0.9930.70
91_V130_F0.9900.70
49_T88_T0.9880.70
303_R308_K0.9860.70
280_L288_R0.9750.69
3_A6_L0.9690.68
279_I282_Q0.9660.68
235_Y244_H0.9650.68
240_T244_H0.9550.67
271_L274_A0.9510.67
283_T286_P0.9510.67
112_E116_A0.9490.67
275_G278_D0.9460.67
241_A247_S0.9420.66
266_I273_Q0.9420.66
274_A277_D0.9380.66
244_H250_P0.9370.66
302_S305_L0.9370.66
252_I255_Q0.9360.66
218_P228_E0.9350.66
328_G332_Q0.9260.65
274_A284_E0.9220.65
77_A165_T0.9200.64
239_V247_S0.9190.64
177_L197_D0.9190.64
8_G122_M0.9150.64
232_K235_Y0.9120.64
271_L281_L0.9110.64
56_R65_A0.9080.63
238_D247_S0.9080.63
277_D288_R0.9060.63
197_D200_T0.9040.63
8_G152_L0.9030.63
99_R167_F0.9030.63
242_L248_P0.9030.63
35_N167_F0.9030.63
247_S250_P0.9010.63
272_L281_L0.8990.63
16_I42_L0.8980.63
270_A286_P0.8970.62
270_A278_D0.8970.62
254_I262_K0.8950.62
367_S376_A0.8950.62
289_T295_I0.8950.62
266_I270_A0.8930.62
109_Q121_A0.8930.62
266_I275_G0.8930.62
202_S210_F0.8920.62
238_D248_P0.8880.62
234_V244_H0.8830.61
85_Q195_F0.8800.61
33_G36_G0.8770.61
145_R149_A0.8740.60
79_L94_T0.8680.60
173_Q195_F0.8670.60
241_A248_P0.8640.59
301_W328_G0.8620.59
237_T247_S0.8580.59
308_K311_P0.8570.59
281_L284_E0.8530.59
68_K71_E0.8530.59
299_F305_L0.8500.58
270_A287_L0.8500.58
271_L282_Q0.8470.58
254_I257_E0.8460.58
21_L216_A0.8440.58
253_V256_P0.8440.58
279_I286_P0.8430.58
338_A344_D0.8420.58
322_A331_L0.8400.57
98_G150_Q0.8360.57
318_E323_C0.8350.57
39_K162_D0.8340.57
234_V243_V0.8340.57
268_F272_L0.8340.57
252_I258_K0.8330.57
236_D245_Q0.8300.56
26_G184_T0.8280.56
39_K163_E0.8270.56
65_A69_P0.8260.56
37_S53_K0.8220.56
271_L288_R0.8190.55
266_I288_R0.8190.55
270_A285_I0.8190.55
209_M219_K0.8180.55
111_T180_I0.8180.55
274_A288_R0.8160.55
323_C327_S0.8070.54
49_T195_F0.8040.54
263_R266_I0.8040.54
236_D250_P0.8030.54
284_E288_R0.8030.54
252_I261_V0.8000.54
78_V197_D0.8000.54
304_T309_R0.7970.53
313_Q316_P0.7930.53
239_V243_V0.7920.53
9_G14_R0.7910.53
254_I259_D0.7900.53
164_P207_G0.7880.53
275_G285_I0.7880.53
130_F138_L0.7870.52
312_D319_G0.7860.52
242_L247_S0.7840.52
243_V247_S0.7840.52
146_V172_Y0.7810.52
322_A326_E0.7810.52
246_S250_P0.7790.52
275_G280_L0.7720.51
267_P271_L0.7720.51
85_Q164_P0.7720.51
35_N47_T0.7710.51
368_I373_N0.7670.51
367_S371_L0.7650.50
299_F308_K0.7640.50
280_L283_T0.7630.50
246_S249_K0.7630.50
320_L323_C0.7610.50
39_K81_Q0.7580.50
145_R168_L0.7570.50
232_K241_A0.7560.50
183_L206_D0.7560.50
299_F303_R0.7500.49
152_L376_A0.7490.49
36_G39_K0.7480.49
314_P319_G0.7470.49
352_E367_S0.7460.49
266_I278_D0.7450.49
289_T293_T0.7440.48
265_S271_L0.7400.48
278_D284_E0.7370.48
94_T195_F0.7370.48
83_M94_T0.7370.48
16_I35_N0.7360.48
96_A118_V0.7340.48
31_I42_L0.7330.47
35_N79_L0.7320.47
271_L285_I0.7310.47
266_I271_L0.7310.47
371_L374_G0.7300.47
205_C212_K0.7290.47
273_Q284_E0.7280.47
52_A64_L0.7280.47
338_A343_L0.7250.47
35_N172_Y0.7240.47
266_I285_I0.7220.46
270_A283_T0.7210.46
48_G201_A0.7210.46
306_I313_Q0.7210.46
41_T196_H0.7190.46
275_G281_L0.7160.46
274_A280_L0.7130.46
233_A240_T0.7130.46
159_L165_T0.7120.45
42_L106_L0.7100.45
81_Q162_D0.7080.45
289_T292_S0.7080.45
245_Q250_P0.7060.45
168_L194_V0.7050.45
232_K237_T0.7040.45
167_F200_T0.7020.45
168_L177_L0.7020.45
94_T166_N0.7010.44
49_T166_N0.7000.44
240_T247_S0.6930.44
299_F304_T0.6920.44
33_G38_G0.6920.44
338_A341_E0.6910.44
318_E367_S0.6900.43
60_A158_I0.6900.43
83_M198_L0.6890.43
33_G39_K0.6870.43
43_L47_T0.6850.43
266_I274_A0.6850.43
312_D316_P0.6840.43
79_L161_L0.6830.43
268_F271_L0.6820.43
40_T182_R0.6820.43
85_Q127_V0.6800.43
244_H247_S0.6790.42
270_A275_G0.6760.42
270_A280_L0.6750.42
251_M254_I0.6730.42
233_A242_L0.6720.42
176_L179_L0.6690.42
243_V250_P0.6690.42
120_E123_E0.6670.41
150_Q167_F0.6660.41
369_W374_G0.6650.41
277_D280_L0.6640.41
79_L144_Q0.6640.41
284_E287_L0.6640.41
368_I376_A0.6630.41
369_W373_N0.6620.41
39_K196_H0.6610.41
40_T88_T0.6590.41
75_I106_L0.6570.40
130_F133_K0.6520.40
291_S309_R0.6490.40
318_E321_T0.6490.40
366_F369_W0.6480.40
272_L282_Q0.6480.40
5_G58_Y0.6480.40
272_L278_D0.6470.40
340_S344_D0.6460.39
92_E118_V0.6430.39
255_Q259_D0.6390.39
328_G331_L0.6380.39
267_P273_Q0.6370.39
266_I286_P0.6370.39
351_Y378_D0.6370.39
83_M88_T0.6360.39
46_L57_V0.6360.39
173_Q204_Y0.6350.39
79_L174_K0.6340.38
233_A244_H0.6340.38
50_L166_N0.6330.38
34_P53_K0.6320.38
15_L42_L0.6310.38
81_Q140_G0.6300.38
71_E74_Q0.6290.38
322_A330_Q0.6290.38
142_E190_A0.6280.38
273_Q283_T0.6280.38
35_N150_Q0.6280.38
17_N30_G0.6280.38
35_N99_R0.6260.38
321_T325_S0.6260.38
325_S334_T0.6220.37
267_P287_L0.6190.37
311_P337_M0.6170.37
40_T69_P0.6150.37
98_G154_Q0.6150.37
177_L195_F0.6140.37
268_F281_L0.6140.37
32_L201_A0.6130.37
1_M46_L0.6130.37
120_E155_Q0.6120.37
258_K276_R0.6120.37
256_P261_V0.6110.36
299_F306_I0.6090.36
297_A305_L0.6080.36
18_N215_T0.6080.36
256_P260_S0.6070.36
270_A288_R0.6070.36
303_R307_H0.6070.36
10_Y16_I0.6060.36
293_T296_G0.5980.35
367_S375_Y0.5960.35
296_G306_I0.5960.35
321_T324_L0.5940.35
259_D263_R0.5930.35
269_E278_D0.5910.35
273_Q285_I0.5910.35
273_Q277_D0.5900.35
251_M261_V0.5900.35
179_L182_R0.5900.35
198_L201_A0.5900.35
372_I375_Y0.5890.35
258_K269_E0.5850.34
229_Q241_A0.5820.34
372_I376_A0.5810.34
271_L276_R0.5790.34
359_F363_Q0.5770.34
40_T155_Q0.5760.33
32_L45_L0.5760.33
118_V126_G0.5720.33
126_G179_L0.5720.33
31_I190_A0.5710.33
44_H190_A0.5710.33
4_E377_A0.5710.33
339_S344_D0.5700.33
369_W372_I0.5690.33
94_T135_I0.5690.33
208_L218_P0.5690.33
252_I259_D0.5680.33
95_V153_A0.5660.33
21_L199_N0.5630.32
24_E179_L0.5630.32
200_T204_Y0.5630.32
267_P272_L0.5620.32
239_V249_K0.5620.32
334_T337_M0.5610.32
252_I260_S0.5610.32
286_P290_L0.5600.32
239_V248_P0.5600.32
193_S204_Y0.5600.32
269_E287_L0.5590.32
244_H249_K0.5590.32
140_G194_V0.5580.32
2_K58_Y0.5570.32
91_V211_M0.5570.32
59_L158_I0.5570.32
225_A228_E0.5560.32
371_L375_Y0.5530.32
273_Q282_Q0.5530.32
16_I95_V0.5510.31
13_S23_V0.5500.31
58_Y155_Q0.5500.31
267_P270_A0.5500.31
92_E132_Q0.5480.31
234_V247_S0.5470.31
64_L71_E0.5430.31
156_P196_H0.5430.31
322_A325_S0.5410.31
275_G286_P0.5410.31
48_G164_P0.5410.31
177_L198_L0.5400.31
127_V146_V0.5380.30
317_I324_L0.5370.30
108_R113_K0.5360.30
262_K265_S0.5350.30
81_Q195_F0.5350.30
201_A207_G0.5350.30
173_Q198_L0.5340.30
7_S206_D0.5340.30
374_G377_A0.5340.30
336_A340_S0.5340.30
328_G333_E0.5330.30
267_P274_A0.5330.30
225_A229_Q0.5330.30
128_A131_A0.5300.30
257_E262_K0.5300.30
150_Q194_V0.5300.30
275_G288_R0.5290.30
99_R161_L0.5290.30
209_M216_A0.5280.30
278_D283_T0.5270.30
334_T355_E0.5250.29
50_L84_D0.5240.29
22_T191_A0.5240.29
257_E260_S0.5240.29
19_V44_H0.5240.29
221_K224_Y0.5220.29
136_R157_R0.5210.29
255_Q261_V0.5200.29
177_L204_Y0.5200.29
107_F154_Q0.5190.29
326_E344_D0.5170.29
42_L211_M0.5160.29
19_V30_G0.5160.29
351_Y356_L0.5150.29
273_Q279_I0.5140.29
73_A172_Y0.5130.28
8_G201_A0.5130.28
238_D246_S0.5130.28
92_E122_M0.5130.28
268_F275_G0.5120.28
92_E96_A0.5120.28
35_N168_L0.5120.28
266_I269_E0.5120.28
227_T266_I0.5120.28
43_L200_T0.5120.28
78_V99_R0.5110.28
358_V363_Q0.5090.28
13_S37_S0.5060.28
275_G283_T0.5060.28
272_L280_L0.5050.28
16_I30_G0.5040.28
167_F194_V0.5040.28
273_Q287_L0.5030.28
120_E377_A0.5020.28
144_Q150_Q0.5010.28
369_W377_A0.5010.28
261_V266_I0.5000.27
257_E265_S0.5000.27
198_L205_C0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f4cA 1 0.509 100 0.316 Contact Map
4ry2A 2 0.5339 100 0.316 Contact Map
3tuiC 2 0.7534 100 0.333 Contact Map
4q9hA 1 0.5385 100 0.34 Contact Map
4a82A 2 0.5317 100 0.344 Contact Map
4yerA 2 0.6357 100 0.345 Contact Map
4mrsA 2 0.552 100 0.346 Contact Map
3b5xA 2 0.5339 100 0.347 Contact Map
3b60A 2 0.5339 100 0.351 Contact Map
3nh6A 1 0.5339 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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