GREMLIN Database
YERH - Uncharacterized lipoprotein YerH
UniProt: O34629 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (368)
Sequences: 332 (273)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A184_M5.3041.00
225_I241_V4.7301.00
161_L187_L4.5271.00
212_T216_Q4.5031.00
216_Q219_K4.0291.00
214_R218_E3.9191.00
210_D245_K3.8901.00
380_V395_Y3.7761.00
217_G243_L3.7270.99
189_L243_L3.4960.99
243_L258_I3.3870.99
261_T270_I3.3780.99
352_L371_I3.1900.98
183_V237_V3.1180.98
90_A167_H3.0740.98
108_D111_T2.9380.97
356_V369_V2.8680.97
335_I352_L2.8550.97
187_L220_I2.7900.96
263_V270_I2.5580.94
61_K102_Q2.5470.93
161_L220_I2.4790.92
30_E33_Q2.4700.92
89_L242_A2.4620.92
217_G221_A2.4480.92
184_M242_A2.4470.92
210_D213_L2.3030.89
192_V205_E2.2780.89
196_R203_Q2.1880.87
82_F186_G2.1680.86
82_F184_M2.1600.86
107_L112_V2.0990.84
277_N326_D2.0780.84
184_M257_F2.0770.84
65_A257_F2.0630.83
63_G90_A2.0610.83
156_S193_Y2.0420.82
373_S378_E1.9840.81
214_R258_I1.9660.80
168_D334_D1.9520.79
89_L240_T1.9230.78
242_A257_F1.9180.78
115_W227_R1.9160.78
160_Y189_L1.8980.77
120_K137_N1.8850.77
283_Y321_A1.8560.76
102_Q106_Y1.8480.75
9_A18_A1.8300.75
89_L184_M1.8160.74
57_V178_I1.7930.73
244_Y369_V1.7460.71
351_F355_E1.7390.71
120_K136_K1.7260.70
213_L245_K1.7220.70
208_I213_L1.7160.70
189_L220_I1.6960.69
281_V292_K1.6380.66
197_E200_G1.6250.65
296_D323_Y1.6040.64
277_N325_N1.5920.64
40_E318_V1.5810.63
317_V323_Y1.5770.63
9_A367_V1.5630.62
218_E375_D1.5620.62
170_L310_Y1.5510.62
74_N249_K1.5390.61
189_L217_G1.5390.61
285_A288_T1.5230.60
89_L260_K1.5210.60
244_Y374_S1.5200.60
145_P156_S1.5090.59
121_T137_N1.4920.58
197_E204_K1.4850.58
97_D276_I1.4800.58
60_F103_E1.4790.58
16_L19_C1.4580.57
167_H184_M1.4420.56
196_R201_D1.4160.54
5_L96_T1.3970.53
183_V228_L1.3930.53
371_I379_A1.3920.53
78_D314_Y1.3920.53
92_D260_K1.3920.53
228_L269_D1.3880.53
228_L233_N1.3860.53
222_Q226_N1.3810.52
379_A395_Y1.3810.52
232_D235_K1.3690.52
144_L153_K1.3610.51
220_I224_V1.3600.51
377_Q395_Y1.3550.51
190_N300_F1.3510.51
224_V227_R1.3410.50
303_F335_I1.3390.50
258_I277_N1.3350.50
287_T319_G1.3340.50
51_D230_K1.3310.50
146_S156_S1.3290.50
218_E259_A1.3260.49
60_F101_F1.3210.49
69_T167_H1.3120.49
189_L270_I1.3040.48
310_Y347_A1.2990.48
18_A184_M1.2950.48
88_R278_E1.2900.47
383_R390_P1.2870.47
96_T135_F1.2820.47
162_A246_Q1.2690.46
339_F361_S1.2660.46
37_K168_D1.2660.46
384_N387_D1.2650.46
240_T262_E1.2640.46
304_K307_I1.2600.46
382_I391_T1.2600.46
144_L156_S1.2530.45
193_Y206_V1.2410.45
84_T87_M1.2370.45
319_G331_M1.2370.45
250_T360_Y1.2350.45
89_L258_I1.2290.44
194_Y205_E1.2230.44
90_A316_G1.2190.44
87_M371_I1.2010.43
310_Y380_V1.1990.43
154_N193_Y1.1940.42
225_I261_T1.1920.42
101_F348_F1.1890.42
222_Q270_I1.1870.42
282_F360_Y1.1860.42
11_A287_T1.1840.42
210_D258_I1.1830.42
196_R204_K1.1790.42
45_P51_D1.1770.41
78_D251_S1.1660.41
103_E115_W1.1520.40
213_L258_I1.1480.40
143_A209_K1.1480.40
78_D82_F1.1330.39
307_I317_V1.1320.39
87_M169_Y1.1320.39
78_D254_P1.1300.39
6_A10_T1.1280.39
380_V392_V1.1230.39
56_M188_A1.1150.38
307_I384_N1.1130.38
306_S351_F1.1060.38
94_F240_T1.1060.38
94_F266_G1.1040.38
171_V309_E1.1040.38
29_E32_T1.1030.38
198_K233_N1.1000.37
47_Y354_G1.0960.37
10_T14_L1.0950.37
110_D204_K1.0920.37
297_T301_K1.0910.37
82_F170_L1.0800.36
197_E202_P1.0780.36
66_R344_E1.0740.36
339_F348_F1.0710.36
75_T162_A1.0670.36
349_T379_A1.0670.36
120_K138_E1.0620.35
328_M383_R1.0570.35
167_H347_A1.0500.35
219_K223_E1.0460.35
68_L187_L1.0420.34
296_D328_M1.0400.34
329_K389_E1.0340.34
19_C350_Q1.0330.34
287_T325_N1.0240.34
296_D316_G1.0220.33
247_A251_S1.0210.33
248_S371_I1.0210.33
73_L162_A1.0200.33
51_D335_I1.0170.33
237_V357_M1.0170.33
11_A14_L1.0150.33
34_K279_K1.0120.33
379_A394_I1.0060.33
298_E307_I1.0040.33
224_V241_V1.0030.33
18_A138_E0.9870.32
186_G311_F0.9790.31
199_T386_G0.9780.31
319_G367_V0.9690.31
225_I239_I0.9660.31
214_R243_L0.9620.31
63_G184_M0.9610.31
200_G204_K0.9600.31
96_T233_N0.9580.30
201_D204_K0.9580.30
75_T246_Q0.9490.30
56_M310_Y0.9440.30
17_S181_G0.9310.29
254_P314_Y0.9240.29
106_Y160_Y0.9240.29
145_P193_Y0.9220.29
15_M333_I0.9210.29
75_T220_I0.9180.29
189_L263_V0.9170.29
112_V164_M0.9150.28
11_A86_L0.9050.28
176_N269_D0.9040.28
38_S371_I0.9020.28
314_Y359_Y0.9020.28
78_D247_A0.9010.28
65_A379_A0.8990.28
370_N377_Q0.8990.28
69_T163_S0.8970.28
16_L321_A0.8960.28
72_Q195_Y0.8950.28
250_T267_S0.8940.28
142_P229_R0.8940.28
221_A273_W0.8900.27
252_I315_T0.8870.27
160_Y220_I0.8830.27
12_A15_M0.8750.27
199_T302_R0.8740.27
169_Y304_K0.8730.27
36_A138_E0.8730.27
137_N183_V0.8710.27
96_T266_G0.8680.26
224_V261_T0.8680.26
300_F304_K0.8650.26
12_A167_H0.8650.26
189_L213_L0.8630.26
228_L356_V0.8600.26
77_L200_G0.8540.26
243_L375_D0.8540.26
279_K291_E0.8490.26
360_Y369_V0.8460.25
135_F168_D0.8460.25
283_Y371_I0.8400.25
144_L147_S0.8390.25
53_Y187_L0.8340.25
9_A240_T0.8340.25
314_Y390_P0.8310.25
102_Q244_Y0.8300.25
285_A381_I0.8280.25
338_Q376_G0.8270.25
58_L240_T0.8260.25
106_Y234_L0.8250.25
96_T383_R0.8240.25
11_A94_F0.8230.25
332_K370_N0.8210.24
93_S262_E0.8200.24
243_L354_G0.8160.24
48_N267_S0.8160.24
321_A376_G0.8160.24
326_D395_Y0.8100.24
313_N340_Y0.8090.24
337_M390_P0.8040.24
93_S394_I0.8030.24
310_Y344_E0.7910.23
197_E201_D0.7890.23
334_D346_V0.7850.23
3_K302_R0.7850.23
53_Y91_Q0.7820.23
107_L211_S0.7800.23
303_F313_N0.7800.23
81_E320_T0.7760.23
312_P328_M0.7750.23
257_F261_T0.7730.23
244_Y365_V0.7720.23
194_Y249_K0.7710.23
324_E329_K0.7710.23
194_Y203_Q0.7700.22
192_V256_N0.7700.22
302_R308_E0.7700.22
165_L341_G0.7680.22
241_V304_K0.7650.22
185_I228_L0.7640.22
274_D358_D0.7630.22
21_S45_P0.7620.22
147_S371_I0.7610.22
228_L241_V0.7600.22
3_K13_V0.7580.22
247_A253_V0.7570.22
273_W311_F0.7560.22
87_M346_V0.7560.22
52_S199_T0.7550.22
241_V261_T0.7500.22
368_E393_H0.7500.22
173_K352_L0.7490.22
221_A243_L0.7480.22
312_P339_F0.7480.22
335_I339_F0.7450.22
216_Q223_E0.7450.22
78_D380_V0.7440.21
276_I371_I0.7430.21
93_S212_T0.7410.21
34_K331_M0.7410.21
196_R200_G0.7390.21
108_D274_D0.7390.21
209_K214_R0.7370.21
106_Y174_D0.7370.21
168_D346_V0.7350.21
202_P233_N0.7330.21
183_V225_I0.7280.21
37_K363_S0.7270.21
56_M392_V0.7250.21
272_N276_I0.7250.21
96_T363_S0.7240.21
186_G221_A0.7210.21
381_I390_P0.7210.21
264_K307_I0.7200.21
98_D324_E0.7190.21
326_D357_M0.7180.21
345_V395_Y0.7180.21
35_T332_K0.7170.21
161_L392_V0.7170.21
11_A65_A0.7160.20
155_E206_V0.7100.20
257_F341_G0.7090.20
260_K296_D0.7090.20
366_D383_R0.7090.20
241_V260_K0.7080.20
23_F46_K0.7070.20
119_K143_A0.7050.20
173_K351_F0.7040.20
277_N358_D0.7030.20
321_A352_L0.7020.20
18_A382_I0.6970.20
196_R202_P0.6960.20
80_D314_Y0.6950.20
173_K325_N0.6950.20
335_I380_V0.6950.20
146_S153_K0.6940.20
356_V360_Y0.6930.20
201_D313_N0.6930.20
96_T109_E0.6930.20
8_A185_I0.6920.20
322_L329_K0.6910.20
216_Q220_I0.6910.20
98_D220_I0.6910.20
13_V271_S0.6900.20
333_I381_I0.6890.20
223_E355_E0.6890.20
111_T371_I0.6870.19
33_Q110_D0.6860.19
174_D272_N0.6850.19
83_E273_W0.6850.19
254_P390_P0.6840.19
244_Y359_Y0.6840.19
160_Y216_Q0.6830.19
74_N270_I0.6820.19
313_N348_F0.6810.19
212_T258_I0.6810.19
115_W311_F0.6790.19
13_V185_I0.6790.19
284_P311_F0.6790.19
360_Y390_P0.6780.19
135_F157_S0.6780.19
308_E395_Y0.6760.19
229_R239_I0.6760.19
81_E88_R0.6710.19
211_S325_N0.6710.19
183_V277_N0.6690.19
354_G392_V0.6670.19
196_R319_G0.6650.19
241_V307_I0.6630.19
139_G142_P0.6580.18
249_K341_G0.6570.18
254_P323_Y0.6550.18
300_F321_A0.6540.18
224_V247_A0.6540.18
155_E195_Y0.6540.18
220_I228_L0.6530.18
45_P283_Y0.6530.18
14_L35_T0.6530.18
66_R285_A0.6500.18
89_L281_V0.6490.18
313_N393_H0.6470.18
171_V181_G0.6450.18
232_D325_N0.6450.18
347_A355_E0.6440.18
231_K325_N0.6440.18
179_Q223_E0.6430.18
121_T136_K0.6430.18
188_A340_Y0.6420.18
345_V379_A0.6410.18
219_K226_N0.6410.18
293_Y394_I0.6370.18
301_K305_N0.6360.18
267_S389_E0.6350.18
256_N381_I0.6340.18
31_I281_V0.6340.18
95_S337_M0.6310.18
20_S271_S0.6300.18
236_N264_K0.6280.18
248_S333_I0.6280.18
82_F165_L0.6270.17
48_N380_V0.6240.17
90_A242_A0.6230.17
383_R395_Y0.6210.17
358_D369_V0.6160.17
103_E333_I0.6160.17
62_A296_D0.6150.17
198_K201_D0.6120.17
45_P76_R0.6120.17
31_I291_E0.6120.17
312_P335_I0.6120.17
191_S234_L0.6100.17
317_V335_I0.6080.17
320_T334_D0.6070.17
215_Q219_K0.6070.17
75_T251_S0.6060.17
17_S327_E0.6050.17
115_W118_R0.6040.17
57_V310_Y0.6040.17
252_I368_E0.6030.17
11_A199_T0.6030.17
163_S188_A0.6020.17
353_T392_V0.6010.17
163_S254_P0.6000.17
103_E316_G0.6000.17
87_M365_V0.6000.17
181_G215_Q0.5990.17
57_V324_E0.5990.17
112_V316_G0.5980.17
347_A378_E0.5980.17
70_T75_T0.5970.17
161_L165_L0.5970.17
313_N333_I0.5960.17
114_S174_D0.5940.16
62_A310_Y0.5940.16
67_G83_E0.5930.16
189_L354_G0.5920.16
192_V235_K0.5910.16
299_V325_N0.5900.16
171_V394_I0.5900.16
37_K272_N0.5890.16
3_K371_I0.5890.16
232_D275_D0.5880.16
81_E254_P0.5880.16
38_S236_N0.5880.16
10_T276_I0.5880.16
164_M185_I0.5880.16
159_I315_T0.5850.16
101_F167_H0.5840.16
326_D379_A0.5830.16
118_R158_P0.5820.16
244_Y298_E0.5820.16
173_K179_Q0.5800.16
189_L193_Y0.5800.16
76_R285_A0.5800.16
57_V63_G0.5800.16
254_P337_M0.5790.16
64_K165_L0.5760.16
291_E295_D0.5760.16
60_F65_A0.5750.16
168_D247_A0.5740.16
17_S237_V0.5720.16
161_L376_G0.5720.16
40_E290_A0.5710.16
41_K161_L0.5710.16
169_Y220_I0.5710.16
136_K241_V0.5700.16
164_M371_I0.5680.16
210_D274_D0.5680.16
297_T326_D0.5680.16
77_L92_D0.5680.16
115_W323_Y0.5670.16
16_L143_A0.5650.16
82_F111_T0.5640.16
370_N395_Y0.5620.16
143_A275_D0.5610.15
168_D351_F0.5610.15
8_A257_F0.5590.15
67_G341_G0.5590.15
63_G358_D0.5570.15
61_K174_D0.5550.15
172_R302_R0.5530.15
99_Y170_L0.5520.15
280_Y356_V0.5520.15
57_V170_L0.5520.15
166_E255_G0.5510.15
234_L262_E0.5500.15
367_V381_I0.5500.15
14_L112_V0.5480.15
36_A189_L0.5470.15
290_A395_Y0.5470.15
180_L208_I0.5460.15
75_T257_F0.5450.15
190_N246_Q0.5450.15
65_A242_A0.5440.15
222_Q244_Y0.5440.15
63_G257_F0.5430.15
13_V95_S0.5420.15
67_G116_L0.5410.15
290_A297_T0.5400.15
170_L229_R0.5380.15
17_S63_G0.5380.15
227_R308_E0.5370.15
36_A333_I0.5370.15
44_V47_Y0.5360.15
73_L159_I0.5360.15
86_L242_A0.5360.15
81_E277_N0.5350.15
263_V267_S0.5340.15
138_E309_E0.5340.15
321_A331_M0.5340.15
277_N292_K0.5330.15
210_D326_D0.5320.15
248_S269_D0.5310.15
241_V263_V0.5300.15
160_Y339_F0.5290.15
228_L318_V0.5290.15
357_M389_E0.5290.15
39_S282_F0.5280.15
186_G240_T0.5270.15
156_S159_I0.5250.14
118_R338_Q0.5220.14
115_W308_E0.5220.14
95_S305_N0.5220.14
106_Y210_D0.5220.14
208_I241_V0.5210.14
254_P315_T0.5210.14
47_Y188_A0.5200.14
176_N272_N0.5200.14
226_N269_D0.5190.14
53_Y346_V0.5170.14
201_D348_F0.5150.14
107_L343_S0.5150.14
40_E183_V0.5140.14
163_S170_L0.5140.14
245_K258_I0.5130.14
249_K286_D0.5120.14
231_K270_I0.5110.14
9_A92_D0.5110.14
20_S194_Y0.5100.14
220_I248_S0.5100.14
37_K277_N0.5100.14
16_L267_S0.5080.14
207_E276_I0.5080.14
314_Y336_P0.5070.14
78_D356_V0.5060.14
186_G284_P0.5050.14
251_S349_T0.5050.14
327_E387_D0.5040.14
24_G102_Q0.5040.14
186_G244_Y0.5040.14
248_S287_T0.5030.14
194_Y260_K0.5030.14
98_D212_T0.5030.14
247_A322_L0.5030.14
114_S117_A0.5020.14
17_S231_K0.5020.14
171_V277_N0.5020.14
169_Y317_V0.5000.14
283_Y297_T0.5000.14
83_E339_F0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hn3A 3 0.8434 100 0.148 Contact Map
3ib5A 2 0.8409 100 0.157 Contact Map
2qx2A 1 0.7904 100 0.16 Contact Map
3n2qA 2 0.7096 100 0.252 Contact Map
3zbiC 1 0.0707 70.2 0.97 Contact Map
4av2M 1 0.1338 21 0.978 Contact Map
4fybB 1 0.2702 17.3 0.979 Contact Map
4n4rB 1 0.2551 17.3 0.979 Contact Map
2qguA 1 0.4343 15.2 0.98 Contact Map
4utoA 1 0.5758 14.1 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.