GREMLIN Database
YVLB - Uncharacterized protein YvlB
UniProt: O34628 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (349)
Sequences: 262 (238)
Seq/√Len: 12.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_V22_A5.0741.00
213_N232_N5.0141.00
10_K14_E4.1171.00
232_N251_N3.8050.99
194_N213_N3.5150.99
251_N269_N3.4640.99
131_A178_L3.3930.98
112_L178_L3.3830.98
305_A337_F3.1960.98
214_G252_G3.0750.97
213_N251_N2.9720.96
211_T249_T2.9080.96
194_N251_N2.8510.95
116_N194_N2.8050.95
17_L25_L2.7220.94
272_I293_V2.7060.94
271_N292_N2.6270.92
11_L25_L2.5810.92
98_H151_L2.4920.90
26_I267_S2.4860.90
15_G22_A2.3760.88
13_E19_A2.3540.87
215_V234_Q2.2770.86
232_N269_N2.2750.86
17_L22_A2.2740.86
194_N232_N2.2620.85
269_N290_T2.2310.84
9_L15_G2.1940.83
119_V190_V2.1340.82
213_N269_N2.0830.80
196_P234_Q2.0780.80
231_A250_I2.0480.79
8_I22_A2.0370.78
291_G312_G2.0290.78
11_L28_K2.0130.77
215_V271_N1.9700.76
287_K352_E1.9690.76
10_K13_E1.9420.75
253_L292_N1.9400.75
183_K254_I1.9350.75
70_L74_I1.9230.74
234_Q292_N1.9220.74
250_I289_T1.9050.73
308_K361_K1.9020.73
22_A25_L1.8820.72
252_G312_G1.8570.71
124_W130_R1.8240.70
96_V135_A1.8220.70
15_G25_L1.8220.70
208_S227_I1.7680.67
116_N213_N1.7650.67
252_G291_G1.7580.67
125_E182_Q1.7550.67
251_N290_T1.7470.66
25_L28_K1.7260.65
150_F337_F1.7030.64
124_W165_I1.6790.63
8_I15_G1.6630.62
11_L17_L1.6550.62
215_V292_N1.6510.62
215_V253_L1.6430.62
11_L16_K1.6340.61
205_K224_E1.6290.61
307_L358_I1.6290.61
8_I25_L1.6230.61
22_A113_Q1.6180.60
48_H52_E1.6150.60
133_C193_F1.6010.59
11_L22_A1.5740.58
121_I178_L1.5630.58
195_G233_G1.5600.57
18_T22_A1.5340.56
256_L265_V1.5220.55
202_L205_K1.5150.55
292_N360_L1.5070.55
233_G252_G1.5070.55
18_T25_L1.4640.52
98_H147_R1.4570.52
124_W127_D1.4280.51
213_N290_T1.4210.50
290_T311_L1.4100.50
213_N355_T1.3770.48
251_N311_L1.3680.47
307_L360_L1.3630.47
10_K292_N1.3590.47
218_F254_I1.3490.47
192_L293_V1.3480.46
52_E56_T1.3400.46
27_E31_S1.3380.46
107_F163_F1.3290.45
294_E317_E1.3140.45
12_V19_A1.3140.45
112_L190_V1.3130.45
12_V24_T1.3050.44
22_A26_I1.2990.44
212_T250_I1.2990.44
82_K136_K1.2940.44
295_L349_V1.2890.43
130_R179_Y1.2820.43
254_I257_R1.2530.42
17_L28_K1.2500.41
78_V221_L1.2410.41
233_G298_P1.2400.41
234_Q271_N1.2370.41
139_R171_T1.2370.41
284_I316_H1.2330.41
231_A268_F1.2240.40
112_L225_K1.2170.40
74_I254_I1.2050.39
11_L102_F1.1970.39
100_F229_E1.1970.39
122_V177_T1.1970.39
133_C176_V1.1890.38
14_E18_T1.1890.38
257_R272_I1.1820.38
20_Q126_D1.1810.38
122_V180_I1.1740.38
57_A60_E1.1710.38
191_K212_T1.1650.37
261_E282_R1.1600.37
150_F227_I1.1580.37
152_Q216_L1.1580.37
133_C137_V1.1540.37
132_E193_F1.1520.37
269_N312_G1.1490.36
9_L12_V1.1490.36
18_T34_K1.1440.36
15_G18_T1.1400.36
10_K16_K1.1360.36
86_L89_N1.1330.36
21_E25_L1.1320.36
228_A342_A1.1310.36
197_V329_D1.1250.35
55_T59_K1.1220.35
8_I26_I1.1190.35
127_D243_G1.1130.35
12_V17_L1.1120.35
311_L355_T1.1110.35
49_D58_K1.1100.35
36_K148_H1.1020.34
9_L22_A1.1010.34
49_D53_P1.0930.34
70_L278_E1.0840.33
48_H51_E1.0810.33
118_S293_V1.0800.33
250_I268_F1.0760.33
110_V178_L1.0710.33
59_K63_K1.0710.33
124_W137_V1.0690.33
8_I18_T1.0620.32
144_D197_V1.0570.32
73_W82_K1.0530.32
195_G270_G1.0440.32
66_L288_T1.0440.32
70_L96_V1.0390.31
211_T216_L1.0390.31
118_S196_P1.0360.31
244_T309_S1.0340.31
272_I282_R1.0300.31
251_N355_T1.0290.31
270_G291_G1.0270.31
116_N251_N1.0230.31
100_F165_I1.0210.31
279_S349_V1.0170.30
27_E285_Y1.0130.30
8_I12_V1.0130.30
154_I339_S1.0120.30
99_I132_E1.0120.30
109_S162_K1.0080.30
173_K229_E1.0040.30
16_K143_Q0.9980.30
101_Q128_D0.9890.29
226_A361_K0.9880.29
224_E243_G0.9860.29
150_F210_K0.9800.29
275_N293_V0.9770.29
78_V114_I0.9760.29
129_I272_I0.9700.28
11_L14_E0.9680.28
119_V247_A0.9680.28
303_V337_F0.9680.28
18_T295_L0.9660.28
134_Q197_V0.9650.28
52_E55_T0.9630.28
289_T292_N0.9610.28
304_K345_Q0.9610.28
253_L271_N0.9610.28
154_I165_I0.9550.28
156_C165_I0.9500.28
51_E54_F0.9490.28
61_S360_L0.9470.27
238_A267_S0.9460.27
67_G212_T0.9450.27
216_L232_N0.9440.27
73_W156_C0.9420.27
69_K211_T0.9410.27
77_A81_V0.9390.27
28_K31_S0.9380.27
307_L351_S0.9300.27
194_N249_T0.9240.26
106_D161_N0.9240.26
121_I188_I0.9170.26
112_L260_S0.9120.26
239_S349_V0.9100.26
8_I17_L0.9070.26
183_K226_A0.9060.26
27_E358_I0.9050.26
265_V342_A0.8960.25
282_R293_V0.8950.25
49_D59_K0.8940.25
124_W326_E0.8910.25
318_L355_T0.8900.25
233_G356_G0.8900.25
239_S295_L0.8890.25
9_L16_K0.8860.25
17_L70_L0.8840.25
18_T313_T0.8820.25
270_G356_G0.8780.25
112_L267_S0.8780.25
24_T353_S0.8750.25
67_G71_F0.8720.24
12_V16_K0.8710.24
234_Q253_L0.8710.24
290_T361_K0.8690.24
47_V50_E0.8670.24
17_L26_I0.8660.24
213_N311_L0.8650.24
316_H360_L0.8640.24
16_K26_I0.8630.24
17_L24_T0.8590.24
315_S353_S0.8560.24
194_N269_N0.8520.24
35_E38_E0.8520.24
197_V293_V0.8510.24
313_T357_A0.8490.24
54_F62_G0.8470.24
10_K20_Q0.8450.23
33_Y41_T0.8450.23
181_P197_V0.8430.23
110_V359_K0.8430.23
30_D35_E0.8400.23
82_K138_Y0.8390.23
98_H326_E0.8390.23
195_G293_V0.8390.23
204_V337_F0.8370.23
191_K262_S0.8330.23
133_C290_T0.8300.23
104_D127_D0.8280.23
253_L339_S0.8250.23
322_E358_I0.8240.23
47_V52_E0.8220.23
350_F358_I0.8220.23
12_V28_K0.8210.23
194_N216_L0.8210.23
115_A191_K0.8190.22
87_D230_T0.8150.22
112_L345_Q0.8140.22
111_E166_R0.8140.22
86_L264_D0.8130.22
80_K310_N0.8040.22
256_L309_S0.8030.22
82_K337_F0.8020.22
99_I284_I0.8020.22
22_A27_E0.8010.22
34_K39_K0.8000.22
232_N290_T0.7920.22
221_L295_L0.7910.21
19_A352_E0.7870.21
47_V54_F0.7860.21
235_I248_E0.7830.21
331_I360_L0.7830.21
112_L121_I0.7810.21
132_E156_C0.7790.21
233_G312_G0.7750.21
17_L329_D0.7740.21
110_V127_D0.7720.21
180_I230_T0.7720.21
49_D52_E0.7680.21
19_A22_A0.7660.21
138_Y308_K0.7640.21
197_V204_V0.7620.20
52_E59_K0.7610.20
294_E315_S0.7590.20
30_D295_L0.7590.20
30_D37_E0.7540.20
9_L17_L0.7530.20
148_H343_H0.7480.20
170_K355_T0.7470.20
167_T216_L0.7460.20
200_E295_L0.7450.20
248_E311_L0.7430.20
18_T26_I0.7430.20
259_K278_E0.7430.20
124_W200_E0.7410.20
106_D254_I0.7410.20
179_Y326_E0.7390.20
308_K349_V0.7380.20
47_V53_P0.7370.20
20_Q25_L0.7360.20
269_N311_L0.7350.20
286_A351_S0.7310.19
64_P149_A0.7290.19
220_Y288_T0.7290.19
65_S75_D0.7280.19
54_F58_K0.7270.19
11_L278_E0.7190.19
30_D110_V0.7180.19
129_I335_M0.7150.19
75_D231_A0.7150.19
135_A150_F0.7130.19
106_D247_A0.7120.19
56_T59_K0.7120.19
86_L202_L0.7100.19
51_E56_T0.7100.19
100_F136_K0.7070.19
290_T309_S0.7060.19
159_K248_E0.7050.19
279_S335_M0.7050.19
53_P56_T0.7050.19
197_V262_S0.7030.19
54_F178_L0.7020.19
79_K83_E0.7020.19
10_K311_L0.6990.18
317_E361_K0.6960.18
102_F156_C0.6950.18
239_S277_T0.6930.18
86_L293_V0.6920.18
245_I299_D0.6910.18
17_L29_L0.6900.18
100_F133_C0.6890.18
26_I41_T0.6880.18
98_H229_E0.6870.18
254_I281_C0.6860.18
112_L262_S0.6840.18
242_C315_S0.6830.18
220_Y243_G0.6820.18
194_N290_T0.6810.18
101_Q351_S0.6780.18
233_G291_G0.6780.18
282_R345_Q0.6780.18
10_K19_A0.6770.18
242_C324_L0.6750.18
12_V80_K0.6740.18
48_H57_A0.6730.18
307_L335_M0.6730.18
34_K37_E0.6730.18
117_G213_N0.6720.18
75_D237_L0.6710.18
204_V315_S0.6680.18
73_W150_F0.6670.17
206_E244_T0.6660.17
188_I202_L0.6640.17
8_I27_E0.6620.17
9_L13_E0.6610.17
323_M327_K0.6600.17
211_T251_N0.6580.17
150_F164_F0.6580.17
32_D39_K0.6530.17
211_T232_N0.6530.17
57_A61_S0.6520.17
128_D150_F0.6510.17
50_E57_A0.6500.17
35_E190_V0.6500.17
18_T121_I0.6500.17
83_E155_E0.6490.17
148_H174_T0.6480.17
115_A263_I0.6450.17
116_N267_S0.6430.17
36_K39_K0.6380.17
162_K177_T0.6360.17
76_S247_A0.6360.17
213_N216_L0.6350.17
293_V356_G0.6350.17
33_Y119_V0.6340.17
115_A206_E0.6330.16
214_G291_G0.6290.16
16_K28_K0.6290.16
64_P293_V0.6270.16
84_V237_L0.6250.16
124_W173_K0.6210.16
143_Q278_E0.6210.16
193_F212_T0.6190.16
326_E332_Q0.6190.16
127_D303_V0.6180.16
77_A288_T0.6160.16
82_K150_F0.6160.16
307_L314_L0.6140.16
180_I184_E0.6130.16
138_Y327_K0.6120.16
269_N355_T0.6100.16
76_S332_Q0.6090.16
272_I286_A0.6060.16
116_N209_A0.6050.16
100_F358_I0.6040.16
219_S349_V0.6030.16
49_D62_G0.6030.16
176_V307_L0.6030.16
291_G356_G0.6010.16
100_F124_W0.6010.16
141_D246_E0.6010.16
78_V237_L0.6000.16
272_I351_S0.5990.16
98_H133_C0.5990.16
177_T314_L0.5990.16
298_P305_A0.5980.16
321_V324_L0.5970.15
100_F150_F0.5950.15
69_K110_V0.5950.15
188_I323_M0.5940.15
32_D42_A0.5940.15
112_L144_D0.5940.15
237_L293_V0.5930.15
110_V208_S0.5910.15
232_N355_T0.5900.15
117_G194_N0.5900.15
124_W320_D0.5870.15
251_N312_G0.5850.15
73_W90_F0.5850.15
16_K30_D0.5850.15
228_A246_E0.5850.15
192_L266_Q0.5830.15
119_V176_V0.5820.15
256_L274_I0.5820.15
31_S36_K0.5820.15
111_E250_I0.5810.15
9_L146_A0.5810.15
251_N318_L0.5760.15
248_E266_Q0.5730.15
108_S128_D0.5720.15
175_N339_S0.5710.15
130_R309_S0.5710.15
9_L25_L0.5700.15
193_F229_E0.5690.15
110_V265_V0.5690.15
31_S263_I0.5670.15
103_K134_Q0.5660.15
294_E360_L0.5660.15
249_T318_L0.5640.15
77_A85_D0.5640.15
122_V295_L0.5630.15
113_Q290_T0.5620.15
103_K161_N0.5610.15
147_R325_K0.5610.15
83_E159_K0.5610.15
193_F231_A0.5610.15
73_W229_E0.5590.14
18_T41_T0.5590.14
82_K355_T0.5590.14
211_T309_S0.5580.14
25_L293_V0.5560.14
29_L134_Q0.5550.14
139_R316_H0.5550.14
89_N96_V0.5550.14
226_A242_C0.5530.14
20_Q24_T0.5530.14
58_K134_Q0.5520.14
197_V218_F0.5520.14
137_V173_K0.5510.14
190_V237_L0.5500.14
232_N312_G0.5480.14
194_N355_T0.5470.14
102_F191_K0.5470.14
9_L20_Q0.5460.14
131_A152_Q0.5460.14
9_L29_L0.5450.14
107_F353_S0.5440.14
154_I294_E0.5440.14
80_K91_G0.5430.14
62_G190_V0.5420.14
125_E128_D0.5400.14
128_D229_E0.5390.14
116_N232_N0.5380.14
35_E47_V0.5380.14
110_V351_S0.5360.14
68_A293_V0.5350.14
156_C326_E0.5340.14
163_F298_P0.5330.14
227_I248_E0.5330.14
195_G214_G0.5330.14
294_E314_L0.5320.14
173_K351_S0.5310.14
190_V211_T0.5250.14
55_T58_K0.5240.14
216_L247_A0.5240.14
118_S289_T0.5230.14
113_Q314_L0.5230.14
11_L23_L0.5210.14
89_N99_I0.5200.14
24_T42_A0.5190.13
13_E91_G0.5190.13
34_K295_L0.5180.13
292_N357_A0.5180.13
110_V223_A0.5160.13
215_V357_A0.5150.13
74_I261_E0.5140.13
82_K170_K0.5130.13
264_D318_L0.5130.13
228_A335_M0.5120.13
308_K312_G0.5110.13
203_H222_T0.5110.13
223_A287_K0.5100.13
326_E333_K0.5090.13
72_D80_K0.5090.13
128_D308_K0.5080.13
11_L15_G0.5070.13
216_L228_A0.5070.13
208_S273_A0.5070.13
8_I11_L0.5060.13
173_K326_E0.5060.13
344_D358_I0.5050.13
247_A254_I0.5040.13
184_E188_I0.5040.13
242_C255_D0.5040.13
26_I201_H0.5030.13
33_Y182_Q0.5030.13
80_K337_F0.5030.13
20_Q201_H0.5030.13
23_L28_K0.5020.13
194_N311_L0.5020.13
139_R273_A0.5010.13
290_T327_K0.5000.13
309_S332_Q0.5000.13
204_V305_A0.5000.13
42_A118_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jx8A 4 0.6274 99.7 0.774 Contact Map
3lycA 2 0.6219 99.7 0.777 Contact Map
4opwA 1 0.6274 99.6 0.801 Contact Map
4yguA 3 0.4603 99.6 0.803 Contact Map
3petA 2 0.5589 99.4 0.818 Contact Map
4qrkA 1 0.5479 99 0.847 Contact Map
4kisA 2 0.2767 36.9 0.958 Contact Map
3hkzY 1 0.1096 21.9 0.962 Contact Map
2lseA 1 0.2575 15 0.965 Contact Map
3lhrA 2 0.0932 8.9 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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