YVLB - BACSU - GREMLIN Contacts

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YVLB - Uncharacterized protein YvlB

UniProt:	O34628	Sequences: MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALSVHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQFKDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKGNKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSFSYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINVTESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKEMMFTSNQAHDQNITVFSESLTGAIKLKYSQR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (349)
Sequences:	262 (238)
Seq/√Len:	12.8

BACSU - YVLB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
12_V	22_A	5.074	1.00
213_N	232_N	5.014	1.00
10_K	14_E	4.117	1.00
232_N	251_N	3.805	0.99
194_N	213_N	3.515	0.99
251_N	269_N	3.464	0.99
131_A	178_L	3.393	0.98
112_L	178_L	3.383	0.98
305_A	337_F	3.196	0.98
214_G	252_G	3.075	0.97
213_N	251_N	2.972	0.96
211_T	249_T	2.908	0.96
194_N	251_N	2.851	0.95
116_N	194_N	2.805	0.95
17_L	25_L	2.722	0.94
272_I	293_V	2.706	0.94
271_N	292_N	2.627	0.92
11_L	25_L	2.581	0.92
98_H	151_L	2.492	0.90
26_I	267_S	2.486	0.90
15_G	22_A	2.376	0.88
13_E	19_A	2.354	0.87
215_V	234_Q	2.277	0.86
232_N	269_N	2.275	0.86
17_L	22_A	2.274	0.86
194_N	232_N	2.262	0.85
269_N	290_T	2.231	0.84
9_L	15_G	2.194	0.83
119_V	190_V	2.134	0.82
213_N	269_N	2.083	0.80
196_P	234_Q	2.078	0.80
231_A	250_I	2.048	0.79
8_I	22_A	2.037	0.78
291_G	312_G	2.029	0.78
11_L	28_K	2.013	0.77
215_V	271_N	1.970	0.76
287_K	352_E	1.969	0.76
10_K	13_E	1.942	0.75
253_L	292_N	1.940	0.75
183_K	254_I	1.935	0.75
70_L	74_I	1.923	0.74
234_Q	292_N	1.922	0.74
250_I	289_T	1.905	0.73
308_K	361_K	1.902	0.73
22_A	25_L	1.882	0.72
252_G	312_G	1.857	0.71
124_W	130_R	1.824	0.70
96_V	135_A	1.822	0.70
15_G	25_L	1.822	0.70
208_S	227_I	1.768	0.67
116_N	213_N	1.765	0.67
252_G	291_G	1.758	0.67
125_E	182_Q	1.755	0.67
251_N	290_T	1.747	0.66
25_L	28_K	1.726	0.65
150_F	337_F	1.703	0.64
124_W	165_I	1.679	0.63
8_I	15_G	1.663	0.62
11_L	17_L	1.655	0.62
215_V	292_N	1.651	0.62
215_V	253_L	1.643	0.62
11_L	16_K	1.634	0.61
205_K	224_E	1.629	0.61
307_L	358_I	1.629	0.61
8_I	25_L	1.623	0.61
22_A	113_Q	1.618	0.60
48_H	52_E	1.615	0.60
133_C	193_F	1.601	0.59
11_L	22_A	1.574	0.58
121_I	178_L	1.563	0.58
195_G	233_G	1.560	0.57
18_T	22_A	1.534	0.56
256_L	265_V	1.522	0.55
202_L	205_K	1.515	0.55
292_N	360_L	1.507	0.55
233_G	252_G	1.507	0.55
18_T	25_L	1.464	0.52
98_H	147_R	1.457	0.52
124_W	127_D	1.428	0.51
213_N	290_T	1.421	0.50
290_T	311_L	1.410	0.50
213_N	355_T	1.377	0.48
251_N	311_L	1.368	0.47
307_L	360_L	1.363	0.47
10_K	292_N	1.359	0.47
218_F	254_I	1.349	0.47
192_L	293_V	1.348	0.46
52_E	56_T	1.340	0.46
27_E	31_S	1.338	0.46
107_F	163_F	1.329	0.45
294_E	317_E	1.314	0.45
12_V	19_A	1.314	0.45
112_L	190_V	1.313	0.45
12_V	24_T	1.305	0.44
22_A	26_I	1.299	0.44
212_T	250_I	1.299	0.44
82_K	136_K	1.294	0.44
295_L	349_V	1.289	0.43
130_R	179_Y	1.282	0.43
254_I	257_R	1.253	0.42
17_L	28_K	1.250	0.41
78_V	221_L	1.241	0.41
233_G	298_P	1.240	0.41
234_Q	271_N	1.237	0.41
139_R	171_T	1.237	0.41
284_I	316_H	1.233	0.41
231_A	268_F	1.224	0.40
112_L	225_K	1.217	0.40
74_I	254_I	1.205	0.39
11_L	102_F	1.197	0.39
100_F	229_E	1.197	0.39
122_V	177_T	1.197	0.39
133_C	176_V	1.189	0.38
14_E	18_T	1.189	0.38
257_R	272_I	1.182	0.38
20_Q	126_D	1.181	0.38
122_V	180_I	1.174	0.38
57_A	60_E	1.171	0.38
191_K	212_T	1.165	0.37
261_E	282_R	1.160	0.37
150_F	227_I	1.158	0.37
152_Q	216_L	1.158	0.37
133_C	137_V	1.154	0.37
132_E	193_F	1.152	0.37
269_N	312_G	1.149	0.36
9_L	12_V	1.149	0.36
18_T	34_K	1.144	0.36
15_G	18_T	1.140	0.36
10_K	16_K	1.136	0.36
86_L	89_N	1.133	0.36
21_E	25_L	1.132	0.36
228_A	342_A	1.131	0.36
197_V	329_D	1.125	0.35
55_T	59_K	1.122	0.35
8_I	26_I	1.119	0.35
127_D	243_G	1.113	0.35
12_V	17_L	1.112	0.35
311_L	355_T	1.111	0.35
49_D	58_K	1.110	0.35
36_K	148_H	1.102	0.34
9_L	22_A	1.101	0.34
49_D	53_P	1.093	0.34
70_L	278_E	1.084	0.33
48_H	51_E	1.081	0.33
118_S	293_V	1.080	0.33
250_I	268_F	1.076	0.33
110_V	178_L	1.071	0.33
59_K	63_K	1.071	0.33
124_W	137_V	1.069	0.33
8_I	18_T	1.062	0.32
144_D	197_V	1.057	0.32
73_W	82_K	1.053	0.32
195_G	270_G	1.044	0.32
66_L	288_T	1.044	0.32
70_L	96_V	1.039	0.31
211_T	216_L	1.039	0.31
118_S	196_P	1.036	0.31
244_T	309_S	1.034	0.31
272_I	282_R	1.030	0.31
251_N	355_T	1.029	0.31
270_G	291_G	1.027	0.31
116_N	251_N	1.023	0.31
100_F	165_I	1.021	0.31
279_S	349_V	1.017	0.30
27_E	285_Y	1.013	0.30
8_I	12_V	1.013	0.30
154_I	339_S	1.012	0.30
99_I	132_E	1.012	0.30
109_S	162_K	1.008	0.30
173_K	229_E	1.004	0.30
16_K	143_Q	0.998	0.30
101_Q	128_D	0.989	0.29
226_A	361_K	0.988	0.29
224_E	243_G	0.986	0.29
150_F	210_K	0.980	0.29
275_N	293_V	0.977	0.29
78_V	114_I	0.976	0.29
129_I	272_I	0.970	0.28
11_L	14_E	0.968	0.28
119_V	247_A	0.968	0.28
303_V	337_F	0.968	0.28
18_T	295_L	0.966	0.28
134_Q	197_V	0.965	0.28
52_E	55_T	0.963	0.28
289_T	292_N	0.961	0.28
304_K	345_Q	0.961	0.28
253_L	271_N	0.961	0.28
154_I	165_I	0.955	0.28
156_C	165_I	0.950	0.28
51_E	54_F	0.949	0.28
61_S	360_L	0.947	0.27
238_A	267_S	0.946	0.27
67_G	212_T	0.945	0.27
216_L	232_N	0.944	0.27
73_W	156_C	0.942	0.27
69_K	211_T	0.941	0.27
77_A	81_V	0.939	0.27
28_K	31_S	0.938	0.27
307_L	351_S	0.930	0.27
194_N	249_T	0.924	0.26
106_D	161_N	0.924	0.26
121_I	188_I	0.917	0.26
112_L	260_S	0.912	0.26
239_S	349_V	0.910	0.26
8_I	17_L	0.907	0.26
183_K	226_A	0.906	0.26
27_E	358_I	0.905	0.26
265_V	342_A	0.896	0.25
282_R	293_V	0.895	0.25
49_D	59_K	0.894	0.25
124_W	326_E	0.891	0.25
318_L	355_T	0.890	0.25
233_G	356_G	0.890	0.25
239_S	295_L	0.889	0.25
9_L	16_K	0.886	0.25
17_L	70_L	0.884	0.25
18_T	313_T	0.882	0.25
270_G	356_G	0.878	0.25
112_L	267_S	0.878	0.25
24_T	353_S	0.875	0.25
67_G	71_F	0.872	0.24
12_V	16_K	0.871	0.24
234_Q	253_L	0.871	0.24
290_T	361_K	0.869	0.24
47_V	50_E	0.867	0.24
17_L	26_I	0.866	0.24
213_N	311_L	0.865	0.24
316_H	360_L	0.864	0.24
16_K	26_I	0.863	0.24
17_L	24_T	0.859	0.24
315_S	353_S	0.856	0.24
194_N	269_N	0.852	0.24
35_E	38_E	0.852	0.24
197_V	293_V	0.851	0.24
313_T	357_A	0.849	0.24
54_F	62_G	0.847	0.24
10_K	20_Q	0.845	0.23
33_Y	41_T	0.845	0.23
181_P	197_V	0.843	0.23
110_V	359_K	0.843	0.23
30_D	35_E	0.840	0.23
82_K	138_Y	0.839	0.23
98_H	326_E	0.839	0.23
195_G	293_V	0.839	0.23
204_V	337_F	0.837	0.23
191_K	262_S	0.833	0.23
133_C	290_T	0.830	0.23
104_D	127_D	0.828	0.23
253_L	339_S	0.825	0.23
322_E	358_I	0.824	0.23
47_V	52_E	0.822	0.23
350_F	358_I	0.822	0.23
12_V	28_K	0.821	0.23
194_N	216_L	0.821	0.23
115_A	191_K	0.819	0.22
87_D	230_T	0.815	0.22
112_L	345_Q	0.814	0.22
111_E	166_R	0.814	0.22
86_L	264_D	0.813	0.22
80_K	310_N	0.804	0.22
256_L	309_S	0.803	0.22
82_K	337_F	0.802	0.22
99_I	284_I	0.802	0.22
22_A	27_E	0.801	0.22
34_K	39_K	0.800	0.22
232_N	290_T	0.792	0.22
221_L	295_L	0.791	0.21
19_A	352_E	0.787	0.21
47_V	54_F	0.786	0.21
235_I	248_E	0.783	0.21
331_I	360_L	0.783	0.21
112_L	121_I	0.781	0.21
132_E	156_C	0.779	0.21
233_G	312_G	0.775	0.21
17_L	329_D	0.774	0.21
110_V	127_D	0.772	0.21
180_I	230_T	0.772	0.21
49_D	52_E	0.768	0.21
19_A	22_A	0.766	0.21
138_Y	308_K	0.764	0.21
197_V	204_V	0.762	0.20
52_E	59_K	0.761	0.20
294_E	315_S	0.759	0.20
30_D	295_L	0.759	0.20
30_D	37_E	0.754	0.20
9_L	17_L	0.753	0.20
148_H	343_H	0.748	0.20
170_K	355_T	0.747	0.20
167_T	216_L	0.746	0.20
200_E	295_L	0.745	0.20
248_E	311_L	0.743	0.20
18_T	26_I	0.743	0.20
259_K	278_E	0.743	0.20
124_W	200_E	0.741	0.20
106_D	254_I	0.741	0.20
179_Y	326_E	0.739	0.20
308_K	349_V	0.738	0.20
47_V	53_P	0.737	0.20
20_Q	25_L	0.736	0.20
269_N	311_L	0.735	0.20
286_A	351_S	0.731	0.19
64_P	149_A	0.729	0.19
220_Y	288_T	0.729	0.19
65_S	75_D	0.728	0.19
54_F	58_K	0.727	0.19
11_L	278_E	0.719	0.19
30_D	110_V	0.718	0.19
129_I	335_M	0.715	0.19
75_D	231_A	0.715	0.19
135_A	150_F	0.713	0.19
106_D	247_A	0.712	0.19
56_T	59_K	0.712	0.19
86_L	202_L	0.710	0.19
51_E	56_T	0.710	0.19
100_F	136_K	0.707	0.19
290_T	309_S	0.706	0.19
159_K	248_E	0.705	0.19
279_S	335_M	0.705	0.19
53_P	56_T	0.705	0.19
197_V	262_S	0.703	0.19
54_F	178_L	0.702	0.19
79_K	83_E	0.702	0.19
10_K	311_L	0.699	0.18
317_E	361_K	0.696	0.18
102_F	156_C	0.695	0.18
239_S	277_T	0.693	0.18
86_L	293_V	0.692	0.18
245_I	299_D	0.691	0.18
17_L	29_L	0.690	0.18
100_F	133_C	0.689	0.18
26_I	41_T	0.688	0.18
98_H	229_E	0.687	0.18
254_I	281_C	0.686	0.18
112_L	262_S	0.684	0.18
242_C	315_S	0.683	0.18
220_Y	243_G	0.682	0.18
194_N	290_T	0.681	0.18
101_Q	351_S	0.678	0.18
233_G	291_G	0.678	0.18
282_R	345_Q	0.678	0.18
10_K	19_A	0.677	0.18
242_C	324_L	0.675	0.18
12_V	80_K	0.674	0.18
48_H	57_A	0.673	0.18
307_L	335_M	0.673	0.18
34_K	37_E	0.673	0.18
117_G	213_N	0.672	0.18
75_D	237_L	0.671	0.18
204_V	315_S	0.668	0.18
73_W	150_F	0.667	0.17
206_E	244_T	0.666	0.17
188_I	202_L	0.664	0.17
8_I	27_E	0.662	0.17
9_L	13_E	0.661	0.17
323_M	327_K	0.660	0.17
211_T	251_N	0.658	0.17
150_F	164_F	0.658	0.17
32_D	39_K	0.653	0.17
211_T	232_N	0.653	0.17
57_A	61_S	0.652	0.17
128_D	150_F	0.651	0.17
50_E	57_A	0.650	0.17
35_E	190_V	0.650	0.17
18_T	121_I	0.650	0.17
83_E	155_E	0.649	0.17
148_H	174_T	0.648	0.17
115_A	263_I	0.645	0.17
116_N	267_S	0.643	0.17
36_K	39_K	0.638	0.17
162_K	177_T	0.636	0.17
76_S	247_A	0.636	0.17
213_N	216_L	0.635	0.17
293_V	356_G	0.635	0.17
33_Y	119_V	0.634	0.17
115_A	206_E	0.633	0.16
214_G	291_G	0.629	0.16
16_K	28_K	0.629	0.16
64_P	293_V	0.627	0.16
84_V	237_L	0.625	0.16
124_W	173_K	0.621	0.16
143_Q	278_E	0.621	0.16
193_F	212_T	0.619	0.16
326_E	332_Q	0.619	0.16
127_D	303_V	0.618	0.16
77_A	288_T	0.616	0.16
82_K	150_F	0.616	0.16
307_L	314_L	0.614	0.16
180_I	184_E	0.613	0.16
138_Y	327_K	0.612	0.16
269_N	355_T	0.610	0.16
76_S	332_Q	0.609	0.16
272_I	286_A	0.606	0.16
116_N	209_A	0.605	0.16
100_F	358_I	0.604	0.16
219_S	349_V	0.603	0.16
49_D	62_G	0.603	0.16
176_V	307_L	0.603	0.16
291_G	356_G	0.601	0.16
100_F	124_W	0.601	0.16
141_D	246_E	0.601	0.16
78_V	237_L	0.600	0.16
272_I	351_S	0.599	0.16
98_H	133_C	0.599	0.16
177_T	314_L	0.599	0.16
298_P	305_A	0.598	0.16
321_V	324_L	0.597	0.15
100_F	150_F	0.595	0.15
69_K	110_V	0.595	0.15
188_I	323_M	0.594	0.15
32_D	42_A	0.594	0.15
112_L	144_D	0.594	0.15
237_L	293_V	0.593	0.15
110_V	208_S	0.591	0.15
232_N	355_T	0.590	0.15
117_G	194_N	0.590	0.15
124_W	320_D	0.587	0.15
251_N	312_G	0.585	0.15
73_W	90_F	0.585	0.15
16_K	30_D	0.585	0.15
228_A	246_E	0.585	0.15
192_L	266_Q	0.583	0.15
119_V	176_V	0.582	0.15
256_L	274_I	0.582	0.15
31_S	36_K	0.582	0.15
111_E	250_I	0.581	0.15
9_L	146_A	0.581	0.15
251_N	318_L	0.576	0.15
248_E	266_Q	0.573	0.15
108_S	128_D	0.572	0.15
175_N	339_S	0.571	0.15
130_R	309_S	0.571	0.15
9_L	25_L	0.570	0.15
193_F	229_E	0.569	0.15
110_V	265_V	0.569	0.15
31_S	263_I	0.567	0.15
103_K	134_Q	0.566	0.15
294_E	360_L	0.566	0.15
249_T	318_L	0.564	0.15
77_A	85_D	0.564	0.15
122_V	295_L	0.563	0.15
113_Q	290_T	0.562	0.15
103_K	161_N	0.561	0.15
147_R	325_K	0.561	0.15
83_E	159_K	0.561	0.15
193_F	231_A	0.561	0.15
73_W	229_E	0.559	0.14
18_T	41_T	0.559	0.14
82_K	355_T	0.559	0.14
211_T	309_S	0.558	0.14
25_L	293_V	0.556	0.14
29_L	134_Q	0.555	0.14
139_R	316_H	0.555	0.14
89_N	96_V	0.555	0.14
226_A	242_C	0.553	0.14
20_Q	24_T	0.553	0.14
58_K	134_Q	0.552	0.14
197_V	218_F	0.552	0.14
137_V	173_K	0.551	0.14
190_V	237_L	0.550	0.14
232_N	312_G	0.548	0.14
194_N	355_T	0.547	0.14
102_F	191_K	0.547	0.14
9_L	20_Q	0.546	0.14
131_A	152_Q	0.546	0.14
9_L	29_L	0.545	0.14
107_F	353_S	0.544	0.14
154_I	294_E	0.544	0.14
80_K	91_G	0.543	0.14
62_G	190_V	0.542	0.14
125_E	128_D	0.540	0.14
128_D	229_E	0.539	0.14
116_N	232_N	0.538	0.14
35_E	47_V	0.538	0.14
110_V	351_S	0.536	0.14
68_A	293_V	0.535	0.14
156_C	326_E	0.534	0.14
163_F	298_P	0.533	0.14
227_I	248_E	0.533	0.14
195_G	214_G	0.533	0.14
294_E	314_L	0.532	0.14
173_K	351_S	0.531	0.14
190_V	211_T	0.525	0.14
55_T	58_K	0.524	0.14
216_L	247_A	0.524	0.14
118_S	289_T	0.523	0.14
113_Q	314_L	0.523	0.14
11_L	23_L	0.521	0.14
89_N	99_I	0.520	0.14
24_T	42_A	0.519	0.13
13_E	91_G	0.519	0.13
34_K	295_L	0.518	0.13
292_N	357_A	0.518	0.13
110_V	223_A	0.516	0.13
215_V	357_A	0.515	0.13
74_I	261_E	0.514	0.13
82_K	170_K	0.513	0.13
264_D	318_L	0.513	0.13
228_A	335_M	0.512	0.13
308_K	312_G	0.511	0.13
203_H	222_T	0.511	0.13
223_A	287_K	0.510	0.13
326_E	333_K	0.509	0.13
72_D	80_K	0.509	0.13
128_D	308_K	0.508	0.13
11_L	15_G	0.507	0.13
216_L	228_A	0.507	0.13
208_S	273_A	0.507	0.13
8_I	11_L	0.506	0.13
173_K	326_E	0.506	0.13
344_D	358_I	0.505	0.13
247_A	254_I	0.504	0.13
184_E	188_I	0.504	0.13
242_C	255_D	0.504	0.13
26_I	201_H	0.503	0.13
33_Y	182_Q	0.503	0.13
80_K	337_F	0.503	0.13
20_Q	201_H	0.503	0.13
23_L	28_K	0.502	0.13
194_N	311_L	0.502	0.13
139_R	273_A	0.501	0.13
290_T	327_K	0.500	0.13
309_S	332_Q	0.500	0.13
204_V	305_A	0.500	0.13
42_A	118_S	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3jx8A	4	0.6274	99.7	0.774	Contact Map
3lycA	2	0.6219	99.7	0.777	Contact Map
4opwA	1	0.6274	99.6	0.801	Contact Map
4yguA	3	0.4603	99.6	0.803	Contact Map
3petA	2	0.5589	99.4	0.818	Contact Map
4qrkA	1	0.5479	99	0.847	Contact Map
4kisA	2	0.2767	36.9	0.958	Contact Map
3hkzY	1	0.1096	21.9	0.962	Contact Map
2lseA	1	0.2575	15	0.965	Contact Map
3lhrA	2	0.0932	8.9	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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