GREMLIN Database
PHOT - Blue-light photoreceptor
UniProt: O34627 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 261 (243)
Sequences: 45658 (38508)
Seq/√Len: 2470.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_V124_N3.6341.00
164_G178_L3.0101.00
96_K100_T2.6751.00
28_V121_G2.5071.00
91_Q130_K2.4041.00
31_D36_D2.3391.00
45_G48_Q2.3221.00
26_G49_M2.2961.00
130_K133_E2.2911.00
93_Q103_W2.2631.00
20_L41_Y2.2341.00
142_E145_A2.1981.00
105_E124_N2.1621.00
89_T105_E2.1481.00
167_T171_F2.1351.00
26_G123_Q2.0711.00
168_E171_F2.0651.00
140_L143_I2.0651.00
161_P182_L2.0421.00
140_L144_T2.0401.00
95_Y101_M2.0391.00
129_Q133_E2.0311.00
213_H244_S2.0221.00
93_Q101_M2.0071.00
13_L17_K1.9981.00
12_Q15_V1.9581.00
96_K102_F1.8981.00
163_V174_I1.8851.00
42_V46_F1.8661.00
29_I118_Y1.8531.00
31_D38_P1.8491.00
52_Y97_K1.8451.00
105_E129_Q1.8431.00
47_V54_T1.8061.00
218_T248_Y1.7681.00
103_W130_K1.7621.00
161_P185_S1.7421.00
106_L123_Q1.7231.00
17_K21_D1.6711.00
135_L139_S1.6481.00
28_V46_F1.6461.00
92_I106_L1.6251.00
60_K64_F1.6241.00
188_D192_I1.6211.00
239_D242_F1.6071.00
40_V118_Y1.6051.00
23_V27_V1.5921.00
44_Q48_Q1.5801.00
179_T185_S1.5731.00
192_I195_S1.5461.00
137_E141_T1.5451.00
163_V177_T1.5391.00
42_V47_V1.5121.00
31_D35_E1.4841.00
113_I116_K1.4811.00
137_E140_L1.4741.00
131_E135_L1.4691.00
146_L150_I1.4631.00
38_P61_N1.4601.00
136_L139_S1.4561.00
31_D40_V1.4521.00
28_V39_I1.4511.00
136_L140_L1.4491.00
164_G179_T1.4471.00
21_D44_Q1.4431.00
29_I120_V1.4331.00
53_E56_E1.4301.00
238_L243_S1.4131.00
80_T84_N1.3891.00
147_S150_I1.3551.00
29_I41_Y1.3521.00
219_G223_I1.3501.00
133_E137_E1.3481.00
222_L255_V1.3441.00
67_G70_T1.3441.00
244_S248_Y1.3351.00
30_T121_G1.3321.00
221_E224_I1.3291.00
252_K256_K1.3271.00
139_S142_E1.3151.00
141_T144_T1.2961.00
152_P156_G1.2791.00
135_L138_D1.2701.00
14_E18_K1.2651.00
134_K137_E1.2591.00
91_Q105_E1.2351.00
242_F245_L1.2341.00
89_T107_N1.2281.00
16_I20_L1.2271.00
132_Y135_L1.2211.00
128_K131_E1.2151.00
165_N179_T1.2101.00
61_N64_F1.2091.00
189_Y241_N1.2061.00
240_A244_S1.1941.00
75_V79_R1.1841.00
15_V29_I1.1821.00
47_V53_E1.1631.00
41_Y54_T1.1611.00
215_L219_G1.1581.00
139_S143_I1.1471.00
217_L248_Y1.1341.00
185_S188_D1.1331.00
173_S177_T1.1181.00
130_K134_K1.1141.00
160_L182_L1.1121.00
15_V41_Y1.1081.00
134_K138_D1.1021.00
138_D142_E1.0971.00
10_P13_L1.0961.00
44_Q47_V1.0881.00
213_H240_A1.0861.00
218_T251_V1.0721.00
159_A181_I1.0721.00
46_F50_T1.0711.00
212_S215_L1.0691.00
79_R83_Q1.0631.00
108_I121_G1.0611.00
212_S231_L1.0601.00
161_P179_T1.0591.00
176_C180_N1.0581.00
177_T181_I1.0451.00
25_V122_I1.0441.00
167_T170_R1.0421.00
54_T58_L1.0411.00
215_L231_L1.0411.00
127_T131_E1.0311.00
162_L166_L1.0291.00
164_G175_V1.0261.00
104_N123_Q1.0261.00
70_T93_Q1.0251.00
146_L149_P1.0231.00
28_V123_Q1.0211.00
162_L165_N1.0181.00
52_Y56_E1.0151.00
63_R75_V1.0141.00
151_V155_N1.0071.00
214_L244_S1.0031.00
113_I117_T1.0021.00
11_G15_V1.0001.00
56_E97_K0.9991.00
10_P14_E0.9931.00
94_N104_N0.9891.00
42_V57_I0.9861.00
67_G101_M0.9861.00
217_L244_S0.9851.00
161_P165_N0.9771.00
73_A77_N0.9761.00
26_G46_F0.9571.00
177_T180_N0.9491.00
108_I119_F0.9461.00
168_E172_N0.9431.00
247_T251_V0.9371.00
131_E134_K0.9351.00
107_N124_N0.9261.00
159_A163_V0.9231.00
102_F125_D0.9211.00
111_M118_Y0.9191.00
152_P155_N0.9161.00
128_K132_Y0.9151.00
18_K22_H0.9121.00
44_Q54_T0.9121.00
109_D120_V0.9061.00
129_Q132_Y0.9061.00
112_E117_T0.9031.00
73_A76_D0.9001.00
216_K219_G0.8981.00
103_W127_T0.8891.00
138_D141_T0.8881.00
132_Y136_L0.8861.00
35_E117_T0.8861.00
29_I40_V0.8831.00
12_Q16_I0.8781.00
160_L178_L0.8741.00
16_I19_A0.8731.00
161_P188_D0.8681.00
191_I195_S0.8641.00
172_N176_C0.8561.00
154_R188_D0.8511.00
212_S216_K0.8491.00
200_V203_Q0.8451.00
170_R173_S0.8421.00
227_I255_V0.8411.00
164_G182_L0.8401.00
111_M120_V0.8371.00
30_T78_I0.8181.00
63_R71_D0.8141.00
181_I186_K0.8061.00
186_K244_S0.8051.00
13_L16_I0.8041.00
30_T39_I0.7901.00
74_E77_N0.7891.00
19_A120_V0.7871.00
171_F174_I0.7871.00
193_D242_F0.7861.00
76_D80_T0.7851.00
30_T119_F0.7851.00
158_S162_L0.7821.00
113_I118_Y0.7801.00
154_R192_I0.7781.00
77_N80_T0.7761.00
23_V122_I0.7741.00
210_K240_A0.7731.00
209_F237_K0.7721.00
50_T94_N0.7721.00
25_V45_G0.7711.00
169_E172_N0.7671.00
222_L227_I0.7631.00
153_I187_D0.7541.00
221_E252_K0.7491.00
217_L221_E0.7461.00
207_Q210_K0.7451.00
47_V57_I0.7431.00
50_T123_Q0.7361.00
66_Q71_D0.7341.00
81_A119_F0.7311.00
216_K220_T0.7311.00
186_K191_I0.7281.00
60_K65_L0.7271.00
159_A162_L0.7251.00
214_L251_V0.7221.00
30_T62_C0.7191.00
218_T221_E0.7181.00
77_N90_V0.7181.00
185_S189_Y0.7171.00
67_G93_Q0.7151.00
182_L188_D0.7101.00
189_Y193_D0.7101.00
29_I111_M0.7081.00
167_T172_N0.7041.00
191_I194_L0.7021.00
24_R45_G0.7011.00
70_T74_E0.6981.00
220_T223_I0.6961.00
110_P119_F0.6951.00
110_P117_T0.6951.00
72_P76_D0.6951.00
27_V122_I0.6901.00
46_F57_I0.6861.00
68_K71_D0.6841.00
176_C179_T0.6831.00
190_L195_S0.6811.00
94_N102_F0.6811.00
220_T224_I0.6791.00
213_H217_L0.6761.00
166_L174_I0.6751.00
215_L229_P0.6731.00
186_K193_D0.6651.00
225_T255_V0.6641.00
81_A84_N0.6641.00
211_L214_L0.6611.00
158_S161_P0.6611.00
20_L27_V0.6581.00
214_L218_T0.6581.00
188_D191_I0.6571.00
12_Q17_K0.6551.00
243_S247_T0.6551.00
218_T255_V0.6541.00
74_E92_I0.6541.00
155_N159_A0.6531.00
26_G45_G0.6501.00
153_I156_G0.6481.00
45_G49_M0.6461.00
242_F246_K0.6451.00
139_S144_T0.6441.00
171_F175_V0.6431.00
103_W126_I0.6421.00
214_L248_Y0.6411.00
163_V178_L0.6401.00
249_S252_K0.6381.00
31_D118_Y0.6361.00
156_G160_L0.6331.00
222_L226_G0.6321.00
228_K231_L0.6311.00
174_I177_T0.6301.00
241_N244_S0.6301.00
227_I231_L0.6291.00
17_K41_Y0.6281.00
66_Q70_T0.6221.00
140_L145_A0.6201.00
67_G95_Y0.6181.00
189_Y192_I0.6161.00
27_V120_V0.6121.00
211_L247_T0.6101.00
35_E38_P0.6091.00
18_K120_V0.6081.00
103_W134_K0.6051.00
30_T108_I0.6031.00
126_I130_K0.5951.00
92_I95_Y0.5941.00
51_G98_D0.5931.00
173_S176_C0.5931.00
214_L217_L0.5931.00
37_N79_R0.5921.00
106_L121_G0.5911.00
112_E116_K0.5901.00
72_P75_V0.5901.00
153_I157_I0.5891.00
70_T73_A0.5881.00
174_I178_L0.5861.00
37_N119_F0.5841.00
192_I196_G0.5821.00
218_T222_L0.5811.00
141_T145_A0.5781.00
71_D74_E0.5761.00
52_Y57_I0.5741.00
151_V156_G0.5741.00
30_T37_N0.5731.00
245_L248_Y0.5711.00
152_P249_S0.5701.00
136_L141_T0.5691.00
27_V43_N0.5661.00
211_L215_L0.5631.00
248_Y252_K0.5631.00
51_G96_K0.5601.00
135_L140_L0.5591.00
155_N162_L0.5571.00
42_V54_T0.5551.00
18_K109_D0.5551.00
26_G43_N0.5551.00
159_A177_T0.5521.00
222_L229_P0.5521.00
91_Q129_Q0.5521.00
126_I129_Q0.5521.00
22_H109_D0.5481.00
26_G104_N0.5471.00
175_V178_L0.5471.00
148_T152_P0.5471.00
245_L249_S0.5421.00
196_G242_F0.5411.00
81_A85_K0.5411.00
52_Y65_L0.5401.00
223_I226_G0.5391.00
213_H216_K0.5381.00
71_D75_V0.5381.00
24_R109_D0.5381.00
105_E126_I0.5381.00
149_P194_L0.5361.00
15_V19_A0.5361.00
212_S233_M0.5361.00
66_Q92_I0.5351.00
187_D191_I0.5321.00
170_R174_I0.5301.00
152_P190_L0.5281.00
42_V58_L0.5261.00
175_V179_T0.5241.00
78_I108_I0.5241.00
218_T252_K0.5211.00
102_F127_T0.5201.00
215_L221_E0.5181.00
163_V166_L0.5161.00
28_V106_L0.5151.00
43_N46_F0.5151.00
18_K21_D0.5141.00
49_M104_N0.5131.00
186_K194_L0.5121.00
38_P59_G0.5121.00
75_V78_I0.5111.00
152_P157_I0.5101.00
62_C121_G0.5071.00
14_E17_K0.5051.00
205_A242_F0.5031.00
180_N213_H0.5001.00
205_A238_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gczA 2 0.9885 100 0.282 Contact Map
3a0rA 2 0.9004 100 0.35 Contact Map
4i5sA 2 0.9157 100 0.373 Contact Map
4r3aA 1 0.8774 100 0.417 Contact Map
3rtyA 4 0.7471 99.9 0.542 Contact Map
3mr0A 1 0.4866 99.8 0.583 Contact Map
3gdiA 2 0.6054 99.8 0.59 Contact Map
3ue6A 5 0.5096 99.8 0.595 Contact Map
4lrzE 2 0.4483 99.8 0.6 Contact Map
4gw9A 2 0.4904 99.8 0.606 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.