GREMLIN Database
YEBE - UPF0316 protein YebE
UniProt: O34624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (165)
Sequences: 418 (302)
Seq/√Len: 23.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_N23_Y5.2331.00
47_T78_G3.6061.00
102_T155_D3.2321.00
143_Y146_Q3.0351.00
66_Q69_N2.9921.00
119_G171_G2.6950.99
121_T125_A2.6520.99
46_S77_Y2.5280.99
92_A141_R2.3250.97
100_V137_I2.3120.97
151_I158_A2.2630.97
39_R89_E2.2490.97
17_L79_L2.0980.95
26_F83_V2.0530.95
88_E141_R2.0410.95
100_V109_L2.0360.95
26_F45_I2.0330.94
53_Y57_L1.9660.93
24_V27_F1.9030.92
13_V72_A1.8280.91
36_K164_E1.7840.89
118_Y146_Q1.7780.89
88_E92_A1.7120.87
29_I91_L1.7010.87
28_T76_G1.7000.87
44_G48_I1.6670.86
51_L74_A1.6460.85
100_V151_I1.5960.83
82_I150_T1.5940.83
144_E162_A1.5890.83
31_M137_I1.5850.83
51_L60_V1.5820.83
27_F81_V1.5510.81
88_E94_G1.5450.81
54_V70_V1.5440.81
116_K150_T1.5150.80
43_A85_M1.5050.79
23_Y159_F1.4900.79
112_Q150_T1.4890.79
63_N72_A1.4880.79
152_K169_H1.4760.78
71_I75_L1.4500.77
114_R120_V1.4440.77
22_V52_V1.4440.77
24_V32_I1.4340.76
22_V32_I1.4180.75
24_V49_E1.4090.75
51_L55_T1.3870.74
52_V72_A1.3570.72
23_Y27_F1.3340.71
148_Y166_K1.3230.70
21_I25_S1.2950.68
31_M35_L1.2710.67
83_V150_T1.2590.66
46_S82_I1.2400.65
42_A159_F1.2400.65
114_R129_E1.2340.64
43_A82_I1.2280.64
23_Y56_G1.2140.63
32_I43_A1.1980.62
57_L132_R1.1930.62
81_V85_M1.1810.61
51_L67_I1.1410.58
36_K116_K1.1360.58
106_D169_H1.1310.57
102_T109_L1.1310.57
132_R170_G1.1290.57
52_V96_I1.1230.57
53_Y132_R1.1140.56
20_N25_S1.1130.56
96_I139_T1.0750.54
46_S81_V1.0640.53
121_T127_G1.0640.53
27_F31_M1.0510.52
105_L109_L1.0420.51
118_Y143_Y1.0340.51
19_I56_G1.0320.51
99_N136_Q1.0310.50
124_V133_T1.0220.50
90_K129_E1.0220.50
47_T50_I1.0100.49
108_D111_K1.0070.49
39_R97_M1.0010.48
57_L70_V0.9850.47
13_V70_V0.9710.46
86_K154_L0.9590.45
14_L18_I0.9590.45
82_I99_N0.9580.45
21_I83_V0.9550.45
27_F53_Y0.9510.45
102_T110_P0.9510.45
137_I147_L0.9480.45
115_E145_L0.9420.44
47_T51_L0.9380.44
86_K115_E0.9240.43
35_L66_Q0.9180.43
68_Q72_A0.9170.43
21_I24_V0.9160.42
47_T75_L0.9140.42
119_G159_F0.8980.41
62_D157_K0.8940.41
87_I122_N0.8930.41
96_I166_K0.8910.41
28_T53_Y0.8910.41
61_L87_I0.8790.40
54_V100_V0.8780.40
121_T130_G0.8760.40
107_L111_K0.8680.39
20_N47_T0.8570.38
114_R170_G0.8490.38
61_L64_L0.8460.38
16_I69_N0.8430.38
26_F129_E0.8370.37
70_V121_T0.8340.37
99_N132_R0.8300.37
36_K118_Y0.8290.37
89_E166_K0.8240.36
25_S61_L0.8160.36
26_F66_Q0.8090.35
19_I173_W0.8040.35
103_K140_P0.7960.34
114_R128_L0.7920.34
77_Y81_V0.7870.34
100_V146_Q0.7840.34
67_I103_K0.7830.34
34_T54_V0.7800.33
117_G120_V0.7700.33
61_L166_K0.7690.33
77_Y155_D0.7680.33
23_Y144_E0.7660.33
34_T51_L0.7650.33
132_R138_L0.7610.32
60_V141_R0.7550.32
149_D152_K0.7550.32
164_E168_I0.7540.32
35_L155_D0.7540.32
160_I163_Y0.7540.32
69_N72_A0.7430.31
30_R49_E0.7380.31
114_R135_L0.7370.31
94_G141_R0.7350.31
132_R163_Y0.7330.31
142_R162_A0.7320.31
20_N27_F0.7300.30
35_L135_L0.7220.30
36_K171_G0.7220.30
14_L108_D0.7170.30
23_Y79_L0.7100.29
79_L96_I0.7080.29
159_F164_E0.7060.29
33_L155_D0.7060.29
33_L87_I0.7050.29
40_Y68_Q0.7000.29
125_A141_R0.6980.29
101_I130_G0.6930.28
128_L151_I0.6930.28
13_V69_N0.6910.28
55_T58_S0.6860.28
41_L44_G0.6850.28
114_R137_I0.6760.27
40_Y67_I0.6730.27
125_A134_A0.6720.27
58_S66_Q0.6680.27
88_E93_L0.6660.27
93_L146_Q0.6650.27
23_Y47_T0.6620.27
25_S87_I0.6610.26
56_G163_Y0.6610.26
77_Y136_Q0.6590.26
164_E171_G0.6590.26
23_Y42_A0.6570.26
38_Q41_L0.6550.26
112_Q116_K0.6550.26
111_K115_E0.6550.26
29_I90_K0.6520.26
46_S142_R0.6460.26
19_I144_E0.6430.26
23_Y75_L0.6410.25
109_L112_Q0.6400.25
11_A55_T0.6380.25
103_K160_I0.6350.25
17_L48_I0.6340.25
46_S73_Y0.6310.25
82_I125_A0.6300.25
56_G106_D0.6300.25
123_W134_A0.6280.25
12_M152_K0.6240.25
54_V88_E0.6220.24
46_S57_L0.6140.24
23_Y57_L0.6080.24
75_L86_K0.6080.24
56_G161_I0.6050.24
114_R122_N0.6030.23
37_G100_V0.6000.23
53_Y70_V0.5940.23
99_N155_D0.5900.23
22_V116_K0.5850.23
12_M83_V0.5830.22
116_K146_Q0.5820.22
13_V142_R0.5780.22
16_I28_T0.5780.22
101_I134_A0.5770.22
48_I56_G0.5730.22
60_V88_E0.5730.22
48_I112_Q0.5730.22
82_I139_T0.5710.22
17_L74_A0.5690.22
138_L165_P0.5560.21
107_L153_T0.5550.21
71_I79_L0.5540.21
102_T135_L0.5530.21
62_D77_Y0.5440.21
37_G97_M0.5430.21
120_V165_P0.5410.20
101_I125_A0.5410.20
34_T169_H0.5390.20
98_V166_K0.5370.20
132_R160_I0.5360.20
107_L115_E0.5350.20
26_F167_T0.5340.20
139_T143_Y0.5320.20
58_S79_L0.5310.20
144_E159_F0.5300.20
54_V132_R0.5270.20
45_I54_V0.5260.20
37_G64_L0.5260.20
64_L151_I0.5230.20
45_I105_L0.5210.20
21_I55_T0.5210.20
91_L143_Y0.5190.19
25_S50_I0.5190.19
51_L111_K0.5180.19
32_I36_K0.5170.19
56_G77_Y0.5150.19
64_L67_I0.5150.19
34_T82_I0.5150.19
14_L118_Y0.5140.19
138_L168_I0.5140.19
33_L119_G0.5130.19
52_V107_L0.5120.19
44_G112_Q0.5100.19
39_R140_P0.5090.19
32_I93_L0.5070.19
112_Q157_K0.5070.19
20_N42_A0.5040.19
87_I100_V0.5020.19
114_R127_G0.5020.19
47_T113_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hluA 2 0.3804 99.6 0.764 Contact Map
2dclA 5 0.4674 88.7 0.925 Contact Map
4rleA 3 0.5163 75.7 0.936 Contact Map
4rwwA 3 0.4239 60.7 0.942 Contact Map
1o51A 3 0.3913 60.5 0.942 Contact Map
4usiA 3 0.4728 55.7 0.944 Contact Map
3m05A 3 0.4185 53.3 0.945 Contact Map
4affA 3 0.4565 53.2 0.945 Contact Map
4wk1A 3 0.4402 52 0.945 Contact Map
2gw8A 3 0.4348 49 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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