GREMLIN Database
YCDB - Uncharacterized protein YcdB
UniProt: O34621 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (446)
Sequences: 260 (224)
Seq/√Len: 10.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_G256_G3.7640.98
129_L132_S3.4880.97
210_V214_L3.1280.95
127_L415_P3.1030.95
460_I467_P3.0760.95
164_D168_A3.0450.94
462_A465_G2.9740.93
327_V332_C2.9180.93
91_F144_I2.8530.92
44_W398_Y2.8530.92
388_V395_I2.8070.91
351_F384_I2.7230.90
182_F436_W2.6880.89
88_M461_D2.6330.88
122_Q156_I2.5980.88
100_L468_V2.5830.87
23_P54_I2.5350.86
124_E156_I2.4820.85
23_P28_L2.4310.84
339_F395_I2.4250.84
211_P215_V2.3990.83
138_V370_F2.3790.82
386_I461_D2.3760.82
26_L54_I2.3670.82
51_N64_L2.3650.82
180_L462_A2.3560.82
40_A60_P2.3520.82
177_E419_V2.3510.82
332_C366_A2.2800.79
12_L40_A2.2470.78
61_D144_I2.1870.76
261_R388_V2.1690.76
92_V376_G2.1650.76
64_L450_L2.1220.74
172_I386_I2.1000.73
163_A168_A2.0970.73
452_Y465_G2.0880.73
452_Y462_A2.0670.72
122_Q151_G2.0520.72
332_C436_W2.0500.71
12_L58_L2.0440.71
61_D84_L2.0250.71
91_F138_V2.0180.70
23_P26_L2.0060.70
170_A216_Q1.9870.69
180_L199_L1.9790.69
82_E305_Y1.9630.68
172_I210_V1.9450.67
167_E170_A1.8940.65
12_L60_P1.8870.65
435_G453_K1.8800.65
16_A20_G1.8760.64
31_E340_L1.8580.64
44_W54_I1.8310.62
436_W448_Y1.8250.62
106_E121_V1.8240.62
306_N311_K1.8130.62
47_P92_V1.8090.61
241_I244_K1.7980.61
11_G340_L1.7950.61
15_K18_E1.7920.61
20_G64_L1.7880.60
76_G83_K1.7730.60
21_R24_T1.7670.59
12_L307_K1.7640.59
256_G261_R1.7620.59
328_T331_E1.7380.58
388_V461_D1.7270.58
339_F388_V1.7260.58
12_L31_E1.7220.57
145_V294_K1.6860.56
178_F426_F1.6860.56
247_P250_M1.6720.55
122_Q129_L1.6620.55
425_I428_Q1.6520.54
351_F382_G1.6500.54
434_L450_L1.6370.53
11_G118_F1.6360.53
330_A420_E1.6210.53
199_L462_A1.6150.52
289_M340_L1.6030.52
144_I335_I1.5990.52
337_L370_F1.5980.52
450_L465_G1.5970.52
125_A214_L1.5910.51
21_R28_L1.5840.51
40_A84_L1.5630.50
144_I466_E1.5600.50
199_L393_G1.5510.49
338_R420_E1.5490.49
434_L452_Y1.5460.49
64_L91_F1.5440.49
90_Q94_T1.5360.49
163_A417_I1.5350.49
212_A436_W1.5220.48
57_E259_K1.5190.48
120_Y262_E1.5140.48
14_Q210_V1.5130.48
16_A42_F1.5100.47
183_E418_S1.5090.47
150_Y388_V1.4960.47
16_A56_V1.4930.47
161_R213_D1.4910.47
64_L180_L1.4730.46
382_G402_D1.4730.46
247_P252_G1.4620.45
168_A210_V1.4530.45
16_A58_L1.4440.44
92_V207_A1.4420.44
44_W118_F1.4240.43
203_P426_F1.4240.43
182_F212_A1.4200.43
129_L156_I1.4150.43
158_K436_W1.4140.43
67_L421_Q1.4100.43
17_L24_T1.4010.42
40_A307_K1.3930.42
125_A436_W1.3910.42
156_I392_T1.3860.42
199_L309_T1.3840.42
423_K431_K1.3830.42
144_I368_F1.3790.41
328_T393_G1.3730.41
59_G62_G1.3670.41
309_T433_E1.3620.41
170_A174_K1.3620.41
366_A390_R1.3400.40
147_F151_G1.3240.39
329_L366_A1.3210.39
203_P460_I1.3170.39
331_E383_Q1.3130.38
214_L305_Y1.3110.38
128_P434_L1.3040.38
422_A462_A1.3000.38
84_L210_V1.2990.38
303_T384_I1.2970.38
58_L307_K1.2930.38
67_L307_K1.2930.38
12_L15_K1.2860.37
310_G465_G1.2860.37
13_K17_L1.2740.37
44_W411_I1.2710.37
58_L64_L1.2680.36
177_E210_V1.2660.36
192_N464_T1.2580.36
259_K429_H1.2560.36
120_Y127_L1.2520.36
336_A452_Y1.2480.36
95_H436_W1.2480.36
250_M256_G1.2420.35
315_V331_E1.2400.35
251_I426_F1.2380.35
231_E255_N1.2370.35
393_G422_A1.2370.35
395_I424_S1.2370.35
138_V144_I1.2260.35
120_Y421_Q1.2260.35
116_V176_V1.2240.35
80_S338_R1.2240.35
331_E334_K1.2230.34
15_K25_H1.2220.34
118_F199_L1.2200.34
83_K101_S1.2200.34
83_K86_D1.2080.34
120_Y289_M1.2010.34
44_W417_I1.1960.33
393_G462_A1.1930.33
65_E463_H1.1850.33
121_V259_K1.1810.33
434_L464_T1.1740.32
208_I451_V1.1740.32
63_E397_V1.1660.32
391_Q395_I1.1650.32
124_E353_I1.1620.32
128_P451_V1.1590.32
156_I344_F1.1520.32
67_L432_V1.1460.31
17_L29_E1.1440.31
388_V434_L1.1400.31
125_A215_V1.1370.31
156_I368_F1.1370.31
116_V372_A1.1340.31
373_H376_G1.1310.31
12_L16_A1.1300.31
112_Y303_T1.1270.31
125_A248_D1.1260.30
417_I432_V1.1250.30
386_I468_V1.1250.30
378_P434_L1.1250.30
122_Q132_S1.1190.30
210_V280_P1.1170.30
33_Y340_L1.0960.29
309_T449_R1.0940.29
23_P44_W1.0930.29
171_F210_V1.0870.29
190_Y200_V1.0850.29
201_Y465_G1.0840.29
450_L462_A1.0830.29
127_L151_G1.0800.29
144_I431_K1.0790.29
323_G460_I1.0770.29
211_P214_L1.0770.29
136_A442_D1.0750.28
411_I436_W1.0730.28
73_P76_G1.0710.28
10_E172_I1.0640.28
64_L133_G1.0630.28
139_S196_Q1.0600.28
22_V453_K1.0590.28
413_P416_A1.0580.28
127_L436_W1.0560.28
61_D375_H1.0560.28
381_F384_I1.0510.28
289_M307_K1.0450.27
170_A193_G1.0410.27
139_S211_P1.0360.27
447_S466_E1.0310.27
64_L235_L1.0270.27
376_G393_G1.0260.27
386_I420_E1.0240.27
345_P448_Y1.0220.26
211_P449_R1.0210.26
235_L399_M1.0130.26
86_D166_E1.0090.26
379_L382_G1.0060.26
298_H315_V1.0060.26
306_N386_I1.0050.26
461_D465_G1.0040.26
254_E314_G1.0020.26
180_L450_L1.0010.26
114_D377_V1.0010.26
422_A450_L0.9970.26
426_F454_P0.9960.26
258_V320_E0.9880.25
57_E231_E0.9870.25
20_G67_L0.9860.25
195_D335_I0.9850.25
84_L436_W0.9830.25
58_L368_F0.9810.25
422_A452_Y0.9780.25
83_K261_R0.9780.25
157_I436_W0.9780.25
68_S144_I0.9770.25
172_I340_L0.9740.25
214_L420_E0.9740.25
173_K179_D0.9730.25
180_L315_V0.9710.25
126_G328_T0.9700.25
253_I257_F0.9680.25
20_G178_F0.9640.24
84_L118_F0.9620.24
147_F287_K0.9590.24
182_F410_T0.9570.24
345_P384_I0.9550.24
56_V116_V0.9550.24
327_V331_E0.9550.24
256_G259_K0.9520.24
22_V42_F0.9510.24
81_E118_F0.9500.24
49_D312_L0.9470.24
28_L64_L0.9440.24
289_M303_T0.9430.24
55_I136_A0.9420.24
65_E368_F0.9400.24
343_L347_A0.9380.24
372_A378_P0.9320.23
130_P448_Y0.9280.23
51_N395_I0.9260.23
327_V335_I0.9240.23
92_V324_P0.9230.23
85_E107_E0.9230.23
66_S141_S0.9230.23
263_A379_L0.9200.23
368_F464_T0.9160.23
53_G394_Y0.9120.23
214_L304_I0.9110.23
40_A129_L0.9100.23
33_Y426_F0.9080.23
42_F54_I0.9000.22
21_R301_L0.8980.22
42_F311_K0.8980.22
16_A296_R0.8950.22
39_R65_E0.8950.22
328_T417_I0.8900.22
91_F368_F0.8870.22
83_K310_G0.8870.22
335_I432_V0.8860.22
306_N389_S0.8850.22
303_T346_N0.8840.22
310_G462_A0.8820.22
109_D136_A0.8810.22
120_Y340_L0.8790.22
42_F332_C0.8780.22
22_V44_W0.8740.21
203_P309_T0.8730.21
339_F344_F0.8720.21
289_M295_G0.8710.21
24_T293_F0.8710.21
327_V423_K0.8700.21
168_A172_I0.8660.21
169_L424_S0.8640.21
260_E309_T0.8630.21
201_Y452_Y0.8620.21
129_L266_G0.8600.21
132_S182_F0.8600.21
341_F457_P0.8590.21
174_K387_C0.8580.21
97_P127_L0.8560.21
76_G328_T0.8550.21
136_A152_E0.8540.21
417_I466_E0.8530.21
96_H384_I0.8510.21
73_P86_D0.8500.21
11_G172_I0.8500.21
195_D395_I0.8480.21
57_E211_P0.8470.21
296_R429_H0.8440.20
55_I58_L0.8440.20
12_L151_G0.8440.20
25_H328_T0.8420.20
40_A44_W0.8390.20
69_R351_F0.8390.20
122_Q436_W0.8380.20
26_L95_H0.8340.20
179_D466_E0.8340.20
335_I439_E0.8330.20
290_D466_E0.8310.20
36_D210_V0.8300.20
14_Q313_E0.8280.20
64_L303_T0.8220.20
132_S436_W0.8180.20
386_I435_G0.8180.20
237_L255_N0.8170.20
432_V456_Y0.8170.20
312_L427_W0.8160.20
172_I389_S0.8150.20
92_V379_L0.8140.20
48_Q171_F0.8110.19
136_A169_L0.8100.19
197_P260_E0.8070.19
124_E345_P0.8060.19
91_F147_F0.8050.19
121_V371_E0.8030.19
169_L431_K0.8020.19
23_P128_P0.7970.19
136_A338_R0.7960.19
32_D87_I0.7960.19
203_P368_F0.7950.19
97_P305_Y0.7930.19
74_E113_G0.7900.19
126_G389_S0.7880.19
452_Y461_D0.7870.19
42_F366_A0.7860.19
125_A341_F0.7850.19
421_Q424_S0.7850.19
138_V412_D0.7840.19
82_E93_E0.7820.19
89_R314_G0.7800.19
86_D276_N0.7780.19
128_P163_A0.7770.18
157_I448_Y0.7770.18
271_G309_T0.7760.18
200_V398_Y0.7740.18
168_A307_K0.7740.18
368_F465_G0.7710.18
122_Q411_I0.7710.18
87_I134_F0.7710.18
260_E460_I0.7700.18
203_P393_G0.7700.18
388_V409_A0.7690.18
134_F332_C0.7690.18
121_V133_G0.7680.18
90_Q96_H0.7660.18
88_M182_F0.7650.18
40_A132_S0.7640.18
170_A266_G0.7640.18
321_K424_S0.7640.18
75_S377_V0.7640.18
385_R413_P0.7630.18
25_H288_S0.7630.18
156_I436_W0.7620.18
120_Y216_Q0.7610.18
122_Q182_F0.7580.18
68_S174_K0.7570.18
234_P398_Y0.7560.18
163_A439_E0.7550.18
298_H340_L0.7530.18
305_Y387_C0.7500.18
108_N136_A0.7470.18
340_L396_T0.7450.18
202_E309_T0.7450.18
62_G65_E0.7440.18
107_E216_Q0.7440.18
323_G401_P0.7390.17
102_A124_E0.7370.17
155_S170_A0.7350.17
137_D271_G0.7350.17
107_E167_E0.7350.17
118_F448_Y0.7340.17
94_T305_Y0.7340.17
284_P420_E0.7330.17
92_V409_A0.7320.17
25_H252_G0.7290.17
335_I388_V0.7280.17
246_D312_L0.7260.17
336_A370_F0.7260.17
419_V423_K0.7260.17
17_L86_D0.7240.17
178_F368_F0.7240.17
256_G260_E0.7210.17
182_F389_S0.7210.17
262_E406_N0.7200.17
312_L460_I0.7190.17
84_L211_P0.7190.17
332_C368_F0.7190.17
138_V323_G0.7180.17
260_E421_Q0.7170.17
386_I418_S0.7150.17
156_I346_N0.7150.17
46_D49_D0.7150.17
30_I40_A0.7150.17
55_I420_E0.7140.17
17_L196_Q0.7130.17
42_F363_N0.7120.17
84_L215_V0.7100.17
291_S307_K0.7090.17
275_R291_S0.7090.17
398_Y432_V0.7090.17
60_P118_F0.7080.17
336_A434_L0.7050.17
293_F351_F0.7050.17
278_D315_V0.7050.17
97_P343_L0.7040.16
90_Q251_I0.7030.16
214_L254_E0.7020.16
59_G65_E0.7020.16
72_E165_V0.7010.16
64_L307_K0.6990.16
182_F411_I0.6980.16
361_E395_I0.6950.16
80_S328_T0.6920.16
424_S449_R0.6910.16
168_A217_E0.6900.16
22_V65_E0.6890.16
48_Q334_K0.6890.16
434_L465_G0.6870.16
91_F393_G0.6860.16
331_E397_V0.6860.16
376_G451_V0.6840.16
108_N118_F0.6810.16
42_F302_K0.6800.16
21_R293_F0.6770.16
13_K20_G0.6770.16
373_H398_Y0.6750.16
42_F418_S0.6730.16
244_K321_K0.6720.16
51_N352_R0.6710.16
80_S83_K0.6710.16
159_P408_L0.6700.16
79_L389_S0.6700.16
120_Y169_L0.6670.16
127_L182_F0.6650.16
44_W56_V0.6640.15
130_P306_N0.6640.15
58_L338_R0.6630.15
389_S436_W0.6610.15
27_K318_F0.6580.15
199_L310_G0.6570.15
336_A379_L0.6550.15
133_G388_V0.6540.15
163_A414_V0.6540.15
19_I23_P0.6540.15
67_L400_G0.6530.15
90_Q266_G0.6500.15
158_K210_V0.6500.15
64_L70_D0.6490.15
129_L373_H0.6470.15
120_Y301_L0.6460.15
178_F203_P0.6460.15
40_A332_C0.6460.15
280_P397_V0.6450.15
121_V426_F0.6430.15
144_I303_T0.6420.15
126_G418_S0.6410.15
252_G436_W0.6390.15
95_H156_I0.6380.15
23_P52_T0.6380.15
73_P442_D0.6360.15
305_Y348_D0.6340.15
221_V413_P0.6340.15
434_L462_A0.6330.15
133_G359_D0.6320.15
214_L311_K0.6320.15
375_H446_H0.6300.15
212_A336_A0.6300.15
367_G387_C0.6300.15
90_Q460_I0.6260.15
156_I168_A0.6250.15
85_E427_W0.6250.15
211_P436_W0.6240.15
156_I182_F0.6230.14
212_A451_V0.6230.14
29_E32_D0.6200.14
199_L376_G0.6180.14
87_I224_D0.6180.14
264_D267_D0.6150.14
70_D315_V0.6150.14
116_V138_V0.6150.14
426_F437_E0.6150.14
378_P460_I0.6150.14
309_T398_Y0.6130.14
98_G101_S0.6130.14
180_L393_G0.6120.14
56_V201_Y0.6110.14
377_V461_D0.6100.14
139_S461_D0.6100.14
334_K433_E0.6100.14
59_G211_P0.6090.14
163_A364_A0.6070.14
58_L303_T0.6050.14
30_I302_K0.6040.14
74_E438_R0.6040.14
87_I293_F0.6040.14
194_D334_K0.6020.14
13_K16_A0.6010.14
109_D417_I0.5990.14
157_I389_S0.5980.14
127_L256_G0.5980.14
244_K442_D0.5980.14
60_P144_I0.5960.14
68_S288_S0.5960.14
92_V205_G0.5950.14
102_A116_V0.5940.14
125_A158_K0.5940.14
146_Y379_L0.5930.14
302_K318_F0.5930.14
54_I410_T0.5920.14
201_Y336_A0.5880.14
229_E265_L0.5880.14
98_G395_I0.5870.14
66_S372_A0.5860.14
315_V333_E0.5860.14
167_E433_E0.5860.14
134_F366_A0.5850.14
65_E144_I0.5830.14
74_E446_H0.5830.14
314_G334_K0.5830.14
31_E40_A0.5810.14
311_K355_Y0.5810.14
386_I456_Y0.5800.14
142_G370_F0.5800.14
69_R413_P0.5790.13
23_P133_G0.5780.13
337_L344_F0.5770.13
302_K433_E0.5770.13
323_G424_S0.5750.13
167_E227_Y0.5740.13
142_G201_Y0.5740.13
38_K175_D0.5730.13
137_D421_Q0.5720.13
133_G460_I0.5710.13
131_M351_F0.5710.13
123_M356_D0.5710.13
256_G395_I0.5700.13
157_I211_P0.5690.13
95_H340_L0.5690.13
345_P381_F0.5670.13
264_D376_G0.5660.13
295_G432_V0.5650.13
35_G55_I0.5650.13
305_Y421_Q0.5640.13
295_G386_I0.5640.13
439_E448_Y0.5640.13
116_V421_Q0.5640.13
178_F467_P0.5630.13
22_V54_I0.5620.13
372_A395_I0.5610.13
285_A309_T0.5600.13
167_E451_V0.5600.13
320_E443_D0.5600.13
428_Q449_R0.5590.13
257_F261_R0.5590.13
324_P426_F0.5570.13
331_E385_R0.5570.13
61_D328_T0.5560.13
114_D162_V0.5540.13
162_V345_P0.5540.13
127_L324_P0.5540.13
59_G144_I0.5510.13
398_Y402_D0.5510.13
79_L305_Y0.5510.13
69_R377_V0.5510.13
19_I85_E0.5500.13
116_V310_G0.5500.13
27_K386_I0.5490.13
435_G439_E0.5490.13
101_S136_A0.5480.13
126_G314_G0.5480.13
170_A428_Q0.5470.13
167_E359_D0.5470.13
165_V460_I0.5470.13
323_G327_V0.5460.13
105_R421_Q0.5450.13
36_D304_I0.5450.13
85_E308_E0.5450.13
410_T436_W0.5450.13
277_P307_K0.5450.13
69_R143_E0.5440.13
254_E302_K0.5430.13
54_I303_T0.5420.13
345_P382_G0.5420.13
60_P100_L0.5420.13
298_H302_K0.5420.13
340_L382_G0.5390.13
138_V273_V0.5360.13
101_S172_I0.5350.13
122_Q260_E0.5350.13
37_D191_K0.5350.13
211_P255_N0.5350.13
158_K392_T0.5350.13
77_E416_A0.5340.13
131_M166_E0.5330.13
158_K401_P0.5330.13
234_P421_Q0.5330.13
120_Y134_F0.5330.13
153_A264_D0.5330.13
257_F460_I0.5320.12
85_E169_L0.5310.12
155_S288_S0.5310.12
56_V163_A0.5290.12
69_R260_E0.5270.12
62_G336_A0.5270.12
246_D388_V0.5270.12
60_P371_E0.5260.12
137_D395_I0.5250.12
11_G387_C0.5240.12
20_G303_T0.5230.12
350_Y436_W0.5220.12
92_V468_V0.5220.12
157_I348_D0.5220.12
315_V351_F0.5210.12
79_L118_F0.5200.12
133_G350_Y0.5200.12
193_G235_L0.5170.12
18_E38_K0.5150.12
60_P222_D0.5150.12
92_V386_I0.5150.12
193_G216_Q0.5140.12
173_K344_F0.5130.12
115_K126_G0.5120.12
56_V80_S0.5120.12
56_V208_I0.5120.12
197_P426_F0.5120.12
56_V65_E0.5100.12
85_E105_R0.5100.12
65_E135_M0.5100.12
260_E467_P0.5090.12
422_A465_G0.5090.12
310_G387_C0.5090.12
120_Y283_Q0.5060.12
355_Y398_Y0.5060.12
169_L356_D0.5060.12
19_I423_K0.5050.12
120_Y335_I0.5040.12
335_I342_A0.5040.12
136_A191_K0.5030.12
14_Q24_T0.5020.12
44_W200_V0.5020.12
169_L210_V0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k90B 1 0.3347 99.7 0.832 Contact Map
3nqzA 1 0.3136 99.6 0.852 Contact Map
4exrA 2 0.2775 98.4 0.909 Contact Map
2o3oA 2 0.4153 98.3 0.913 Contact Map
2fgtA 1 0.3602 97.5 0.927 Contact Map
3db7A 2 0.2564 86.8 0.955 Contact Map
2gu3A 1 0.1441 77.6 0.96 Contact Map
4dsdA 1 0.2542 76.6 0.96 Contact Map
3u1wA 3 0.3898 76.5 0.96 Contact Map
4qoaA 2 0.2585 74.7 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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