GREMLIN Database
YTNA - Uncharacterized amino acid permease YtnA
UniProt: O34618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (421)
Sequences: 24752 (15866)
Seq/√Len: 773.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_T340_A4.4631.00
322_A334_K4.4161.00
382_K386_S3.4341.00
374_A410_L3.3051.00
53_G245_L3.2971.00
325_Q334_K3.1551.00
231_K235_K3.1281.00
13_E227_K2.9061.00
77_S316_Q2.8081.00
226_V232_S2.8061.00
93_G313_L2.6941.00
314_A324_G2.6861.00
18_S239_T2.6341.00
228_N231_K2.6101.00
327_T333_G2.5951.00
129_L344_L2.5871.00
282_S286_I2.5151.00
322_A325_Q2.5051.00
14_E239_T2.4051.00
224_G315_E2.3771.00
377_L409_S2.3551.00
168_G254_V2.3351.00
65_E384_R2.2901.00
337_L341_G2.2431.00
81_R89_G2.2151.00
225_E308_R2.2041.00
311_F315_E2.1941.00
137_G141_L2.1791.00
133_V344_L2.1611.00
436_W440_L2.1561.00
166_A170_L2.1511.00
17_I226_V2.1131.00
14_E232_S2.1091.00
136_T336_V2.1041.00
273_L276_Q2.0871.00
140_F333_G2.0661.00
144_K148_E2.0461.00
14_E18_S2.0461.00
235_K239_T2.0361.00
37_A45_I2.0221.00
442_A446_G2.0221.00
407_Y411_A2.0211.00
18_S243_R2.0191.00
128_A347_V2.0001.00
84_L382_K1.9971.00
155_L159_V1.9871.00
13_E16_H1.9751.00
323_Y338_A1.9671.00
263_E277_K1.9551.00
129_L347_V1.9511.00
97_W339_S1.9481.00
317_K321_Q1.9451.00
62_A377_L1.9361.00
81_R86_P1.9351.00
8_L326_L1.9091.00
84_L378_L1.8891.00
260_P263_E1.8861.00
122_V125_W1.8731.00
378_L410_L1.8721.00
54_L58_F1.8711.00
327_T331_I1.8231.00
411_A415_F1.8171.00
85_G88_A1.8081.00
133_V340_A1.7991.00
404_F408_V1.7791.00
228_N232_S1.7671.00
273_L277_K1.7421.00
391_E395_L1.7421.00
238_D242_W1.7361.00
80_A92_T1.7201.00
16_H151_F1.7141.00
139_N300_N1.7141.00
12_L16_H1.7081.00
132_L343_L1.7011.00
21_S240_V1.7011.00
140_F337_L1.6961.00
55_V412_F1.6901.00
92_T375_I1.6861.00
94_W440_L1.6811.00
159_V163_S1.6671.00
48_A205_S1.6531.00
104_C343_L1.6501.00
329_G333_G1.6461.00
44_G202_V1.6461.00
108_I299_C1.6381.00
434_P438_L1.6261.00
382_K385_K1.6161.00
115_M127_W1.5621.00
276_Q284_A1.5511.00
84_L88_A1.5501.00
242_W246_I1.5201.00
58_F408_V1.5051.00
311_F326_L1.4961.00
222_T304_F1.4951.00
310_L335_A1.4911.00
228_N235_K1.4841.00
141_L329_G1.4811.00
60_M241_F1.4791.00
52_S209_V1.4731.00
334_K338_A1.4711.00
129_L133_V1.4541.00
306_T339_S1.4351.00
160_A290_V1.4351.00
9_H330_G1.4151.00
378_L382_K1.4151.00
54_L408_V1.4091.00
321_Q324_G1.4071.00
80_A375_I1.4061.00
44_G195_F1.4051.00
229_P234_A1.4041.00
321_Q325_Q1.3981.00
132_L340_A1.3931.00
8_L311_F1.3881.00
108_I132_L1.3871.00
136_T337_L1.3871.00
325_Q333_G1.3851.00
307_G336_V1.3781.00
73_A224_G1.3751.00
16_H147_G1.3681.00
285_G289_F1.3601.00
158_I162_L1.3551.00
267_Q273_L1.3361.00
169_L254_V1.3331.00
12_L17_I1.3321.00
164_M168_G1.3291.00
276_Q281_P1.3251.00
60_M237_I1.3191.00
70_K82_D1.3181.00
59_I377_L1.3061.00
170_L175_G1.3001.00
441_L445_Y1.3001.00
246_I250_G1.2991.00
72_V78_R1.2921.00
415_F419_L1.2851.00
111_V292_L1.2841.00
83_Y379_S1.2841.00
401_L405_T1.2831.00
46_L253_F1.2781.00
78_R82_D1.2751.00
269_S273_L1.2751.00
381_I407_Y1.2741.00
69_Q395_L1.2721.00
111_V131_A1.2671.00
61_R238_D1.2641.00
435_I439_I1.2571.00
135_M299_C1.2551.00
446_G449_F1.2521.00
25_A244_I1.2521.00
15_R19_L1.2471.00
12_L147_G1.2411.00
232_S235_K1.2381.00
107_E298_S1.2361.00
431_I435_I1.2291.00
62_A406_S1.2281.00
443_V447_K1.2231.00
14_E235_K1.2211.00
172_I257_S1.2191.00
97_W310_L1.2151.00
72_V82_D1.2121.00
173_I176_V1.2051.00
87_L447_K1.2051.00
227_K232_S1.1951.00
374_A414_A1.1931.00
392_K395_L1.1911.00
310_L319_A1.1851.00
138_V149_L1.1821.00
17_I236_A1.1801.00
385_K403_P1.1751.00
445_Y449_F1.1641.00
32_L110_A1.1621.00
21_S219_I1.1571.00
443_V446_G1.1391.00
165_I250_G1.1381.00
149_L153_F1.1361.00
63_L76_F1.1301.00
20_M222_T1.1271.00
169_L173_I1.1261.00
126_I130_S1.1191.00
402_F406_S1.1191.00
77_S312_N1.1161.00
22_L243_R1.1111.00
150_E300_N1.1071.00
11_G227_K1.0941.00
404_F407_Y1.0921.00
315_E324_G1.0921.00
326_L330_G1.0881.00
82_D387_L1.0871.00
401_L404_F1.0821.00
403_P407_Y1.0781.00
67_A79_Y1.0741.00
380_Q406_S1.0731.00
410_L414_A1.0721.00
393_K396_K1.0691.00
168_G258_I1.0641.00
334_K337_L1.0641.00
148_E152_W1.0631.00
163_S167_V1.0631.00
143_V304_F1.0611.00
90_Y94_W1.0571.00
130_S134_I1.0511.00
112_G127_W1.0511.00
203_L415_F1.0451.00
387_L392_K1.0391.00
50_A249_V1.0371.00
65_E68_I1.0341.00
69_Q393_K1.0321.00
414_A418_I1.0221.00
440_L444_Y1.0191.00
341_G345_V1.0181.00
430_V433_G1.0141.00
438_L442_A1.0101.00
377_L410_L1.0091.00
136_T140_F1.0071.00
435_I438_L1.0071.00
58_F405_T1.0061.00
140_F331_I1.0001.00
192_G196_P0.9961.00
374_A413_L0.9881.00
174_A177_G0.9771.00
170_L174_A0.9741.00
429_A433_G0.9691.00
133_V137_G0.9681.00
22_L244_I0.9671.00
394_Q398_K0.9661.00
134_I296_L0.9661.00
140_F327_T0.9611.00
158_I247_F0.9591.00
418_I422_Y0.9571.00
121_D124_N0.9521.00
80_A88_A0.9491.00
223_A233_L0.9471.00
170_L173_I0.9441.00
162_L166_A0.9411.00
217_E221_V0.9401.00
74_G77_S0.9401.00
239_T243_R0.9401.00
19_L151_F0.9391.00
115_M292_L0.9391.00
135_M300_N0.9381.00
214_L369_A0.9301.00
68_I396_K0.9281.00
436_W443_V0.9251.00
327_T330_G0.9231.00
281_P285_G0.9191.00
121_D125_W0.9161.00
198_G201_G0.9151.00
279_G283_A0.9121.00
53_G213_Y0.9111.00
46_L256_M0.9071.00
153_F297_S0.9071.00
195_F202_V0.9071.00
172_I176_V0.9061.00
409_S413_L0.9011.00
391_E394_Q0.9011.00
323_Y334_K0.8971.00
440_L443_V0.8971.00
81_R316_Q0.8971.00
415_F418_I0.8951.00
431_I434_P0.8931.00
245_L249_V0.8931.00
38_I45_I0.8921.00
157_K294_A0.8901.00
428_V432_I0.8891.00
439_I443_V0.8861.00
172_I175_G0.8861.00
333_G337_L0.8841.00
112_G128_A0.8811.00
260_P277_K0.8801.00
267_Q270_P0.8781.00
66_M380_Q0.8781.00
74_G78_R0.8761.00
148_E151_F0.8751.00
303_I340_A0.8741.00
168_G172_I0.8741.00
367_F433_G0.8721.00
15_R151_F0.8711.00
190_N193_G0.8681.00
374_A378_L0.8681.00
439_I442_A0.8671.00
173_I177_G0.8621.00
319_A323_Y0.8621.00
123_P126_I0.8611.00
127_W130_S0.8601.00
164_M275_F0.8591.00
11_G144_K0.8571.00
429_A432_I0.8551.00
106_A362_T0.8541.00
204_L208_M0.8501.00
428_V433_G0.8501.00
433_G437_F0.8491.00
8_L225_E0.8491.00
165_I254_V0.8481.00
16_H148_E0.8481.00
258_I274_T0.8461.00
57_F61_R0.8461.00
50_A54_L0.8451.00
381_I406_S0.8441.00
428_V431_I0.8431.00
94_W319_A0.8381.00
106_A211_F0.8371.00
96_Y100_W0.8351.00
387_L393_K0.8341.00
193_G196_P0.8331.00
8_L308_R0.8261.00
109_T361_V0.8251.00
340_A344_L0.8221.00
395_L398_K0.8211.00
218_M305_S0.8211.00
59_I413_L0.8191.00
199_L202_V0.8171.00
165_I169_L0.8161.00
132_L347_V0.8111.00
111_V296_L0.8111.00
112_G115_M0.8081.00
280_I283_A0.8071.00
137_G140_F0.8041.00
261_W264_I0.8031.00
26_I29_G0.8031.00
135_M303_I0.8011.00
364_I368_G0.8001.00
430_V434_P0.7981.00
58_F62_A0.7961.00
434_P437_F0.7951.00
14_E236_A0.7941.00
253_F257_S0.7931.00
192_G195_F0.7901.00
80_A379_S0.7891.00
111_V295_A0.7861.00
87_L441_L0.7851.00
88_A375_I0.7841.00
115_M119_F0.7821.00
265_G270_P0.7821.00
402_F405_T0.7811.00
18_S236_A0.7791.00
108_I112_G0.7781.00
387_L391_E0.7771.00
85_G448_G0.7751.00
87_L91_L0.7751.00
57_F238_D0.7701.00
47_V202_V0.7691.00
194_F197_H0.7681.00
435_I442_A0.7681.00
269_S272_V0.7671.00
214_L373_W0.7671.00
433_G436_W0.7651.00
332_P335_A0.7631.00
26_I157_K0.7601.00
228_N234_A0.7591.00
116_G120_P0.7581.00
84_L87_L0.7581.00
400_P404_F0.7561.00
11_G143_V0.7541.00
234_A237_I0.7531.00
380_Q384_R0.7531.00
69_Q396_K0.7501.00
322_A338_A0.7501.00
66_M79_Y0.7491.00
61_R405_T0.7471.00
46_L50_A0.7421.00
195_F198_G0.7401.00
169_L250_G0.7391.00
58_F409_S0.7341.00
381_I403_P0.7291.00
417_V420_M0.7281.00
15_R148_E0.7271.00
139_N336_V0.7261.00
101_V342_A0.7241.00
129_L348_L0.7231.00
275_F278_V0.7231.00
47_V51_A0.7221.00
141_L145_A0.7201.00
270_P275_F0.7201.00
432_I435_I0.7191.00
147_G151_F0.7181.00
103_T107_E0.7131.00
381_I385_K0.7101.00
11_G15_R0.7091.00
328_K333_G0.7091.00
308_R311_F0.7071.00
43_P256_M0.7071.00
25_A240_V0.7061.00
436_W439_I0.7041.00
282_S285_G0.7041.00
307_G335_A0.7021.00
83_Y382_K0.6991.00
103_T365_A0.6941.00
122_V126_I0.6941.00
145_A148_E0.6881.00
185_I189_W0.6881.00
172_I177_G0.6871.00
265_G269_S0.6841.00
77_S81_R0.6831.00
379_S383_Y0.6831.00
56_M216_I0.6821.00
442_A445_Y0.6801.00
403_P406_S0.6801.00
47_V50_A0.6801.00
310_L338_A0.6791.00
323_Y335_A0.6791.00
140_F329_G0.6781.00
303_I307_G0.6781.00
250_G254_V0.6761.00
314_A323_Y0.6761.00
33_G362_T0.6751.00
30_L251_A0.6751.00
26_I247_F0.6721.00
409_S412_F0.6721.00
433_G438_L0.6721.00
105_M361_V0.6711.00
63_L376_I0.6701.00
413_L416_V0.6701.00
83_Y383_Y0.6691.00
432_I444_Y0.6691.00
135_M296_L0.6681.00
23_G154_A0.6671.00
203_L419_L0.6651.00
73_A311_F0.6651.00
24_A301_S0.6651.00
102_V364_I0.6591.00
341_G344_L0.6591.00
103_T106_A0.6581.00
224_G311_F0.6571.00
24_A302_G0.6571.00
243_R247_F0.6561.00
437_F441_L0.6561.00
139_N304_F0.6531.00
416_V420_M0.6531.00
60_M216_I0.6511.00
45_I252_L0.6511.00
140_F336_V0.6501.00
8_L11_G0.6481.00
431_I436_W0.6461.00
406_S410_L0.6451.00
367_F417_V0.6451.00
185_I257_S0.6451.00
84_L379_S0.6441.00
266_S270_P0.6421.00
387_L395_L0.6381.00
142_A145_A0.6371.00
30_L33_G0.6361.00
233_L237_I0.6361.00
201_G204_L0.6351.00
239_T242_W0.6341.00
77_S89_G0.6331.00
171_M174_A0.6321.00
428_V444_Y0.6311.00
190_N194_F0.6301.00
95_N372_T0.6281.00
99_L369_A0.6281.00
306_T310_L0.6271.00
62_A409_S0.6251.00
64_G68_I0.6241.00
49_Y212_A0.6231.00
67_A233_L0.6221.00
22_L154_A0.6221.00
61_R400_P0.6201.00
432_I436_W0.6201.00
443_V449_F0.6191.00
230_Q396_K0.6191.00
251_A255_I0.6191.00
37_A41_A0.6191.00
428_V443_V0.6181.00
172_I254_V0.6171.00
132_L344_L0.6151.00
115_M131_A0.6141.00
220_G237_I0.6111.00
111_V115_M0.6111.00
438_L441_L0.6101.00
189_W193_G0.6101.00
147_G300_N0.6101.00
191_N196_P0.6101.00
66_M83_Y0.6091.00
34_S252_L0.6091.00
418_I421_A0.6081.00
225_E326_L0.6081.00
156_I290_V0.6071.00
266_S269_S0.6061.00
243_R246_I0.6051.00
214_L217_E0.6051.00
368_G372_T0.6041.00
77_S93_G0.6031.00
131_A299_C0.6001.00
76_F217_E0.6001.00
432_I438_L0.6001.00
384_R402_F0.5991.00
435_I440_L0.5981.00
27_G248_Y0.5971.00
167_V171_M0.5961.00
51_A206_L0.5951.00
133_V136_T0.5951.00
168_G173_I0.5941.00
430_V435_I0.5931.00
117_F120_P0.5931.00
229_P232_S0.5931.00
143_V222_T0.5921.00
395_L399_M0.5911.00
294_A297_S0.5901.00
221_V305_S0.5901.00
21_S25_A0.5901.00
436_W441_L0.5891.00
226_V233_L0.5881.00
15_R18_S0.5851.00
114_Y291_V0.5851.00
134_I138_V0.5801.00
445_Y448_G0.5801.00
60_M64_G0.5781.00
36_S359_T0.5781.00
417_V430_V0.5771.00
359_T362_T0.5751.00
30_L34_S0.5751.00
18_S21_S0.5751.00
105_M346_G0.5741.00
136_T303_I0.5741.00
428_V440_L0.5731.00
130_S133_V0.5731.00
100_W302_G0.5721.00
433_G443_V0.5721.00
399_M402_F0.5721.00
146_Y304_F0.5701.00
67_A220_G0.5681.00
46_L249_V0.5681.00
156_I160_A0.5681.00
265_G268_G0.5671.00
443_V448_G0.5651.00
154_A157_K0.5651.00
391_E396_K0.5631.00
275_F283_A0.5631.00
75_S220_G0.5621.00
326_L329_G0.5611.00
429_A436_W0.5611.00
110_A114_Y0.5591.00
76_F221_V0.5581.00
40_L204_L0.5561.00
394_Q397_Y0.5561.00
392_K396_K0.5561.00
374_A417_V0.5561.00
225_E332_P0.5561.00
85_G89_G0.5561.00
19_L154_A0.5541.00
381_I410_L0.5541.00
254_V257_S0.5531.00
117_F288_N0.5531.00
369_A372_T0.5521.00
107_E110_A0.5511.00
59_I217_E0.5511.00
34_S38_I0.5501.00
145_A149_L0.5501.00
199_L203_L0.5501.00
37_A209_V0.5491.00
393_K398_K0.5471.00
52_S213_Y0.5461.00
114_Y272_V0.5461.00
370_I413_L0.5451.00
101_V339_S0.5431.00
191_N194_F0.5421.00
52_S210_M0.5421.00
46_L49_Y0.5411.00
151_F155_L0.5411.00
243_R250_G0.5401.00
10_R227_K0.5401.00
411_A414_A0.5401.00
322_A326_L0.5401.00
118_W288_N0.5391.00
433_G440_L0.5381.00
383_Y387_L0.5371.00
289_F293_T0.5371.00
107_E295_A0.5361.00
308_R326_L0.5351.00
92_T372_T0.5341.00
17_I222_T0.5341.00
37_A205_S0.5321.00
86_P448_G0.5311.00
406_S420_M0.5311.00
13_E144_K0.5311.00
259_Y263_E0.5311.00
229_P233_L0.5301.00
80_A89_G0.5281.00
310_L314_A0.5281.00
31_F157_K0.5281.00
165_I251_A0.5271.00
345_V348_L0.5271.00
34_S37_A0.5271.00
431_I441_L0.5241.00
107_E299_C0.5231.00
95_N371_W0.5231.00
402_F407_Y0.5221.00
396_K399_M0.5221.00
156_I293_T0.5221.00
49_Y252_L0.5221.00
40_L43_P0.5211.00
391_E397_Y0.5191.00
43_P46_L0.5191.00
431_I440_L0.5181.00
171_M176_V0.5181.00
401_L406_S0.5181.00
212_A248_Y0.5171.00
69_Q391_E0.5161.00
433_G442_A0.5151.00
116_G124_N0.5151.00
231_K234_A0.5141.00
333_G336_V0.5131.00
444_Y448_G0.5131.00
193_G197_H0.5131.00
150_E297_S0.5131.00
118_W289_F0.5131.00
299_C302_G0.5131.00
31_F161_I0.5131.00
433_G447_K0.5131.00
413_L417_V0.5121.00
107_E112_G0.5121.00
435_I446_G0.5121.00
36_S39_Q0.5111.00
214_L365_A0.5111.00
152_W155_L0.5101.00
167_V280_I0.5091.00
133_V337_L0.5091.00
270_P278_V0.5091.00
286_I290_V0.5091.00
36_S40_L0.5091.00
108_I111_V0.5081.00
105_M343_L0.5061.00
392_K398_K0.5051.00
61_R397_Y0.5041.00
399_M405_T0.5031.00
27_G157_K0.5021.00
419_L423_S0.5021.00
437_F440_L0.5021.00
105_M108_I0.5021.00
437_F444_Y0.5011.00
274_T278_V0.5011.00
40_L205_S0.5001.00
189_W192_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9006 100 0.287 Contact Map
4djkA 2 0.8855 100 0.358 Contact Map
3giaA 1 0.9179 100 0.359 Contact Map
3dh4A 3 0.9266 99 0.854 Contact Map
2jlnA 1 0.8963 98.9 0.859 Contact Map
2xq2A 2 0.9222 98.9 0.861 Contact Map
4wgvA 2 0.8035 98 0.892 Contact Map
2a65A 2 0.9201 97.7 0.9 Contact Map
4xp4A 1 0.9352 97.6 0.902 Contact Map
4us3A 1 0.8359 93.9 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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