GREMLIN Database
RLMN - Probable dual-specificity RNA methyltransferase RlmN
UniProt: O34617 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (336)
Sequences: 3176 (1748)
Seq/√Len: 95.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_N289_E4.1431.00
217_Y261_Y3.6481.00
215_K218_E3.5781.00
81_K98_E3.0951.00
237_T253_P3.0671.00
58_E72_N3.0261.00
27_E187_A2.9471.00
241_S247_N2.9191.00
32_L45_I2.9131.00
95_F159_A2.9071.00
131_T314_Y2.7021.00
291_A332_R2.6091.00
172_I188_F2.5091.00
301_V334_V2.4851.00
127_R180_D2.4501.00
256_M293_L2.4481.00
37_E70_K2.4321.00
278_G315_V2.3751.00
56_S59_D2.3611.00
221_D261_Y2.3591.00
327_K331_S2.3461.00
29_K39_P2.3261.00
284_V328_T2.2991.00
283_Q286_H2.2661.00
260_K297_V2.2331.00
30_Q34_D2.2181.00
185_M207_V2.1461.00
120_V149_I2.1341.00
239_I286_H2.1271.00
189_L207_V2.0481.00
221_D265_K2.0331.00
69_E73_T2.0141.00
276_L317_T1.9911.00
31_W75_F1.9871.00
288_E328_T1.9861.00
86_Q347_D1.9521.00
237_T247_N1.9201.00
235_P286_H1.9101.00
47_E62_N1.8961.00
127_R140_L1.8841.00
259_V270_I1.8461.00
88_S345_D1.8401.00
214_P250_Y1.8241.00
85_K159_A1.8091.00
284_V321_Q1.8081.00
170_V192_I1.8001.00
128_I210_S1.7761.00
33_T39_P1.7731.00
235_P289_E1.7721.00
48_W62_N1.7551.00
118_V156_V1.7531.00
236_N239_I1.7481.00
31_W35_N1.7261.00
278_G318_P1.7151.00
83_A98_E1.7041.00
48_W60_M1.6641.00
179_F219_F1.6591.00
172_I185_M1.6421.00
29_K43_A1.6331.00
47_E51_E1.6181.00
55_S158_K1.5931.00
172_I207_V1.5781.00
47_E52_K1.5721.00
25_L194_H1.5441.00
32_L67_L1.5291.00
202_A225_Q1.5251.00
24_E27_E1.5241.00
43_A196_K1.5171.00
180_D212_I1.5051.00
85_K93_M1.5011.00
241_S248_R1.4751.00
70_K74_R1.4581.00
237_T241_S1.4391.00
257_E261_Y1.4321.00
95_F156_V1.4311.00
217_Y257_E1.4301.00
21_Y151_A1.4180.99
20_I57_F1.3950.99
230_I255_L1.3920.99
347_D356_K1.3870.99
182_F218_E1.3590.99
98_E104_T1.3560.99
122_T172_I1.3550.99
122_T185_M1.3530.99
80_L151_A1.3530.99
26_D29_K1.3440.99
288_E332_R1.3420.99
326_E330_K1.3410.99
286_H289_E1.3390.99
272_F299_C1.3380.99
284_V324_A1.3350.99
323_F326_E1.3180.99
201_G204_H1.3110.99
25_L29_K1.2950.99
251_K254_D1.2810.99
326_E336_V1.2800.99
138_G355_A1.2800.99
97_F107_T1.2780.99
278_G321_Q1.2710.99
19_S22_S1.2640.99
153_V192_I1.2580.99
97_F155_K1.2500.99
63_L68_R1.2490.99
135_S175_I1.2320.99
67_L70_K1.2310.99
260_K296_G1.2210.98
318_P321_Q1.2160.98
146_A184_E1.2110.98
41_R44_Q1.2080.98
252_L293_L1.2030.98
190_K224_M1.1990.98
179_F207_V1.1980.98
272_F294_L1.1960.98
35_N70_K1.1940.98
319_R323_F1.1900.98
65_K69_E1.1880.98
80_L97_F1.1870.98
236_N286_H1.1870.98
235_P239_I1.1850.98
69_E72_N1.1820.98
37_E41_R1.1790.98
212_I215_K1.1770.98
109_L116_N1.1700.98
79_T151_A1.1680.98
276_L322_I1.1680.98
328_T332_R1.1590.98
193_N205_I1.1510.98
32_L42_A1.1450.98
217_Y221_D1.1450.98
54_V59_D1.1450.98
87_T93_M1.1430.98
18_P75_F1.1410.98
23_F31_W1.1330.97
237_T251_K1.1320.97
109_L156_V1.1290.97
272_F297_V1.1290.97
213_I258_A1.1270.97
193_N202_A1.1230.97
182_F190_K1.1200.97
66_D69_E1.1190.97
234_A239_I1.1180.97
220_A261_Y1.1170.97
24_E187_A1.1160.97
294_L301_V1.1110.97
182_F186_L1.1090.97
37_E67_L1.1080.97
50_Y198_L1.0920.97
103_Y141_K1.0910.97
99_L105_I1.0910.97
279_G321_Q1.0830.97
322_I338_I1.0770.97
323_F338_I1.0750.97
99_L124_V1.0750.97
241_S244_M1.0730.96
107_T156_V1.0720.96
256_M297_V1.0660.96
57_F76_V1.0620.96
40_F44_Q1.0540.96
101_D142_R1.0530.96
53_R157_Q1.0510.96
193_N201_G1.0450.96
140_L180_D1.0450.96
149_I188_F1.0430.96
146_A187_A1.0400.96
25_L43_A1.0400.96
45_I63_L1.0370.96
238_E242_R1.0370.96
254_D257_E1.0350.96
25_L42_A1.0340.96
118_V167_V1.0330.96
24_E190_K1.0290.96
52_K62_N1.0200.95
193_N225_Q1.0190.95
261_Y265_K1.0190.95
29_K33_T1.0190.95
256_M259_V1.0190.95
61_T64_S1.0160.95
37_E66_D1.0120.95
31_W34_D1.0110.95
140_L143_N1.0110.95
316_R344_H1.0070.95
284_V288_E1.0030.95
82_T85_K1.0020.95
277_F280_V1.0000.95
20_I75_F0.9990.95
43_A62_N0.9970.95
117_S169_S0.9970.95
287_A328_T0.9950.95
61_T68_R0.9930.95
247_N251_K0.9890.94
26_D190_K0.9800.94
157_Q198_L0.9760.94
150_V191_I0.9750.94
137_L311_E0.9710.94
294_L334_V0.9700.94
329_L336_V0.9650.94
253_P293_L0.9630.94
230_I259_V0.9560.93
219_F226_I0.9530.93
57_F77_L0.9480.93
256_M260_K0.9460.93
227_N268_R0.9450.93
324_A327_K0.9410.93
287_A325_F0.9330.93
172_I189_L0.9320.93
308_Y344_H0.9260.92
128_I180_D0.9260.92
206_T229_A0.9250.92
212_I246_I0.9230.92
33_T38_K0.9220.92
57_F60_M0.9200.92
263_I298_K0.9180.92
291_A334_V0.9170.92
172_I192_I0.9150.92
83_A104_T0.9140.92
66_D70_K0.9130.92
239_I289_E0.9080.92
183_N218_E0.9070.91
80_L155_K0.9050.91
56_S72_N0.9050.91
80_L107_T0.9040.91
22_S147_G0.8940.91
216_I230_I0.8930.91
275_G306_V0.8900.91
107_T118_V0.8890.91
43_A47_E0.8880.91
185_M189_L0.8870.91
142_R148_E0.8840.90
93_M159_A0.8770.90
134_A347_D0.8760.90
18_P23_F0.8750.90
317_T322_I0.8720.90
97_F156_V0.8650.89
252_L257_E0.8650.89
327_K330_K0.8610.89
320_D324_A0.8600.89
115_G135_S0.8490.89
239_I242_R0.8480.89
111_R165_E0.8440.88
282_D317_T0.8440.88
195_D199_N0.8410.88
48_W52_K0.8400.88
223_Q265_K0.8390.88
252_L256_M0.8390.88
138_G354_R0.8380.88
30_Q33_T0.8340.88
32_L35_N0.8340.88
89_Q345_D0.8290.87
96_L354_R0.8280.87
210_S244_M0.8240.87
84_V357_E0.8240.87
21_Y50_Y0.8230.87
79_T158_K0.8190.87
115_G342_Q0.8170.87
186_L219_F0.8170.87
277_F306_V0.8140.86
306_V312_R0.8140.86
26_D30_Q0.8110.86
128_I246_I0.8100.86
308_Y315_V0.7990.85
234_A237_T0.7970.85
154_V198_L0.7970.85
289_E292_D0.7960.85
114_Y169_S0.7920.85
305_P341_E0.7900.85
50_Y154_V0.7870.84
241_S251_K0.7860.84
186_L190_K0.7860.84
80_L99_L0.7840.84
192_I198_L0.7840.84
57_F71_L0.7830.84
134_A309_V0.7830.84
259_V272_F0.7810.84
291_A329_L0.7780.84
217_Y258_A0.7780.84
48_W54_V0.7710.83
22_S145_E0.7710.83
170_V200_I0.7710.83
54_V60_M0.7640.83
155_K158_K0.7620.83
170_V205_I0.7610.82
45_I57_F0.7570.82
18_P31_W0.7550.82
190_K223_Q0.7550.82
131_T137_L0.7530.82
341_E344_H0.7520.82
31_W74_R0.7510.82
206_T271_S0.7490.81
150_V154_V0.7470.81
46_F191_I0.7440.81
49_L77_L0.7440.81
137_L312_R0.7430.81
35_N74_R0.7430.81
63_L67_L0.7430.81
57_F75_F0.7420.81
85_K95_F0.7410.81
317_T321_Q0.7390.81
111_R116_N0.7370.80
321_Q324_A0.7370.80
92_T110_M0.7360.80
138_G175_I0.7320.80
323_F327_K0.7310.80
207_V226_I0.7300.80
179_F215_K0.7270.80
210_S246_I0.7220.79
300_H337_T0.7220.79
134_A310_P0.7200.79
316_R322_I0.7190.79
216_I258_A0.7180.79
233_H244_M0.7160.78
41_R64_S0.7110.78
39_P42_A0.7090.78
135_S138_G0.7070.78
46_F50_Y0.7050.77
330_K336_V0.7050.77
38_K64_S0.7040.77
38_K41_R0.7030.77
80_L105_I0.6960.76
218_E221_D0.6950.76
292_D332_R0.6930.76
150_V192_I0.6930.76
114_Y135_S0.6920.76
292_D295_E0.6910.76
55_S59_D0.6900.76
306_V309_V0.6900.76
128_I212_I0.6870.76
217_Y254_D0.6840.75
157_Q167_V0.6820.75
252_L255_L0.6810.75
186_L226_I0.6810.75
137_L309_V0.6810.75
135_S169_S0.6800.75
70_K73_T0.6800.75
135_S172_I0.6800.75
291_A328_T0.6800.75
320_D323_F0.6760.74
86_Q356_K0.6750.74
117_S168_S0.6660.73
127_R139_G0.6660.73
295_E332_R0.6640.73
188_F192_I0.6640.73
27_E30_Q0.6610.73
65_K68_R0.6580.72
263_I267_G0.6570.72
112_H115_G0.6560.72
193_N200_I0.6540.72
98_E102_G0.6530.72
190_K194_H0.6500.71
285_E289_E0.6500.71
251_K255_L0.6480.71
111_R342_Q0.6470.71
246_I250_Y0.6460.71
249_A254_D0.6460.71
233_H337_T0.6430.71
131_T242_R0.6420.71
305_P338_I0.6420.71
115_G169_S0.6400.70
49_L53_R0.6400.70
327_K338_I0.6400.70
282_D321_Q0.6380.70
60_M63_L0.6370.70
45_I67_L0.6360.70
311_E354_R0.6350.70
41_R67_L0.6350.70
116_N165_E0.6340.70
20_I49_L0.6320.69
285_E288_E0.6320.69
134_A354_R0.6310.69
129_G136_T0.6300.69
220_A258_A0.6290.69
213_I254_D0.6290.69
253_P257_E0.6270.69
137_L140_L0.6270.69
178_P185_M0.6260.69
135_S188_F0.6230.68
153_V167_V0.6230.68
234_A289_E0.6220.68
187_A191_I0.6220.68
82_T97_F0.6210.68
235_P274_Y0.6210.68
213_I250_Y0.6210.68
324_A328_T0.6210.68
151_A155_K0.6200.68
242_R280_V0.6200.68
68_R72_N0.6190.68
120_V172_I0.6190.68
273_E302_N0.6180.68
117_S171_V0.6160.67
153_V157_Q0.6150.67
227_N300_H0.6110.67
40_F43_A0.6090.67
20_I28_I0.6080.66
218_E223_Q0.6050.66
239_I280_V0.6050.66
82_T155_K0.6040.66
269_R300_H0.6040.66
37_E64_S0.6030.66
123_Q143_N0.6030.66
260_K293_L0.6030.66
23_F27_E0.6000.65
316_R341_E0.5950.65
288_E292_D0.5940.65
191_I197_G0.5920.64
46_F197_G0.5900.64
294_L299_C0.5900.64
120_V153_V0.5890.64
271_S300_H0.5880.64
51_E199_N0.5870.64
109_L160_L0.5870.64
117_S271_S0.5860.64
255_L259_V0.5840.63
76_V100_H0.5830.63
184_E187_A0.5830.63
46_F194_H0.5830.63
83_A324_A0.5830.63
283_Q287_A0.5820.63
124_V141_K0.5820.63
305_P322_I0.5820.63
112_H342_Q0.5820.63
233_H275_G0.5820.63
50_Y150_V0.5800.63
261_Y264_N0.5800.63
32_L37_E0.5780.63
263_I266_T0.5750.62
252_L272_F0.5750.62
136_T233_H0.5740.62
296_G299_C0.5730.62
306_V314_Y0.5730.62
20_I77_L0.5730.62
305_P316_R0.5730.62
131_T243_L0.5710.62
53_R158_K0.5700.61
115_G175_I0.5700.61
31_W57_F0.5680.61
283_Q321_Q0.5680.61
157_Q166_R0.5680.61
25_L196_K0.5670.61
40_F62_N0.5670.61
29_K32_L0.5670.61
95_F107_T0.5600.60
326_E338_I0.5580.60
230_I272_F0.5570.60
136_T312_R0.5570.60
274_Y349_A0.5540.59
260_K264_N0.5510.59
153_V200_I0.5490.59
95_F109_L0.5490.59
92_T346_I0.5490.59
49_L57_F0.5480.58
25_L46_F0.5480.58
91_G111_R0.5470.58
117_S172_I0.5460.58
26_D31_W0.5420.58
300_H335_N0.5420.58
160_L167_V0.5420.58
233_H317_T0.5410.57
38_K44_Q0.5410.57
235_P293_L0.5410.57
50_Y78_T0.5410.57
35_N75_F0.5360.57
60_M68_R0.5360.57
44_Q48_W0.5350.57
112_H300_H0.5340.57
238_E292_D0.5330.56
310_P356_K0.5320.56
276_L338_I0.5300.56
135_S354_R0.5300.56
322_I326_E0.5280.56
215_K255_L0.5270.56
129_G137_L0.5260.55
44_Q62_N0.5240.55
277_F317_T0.5240.55
109_L167_V0.5230.55
136_T175_I0.5210.55
295_E334_V0.5200.55
115_G229_A0.5190.54
307_N352_Q0.5190.54
78_T151_A0.5170.54
325_F348_A0.5170.54
189_L270_I0.5160.54
267_G298_K0.5160.54
58_E65_K0.5160.54
288_E331_S0.5150.54
234_A287_A0.5150.54
244_M275_G0.5140.54
277_F314_Y0.5140.54
310_P313_D0.5130.54
91_G269_R0.5120.53
21_Y49_L0.5120.53
44_Q68_R0.5110.53
237_T252_L0.5090.53
78_T81_K0.5080.53
294_L297_V0.5060.53
115_G341_E0.5060.53
114_Y188_F0.5050.52
23_F283_Q0.5050.52
184_E188_F0.5040.52
243_L277_F0.5020.52
82_T159_A0.5020.52
138_G348_A0.5010.52
35_N69_E0.5010.52
134_A137_L0.5010.52
48_W271_S0.5000.52
179_F216_I0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfaA 1 0.9504 100 0.385 Contact Map
2z2uA 1 0.6832 100 0.714 Contact Map
2yx0A 1 0.7824 100 0.717 Contact Map
2a5hA 4 0.8815 100 0.788 Contact Map
4r33A 2 0.832 99.9 0.82 Contact Map
3c8fA 1 0.6171 99.9 0.823 Contact Map
4wcxA 1 0.8567 99.9 0.825 Contact Map
4rtbA 2 0.8072 99.9 0.829 Contact Map
3iixA 1 0.7658 99.9 0.844 Contact Map
3t7vA 1 0.7548 99.9 0.844 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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