GREMLIN Database
SDPB - Sporulation-delaying protein SdpB
UniProt: O34616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (274)
Sequences: 930 (718)
Seq/√Len: 43.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_I141_W5.2791.00
29_G88_V4.3151.00
120_I171_I4.2401.00
86_L96_T4.1011.00
32_T100_H3.8831.00
172_Y255_H3.4691.00
33_L88_V3.3701.00
141_W144_K3.2811.00
85_T89_I3.1061.00
98_L129_L3.0821.00
33_L81_I2.7391.00
126_F129_L2.7301.00
146_N150_S2.7141.00
86_L89_I2.6301.00
93_P134_L2.5341.00
87_V100_H2.5321.00
83_I99_F2.5091.00
93_P142_N2.4831.00
30_F88_V2.4731.00
134_L142_N2.4621.00
171_I271_M2.3971.00
251_G275_L2.3861.00
93_P140_H2.3411.00
100_H125_S2.2201.00
162_T165_K2.2061.00
92_R145_K2.1250.99
286_I290_W2.0970.99
180_L227_T2.0910.99
83_I96_T2.0190.99
141_W145_K2.0110.99
176_A231_L1.9860.99
101_W126_F1.9530.99
222_I257_G1.9250.99
63_F76_I1.9000.99
33_L85_T1.8970.99
254_F258_I1.8470.99
168_V275_L1.7650.98
116_G267_F1.7630.98
44_L49_A1.7430.98
191_I222_I1.7190.98
126_F130_P1.7140.98
233_L251_G1.6530.97
21_Y180_L1.6160.97
85_T88_V1.6100.97
61_T106_S1.5950.96
116_G264_I1.5790.96
27_L273_S1.5720.96
87_V97_G1.5670.96
243_I247_A1.5660.96
190_A194_F1.5570.96
254_F268_G1.5550.96
266_S270_I1.5320.95
26_S140_H1.5280.95
123_V127_L1.5240.95
29_G84_L1.5200.95
14_Y158_F1.5090.95
97_G129_L1.4910.95
18_K22_A1.4620.94
91_W141_W1.4620.94
226_V230_E1.4550.94
289_N293_P1.4430.94
17_W20_T1.3980.92
173_L231_L1.3600.91
87_V125_S1.3550.91
91_W145_K1.3500.91
110_S113_T1.3490.91
158_F162_T1.3460.91
83_I86_L1.3440.91
188_G220_V1.3370.91
33_L242_R1.3230.90
93_P97_G1.3160.90
240_N243_I1.3090.90
290_W294_L1.3070.90
207_L210_M1.3020.90
273_S277_I1.2950.89
255_H258_I1.2870.89
192_Y196_S1.2830.89
180_L261_S1.2830.89
87_V134_L1.2710.88
164_I211_N1.2570.88
105_Y122_T1.2440.87
244_K267_F1.2350.87
32_T125_S1.2290.87
168_V274_A1.2280.87
182_N194_F1.2230.86
242_R245_R1.2110.86
77_R81_I1.2060.86
18_K138_R1.1990.85
101_W129_L1.1890.85
230_E254_F1.1800.84
80_M103_I1.1790.84
259_I264_I1.1780.84
245_R279_L1.1770.84
26_S88_V1.1690.84
11_I162_T1.1630.83
252_I272_I1.1570.83
130_P260_F1.1480.83
84_L100_H1.1380.82
31_S266_S1.1380.82
179_R230_E1.1370.82
246_I250_L1.1280.81
86_L99_F1.1260.81
22_A26_S1.1190.81
200_F262_I1.1180.81
292_S295_F1.1120.81
216_S260_F1.1070.80
233_L275_L1.1060.80
18_K137_R1.0920.79
20_T284_Q1.0900.79
146_N151_F1.0890.79
76_I106_S1.0850.79
20_T233_L1.0790.78
36_L125_S1.0770.78
171_I274_A1.0660.78
172_Y267_F1.0620.77
253_L257_G1.0610.77
38_F42_D1.0570.77
172_Y271_M1.0570.77
15_N155_T1.0390.76
29_G87_V1.0380.76
291_C294_L1.0360.76
169_F273_S1.0350.75
241_I245_R1.0270.75
36_L80_M1.0200.74
290_W293_P1.0190.74
120_I167_Q1.0190.74
287_T291_C1.0180.74
130_P140_H1.0130.74
283_Q287_T1.0130.74
166_I218_F1.0040.73
244_K265_V1.0010.73
101_W125_S0.9970.73
28_L125_S0.9960.73
225_L249_V0.9930.72
124_L274_A0.9920.72
93_P100_H0.9910.72
93_P133_L0.9880.72
11_I165_K0.9850.72
249_V253_L0.9710.71
143_I151_F0.9700.71
126_F225_L0.9680.70
264_I267_F0.9610.70
175_A226_V0.9480.69
42_D118_E0.9460.69
156_V160_I0.9390.68
28_L32_T0.9320.68
282_V286_I0.9280.67
19_N139_N0.9270.67
33_L75_I0.9220.67
256_I272_I0.9170.66
106_S117_G0.9120.66
229_F251_G0.9070.65
190_A223_T0.8950.64
137_R140_H0.8840.63
43_I74_E0.8830.63
76_I83_I0.8800.63
77_R107_I0.8760.63
115_D230_E0.8730.62
164_I174_N0.8710.62
283_Q286_I0.8700.62
116_G167_Q0.8700.62
79_L150_S0.8690.62
37_L83_I0.8630.61
96_T99_F0.8610.61
116_G262_I0.8610.61
127_L163_I0.8600.61
119_Q262_I0.8590.61
128_I133_L0.8590.61
116_G271_M0.8580.61
256_I294_L0.8580.61
69_Y112_L0.8570.61
52_V56_N0.8500.60
230_E233_L0.8490.60
106_S110_S0.8480.60
17_W285_N0.8470.60
134_L140_H0.8470.60
285_N288_M0.8440.60
24_F47_Y0.8420.60
116_G119_Q0.8420.60
47_Y219_I0.8390.59
88_V221_V0.8360.59
229_F237_I0.8320.59
112_L197_D0.8300.58
232_F236_S0.8290.58
79_L146_N0.8270.58
137_R141_W0.8270.58
17_W21_Y0.8250.58
229_F253_L0.8230.58
125_S225_L0.8170.57
38_F60_P0.8130.57
134_L151_F0.8120.57
29_G268_G0.8120.57
251_G258_I0.8110.57
189_T267_F0.8110.57
282_V285_N0.8100.57
104_C108_Q0.8070.56
248_L279_L0.8070.56
48_S81_I0.8030.56
36_L107_I0.8020.56
137_R143_I0.8010.56
143_I177_L0.7980.55
280_H283_Q0.7940.55
92_R96_T0.7940.55
89_I129_L0.7890.55
123_V175_A0.7850.54
101_W122_T0.7840.54
182_N190_A0.7800.54
187_E250_L0.7780.54
21_Y140_H0.7780.54
226_V254_F0.7750.53
85_T289_N0.7720.53
165_K277_I0.7710.53
82_F86_L0.7700.53
161_M164_I0.7700.53
66_A75_I0.7680.53
26_S238_I0.7650.52
115_D265_V0.7610.52
36_L139_N0.7600.52
200_F268_G0.7540.51
21_Y244_K0.7540.51
137_R146_N0.7530.51
146_N149_E0.7520.51
168_V290_W0.7510.51
31_S273_S0.7490.51
164_I287_T0.7440.50
195_F256_I0.7420.50
36_L100_H0.7410.50
98_L289_N0.7400.50
115_D263_G0.7390.50
21_Y25_R0.7340.49
86_L97_G0.7320.49
230_E268_G0.7300.49
116_G230_E0.7280.49
22_A138_R0.7230.48
78_Y127_L0.7210.48
130_P134_L0.7200.48
145_K282_V0.7190.48
89_I286_I0.7170.48
63_F183_K0.7160.48
176_A191_I0.7120.47
220_V264_I0.7100.47
258_I262_I0.7090.47
20_T161_M0.7070.47
172_Y188_G0.7020.46
218_F270_I0.7000.46
170_I282_V0.6940.46
84_L121_A0.6900.45
258_I268_G0.6900.45
208_N211_N0.6890.45
116_G258_I0.6890.45
104_C226_V0.6870.45
91_W134_L0.6870.45
97_G130_P0.6850.45
115_D258_I0.6850.45
254_F257_G0.6840.45
220_V228_I0.6810.44
29_G101_W0.6800.44
249_V291_C0.6800.44
128_I231_L0.6780.44
51_N249_V0.6770.44
138_R287_T0.6730.44
124_L168_V0.6720.43
34_L88_V0.6710.43
149_E209_L0.6690.43
163_I191_I0.6690.43
261_S271_M0.6650.43
253_L262_I0.6620.43
39_N118_E0.6570.42
193_Y223_T0.6540.42
262_I280_H0.6540.42
120_I124_L0.6540.42
289_N292_S0.6530.42
39_N47_Y0.6500.41
30_F62_A0.6500.41
22_A142_N0.6470.41
158_F285_N0.6450.41
179_R255_H0.6450.41
129_L137_R0.6450.41
222_I273_S0.6440.41
90_G142_N0.6430.41
161_M165_K0.6420.41
186_A238_I0.6410.41
93_P141_W0.6400.41
105_Y109_T0.6400.41
118_E258_I0.6370.40
26_S142_N0.6340.40
40_S43_I0.6330.40
15_N19_N0.6320.40
228_I287_T0.6320.40
35_V39_N0.6310.40
255_H278_Y0.6310.40
95_F99_F0.6310.40
91_W144_K0.6280.39
158_F199_V0.6280.39
175_A230_E0.6250.39
177_L180_L0.6250.39
138_R221_V0.6250.39
265_V268_G0.6250.39
117_G167_Q0.6230.39
255_H264_I0.6230.39
259_I269_L0.6220.39
53_T59_I0.6210.39
235_A238_I0.6200.39
22_A144_K0.6200.39
33_L145_K0.6180.39
91_W142_N0.6180.39
52_V55_E0.6140.38
109_T117_G0.6140.38
78_Y242_R0.6120.38
46_S107_I0.6120.38
140_H145_K0.6110.38
63_F73_F0.6100.38
188_G219_I0.6080.38
121_A210_M0.6080.38
89_I187_E0.6070.38
153_K156_V0.6060.37
144_K151_F0.6050.37
183_K191_I0.6030.37
195_F276_I0.6030.37
175_A202_L0.6020.37
289_N294_L0.6020.37
32_T84_L0.6000.37
96_T130_P0.5990.37
237_I271_M0.5980.37
117_G268_G0.5980.37
163_I166_I0.5980.37
169_F173_L0.5970.37
171_I267_F0.5950.36
23_L289_N0.5920.36
39_N271_M0.5910.36
37_L81_I0.5890.36
23_L86_L0.5890.36
14_Y249_V0.5870.36
82_F294_L0.5820.35
121_A288_M0.5810.35
92_R141_W0.5800.35
143_I152_T0.5800.35
14_Y19_N0.5780.35
127_L167_Q0.5780.35
208_N215_E0.5770.35
245_R249_V0.5770.35
88_V286_I0.5760.35
160_I163_I0.5760.35
85_T149_E0.5750.35
29_G90_G0.5740.35
260_F263_G0.5730.35
54_C57_V0.5730.35
49_A169_F0.5720.34
203_P280_H0.5700.34
103_I161_M0.5700.34
164_I252_I0.5660.34
30_F253_L0.5660.34
92_R98_L0.5640.34
32_T87_V0.5630.34
151_F291_C0.5630.34
152_T249_V0.5610.34
62_A288_M0.5600.33
142_N145_K0.5600.33
58_Y129_L0.5580.33
118_E276_I0.5550.33
267_F273_S0.5530.33
95_F152_T0.5530.33
286_I295_F0.5500.33
97_G132_T0.5480.32
192_Y223_T0.5470.32
164_I278_Y0.5470.32
19_N285_N0.5470.32
236_S243_I0.5460.32
194_F226_V0.5450.32
33_L125_S0.5440.32
32_T83_I0.5430.32
232_F282_V0.5420.32
94_R142_N0.5410.32
77_R80_M0.5400.32
82_F85_T0.5390.32
114_I117_G0.5390.32
108_Q118_E0.5370.31
291_C295_F0.5300.31
230_E258_I0.5300.31
124_L275_L0.5290.31
126_F173_L0.5290.31
154_K256_I0.5290.31
123_V254_F0.5270.31
232_F235_A0.5270.31
35_V251_G0.5260.31
128_I285_N0.5240.30
108_Q122_T0.5240.30
175_A254_F0.5240.30
167_Q171_I0.5230.30
122_T126_F0.5210.30
236_S244_K0.5190.30
33_L168_V0.5180.30
149_E221_V0.5180.30
89_I290_W0.5170.30
228_I232_F0.5150.30
206_Q241_I0.5150.30
146_N289_N0.5140.30
208_N217_N0.5130.30
82_F95_F0.5120.29
11_I177_L0.5110.29
14_Y151_F0.5100.29
290_W295_F0.5100.29
91_W263_G0.5080.29
226_V258_I0.5070.29
103_I107_I0.5060.29
79_L215_E0.5050.29
75_I289_N0.5040.29
175_A258_I0.5030.29
197_D203_P0.5030.29
60_P115_D0.5020.29
111_A175_A0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l16A 1 0.1579 12.6 0.962 Contact Map
2mn6B 2 0.1393 8.2 0.965 Contact Map
2mi2A 1 0.192 3.7 0.97 Contact Map
4h33A 3 0.2724 3 0.972 Contact Map
2y69J 1 0.0433 1.6 0.976 Contact Map
2lzrA 1 0.1486 1.4 0.977 Contact Map
3pjsK 4 0.4118 1.3 0.977 Contact Map
1j2jB 1 0.1269 1.1 0.978 Contact Map
1bm4A 1 0.0774 1.1 0.978 Contact Map
3v9rB 1 0.1115 1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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