GREMLIN Database
YOAR - Uncharacterized protein YoaR
UniProt: O34611 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (259)
Sequences: 1154 (981)
Seq/√Len: 61.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_Q274_T3.6631.00
169_T223_V3.5841.00
83_G123_S3.5121.00
171_S249_D3.4321.00
190_I199_G3.3241.00
223_V253_Q3.0101.00
215_V250_F2.9641.00
138_V272_I2.9591.00
155_S207_V2.8101.00
180_T183_K2.7781.00
215_V222_I2.7191.00
221_Q255_Q2.6351.00
71_N120_K2.5681.00
141_F266_R2.5621.00
221_Q253_Q2.4761.00
90_Y115_M2.4541.00
158_A185_Y2.4381.00
224_Q251_R2.4151.00
85_V118_Y2.4061.00
258_Q277_S2.3751.00
242_T248_P2.3411.00
147_S186_K2.3361.00
94_F113_P2.1931.00
155_S204_I2.1871.00
90_Y93_A2.1801.00
181_R200_V2.1781.00
213_N239_R2.1271.00
70_I84_R2.0981.00
264_A273_I2.0721.00
85_V119_P2.0611.00
165_F259_P2.0141.00
156_A264_A1.9831.00
169_T251_R1.9491.00
172_F243_V1.9171.00
83_G119_P1.8851.00
150_H186_K1.8251.00
172_F176_V1.8231.00
209_S235_V1.7450.99
226_Y248_P1.7210.99
94_F112_V1.7180.99
187_S198_E1.7150.99
178_M245_W1.7070.99
162_H175_V1.6940.99
169_T253_Q1.6870.99
191_I196_L1.6840.99
189_P196_L1.6830.99
158_A183_K1.6780.99
173_N179_R1.6290.99
62_D66_Y1.5800.99
139_T210_T1.5770.99
133_Q274_T1.5730.99
189_P198_E1.5420.98
220_L260_I1.5370.98
130_S278_S1.5270.98
262_I275_L1.5230.98
220_L255_Q1.5180.98
122_D125_L1.5140.98
137_Y213_N1.4760.98
133_Q276_Y1.4540.98
154_L158_A1.4280.98
59_K91_Q1.4230.97
244_S247_G1.4180.97
217_R239_R1.4130.97
159_I170_F1.4120.97
173_N177_G1.4000.97
135_G218_A1.3990.97
82_P123_S1.3940.97
263_R274_T1.3840.97
132_Q279_D1.3800.97
137_Y236_P1.3730.97
173_N243_V1.3710.97
179_R204_I1.3680.97
134_L277_S1.3680.97
260_I275_L1.3490.96
190_I197_S1.3430.96
133_Q136_Q1.3410.96
150_H153_S1.3400.96
159_I207_V1.3170.96
132_Q278_S1.3050.96
67_R84_R1.2880.95
159_I162_H1.2870.95
162_H170_F1.2790.95
73_V81_V1.2730.95
130_S259_P1.2680.95
181_R187_S1.2520.95
161_N261_L1.2380.94
213_N235_V1.2340.94
211_L252_F1.2070.94
138_V270_S1.2050.93
145_N149_S1.2040.93
51_Y99_Y1.2030.93
208_S250_F1.1950.93
74_L81_V1.1890.93
85_V116_N1.1880.93
215_V220_L1.1870.93
192_V197_S1.1830.93
191_I232_V1.1780.93
196_L230_R1.1730.93
205_C234_Y1.1720.92
88_K115_M1.1710.92
165_F168_E1.1570.92
97_K113_P1.1510.92
289_P292_P1.1440.92
252_F262_I1.1400.91
155_S179_R1.1360.91
137_Y209_S1.1330.91
55_S95_M1.1320.91
121_V125_L1.1300.91
172_F208_S1.1280.91
205_C225_R1.1250.91
265_K272_I1.1200.91
179_R245_W1.1120.90
95_M99_Y1.0990.90
93_A97_K1.0830.89
205_C240_D1.0760.89
176_V179_R1.0510.88
149_S269_G1.0500.88
225_R240_D1.0500.88
265_K274_T1.0480.88
137_Y239_R1.0480.88
140_Y270_S1.0400.87
160_D263_R1.0290.87
141_F148_R1.0220.86
176_V185_Y1.0210.86
65_V114_E1.0180.86
147_S188_A1.0110.86
222_I225_R1.0070.85
129_I278_S1.0050.85
258_Q278_S1.0040.85
72_A82_P0.9990.85
173_N245_W0.9940.85
172_F177_G0.9940.85
80_I123_S0.9900.84
89_L112_V0.9890.84
124_E127_A0.9760.83
154_L157_K0.9670.83
266_R269_G0.9640.83
129_I259_P0.9610.83
139_T206_Q0.9570.82
74_L129_I0.9540.82
163_V259_P0.9530.82
62_D91_Q0.9520.82
156_A271_M0.9330.81
183_K245_W0.9290.80
170_F252_F0.9260.80
176_V243_V0.9240.80
141_F149_S0.9210.80
153_S157_K0.9190.80
52_E56_K0.9190.80
207_V271_M0.9080.79
50_D53_K0.9070.79
170_F175_V0.9050.79
176_V245_W0.9050.79
244_S248_P0.9030.78
101_Y110_I0.9020.78
141_F153_S0.8990.78
150_H154_L0.8720.76
136_Q251_R0.8710.76
91_Q94_F0.8700.76
51_Y55_S0.8670.76
92_Q96_E0.8660.75
191_I230_R0.8610.75
164_V262_I0.8590.75
123_S126_L0.8550.75
209_S232_V0.8550.75
75_N110_I0.8470.74
152_I176_V0.8460.74
199_G244_S0.8380.73
212_F219_G0.8350.73
231_S237_P0.8310.72
96_E99_Y0.8300.72
225_R234_Y0.8280.72
138_V152_I0.8260.72
87_Y116_N0.8210.71
177_G184_G0.8200.71
277_S281_I0.8200.71
132_Q259_P0.8170.71
75_N81_V0.8090.70
201_G208_S0.8060.70
154_L177_G0.8040.70
160_D212_F0.8020.70
148_R208_S0.8020.70
259_P276_Y0.8010.70
156_A273_I0.7950.69
83_G126_L0.7950.69
141_F152_I0.7930.69
149_S266_R0.7890.68
88_K117_I0.7870.68
173_N176_V0.7830.68
165_F256_Y0.7820.68
196_L232_V0.7810.68
83_G121_V0.7790.67
211_L215_V0.7790.67
215_V275_L0.7770.67
66_Y91_Q0.7750.67
72_A122_D0.7740.67
177_G243_V0.7720.67
143_S149_S0.7700.67
142_N269_G0.7660.66
192_V199_G0.7650.66
119_P192_V0.7650.66
155_S243_V0.7600.66
172_F207_V0.7590.65
261_L276_Y0.7570.65
257_N260_I0.7560.65
205_C228_H0.7560.65
179_R244_S0.7530.65
199_G248_P0.7530.65
225_R232_V0.7500.64
97_K110_I0.7490.64
209_S242_T0.7470.64
168_E260_I0.7450.64
187_S200_V0.7440.64
215_V252_F0.7370.63
211_L262_I0.7370.63
177_G245_W0.7360.63
234_Y240_D0.7330.63
292_P295_I0.7310.63
154_L183_K0.7260.62
72_A83_G0.7240.62
291_A295_I0.7210.61
267_Y270_S0.7200.61
227_S230_R0.7160.61
266_R271_M0.7150.61
54_Y82_P0.7140.61
38_D42_P0.7130.61
188_A208_S0.7090.60
188_A199_G0.7080.60
289_P295_I0.7040.60
134_L281_I0.7030.59
87_Y114_E0.7010.59
171_S251_R0.7000.59
231_S234_Y0.6960.59
222_I250_F0.6950.59
36_R121_V0.6910.58
80_I126_L0.6900.58
141_F271_M0.6860.58
219_G235_V0.6760.57
90_Y113_P0.6750.56
256_Y275_L0.6750.56
97_K100_A0.6750.56
291_A294_R0.6710.56
137_Y235_V0.6690.56
118_Y122_D0.6650.55
190_I243_V0.6640.55
180_T245_W0.6620.55
154_L208_S0.6590.55
120_K124_E0.6590.55
179_R183_K0.6560.54
211_L220_L0.6560.54
159_I172_F0.6530.54
94_F125_L0.6510.54
188_A195_E0.6500.54
216_D234_Y0.6490.53
83_G118_Y0.6490.53
70_I120_K0.6490.53
61_L64_K0.6480.53
213_N217_R0.6460.53
134_L218_A0.6430.53
158_A179_R0.6430.53
37_E40_T0.6430.53
179_R243_V0.6410.53
289_P294_R0.6390.52
219_G289_P0.6350.52
210_T214_A0.6350.52
177_G238_G0.6330.52
58_I116_N0.6320.52
188_A228_H0.6270.51
219_G231_S0.6270.51
205_C222_I0.6260.51
139_T213_N0.6260.51
152_I208_S0.6260.51
53_K253_Q0.6260.51
52_E100_A0.6250.51
191_I229_T0.6240.51
256_Y280_V0.6240.51
226_Y251_R0.6220.50
152_I249_D0.6220.50
142_N146_K0.6200.50
60_Q63_Q0.6190.50
86_G249_D0.6180.50
69_P275_L0.6170.50
59_K115_M0.6150.50
216_D235_V0.6150.50
223_V251_R0.6140.50
228_H242_T0.6140.50
129_I163_V0.6130.49
159_I264_A0.6100.49
201_G228_H0.6100.49
204_I245_W0.6070.49
39_F43_L0.6060.49
186_K190_I0.6060.49
190_I262_I0.6050.49
38_D41_M0.6030.48
72_A119_P0.6020.48
61_L65_V0.6000.48
194_G213_N0.5950.47
231_S235_V0.5940.47
142_N149_S0.5930.47
58_I64_K0.5920.47
58_I94_F0.5920.47
146_K149_S0.5910.47
213_N236_P0.5910.47
152_I213_N0.5910.47
74_L261_L0.5900.47
149_S152_I0.5890.47
87_Y168_E0.5880.47
51_Y56_K0.5860.46
209_S273_I0.5860.46
81_V110_I0.5840.46
55_S59_K0.5840.46
121_V126_L0.5840.46
64_K107_P0.5800.46
83_G243_V0.5790.46
212_F287_K0.5780.45
72_A242_T0.5780.45
154_L185_Y0.5750.45
67_R147_S0.5740.45
89_L117_I0.5710.45
164_V168_E0.5660.44
69_P86_G0.5640.44
74_L80_I0.5640.44
125_L128_H0.5630.44
93_A113_P0.5600.43
54_Y58_I0.5570.43
209_S237_P0.5560.43
216_D231_S0.5560.43
256_Y260_I0.5560.43
159_I271_M0.5560.43
209_S240_D0.5550.43
71_N276_Y0.5550.43
97_K101_Y0.5540.43
227_S266_R0.5530.43
74_L163_V0.5520.43
73_V79_S0.5490.42
120_K125_L0.5480.42
236_P239_R0.5470.42
62_D112_V0.5460.42
207_V287_K0.5450.42
200_V266_R0.5450.42
116_N124_E0.5450.42
163_V261_L0.5450.42
287_K291_A0.5440.42
140_Y149_S0.5430.42
205_C281_I0.5410.41
92_Q153_S0.5410.41
226_Y242_T0.5390.41
64_K92_Q0.5380.41
52_E84_R0.5380.41
185_Y188_A0.5370.41
155_S175_V0.5370.41
218_A268_G0.5370.41
232_V244_S0.5360.41
141_F269_G0.5360.41
190_I196_L0.5360.41
191_I219_G0.5340.41
155_S183_K0.5330.40
208_S228_H0.5320.40
177_G186_K0.5310.40
41_M44_P0.5300.40
66_Y89_L0.5290.40
63_Q124_E0.5280.40
191_I212_F0.5280.40
219_G242_T0.5270.40
56_K63_Q0.5250.40
58_I91_Q0.5220.39
137_Y230_R0.5210.39
193_K244_S0.5200.39
139_T240_D0.5190.39
157_K178_M0.5180.39
37_E45_G0.5160.39
215_V244_S0.5160.39
194_G278_S0.5160.39
165_F276_Y0.5160.39
119_P122_D0.5140.38
94_F245_W0.5120.38
37_E41_M0.5100.38
213_N281_I0.5100.38
53_K70_I0.5090.38
289_P293_S0.5080.38
141_F176_V0.5070.38
36_R41_M0.5070.38
139_T188_A0.5050.37
171_S243_V0.5040.37
141_F207_V0.5040.37
51_Y100_A0.5020.37
220_L252_F0.5010.37
153_S262_I0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zatA 1 0.736 50.1 0.962 Contact Map
4bg7A 2 0.3069 12.1 0.972 Contact Map
2co7B 1 0.231 11.8 0.972 Contact Map
1o0sA 4 0.7558 9.8 0.973 Contact Map
2f8aA 3 0.1947 9.7 0.973 Contact Map
4djmA 1 0.2376 9.6 0.973 Contact Map
2iiiA 2 0.3531 5.5 0.976 Contact Map
3pe5A 1 0.6139 5.4 0.976 Contact Map
1s3cA 2 0.2607 5.4 0.976 Contact Map
4xvhA 1 0.3234 5.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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