GREMLIN Database
ZNUB - High-affinity zinc uptake system membrane protein ZnuB
UniProt: O34610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (260)
Sequences: 5164 (3275)
Seq/√Len: 203.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_I259_G4.1041.00
16_G230_V3.9051.00
133_Y137_I3.6011.00
229_S255_L3.2181.00
96_A253_I2.9021.00
232_T251_L2.8731.00
214_G217_M2.7691.00
229_S252_L2.7621.00
221_T225_I2.6581.00
212_A218_V2.5891.00
242_T247_S2.5611.00
15_A127_V2.5471.00
220_I224_L2.4831.00
212_A217_M2.4811.00
18_M139_T2.3911.00
207_F225_I2.3031.00
17_G227_L2.2721.00
207_F259_G2.2461.00
145_Y176_S2.2391.00
169_N172_V2.2331.00
212_A221_T2.2201.00
7_E10_R2.1731.00
213_K217_M2.1081.00
18_M136_S2.0791.00
88_V206_A2.0741.00
27_G205_A1.9701.00
53_G63_A1.9411.00
103_F250_L1.9331.00
209_I218_V1.9101.00
199_A249_T1.7891.00
207_F255_L1.7811.00
236_S251_L1.7741.00
172_V176_S1.7721.00
208_A221_T1.7631.00
15_A135_I1.7601.00
22_M139_T1.7601.00
229_S251_L1.7541.00
236_S240_L1.7021.00
15_A132_V1.6991.00
258_I262_V1.6771.00
164_K171_N1.6581.00
155_L162_T1.6571.00
25_I146_F1.6541.00
162_T166_S1.6421.00
149_L152_P1.6331.00
16_G124_L1.6291.00
225_I255_L1.6201.00
25_I143_L1.6171.00
21_V223_I1.6161.00
225_I229_S1.6071.00
20_A230_V1.5911.00
237_S244_P1.5891.00
140_L144_L1.5881.00
129_Q133_Y1.5791.00
145_Y180_V1.5121.00
228_F255_L1.5091.00
69_T179_I1.4961.00
160_E174_S1.4871.00
228_F232_T1.4771.00
235_T239_Q1.4741.00
28_V218_V1.4691.00
134_I137_I1.4611.00
73_I179_I1.4371.00
145_Y149_L1.4211.00
138_I187_V1.4181.00
207_F252_L1.4131.00
9_M238_Y1.3921.00
243_P246_P1.3851.00
39_A201_L1.3811.00
45_I71_G1.3551.00
153_L177_F1.3511.00
149_L176_S1.3481.00
250_L254_V1.3371.00
131_Q190_P1.3331.00
156_L170_T1.3291.00
163_A170_T1.3261.00
80_R171_N1.3221.00
150_R219_F1.3221.00
261_A265_V1.3211.00
28_V219_F1.2971.00
149_L173_L1.2941.00
213_K265_V1.2791.00
48_S101_A1.2671.00
217_M220_I1.2561.00
65_I183_L1.2541.00
98_L195_L1.2431.00
223_I227_L1.2401.00
262_V265_V1.2391.00
210_R259_G1.2301.00
17_G231_F1.2251.00
254_V258_I1.2231.00
137_I141_L1.2231.00
11_R129_Q1.2061.00
154_Y215_F1.2031.00
210_R263_Q1.1931.00
73_I77_Y1.1911.00
84_T256_L1.1891.00
217_M221_T1.1871.00
257_L261_A1.1731.00
168_I173_L1.1681.00
55_F104_L1.1681.00
40_D44_H1.1571.00
234_L244_P1.1571.00
200_L252_L1.1541.00
220_I223_I1.1521.00
208_A225_I1.1491.00
7_E11_R1.1431.00
40_D94_M1.1381.00
33_R160_E1.1301.00
143_L147_I1.1281.00
163_A168_I1.1221.00
145_Y153_L1.1201.00
233_G248_I1.1121.00
33_R157_T1.1071.00
216_N220_I1.1001.00
19_I23_A1.0901.00
12_A234_L1.0831.00
29_Y146_F1.0801.00
13_F231_F1.0771.00
207_F229_S1.0761.00
51_A104_L1.0761.00
24_P222_A1.0721.00
150_R216_N1.0711.00
28_V222_A1.0681.00
30_L181_T1.0371.00
169_N173_L1.0321.00
255_L259_G1.0321.00
129_Q132_V1.0311.00
47_L101_A1.0301.00
203_L252_L1.0241.00
92_I206_A1.0121.00
211_I221_T1.0101.00
14_L132_V1.0091.00
186_S195_L1.0081.00
224_L228_F1.0071.00
236_S247_S1.0021.00
172_V175_L0.9961.00
77_Y81_A0.9911.00
16_G248_I0.9881.00
133_Y136_S0.9861.00
208_A212_A0.9841.00
144_L148_V0.9791.00
51_A105_I0.9721.00
153_L173_L0.9670.99
261_A264_G0.9530.99
59_N62_A0.9530.99
30_L37_L0.9420.99
207_F210_R0.9420.99
29_Y219_F0.9380.99
152_P173_L0.9380.99
155_L163_A0.9370.99
141_L144_L0.9350.99
70_I74_G0.9320.99
62_A66_V0.9250.99
103_F242_T0.9220.99
41_T90_I0.9170.99
52_I67_V0.9050.99
138_I142_I0.9040.99
210_R260_F0.9030.99
226_S230_V0.8980.99
76_E178_S0.8960.99
123_S246_P0.8960.99
130_Q133_Y0.8930.99
45_I48_S0.8890.99
153_L156_L0.8880.99
14_L18_M0.8870.99
136_S140_L0.8850.99
22_M184_A0.8820.99
123_S194_V0.8790.99
10_R14_L0.8750.99
139_T143_L0.8750.99
106_S243_P0.8620.99
156_L173_L0.8600.99
64_S68_V0.8550.99
149_L177_F0.8500.99
47_L105_I0.8470.99
84_T89_S0.8410.99
58_T63_A0.8360.99
39_A121_F0.8330.99
52_I104_L0.8280.98
16_G234_L0.8240.98
24_P223_I0.8210.98
131_Q134_I0.8130.98
171_N174_S0.8130.98
55_F108_S0.8110.98
84_T88_V0.8070.98
162_T165_T0.8070.98
22_M187_V0.8050.98
219_F223_I0.8030.98
91_A202_V0.7990.98
53_G57_S0.7980.98
78_M93_L0.7970.98
12_A125_V0.7940.98
29_Y150_R0.7920.98
27_G252_L0.7870.98
150_R154_Y0.7850.98
130_Q140_L0.7840.98
219_F222_A0.7780.98
207_F256_L0.7780.98
46_S68_V0.7780.98
96_A100_F0.7770.98
32_L157_T0.7740.98
103_F246_P0.7730.98
66_V70_I0.7710.98
24_P205_A0.7690.97
9_M235_T0.7690.97
203_L253_I0.7650.97
40_D202_V0.7650.97
63_A67_V0.7630.97
207_F211_I0.7620.97
9_M12_A0.7620.97
10_R13_F0.7610.97
8_F12_A0.7600.97
188_I197_V0.7600.97
160_E164_K0.7570.97
15_A191_I0.7570.97
124_L244_P0.7560.97
142_I184_A0.7470.97
259_G263_Q0.7470.97
155_L166_S0.7440.97
8_F11_R0.7440.97
51_A97_G0.7430.97
25_I219_F0.7430.97
84_T87_E0.7420.97
69_T73_I0.7410.97
33_R174_S0.7410.97
73_I175_L0.7410.97
13_F234_L0.7380.97
177_F181_T0.7370.97
181_T201_L0.7310.97
231_F235_T0.7310.97
77_Y175_L0.7250.96
9_M234_L0.7240.96
115_S118_Q0.7240.96
16_G20_A0.7240.96
36_A202_V0.7200.96
29_Y33_R0.7180.96
20_A227_L0.7130.96
43_S158_F0.7120.96
259_G262_V0.7090.96
58_T62_A0.7010.96
125_V226_S0.7000.96
225_I259_G0.7000.96
148_V152_P0.6990.96
146_F219_F0.6990.96
128_N131_Q0.6970.96
17_G20_A0.6950.95
53_G59_N0.6920.95
124_L248_I0.6900.95
29_Y153_L0.6850.95
22_M142_I0.6840.95
100_F103_F0.6820.95
43_S85_Y0.6770.95
52_I66_V0.6750.95
79_R86_S0.6740.95
142_I180_V0.6730.95
76_E174_S0.6700.94
260_F264_G0.6700.94
254_V261_A0.6690.94
19_I188_I0.6680.94
62_A65_I0.6680.94
147_I220_I0.6670.94
221_T224_L0.6670.94
20_A24_P0.6650.94
147_I151_R0.6640.94
39_A202_V0.6590.94
179_I183_L0.6580.94
42_L68_V0.6570.94
40_D198_S0.6560.94
49_G63_A0.6540.94
6_L10_R0.6530.94
247_S251_L0.6510.94
19_I191_I0.6500.94
21_V227_L0.6500.94
178_S189_I0.6490.93
31_V36_A0.6480.93
26_L180_V0.6440.93
260_F263_Q0.6410.93
159_D162_T0.6400.93
24_P28_V0.6400.93
135_I187_V0.6390.93
137_I140_L0.6360.93
29_Y177_F0.6340.93
174_S178_S0.6330.93
133_Y236_S0.6290.92
21_V226_S0.6270.92
18_M132_V0.6270.92
86_S178_S0.6220.92
25_I223_I0.6210.92
132_V136_S0.6200.92
253_I257_L0.6190.92
15_A124_L0.6190.92
127_V191_I0.6160.92
41_T47_L0.6160.92
251_L255_L0.6120.91
28_V31_V0.6110.91
232_T236_S0.6100.91
44_H47_L0.6090.91
214_G218_V0.6070.91
43_S46_S0.6060.91
51_A98_L0.6060.91
41_T48_S0.6050.91
153_L161_A0.6020.91
21_V143_L0.6000.91
24_P201_L0.5980.90
116_I249_T0.5970.90
67_V70_I0.5970.90
71_G97_G0.5950.90
135_I191_I0.5940.90
221_T259_G0.5920.90
79_R174_S0.5890.90
232_T255_L0.5870.90
76_E205_A0.5870.90
101_A244_P0.5850.89
43_S47_L0.5850.89
23_A196_L0.5850.89
32_L39_A0.5850.89
91_A206_A0.5850.89
152_P169_N0.5840.89
20_A245_G0.5830.89
69_T183_L0.5830.89
80_R174_S0.5780.89
118_Q123_S0.5720.88
105_I114_M0.5710.88
5_D10_R0.5710.88
236_S239_Q0.5670.88
81_A164_K0.5660.88
6_L238_Y0.5660.88
74_G77_Y0.5650.88
150_R215_F0.5650.88
149_L153_L0.5640.88
39_A43_S0.5620.87
136_S139_T0.5620.87
74_G93_L0.5610.87
72_A182_G0.5610.87
19_I195_L0.5600.87
173_L176_S0.5590.87
64_S94_M0.5570.87
232_T262_V0.5570.87
13_F235_T0.5560.87
138_I183_L0.5560.87
27_G33_R0.5550.87
12_A124_L0.5550.87
147_I150_R0.5550.87
147_I254_V0.5540.87
64_S177_F0.5540.87
46_S119_Y0.5530.87
251_L254_V0.5520.87
172_V265_V0.5510.86
77_Y80_R0.5500.86
106_S123_S0.5490.86
48_S90_I0.5460.86
28_V50_V0.5450.86
94_M99_S0.5430.86
208_A222_A0.5400.85
144_L147_I0.5400.85
65_I69_T0.5390.85
244_P247_S0.5370.85
217_M254_V0.5360.85
95_A99_S0.5350.85
11_R31_V0.5340.85
37_L82_Y0.5340.85
93_L97_G0.5330.85
130_Q134_I0.5330.85
111_T117_D0.5320.85
53_G58_T0.5290.84
54_F114_M0.5290.84
131_Q243_P0.5270.84
29_Y157_T0.5250.84
114_M117_D0.5250.84
164_K172_V0.5240.84
184_A197_V0.5240.84
156_L174_S0.5240.84
46_S189_I0.5230.84
157_T178_S0.5210.83
48_S98_L0.5180.83
45_I97_G0.5170.83
171_N175_L0.5160.83
148_V172_V0.5160.83
27_G226_S0.5140.82
39_A198_S0.5110.82
38_M158_F0.5100.82
102_M106_S0.5090.82
88_V256_L0.5080.82
176_S254_V0.5070.82
185_I198_S0.5060.81
94_M97_G0.5030.81
71_G75_I0.5030.81
96_A99_S0.5020.81
174_S247_S0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9143 100 0.529 Contact Map
2qi9A 2 0.9179 100 0.535 Contact Map
4g1uA 2 0.9143 100 0.556 Contact Map
4p6vB 1 0.7821 41.5 0.947 Contact Map
3zuxA 1 0.8929 16.3 0.957 Contact Map
2zy9A 2 0.3643 15 0.957 Contact Map
4wgvA 2 0.85 11.9 0.959 Contact Map
4n7wA 2 0.925 9 0.961 Contact Map
2m20A 2 0.1357 7.8 0.963 Contact Map
3ukxC 1 0.025 5.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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