GREMLIN Database
SDHAA - Probable L-serine dehydratase, alpha chain
UniProt: O34607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (271)
Sequences: 2345 (1183)
Seq/√Len: 71.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V172_S3.8791.00
43_D136_R3.6921.00
43_D140_I3.4711.00
13_K190_E3.2631.00
20_S183_E3.0551.00
164_G168_A2.9951.00
53_V126_F2.8651.00
182_V187_G2.6701.00
255_Y259_Q2.6701.00
17_I25_A2.6461.00
200_L250_V2.6001.00
28_M35_K2.5981.00
252_D256_K2.5721.00
135_T138_Q2.4831.00
149_F179_A2.4681.00
10_E14_E2.4641.00
24_I39_F2.4441.00
247_C251_I2.4441.00
188_T191_Q2.4371.00
28_M38_I2.3391.00
69_G214_L2.3251.00
93_V231_M2.3191.00
11_I15_K2.2861.00
182_V234_A2.2491.00
141_R183_E2.1461.00
120_V170_V2.1361.00
20_S141_R2.1341.00
34_T37_D2.0391.00
174_S199_T2.0231.00
94_S232_I2.0131.00
23_M148_A1.9561.00
11_I22_V1.9371.00
153_V175_G1.9061.00
47_S136_R1.9041.00
55_K102_V1.8981.00
12_T189_P1.8841.00
207_V265_L1.8731.00
128_V138_Q1.8721.00
124_T227_A1.8291.00
50_E136_R1.7901.00
145_T183_E1.7781.00
42_M143_L1.7131.00
21_D35_K1.7101.00
39_F140_I1.7021.00
46_L139_M1.6681.00
6_K10_E1.6581.00
17_I22_V1.6561.00
35_K39_F1.6320.99
136_R140_I1.6030.99
74_L241_I1.5860.99
158_S164_G1.5830.99
42_M144_F1.5560.99
19_I145_T1.5430.99
15_K25_A1.5230.99
245_I277_P1.5200.99
128_V181_I1.5150.99
54_Q58_E1.4980.99
249_E278_T1.4940.99
36_E40_Q1.4910.99
152_V251_I1.4820.99
65_G71_A1.4550.99
33_K41_Q1.4480.99
9_I189_P1.4450.99
8_L22_V1.4340.99
178_A199_T1.4220.99
50_E126_F1.4210.99
138_Q141_R1.4200.99
138_Q184_M1.4120.98
50_E129_K1.3980.98
33_K37_D1.3790.98
44_H48_V1.3790.98
2_F23_M1.3740.98
153_V200_L1.3660.98
8_L148_A1.3500.98
260_T265_L1.3460.98
175_G200_L1.3340.98
174_S226_G1.3330.98
187_G238_L1.3300.98
187_G191_Q1.3260.98
201_K221_K1.3190.98
24_I35_K1.3070.97
21_D25_A1.3050.97
56_G98_A1.2910.97
161_G224_A1.2860.97
3_R155_N1.2720.97
18_L21_D1.2700.97
252_D255_Y1.2690.97
217_V244_R1.2560.97
39_F43_D1.2430.97
67_T220_V1.2250.96
39_F141_R1.2250.96
189_P192_S1.2210.96
4_N7_E1.2180.96
190_E242_T1.2160.96
5_V193_A1.2010.96
25_A28_M1.1950.96
134_P138_Q1.1940.96
198_I233_A1.1900.96
179_A192_S1.1840.95
181_I231_M1.1730.95
86_G235_D1.1710.95
228_S232_I1.1700.95
39_F137_E1.1590.95
194_E242_T1.1560.95
263_T270_Q1.1550.95
54_Q130_E1.1520.95
59_G105_A1.1500.95
196_M247_C1.1480.95
18_L141_R1.1460.95
40_Q43_D1.1450.94
7_E10_E1.1430.94
203_M206_L1.1360.94
126_F130_E1.1260.94
46_L50_E1.1260.94
145_T179_A1.1230.94
158_S168_A1.1220.94
23_M151_F1.1130.94
51_A55_K1.1120.94
128_V132_L1.1110.94
65_G69_G1.1040.93
47_S51_A1.1030.93
137_E141_R1.1020.93
124_T177_A1.1000.93
52_A99_T1.1000.93
91_D130_E1.0970.93
203_M225_M1.0910.93
128_V134_P1.0850.93
129_K136_R1.0850.93
12_T22_V1.0660.92
96_A123_G1.0620.92
121_V146_A1.0620.92
204_L273_L1.0580.92
194_E243_S1.0510.92
201_K243_S1.0460.91
263_T266_R1.0430.91
55_K107_G1.0430.91
137_E140_I1.0410.91
183_E192_S1.0400.91
120_V206_L1.0340.91
5_V247_C1.0310.91
43_D137_E1.0300.91
120_V161_G1.0280.91
234_A238_L1.0170.90
33_K38_I1.0150.90
260_T264_A1.0100.90
55_K59_G1.0090.90
250_V273_L1.0030.90
264_A270_Q1.0020.89
117_S159_I1.0000.89
207_V257_I0.9990.89
132_L185_A0.9980.89
129_K139_M0.9970.89
253_A276_T0.9960.89
46_L129_K0.9910.89
8_L19_I0.9910.89
95_K130_E0.9820.89
149_F196_M0.9810.88
142_F184_M0.9800.88
158_S163_A0.9780.88
194_E240_G0.9780.88
183_E189_P0.9750.88
24_I28_M0.9740.88
156_N252_D0.9660.88
97_V100_N0.9560.87
197_A201_K0.9550.87
4_N156_N0.9430.86
53_V99_T0.9410.86
100_N117_S0.9410.86
54_Q126_F0.9340.86
95_K131_K0.9340.86
124_T181_I0.9320.86
28_M34_T0.9240.85
261_M266_R0.9120.85
120_V227_A0.9070.84
18_L183_E0.9070.84
270_Q275_A0.9050.84
21_D141_R0.9000.84
3_R7_E0.8990.84
125_L180_A0.8910.83
93_V224_A0.8840.83
72_V76_A0.8820.82
174_S203_M0.8790.82
193_A247_C0.8730.82
161_G170_V0.8710.82
39_F136_R0.8620.81
15_K22_V0.8530.80
162_A267_E0.8510.80
24_I38_I0.8490.80
27_E38_I0.8480.80
95_K127_A0.8440.80
118_A184_M0.8400.79
204_L257_I0.8350.79
46_L143_L0.8250.78
198_I224_A0.8190.78
12_T15_K0.8190.78
252_D276_T0.8170.77
269_G275_A0.8160.77
134_P142_F0.8160.77
160_S163_A0.8100.77
41_Q44_H0.8060.76
84_L132_L0.8040.76
211_V245_I0.8020.76
91_D131_K0.8010.76
172_S226_G0.7990.76
102_V107_G0.7990.76
100_N142_F0.7910.75
74_L97_V0.7900.75
178_A233_A0.7880.75
44_H47_S0.7870.75
249_E277_P0.7840.74
256_K259_Q0.7780.74
174_S229_N0.7770.74
255_Y266_R0.7710.73
34_T38_I0.7710.73
94_S225_M0.7670.73
190_E194_E0.7640.73
203_M229_N0.7550.72
173_A258_G0.7550.72
89_I93_V0.7480.71
50_E54_Q0.7440.71
121_V142_F0.7390.70
120_V203_M0.7370.70
161_G258_G0.7360.70
41_Q45_N0.7340.69
5_V251_I0.7340.69
158_S258_G0.7330.69
217_V220_V0.7290.69
40_Q44_H0.7270.69
253_A260_T0.7260.69
180_A214_L0.7240.68
38_I144_F0.7190.68
249_E270_Q0.7180.68
51_A108_T0.7170.68
9_I193_A0.7140.67
12_T19_I0.7130.67
24_I144_F0.7110.67
156_N161_G0.7090.67
20_S24_I0.7080.67
197_A221_K0.7060.66
59_G64_T0.7010.66
53_V56_G0.6920.65
153_V196_M0.6880.64
13_K133_N0.6850.64
93_V232_I0.6850.64
172_S255_Y0.6770.63
52_A109_I0.6750.63
202_N229_N0.6750.63
77_Y80_S0.6740.63
151_F155_N0.6730.63
35_K38_I0.6730.63
226_G229_N0.6690.62
244_R249_E0.6690.62
64_T70_D0.6680.62
193_A243_S0.6670.62
8_L11_I0.6670.62
92_A127_A0.6670.62
37_D41_Q0.6600.61
185_A234_A0.6600.61
37_D40_Q0.6590.61
52_A55_K0.6590.61
77_Y81_G0.6540.61
51_A54_Q0.6490.60
153_V251_I0.6460.60
11_I14_E0.6460.60
199_T233_A0.6460.60
99_T118_A0.6440.59
20_S39_F0.6420.59
203_M220_V0.6400.59
127_A131_K0.6320.58
57_L98_A0.6320.58
146_A180_A0.6310.58
11_I17_I0.6310.58
118_A142_F0.6310.58
48_V269_G0.6300.58
5_V9_I0.6290.58
47_S54_Q0.6290.58
123_G127_A0.6280.57
6_K58_E0.6270.57
170_V174_S0.6270.57
211_V217_V0.6270.57
164_G239_A0.6260.57
7_E14_E0.6230.57
5_V196_M0.6220.57
89_I228_S0.6200.57
266_R269_G0.6200.57
47_S50_E0.6180.56
93_V228_S0.6110.55
224_A232_I0.6090.55
6_K133_N0.6080.55
271_G275_A0.6070.55
52_A123_G0.6060.55
97_V224_A0.6050.55
199_T203_M0.6040.55
10_E15_K0.6010.54
46_L184_M0.5970.54
20_S145_T0.5970.54
168_A267_E0.5940.53
42_M147_G0.5940.53
192_S269_G0.5930.53
253_A273_L0.5920.53
24_I141_R0.5920.53
161_G267_E0.5910.53
68_G101_E0.5900.53
20_S192_S0.5900.53
262_P266_R0.5900.53
46_L182_V0.5890.53
13_K21_D0.5880.53
108_T123_G0.5860.52
91_D235_D0.5860.52
95_K126_F0.5850.52
43_D47_S0.5850.52
240_G243_S0.5830.52
135_T141_R0.5790.52
199_T229_N0.5790.52
10_E13_K0.5790.52
49_M143_L0.5790.52
70_D201_K0.5790.52
66_L105_A0.5780.51
211_V249_E0.5780.51
246_P250_V0.5770.51
32_E38_I0.5770.51
175_G247_C0.5730.51
81_G87_P0.5730.51
6_K13_K0.5720.51
100_N170_V0.5720.51
84_L185_A0.5710.51
224_A228_S0.5700.50
12_T193_A0.5650.50
179_A196_M0.5650.50
262_P270_Q0.5640.50
145_T189_P0.5640.50
261_M264_A0.5630.50
257_I260_T0.5590.49
132_L138_Q0.5590.49
112_T196_M0.5590.49
216_E241_I0.5590.49
153_V247_C0.5550.49
118_A201_K0.5540.48
129_K134_P0.5530.48
86_G130_E0.5510.48
253_A275_A0.5510.48
19_I192_S0.5510.48
14_E36_E0.5500.48
13_K16_Q0.5490.48
5_V152_V0.5450.47
41_Q48_V0.5440.47
92_A131_K0.5440.47
9_I238_L0.5430.47
21_D24_I0.5430.47
194_E253_A0.5390.47
81_G84_L0.5390.47
129_K135_T0.5370.46
217_V243_S0.5360.46
2_F148_A0.5350.46
46_L126_F0.5330.46
124_T231_M0.5290.45
157_A255_Y0.5280.45
170_V203_M0.5270.45
142_F180_A0.5260.45
77_Y82_K0.5260.45
121_V177_A0.5250.45
111_A216_E0.5250.45
172_S245_I0.5240.45
266_R276_T0.5230.45
253_A262_P0.5230.45
38_I212_A0.5230.45
46_L136_R0.5220.45
181_I232_I0.5200.44
98_A273_L0.5200.44
145_T192_S0.5200.44
129_K138_Q0.5200.44
72_V75_Q0.5200.44
10_E36_E0.5190.44
94_S226_G0.5190.44
110_C207_V0.5170.44
70_D73_K0.5170.44
194_E237_A0.5150.44
120_V224_A0.5150.44
137_E259_Q0.5130.43
64_T67_T0.5120.43
2_F97_V0.5110.43
161_G173_A0.5100.43
214_L267_E0.5100.43
74_L236_M0.5090.43
2_F26_Q0.5090.43
90_L235_D0.5090.43
123_G228_S0.5090.43
126_F129_K0.5090.43
6_K82_K0.5080.43
34_T41_Q0.5080.43
67_T159_I0.5080.43
99_T121_V0.5080.43
27_E144_F0.5060.43
69_G206_L0.5050.42
91_D239_A0.5050.42
90_L228_S0.5050.42
161_G172_S0.5040.42
107_G189_P0.5040.42
168_A254_M0.5040.42
121_V143_L0.5040.42
65_G74_L0.5030.42
159_I220_V0.5020.42
9_I64_T0.5020.42
68_G226_G0.5020.42
161_G225_M0.5010.42
164_G167_Q0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rqoA 2 0.9167 100 0.282 Contact Map
1szqA 2 0.8567 86.7 0.958 Contact Map
1c3cA 4 0.2 45.6 0.969 Contact Map
2hp0A 2 0.8933 32.3 0.972 Contact Map
2pfmA 4 0.21 19.5 0.975 Contact Map
3bv8A 5 0.1267 14.1 0.976 Contact Map
1tj7A 4 0.2467 14.1 0.976 Contact Map
1c1dA 1 0.2533 12.2 0.977 Contact Map
3hhwA 3 0.14 12.1 0.977 Contact Map
1q5nA 4 0.2067 11.8 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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