SDHAA - BACSU - GREMLIN Contacts

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SDHAA - Probable L-serine dehydratase, alpha chain

UniProt:	O34607	Sequences: MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDHNLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEVNAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASISGAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVPCVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAATPTGRELEKKIFGGALGSRETTSAN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	300 (271)
Sequences:	2345 (1183)
Seq/√Len:	71.8

ECOLI - SDHM SDHL TDCG
BACSU - SDHAA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
153_V	172_S	3.879	1.00
43_D	136_R	3.692	1.00
43_D	140_I	3.471	1.00
13_K	190_E	3.263	1.00
20_S	183_E	3.055	1.00
164_G	168_A	2.995	1.00
53_V	126_F	2.865	1.00
182_V	187_G	2.670	1.00
255_Y	259_Q	2.670	1.00
17_I	25_A	2.646	1.00
200_L	250_V	2.600	1.00
28_M	35_K	2.598	1.00
252_D	256_K	2.572	1.00
135_T	138_Q	2.483	1.00
149_F	179_A	2.468	1.00
10_E	14_E	2.464	1.00
24_I	39_F	2.444	1.00
247_C	251_I	2.444	1.00
188_T	191_Q	2.437	1.00
28_M	38_I	2.339	1.00
69_G	214_L	2.325	1.00
93_V	231_M	2.319	1.00
11_I	15_K	2.286	1.00
182_V	234_A	2.249	1.00
141_R	183_E	2.146	1.00
120_V	170_V	2.136	1.00
20_S	141_R	2.134	1.00
34_T	37_D	2.039	1.00
174_S	199_T	2.023	1.00
94_S	232_I	2.013	1.00
23_M	148_A	1.956	1.00
11_I	22_V	1.937	1.00
153_V	175_G	1.906	1.00
47_S	136_R	1.904	1.00
55_K	102_V	1.898	1.00
12_T	189_P	1.884	1.00
207_V	265_L	1.873	1.00
128_V	138_Q	1.872	1.00
124_T	227_A	1.829	1.00
50_E	136_R	1.790	1.00
145_T	183_E	1.778	1.00
42_M	143_L	1.713	1.00
21_D	35_K	1.710	1.00
39_F	140_I	1.702	1.00
46_L	139_M	1.668	1.00
6_K	10_E	1.658	1.00
17_I	22_V	1.656	1.00
35_K	39_F	1.632	0.99
136_R	140_I	1.603	0.99
74_L	241_I	1.586	0.99
158_S	164_G	1.583	0.99
42_M	144_F	1.556	0.99
19_I	145_T	1.543	0.99
15_K	25_A	1.523	0.99
245_I	277_P	1.520	0.99
128_V	181_I	1.515	0.99
54_Q	58_E	1.498	0.99
249_E	278_T	1.494	0.99
36_E	40_Q	1.491	0.99
152_V	251_I	1.482	0.99
65_G	71_A	1.455	0.99
33_K	41_Q	1.448	0.99
9_I	189_P	1.445	0.99
8_L	22_V	1.434	0.99
178_A	199_T	1.422	0.99
50_E	126_F	1.421	0.99
138_Q	141_R	1.420	0.99
138_Q	184_M	1.412	0.98
50_E	129_K	1.398	0.98
33_K	37_D	1.379	0.98
44_H	48_V	1.379	0.98
2_F	23_M	1.374	0.98
153_V	200_L	1.366	0.98
8_L	148_A	1.350	0.98
260_T	265_L	1.346	0.98
175_G	200_L	1.334	0.98
174_S	226_G	1.333	0.98
187_G	238_L	1.330	0.98
187_G	191_Q	1.326	0.98
201_K	221_K	1.319	0.98
24_I	35_K	1.307	0.97
21_D	25_A	1.305	0.97
56_G	98_A	1.291	0.97
161_G	224_A	1.286	0.97
3_R	155_N	1.272	0.97
18_L	21_D	1.270	0.97
252_D	255_Y	1.269	0.97
217_V	244_R	1.256	0.97
39_F	43_D	1.243	0.97
67_T	220_V	1.225	0.96
39_F	141_R	1.225	0.96
189_P	192_S	1.221	0.96
4_N	7_E	1.218	0.96
190_E	242_T	1.216	0.96
5_V	193_A	1.201	0.96
25_A	28_M	1.195	0.96
134_P	138_Q	1.194	0.96
198_I	233_A	1.190	0.96
179_A	192_S	1.184	0.95
181_I	231_M	1.173	0.95
86_G	235_D	1.171	0.95
228_S	232_I	1.170	0.95
39_F	137_E	1.159	0.95
194_E	242_T	1.156	0.95
263_T	270_Q	1.155	0.95
54_Q	130_E	1.152	0.95
59_G	105_A	1.150	0.95
196_M	247_C	1.148	0.95
18_L	141_R	1.146	0.95
40_Q	43_D	1.145	0.94
7_E	10_E	1.143	0.94
203_M	206_L	1.136	0.94
126_F	130_E	1.126	0.94
46_L	50_E	1.126	0.94
145_T	179_A	1.123	0.94
158_S	168_A	1.122	0.94
23_M	151_F	1.113	0.94
51_A	55_K	1.112	0.94
128_V	132_L	1.111	0.94
65_G	69_G	1.104	0.93
47_S	51_A	1.103	0.93
137_E	141_R	1.102	0.93
124_T	177_A	1.100	0.93
52_A	99_T	1.100	0.93
91_D	130_E	1.097	0.93
203_M	225_M	1.091	0.93
128_V	134_P	1.085	0.93
129_K	136_R	1.085	0.93
12_T	22_V	1.066	0.92
96_A	123_G	1.062	0.92
121_V	146_A	1.062	0.92
204_L	273_L	1.058	0.92
194_E	243_S	1.051	0.92
201_K	243_S	1.046	0.91
263_T	266_R	1.043	0.91
55_K	107_G	1.043	0.91
137_E	140_I	1.041	0.91
183_E	192_S	1.040	0.91
120_V	206_L	1.034	0.91
5_V	247_C	1.031	0.91
43_D	137_E	1.030	0.91
120_V	161_G	1.028	0.91
234_A	238_L	1.017	0.90
33_K	38_I	1.015	0.90
260_T	264_A	1.010	0.90
55_K	59_G	1.009	0.90
250_V	273_L	1.003	0.90
264_A	270_Q	1.002	0.89
117_S	159_I	1.000	0.89
207_V	257_I	0.999	0.89
132_L	185_A	0.998	0.89
129_K	139_M	0.997	0.89
253_A	276_T	0.996	0.89
46_L	129_K	0.991	0.89
8_L	19_I	0.991	0.89
95_K	130_E	0.982	0.89
149_F	196_M	0.981	0.88
142_F	184_M	0.980	0.88
158_S	163_A	0.978	0.88
194_E	240_G	0.978	0.88
183_E	189_P	0.975	0.88
24_I	28_M	0.974	0.88
156_N	252_D	0.966	0.88
97_V	100_N	0.956	0.87
197_A	201_K	0.955	0.87
4_N	156_N	0.943	0.86
53_V	99_T	0.941	0.86
100_N	117_S	0.941	0.86
54_Q	126_F	0.934	0.86
95_K	131_K	0.934	0.86
124_T	181_I	0.932	0.86
28_M	34_T	0.924	0.85
261_M	266_R	0.912	0.85
120_V	227_A	0.907	0.84
18_L	183_E	0.907	0.84
270_Q	275_A	0.905	0.84
21_D	141_R	0.900	0.84
3_R	7_E	0.899	0.84
125_L	180_A	0.891	0.83
93_V	224_A	0.884	0.83
72_V	76_A	0.882	0.82
174_S	203_M	0.879	0.82
193_A	247_C	0.873	0.82
161_G	170_V	0.871	0.82
39_F	136_R	0.862	0.81
15_K	22_V	0.853	0.80
162_A	267_E	0.851	0.80
24_I	38_I	0.849	0.80
27_E	38_I	0.848	0.80
95_K	127_A	0.844	0.80
118_A	184_M	0.840	0.79
204_L	257_I	0.835	0.79
46_L	143_L	0.825	0.78
198_I	224_A	0.819	0.78
12_T	15_K	0.819	0.78
252_D	276_T	0.817	0.77
269_G	275_A	0.816	0.77
134_P	142_F	0.816	0.77
160_S	163_A	0.810	0.77
41_Q	44_H	0.806	0.76
84_L	132_L	0.804	0.76
211_V	245_I	0.802	0.76
91_D	131_K	0.801	0.76
172_S	226_G	0.799	0.76
102_V	107_G	0.799	0.76
100_N	142_F	0.791	0.75
74_L	97_V	0.790	0.75
178_A	233_A	0.788	0.75
44_H	47_S	0.787	0.75
249_E	277_P	0.784	0.74
256_K	259_Q	0.778	0.74
174_S	229_N	0.777	0.74
255_Y	266_R	0.771	0.73
34_T	38_I	0.771	0.73
94_S	225_M	0.767	0.73
190_E	194_E	0.764	0.73
203_M	229_N	0.755	0.72
173_A	258_G	0.755	0.72
89_I	93_V	0.748	0.71
50_E	54_Q	0.744	0.71
121_V	142_F	0.739	0.70
120_V	203_M	0.737	0.70
161_G	258_G	0.736	0.70
41_Q	45_N	0.734	0.69
5_V	251_I	0.734	0.69
158_S	258_G	0.733	0.69
217_V	220_V	0.729	0.69
40_Q	44_H	0.727	0.69
253_A	260_T	0.726	0.69
180_A	214_L	0.724	0.68
38_I	144_F	0.719	0.68
249_E	270_Q	0.718	0.68
51_A	108_T	0.717	0.68
9_I	193_A	0.714	0.67
12_T	19_I	0.713	0.67
24_I	144_F	0.711	0.67
156_N	161_G	0.709	0.67
20_S	24_I	0.708	0.67
197_A	221_K	0.706	0.66
59_G	64_T	0.701	0.66
53_V	56_G	0.692	0.65
153_V	196_M	0.688	0.64
13_K	133_N	0.685	0.64
93_V	232_I	0.685	0.64
172_S	255_Y	0.677	0.63
52_A	109_I	0.675	0.63
202_N	229_N	0.675	0.63
77_Y	80_S	0.674	0.63
151_F	155_N	0.673	0.63
35_K	38_I	0.673	0.63
226_G	229_N	0.669	0.62
244_R	249_E	0.669	0.62
64_T	70_D	0.668	0.62
193_A	243_S	0.667	0.62
8_L	11_I	0.667	0.62
92_A	127_A	0.667	0.62
37_D	41_Q	0.660	0.61
185_A	234_A	0.660	0.61
37_D	40_Q	0.659	0.61
52_A	55_K	0.659	0.61
77_Y	81_G	0.654	0.61
51_A	54_Q	0.649	0.60
153_V	251_I	0.646	0.60
11_I	14_E	0.646	0.60
199_T	233_A	0.646	0.60
99_T	118_A	0.644	0.59
20_S	39_F	0.642	0.59
203_M	220_V	0.640	0.59
127_A	131_K	0.632	0.58
57_L	98_A	0.632	0.58
146_A	180_A	0.631	0.58
11_I	17_I	0.631	0.58
118_A	142_F	0.631	0.58
48_V	269_G	0.630	0.58
5_V	9_I	0.629	0.58
47_S	54_Q	0.629	0.58
123_G	127_A	0.628	0.57
6_K	58_E	0.627	0.57
170_V	174_S	0.627	0.57
211_V	217_V	0.627	0.57
164_G	239_A	0.626	0.57
7_E	14_E	0.623	0.57
5_V	196_M	0.622	0.57
89_I	228_S	0.620	0.57
266_R	269_G	0.620	0.57
47_S	50_E	0.618	0.56
93_V	228_S	0.611	0.55
224_A	232_I	0.609	0.55
6_K	133_N	0.608	0.55
271_G	275_A	0.607	0.55
52_A	123_G	0.606	0.55
97_V	224_A	0.605	0.55
199_T	203_M	0.604	0.55
10_E	15_K	0.601	0.54
46_L	184_M	0.597	0.54
20_S	145_T	0.597	0.54
168_A	267_E	0.594	0.53
42_M	147_G	0.594	0.53
192_S	269_G	0.593	0.53
253_A	273_L	0.592	0.53
24_I	141_R	0.592	0.53
161_G	267_E	0.591	0.53
68_G	101_E	0.590	0.53
20_S	192_S	0.590	0.53
262_P	266_R	0.590	0.53
46_L	182_V	0.589	0.53
13_K	21_D	0.588	0.53
108_T	123_G	0.586	0.52
91_D	235_D	0.586	0.52
95_K	126_F	0.585	0.52
43_D	47_S	0.585	0.52
240_G	243_S	0.583	0.52
135_T	141_R	0.579	0.52
199_T	229_N	0.579	0.52
10_E	13_K	0.579	0.52
49_M	143_L	0.579	0.52
70_D	201_K	0.579	0.52
66_L	105_A	0.578	0.51
211_V	249_E	0.578	0.51
246_P	250_V	0.577	0.51
32_E	38_I	0.577	0.51
175_G	247_C	0.573	0.51
81_G	87_P	0.573	0.51
6_K	13_K	0.572	0.51
100_N	170_V	0.572	0.51
84_L	185_A	0.571	0.51
224_A	228_S	0.570	0.50
12_T	193_A	0.565	0.50
179_A	196_M	0.565	0.50
262_P	270_Q	0.564	0.50
145_T	189_P	0.564	0.50
261_M	264_A	0.563	0.50
257_I	260_T	0.559	0.49
132_L	138_Q	0.559	0.49
112_T	196_M	0.559	0.49
216_E	241_I	0.559	0.49
153_V	247_C	0.555	0.49
118_A	201_K	0.554	0.48
129_K	134_P	0.553	0.48
86_G	130_E	0.551	0.48
253_A	275_A	0.551	0.48
19_I	192_S	0.551	0.48
14_E	36_E	0.550	0.48
13_K	16_Q	0.549	0.48
5_V	152_V	0.545	0.47
41_Q	48_V	0.544	0.47
92_A	131_K	0.544	0.47
9_I	238_L	0.543	0.47
21_D	24_I	0.543	0.47
194_E	253_A	0.539	0.47
81_G	84_L	0.539	0.47
129_K	135_T	0.537	0.46
217_V	243_S	0.536	0.46
2_F	148_A	0.535	0.46
46_L	126_F	0.533	0.46
124_T	231_M	0.529	0.45
157_A	255_Y	0.528	0.45
170_V	203_M	0.527	0.45
142_F	180_A	0.526	0.45
77_Y	82_K	0.526	0.45
121_V	177_A	0.525	0.45
111_A	216_E	0.525	0.45
172_S	245_I	0.524	0.45
266_R	276_T	0.523	0.45
253_A	262_P	0.523	0.45
38_I	212_A	0.523	0.45
46_L	136_R	0.522	0.45
181_I	232_I	0.520	0.44
98_A	273_L	0.520	0.44
145_T	192_S	0.520	0.44
129_K	138_Q	0.520	0.44
72_V	75_Q	0.520	0.44
10_E	36_E	0.519	0.44
94_S	226_G	0.519	0.44
110_C	207_V	0.517	0.44
70_D	73_K	0.517	0.44
194_E	237_A	0.515	0.44
120_V	224_A	0.515	0.44
137_E	259_Q	0.513	0.43
64_T	67_T	0.512	0.43
2_F	97_V	0.511	0.43
161_G	173_A	0.510	0.43
214_L	267_E	0.510	0.43
74_L	236_M	0.509	0.43
2_F	26_Q	0.509	0.43
90_L	235_D	0.509	0.43
123_G	228_S	0.509	0.43
126_F	129_K	0.509	0.43
6_K	82_K	0.508	0.43
34_T	41_Q	0.508	0.43
67_T	159_I	0.508	0.43
99_T	121_V	0.508	0.43
27_E	144_F	0.506	0.43
69_G	206_L	0.505	0.42
91_D	239_A	0.505	0.42
90_L	228_S	0.505	0.42
161_G	172_S	0.504	0.42
107_G	189_P	0.504	0.42
168_A	254_M	0.504	0.42
121_V	143_L	0.504	0.42
65_G	74_L	0.503	0.42
159_I	220_V	0.502	0.42
9_I	64_T	0.502	0.42
68_G	226_G	0.502	0.42
161_G	225_M	0.501	0.42
164_G	167_Q	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rqoA	2	0.9167	100	0.282	Contact Map
1szqA	2	0.8567	86.7	0.958	Contact Map
1c3cA	4	0.2	45.6	0.969	Contact Map
2hp0A	2	0.8933	32.3	0.972	Contact Map
2pfmA	4	0.21	19.5	0.975	Contact Map
3bv8A	5	0.1267	14.1	0.976	Contact Map
1tj7A	4	0.2467	14.1	0.976	Contact Map
1c1dA	1	0.2533	12.2	0.977	Contact Map
3hhwA	3	0.14	12.1	0.977	Contact Map
1q5nA	4	0.2067	11.8	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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