GREMLIN Database
YIDD - Putative membrane protein insertion efficiency factor
UniProt: O34601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 75 (67)
Sequences: 2712 (1600)
Seq/√Len: 195.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G50_T4.2561.00
5_F43_A2.6851.00
6_I35_I2.3001.00
42_G46_G2.2271.00
20_T23_T2.0781.00
13_Q32_Q1.9981.00
26_F61_H1.8901.00
32_Q36_E1.7641.00
48_W52_K1.6961.00
5_F38_I1.6471.00
52_K56_K1.6441.00
11_G15_F1.6401.00
38_I47_G1.6211.00
26_F62_P1.6091.00
27_Y65_V1.4871.00
10_R13_Q1.4831.00
13_Q35_I1.4241.00
35_I39_K1.4221.00
52_K58_H1.3761.00
49_L69_P1.3501.00
10_R35_I1.3171.00
36_E40_T1.3141.00
38_I50_T1.2831.00
7_A11_G1.2471.00
25_R61_H1.2361.00
56_K61_H1.1951.00
9_I13_Q1.1821.00
9_I38_I1.1511.00
9_I34_G1.1071.00
49_L52_K1.0991.00
38_I43_A1.0981.00
26_F56_K1.0541.00
58_H61_H1.0501.00
51_I55_L1.0401.00
15_F19_L0.9961.00
10_R14_K0.9860.99
41_H68_V0.9830.99
15_F18_P0.9810.99
34_G47_G0.9780.99
54_I58_H0.9530.99
3_T7_A0.9350.99
27_Y32_Q0.9290.99
55_L58_H0.9280.99
16_I20_T0.9110.99
32_Q35_I0.9070.99
47_G51_I0.9010.99
36_E68_V0.8830.99
41_H45_K0.8770.99
6_I39_K0.8440.98
41_H69_P0.8380.98
37_A68_V0.8250.98
43_A47_G0.8190.98
50_T54_I0.8140.98
6_I10_R0.8130.98
49_L68_V0.7720.97
7_A10_R0.7580.97
34_G38_I0.7420.96
36_E67_P0.7390.96
4_L7_A0.7230.96
16_I23_T0.6980.95
9_I35_I0.6960.95
25_R62_P0.6950.95
38_I46_G0.6940.95
19_L22_P0.6880.95
36_E39_K0.6870.95
12_Y16_I0.6750.94
17_S21_P0.6710.94
27_Y63_G0.6570.93
60_F65_V0.6330.92
12_Y20_T0.6330.92
16_I22_P0.6320.92
26_F67_P0.6200.91
9_I54_I0.6140.91
5_F8_L0.6130.91
37_A49_L0.6120.91
48_W55_L0.6120.91
52_K55_L0.5980.90
34_G54_I0.5950.89
5_F47_G0.5820.88
9_I12_Y0.5790.88
44_L55_L0.5700.87
6_I38_I0.5700.87
15_F20_T0.5690.87
3_T39_K0.5580.86
52_K61_H0.5550.86
4_L8_L0.5540.86
16_I21_P0.5450.85
46_G50_T0.5420.84
4_L44_L0.5410.84
11_G14_K0.5360.84
45_K49_L0.5340.84
44_L47_G0.5320.83
61_H64_G0.5250.83
17_S29_T0.5250.83
10_R39_K0.5200.82
14_K60_F0.5190.82
21_P25_R0.5100.81
8_L11_G0.5070.80
26_F58_H0.5040.80
16_I19_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fccA 5 0.8533 31.4 0.908 Contact Map
3mw9A 5 0.8533 11.6 0.924 Contact Map
1bgvA 5 0.9067 10.8 0.926 Contact Map
3qpiA 1 0.4667 6.1 0.933 Contact Map
2bmaA 5 0.8533 5.7 0.934 Contact Map
2tmgA 5 0.9067 5.6 0.935 Contact Map
3r3jA 5 0.8533 5.4 0.935 Contact Map
2jlnA 1 0.2667 5.4 0.935 Contact Map
3k92A 5 0.84 5.2 0.935 Contact Map
3aoeE 3 0.8533 4.9 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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