GREMLIN Database
NRNA - Bifunctional oligoribonuclease and PAP phosphatase NrnA
UniProt: O34600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (280)
Sequences: 5636 (4172)
Seq/√Len: 249.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_E168_K4.2591.00
124_S152_G3.5591.00
135_K175_E3.1871.00
40_E142_N3.1821.00
171_K178_Q3.0761.00
37_I131_Y3.0531.00
19_R27_A2.8401.00
182_S185_E2.7781.00
128_Y175_E2.7271.00
35_T39_R2.5391.00
160_F173_A2.5321.00
128_Y172_Y2.4711.00
142_N145_A2.3971.00
36_E142_N2.3581.00
115_W126_M2.2791.00
14_T44_E2.1631.00
35_T45_K2.1561.00
12_Y15_I2.1521.00
221_K224_T2.0941.00
16_I74_A2.0911.00
150_Y181_F2.0871.00
15_I75_L2.0281.00
151_A186_L1.9771.00
208_V216_A1.9721.00
185_E189_Q1.9521.00
36_E145_A1.9491.00
30_S124_S1.9261.00
167_E178_Q1.9241.00
17_L79_C1.9161.00
158_G162_F1.8921.00
167_E171_K1.8891.00
171_K174_G1.8841.00
216_A248_I1.7901.00
36_E40_E1.7811.00
33_G127_I1.7591.00
263_V290_A1.7371.00
274_G277_R1.7041.00
254_F261_I1.7021.00
203_F206_Q1.6951.00
121_S125_E1.6791.00
21_V89_D1.6661.00
214_G249_R1.6621.00
30_S123_V1.6611.00
153_I173_A1.6491.00
17_L35_T1.6381.00
78_V87_I1.6331.00
260_Q293_Y1.6261.00
207_N218_V1.5941.00
38_L47_I1.5911.00
79_C123_V1.5731.00
34_L77_I1.5711.00
14_T46_N1.5681.00
33_G149_I1.5581.00
36_E39_R1.5531.00
78_V81_T1.5431.00
121_S157_T1.5361.00
17_L34_L1.5351.00
195_L199_K1.5271.00
211_S217_S1.5221.00
171_K175_E1.5211.00
18_H76_V1.5011.00
17_L31_Q1.4951.00
150_Y173_A1.4741.00
170_L174_G1.4701.00
75_L96_A1.4701.00
267_S272_I1.4571.00
77_I99_M1.4561.00
147_E181_F1.4531.00
120_A126_M1.4511.00
265_F276_A1.4361.00
175_E178_Q1.4291.00
58_S62_S1.4211.00
31_Q47_I1.4181.00
201_N241_T1.4061.00
101_I130_L1.4031.00
128_Y135_K1.3981.00
199_K202_G1.3971.00
36_E144_K1.3801.00
37_I139_W1.3531.00
170_L177_I1.3461.00
15_I43_P1.3441.00
30_S79_C1.3351.00
62_S65_E1.3341.00
124_S149_I1.3001.00
117_D168_K1.2981.00
149_I176_L1.2981.00
168_K172_Y1.2951.00
25_P151_A1.2931.00
249_R270_P1.2921.00
125_E169_T1.2921.00
231_T234_E1.2831.00
198_V245_I1.2701.00
265_F272_I1.2681.00
56_S61_Y1.2661.00
124_S153_I1.2541.00
32_C148_L1.2531.00
174_G178_Q1.2521.00
209_S217_S1.2481.00
208_V242_L1.2441.00
41_T139_W1.2441.00
35_T47_I1.2421.00
143_T180_P1.2421.00
207_N224_T1.2341.00
76_V95_G1.2331.00
81_T87_I1.2311.00
14_T74_A1.2201.00
167_E170_L1.2191.00
55_P58_S1.2171.00
57_L61_Y1.2141.00
177_I183_S1.2061.00
165_T170_L1.2051.00
154_V159_R1.2001.00
143_T181_F1.1951.00
33_G145_A1.1661.00
204_I218_V1.1461.00
25_P155_G1.1451.00
203_F224_T1.1421.00
203_F207_N1.1421.00
37_I41_T1.1411.00
260_Q291_S1.1331.00
46_N73_G1.1281.00
109_P112_D1.1161.00
97_K112_D1.1151.00
128_Y149_I1.1121.00
141_L179_Y1.1081.00
37_I137_H1.1051.00
15_I77_I1.1021.00
34_L127_I1.0961.00
256_E259_D1.0941.00
33_G124_S1.0911.00
250_A271_V1.0901.00
99_M113_L1.0811.00
36_E131_Y1.0801.00
203_F228_F1.0761.00
143_T147_E1.0761.00
122_S152_G1.0751.00
41_T137_H1.0741.00
249_R269_G1.0691.00
33_G36_E1.0691.00
16_I73_G1.0681.00
222_K226_E1.0641.00
12_Y75_L1.0611.00
19_R31_Q1.0571.00
240_G243_G1.0551.00
217_S254_F1.0541.00
120_A129_E1.0521.00
155_G190_L1.0371.00
31_Q79_C1.0281.00
240_G244_N1.0271.00
146_A176_L1.0111.00
84_Q93_P1.0061.00
29_G124_S1.0031.00
226_E229_G1.0021.00
172_Y175_E1.0011.00
204_I238_L0.9991.00
18_H48_F0.9941.00
239_V251_W0.9881.00
167_E174_G0.9781.00
210_L248_I0.9731.00
13_D71_Y0.9721.00
241_T245_I0.9641.00
98_L111_G0.9541.00
69_E73_G0.9431.00
195_L210_L0.9411.00
38_L99_M0.9371.00
208_V218_V0.9361.00
272_I288_S0.9211.00
61_Y147_E0.9201.00
121_S169_T0.9191.00
18_H87_I0.9161.00
34_L38_L0.9161.00
73_G96_A0.9141.00
56_S59_F0.9141.00
42_Y45_K0.9141.00
200_L234_E0.9101.00
168_K171_K0.9051.00
201_N205_F0.9021.00
159_R187_F0.9011.00
116_V136_E0.8991.00
34_L79_C0.8961.00
39_R65_E0.8961.00
181_F186_L0.8941.00
194_K246_S0.8931.00
222_K256_E0.8821.00
61_Y64_D0.8811.00
196_N230_T0.8811.00
105_P285_P0.8761.00
218_V242_L0.8751.00
25_P60_L0.8670.99
60_L151_A0.8670.99
75_L97_K0.8650.99
243_G251_W0.8640.99
145_A149_I0.8610.99
207_N219_F0.8570.99
13_D44_E0.8520.99
200_L238_L0.8450.99
201_N204_I0.8440.99
280_N293_Y0.8440.99
187_F191_Y0.8420.99
117_D126_M0.8410.99
222_K225_L0.8400.99
56_S60_L0.8390.99
129_E172_Y0.8390.99
61_Y148_L0.8380.99
54_E57_L0.8340.99
38_L77_I0.8290.99
117_D129_E0.8250.99
64_D147_E0.8240.99
194_K197_V0.8240.99
69_E72_E0.8220.99
143_T182_S0.8200.99
107_E114_L0.8180.99
37_I145_A0.8160.99
199_K203_F0.8090.99
53_P58_S0.8010.99
123_V127_I0.7980.99
170_L173_A0.7970.99
13_D74_A0.7970.99
257_E260_Q0.7950.99
29_G33_G0.7950.99
241_T244_N0.7940.99
175_E179_Y0.7920.99
127_I131_Y0.7910.99
40_E140_K0.7880.99
264_R289_G0.7880.99
106_N114_L0.7880.99
267_S286_L0.7870.99
63_L189_Q0.7840.99
29_G148_L0.7780.99
59_F63_L0.7760.99
32_C61_Y0.7760.99
273_N277_R0.7720.99
129_E136_E0.7720.99
53_P63_L0.7680.99
238_L241_T0.7640.99
92_Y95_G0.7630.99
196_N229_G0.7610.99
11_L97_K0.7610.99
76_V92_Y0.7610.99
215_A250_A0.7560.99
213_N249_R0.7520.99
225_L230_T0.7500.99
232_A236_S0.7490.98
202_G206_Q0.7470.98
223_D256_E0.7450.98
143_T179_Y0.7450.98
122_S125_E0.7430.98
223_D226_E0.7370.98
198_V202_G0.7360.98
127_I149_I0.7340.98
201_N238_L0.7320.98
27_A79_C0.7300.98
242_L248_I0.7250.98
100_K107_E0.7240.98
243_G266_R0.7240.98
141_L146_A0.7230.98
24_D156_D0.7170.98
199_K206_Q0.7160.98
269_G286_L0.7150.98
200_L220_I0.7110.98
34_L99_M0.7050.98
256_E261_I0.7050.98
82_A111_G0.7040.98
83_N107_E0.7020.98
259_D293_Y0.7020.98
63_L66_V0.7000.98
239_V253_F0.6970.98
201_N245_I0.6960.98
118_T129_E0.6950.98
237_Q241_T0.6940.98
265_F275_L0.6930.97
78_V111_G0.6920.97
141_L149_I0.6920.97
109_P114_L0.6910.97
147_E185_E0.6890.97
207_N211_S0.6890.97
219_F261_I0.6860.97
20_H24_D0.6840.97
242_L251_W0.6820.97
25_P57_L0.6800.97
279_Y292_I0.6720.97
146_A181_F0.6720.97
20_H23_P0.6710.97
23_P27_A0.6710.97
16_I48_F0.6710.97
252_V275_L0.6700.97
72_E94_S0.6690.97
60_L148_L0.6670.97
210_L216_A0.6640.97
29_G152_G0.6640.97
235_A255_V0.6590.97
167_E177_I0.6590.97
120_A125_E0.6590.97
265_F290_A0.6570.97
66_V144_K0.6570.97
106_N109_P0.6560.97
40_E145_A0.6540.96
160_F170_L0.6520.96
221_K256_E0.6520.96
85_E108_D0.6490.96
79_C124_S0.6420.96
212_E215_A0.6400.96
150_Y154_V0.6370.96
57_L60_L0.6370.96
200_L204_I0.6370.96
120_A168_K0.6340.96
135_K138_G0.6330.96
218_V253_F0.6280.96
71_Y74_A0.6260.95
27_A31_Q0.6250.95
35_T49_A0.6240.95
195_L208_V0.6230.95
125_E168_K0.6230.95
162_F287_A0.6220.95
111_G114_L0.6190.95
193_T246_S0.6190.95
252_V265_F0.6190.95
104_H156_D0.6170.95
240_G266_R0.6160.95
52_T56_S0.6140.95
18_H50_V0.6130.95
14_T72_E0.6120.95
68_N71_Y0.6020.94
276_A289_G0.6010.94
38_L45_K0.6010.94
141_L145_A0.6010.94
147_E186_L0.5990.94
197_V234_E0.5960.94
159_R191_Y0.5950.94
28_Y49_A0.5940.94
12_Y74_A0.5930.94
192_E246_S0.5920.94
41_T45_K0.5910.94
131_Y145_A0.5880.94
161_L187_F0.5870.94
14_T71_Y0.5860.94
24_D80_D0.5830.93
13_D43_P0.5820.93
78_V100_K0.5810.93
39_R44_E0.5800.93
232_A257_E0.5790.93
106_N273_N0.5780.93
250_A267_S0.5780.93
220_I224_T0.5760.93
215_A275_L0.5760.93
202_G205_F0.5750.93
141_L176_L0.5740.93
280_N290_A0.5730.93
107_E277_R0.5730.93
80_D156_D0.5720.93
281_G287_A0.5690.93
144_K147_E0.5670.92
131_Y138_G0.5670.92
156_D281_G0.5660.92
41_T140_K0.5620.92
20_H86_R0.5580.92
263_V276_A0.5570.92
243_G248_I0.5550.92
39_R45_K0.5540.92
79_C127_I0.5530.92
219_F256_E0.5520.91
238_L253_F0.5520.91
33_G148_L0.5520.91
117_D120_A0.5510.91
15_I45_K0.5500.91
36_E148_L0.5490.91
282_G289_G0.5490.91
101_I127_I0.5490.91
163_P286_L0.5480.91
131_Y139_W0.5470.91
16_I76_V0.5450.91
52_T55_P0.5450.91
29_G145_A0.5430.91
276_A279_Y0.5430.91
17_L38_L0.5410.91
204_I209_S0.5410.91
54_E64_D0.5410.91
50_V89_D0.5390.90
100_K111_G0.5390.90
233_S236_S0.5390.90
97_K113_L0.5390.90
183_S187_F0.5360.90
225_L228_F0.5360.90
131_Y137_H0.5360.90
13_D73_G0.5350.90
272_I275_L0.5340.90
28_Y32_C0.5340.90
122_S153_I0.5330.90
154_V190_L0.5310.90
82_A110_Y0.5310.90
15_I38_L0.5310.90
225_L229_G0.5300.90
16_I95_G0.5250.89
17_L45_K0.5250.89
21_V86_R0.5240.89
153_I172_Y0.5210.89
236_S239_V0.5200.89
184_S188_N0.5190.89
53_P59_F0.5170.89
151_A154_V0.5170.89
40_E139_W0.5150.88
130_L136_E0.5140.88
193_T201_N0.5130.88
125_E172_Y0.5120.88
73_G95_G0.5120.88
62_S66_V0.5110.88
113_L117_D0.5100.88
75_L99_M0.5090.88
106_N115_W0.5080.88
74_A95_G0.5080.88
265_F270_P0.5070.88
239_V266_R0.5030.87
160_F165_T0.5030.87
38_L41_T0.5030.87
113_L130_L0.5020.87
150_Y183_S0.5020.87
32_C62_S0.5010.87
100_K116_V0.5010.87
157_T164_N0.5010.87
12_Y97_K0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3devA 2 0.9968 100 0.18 Contact Map
4py9A 2 0.9776 100 0.202 Contact Map
4ls9A 2 0.9617 100 0.23 Contact Map
4rpaA 3 0.9329 100 0.309 Contact Map
2hawA 2 0.9329 100 0.311 Contact Map
1k20A 2 0.9233 100 0.347 Contact Map
2eb0A 2 0.9042 100 0.353 Contact Map
2qb7A 1 0.9744 100 0.407 Contact Map
1wpnA 2 0.5687 100 0.476 Contact Map
2zxrA 1 0.8115 100 0.542 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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