GREMLIN Database
ISCS1 - Putative cysteine desulfurase IscS 1
UniProt: O34599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (331)
Sequences: 28674 (19298)
Seq/√Len: 1060.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_I365_K3.4231.00
92_H118_T3.3051.00
163_G173_F3.2311.00
270_I361_A3.1901.00
148_Y180_A3.1641.00
274_T368_A3.1291.00
53_Q251_K2.9351.00
158_P161_E2.9061.00
134_K165_L2.7671.00
177_A196_L2.6951.00
97_K121_D2.6191.00
248_E251_K2.4841.00
278_A372_A2.4601.00
187_D190_N2.3921.00
92_H138_R2.3621.00
198_V211_F2.3491.00
134_K168_E2.2991.00
92_H116_D2.2981.00
239_N242_G2.2911.00
166_L171_A2.2821.00
315_A373_D2.2511.00
144_V166_L2.1681.00
59_G187_D2.1661.00
270_I274_T2.1361.00
132_Q135_E2.0291.00
266_S361_A1.9971.00
283_E299_Y1.9821.00
353_I367_A1.9771.00
160_E190_N1.9511.00
274_T277_D1.9511.00
274_T365_K1.9491.00
92_H141_T1.8941.00
19_L23_I1.8871.00
285_N299_Y1.8831.00
121_D132_Q1.8661.00
118_T136_A1.8611.00
132_Q136_A1.8301.00
53_Q247_K1.8301.00
283_E301_P1.8131.00
56_A254_S1.7821.00
315_A370_H1.7801.00
123_D127_R1.7741.00
160_E164_E1.7721.00
146_V162_I1.7711.00
69_S73_E1.7691.00
164_E168_E1.7411.00
366_T370_H1.7311.00
129_S132_Q1.7011.00
263_K267_F1.6991.00
175_T193_I1.6951.00
24_P28_G1.6911.00
92_H140_D1.6781.00
75_D102_A1.6751.00
166_L173_F1.6661.00
130_A165_L1.5641.00
271_F355_F1.5631.00
68_T74_A1.5561.00
200_G246_L1.5311.00
20_E24_P1.5211.00
311_N314_M1.5071.00
78_A195_L1.5021.00
165_L169_H1.5001.00
53_Q254_S1.4961.00
84_L113_D1.4961.00
193_I196_L1.4911.00
278_A281_A1.4831.00
91_R140_D1.4771.00
21_Q248_E1.4591.00
91_R142_I1.4531.00
22_M245_G1.4441.00
276_R288_K1.4431.00
75_D174_H1.4421.00
261_N265_Q1.4391.00
269_A273_D1.4391.00
297_N350_S1.4371.00
130_A161_E1.4351.00
274_T278_A1.4271.00
161_E164_E1.4131.00
97_K119_Y1.4121.00
71_G178_V1.4111.00
167_K194_D1.4061.00
64_E216_K1.4011.00
49_E247_K1.3901.00
80_M225_F1.3781.00
206_P245_G1.3711.00
29_S42_E1.3691.00
268_K272_A1.3691.00
265_Q269_A1.3611.00
20_E23_I1.3581.00
274_T372_A1.3571.00
143_L174_H1.3561.00
159_I175_T1.3541.00
149_G292_L1.3531.00
165_L168_E1.3531.00
21_Q24_P1.3511.00
137_L165_L1.3401.00
109_K225_F1.3301.00
167_K192_H1.3261.00
304_S307_A1.3251.00
61_A189_K1.3211.00
134_K169_H1.3111.00
123_D129_S1.3031.00
163_G167_K1.2961.00
272_A296_L1.2961.00
49_E53_Q1.2951.00
50_A247_K1.2861.00
258_D262_E1.2831.00
52_A56_A1.2831.00
370_H373_D1.2781.00
272_A276_R1.2711.00
203_L246_L1.2641.00
262_E266_S1.2611.00
224_L229_Q1.2611.00
131_K134_K1.2571.00
95_T107_C1.2571.00
146_V173_F1.2491.00
204_N356_G1.2491.00
361_A365_K1.2481.00
82_T172_Y1.2471.00
94_I136_A1.2471.00
131_K135_E1.2381.00
54_I211_F1.2311.00
163_G192_H1.2241.00
95_T119_Y1.2241.00
125_N287_D1.2191.00
195_L214_A1.2181.00
164_E192_H1.2161.00
311_N374_V1.2131.00
146_V159_I1.2131.00
181_F198_V1.2091.00
319_V351_I1.2041.00
120_L136_A1.2021.00
149_G180_A1.1961.00
57_E181_F1.1741.00
256_E259_E1.1711.00
52_A55_A1.1671.00
271_F364_V1.1631.00
46_W244_V1.1621.00
74_A197_S1.1561.00
366_T369_K1.1551.00
281_A301_P1.1541.00
104_L119_Y1.1521.00
134_K138_R1.1481.00
156_V184_L1.1411.00
133_V144_V1.1381.00
144_V171_A1.1341.00
273_D277_D1.1221.00
63_Q216_K1.1091.00
174_H197_S1.1081.00
247_K251_K1.1061.00
45_K49_E1.1051.00
94_I141_T1.1001.00
273_D276_R1.0961.00
180_A196_L1.0921.00
267_F364_V1.0891.00
188_V213_Y1.0871.00
116_D138_R1.0861.00
148_Y196_L1.0851.00
311_N315_A1.0771.00
98_I157_Q1.0761.00
53_Q56_A1.0761.00
59_G189_K1.0721.00
130_A134_K1.0701.00
105_H108_E1.0671.00
133_V162_I1.0621.00
138_R169_H1.0611.00
61_A216_K1.0561.00
47_V243_I1.0461.00
272_A284_V1.0461.00
65_I213_Y1.0411.00
360_T363_Q1.0361.00
167_K173_F1.0341.00
145_T174_H1.0341.00
185_P258_D1.0311.00
368_A372_A1.0281.00
138_R141_T1.0211.00
317_V366_T1.0131.00
172_Y195_L0.9991.00
268_K296_L0.9981.00
251_K255_E0.9941.00
148_Y191_S0.9881.00
83_A115_F0.9861.00
149_G293_P0.9861.00
248_E252_L0.9791.00
274_T369_K0.9781.00
134_K161_E0.9761.00
309_L321_S0.9751.00
194_D215_S0.9721.00
80_M109_K0.9711.00
90_G142_I0.9651.00
57_E250_I0.9591.00
79_I107_C0.9511.00
160_E191_S0.9431.00
259_E262_E0.9401.00
355_F364_V0.9391.00
54_I250_I0.9381.00
310_V313_D0.9381.00
195_L218_V0.9351.00
277_D372_A0.9341.00
312_L319_V0.9331.00
263_K266_S0.9311.00
259_E263_K0.9311.00
58_I198_V0.9301.00
103_V145_T0.9281.00
298_L353_I0.9271.00
317_V370_H0.9271.00
260_K357_L0.9251.00
19_L26_F0.9241.00
317_V367_A0.9141.00
108_E111_E0.9131.00
93_I107_C0.9121.00
200_G209_T0.9101.00
319_V353_I0.9061.00
365_K369_K0.9031.00
275_L298_L0.9031.00
38_S42_E0.9001.00
369_K373_D0.9001.00
359_N364_V0.9001.00
260_K264_Y0.8941.00
137_L141_T0.8931.00
209_T243_I0.8861.00
174_H195_L0.8791.00
148_Y186_I0.8721.00
61_A64_E0.8711.00
260_K263_K0.8701.00
147_M151_N0.8691.00
130_A133_V0.8691.00
362_E365_K0.8671.00
200_G205_G0.8661.00
109_K112_G0.8641.00
285_N297_N0.8641.00
58_I213_Y0.8591.00
307_A311_N0.8581.00
50_A53_Q0.8571.00
80_M84_L0.8561.00
203_L250_I0.8551.00
163_G191_S0.8541.00
362_E366_T0.8521.00
271_F296_L0.8471.00
172_Y218_V0.8401.00
55_A60_A0.8381.00
87_K91_R0.8351.00
285_N350_S0.8321.00
42_E45_K0.8261.00
271_F367_A0.8221.00
82_T195_L0.8221.00
306_E310_V0.8211.00
148_Y159_I0.8181.00
22_M26_F0.8171.00
144_V162_I0.8161.00
137_L169_H0.8151.00
18_V249_A0.8151.00
84_L112_G0.8131.00
215_S218_V0.8131.00
267_F361_A0.8121.00
49_E251_K0.8101.00
209_T242_G0.8081.00
278_A368_A0.8041.00
166_L170_K0.8031.00
39_F318_A0.8021.00
123_D132_Q0.7991.00
256_E260_K0.7981.00
118_T138_R0.7951.00
97_K122_V0.7891.00
276_R287_D0.7891.00
282_F300_F0.7841.00
91_R116_D0.7781.00
223_L227_G0.7781.00
24_P29_S0.7761.00
309_L319_V0.7751.00
53_Q57_E0.7741.00
271_F353_I0.7711.00
118_T141_T0.7711.00
78_A212_L0.7711.00
181_F250_I0.7701.00
367_A371_V0.7691.00
121_D136_A0.7681.00
75_D197_S0.7651.00
66_I77_L0.7651.00
187_D191_S0.7641.00
93_I143_L0.7631.00
222_P225_F0.7621.00
177_A181_F0.7611.00
127_R157_Q0.7601.00
181_F203_L0.7581.00
192_H215_S0.7571.00
94_I118_T0.7531.00
177_A180_A0.7511.00
356_G359_N0.7511.00
226_G229_Q0.7501.00
310_V314_M0.7481.00
359_N363_Q0.7461.00
80_M223_L0.7451.00
185_P261_N0.7441.00
292_L295_V0.7441.00
221_S225_F0.7431.00
181_F186_I0.7431.00
224_L227_G0.7401.00
247_K250_I0.7391.00
25_H46_W0.7391.00
46_W49_E0.7391.00
133_V137_L0.7381.00
204_N357_L0.7331.00
266_S270_I0.7331.00
225_F229_Q0.7301.00
96_T146_V0.7271.00
108_E119_Y0.7251.00
95_T117_I0.7241.00
26_F241_P0.7241.00
139_D169_H0.7241.00
137_L171_A0.7151.00
291_S295_V0.7141.00
299_Y349_S0.7121.00
57_E254_S0.7101.00
87_K90_G0.7081.00
172_Y194_D0.7081.00
186_I190_N0.7061.00
308_L374_V0.7061.00
58_I188_V0.7041.00
166_L169_H0.7031.00
95_T145_T0.7001.00
180_A184_L0.6991.00
60_A213_Y0.6991.00
50_A243_I0.6971.00
38_S313_D0.6961.00
88_D91_R0.6941.00
223_L226_G0.6911.00
272_A292_L0.6901.00
64_E189_K0.6891.00
92_H139_D0.6881.00
272_A288_K0.6871.00
188_V192_H0.6861.00
308_L371_V0.6861.00
53_Q250_I0.6861.00
369_K372_A0.6821.00
147_M157_Q0.6811.00
49_E52_A0.6781.00
54_I67_F0.6781.00
104_L108_E0.6761.00
60_A64_E0.6751.00
47_V240_V0.6741.00
107_C117_I0.6731.00
275_L282_F0.6721.00
264_Y294_H0.6691.00
178_V199_S0.6681.00
148_Y156_V0.6661.00
188_V191_S0.6651.00
44_R48_D0.6651.00
163_G193_I0.6641.00
116_D140_D0.6631.00
78_A174_H0.6611.00
365_K368_A0.6591.00
73_E224_L0.6561.00
31_G34_S0.6541.00
120_L133_V0.6541.00
161_E165_L0.6501.00
278_A369_K0.6501.00
159_I173_F0.6491.00
303_V308_L0.6491.00
52_A62_E0.6481.00
271_F275_L0.6451.00
71_G75_D0.6431.00
56_A59_G0.6421.00
120_L132_Q0.6411.00
95_T99_E0.6401.00
163_G175_T0.6401.00
164_E167_K0.6361.00
272_A291_S0.6341.00
58_I181_F0.6331.00
94_I120_L0.6331.00
294_H297_N0.6311.00
211_F246_L0.6281.00
367_A370_H0.6281.00
21_Q25_H0.6261.00
307_A310_V0.6261.00
71_G197_S0.6241.00
222_P227_G0.6221.00
270_I273_D0.6221.00
322_G325_C0.6211.00
295_V354_S0.6191.00
257_R261_N0.6181.00
51_R230_E0.6161.00
258_D261_N0.6121.00
100_H151_N0.6111.00
222_P226_G0.6111.00
163_G166_L0.6111.00
271_F368_A0.6101.00
96_T99_E0.6101.00
220_L224_L0.6091.00
223_L229_Q0.6091.00
189_K192_H0.6061.00
109_K113_D0.6051.00
130_A162_I0.6041.00
149_G156_V0.6031.00
148_Y175_T0.6031.00
101_H105_H0.6021.00
200_G203_L0.6011.00
107_C145_T0.5981.00
37_H40_G0.5981.00
271_F274_T0.5981.00
262_E265_Q0.5981.00
25_H244_V0.5971.00
185_P257_R0.5961.00
47_V238_E0.5941.00
120_L128_V0.5911.00
60_A196_L0.5911.00
110_L113_D0.5891.00
270_I364_V0.5881.00
186_I196_L0.5851.00
123_D126_G0.5831.00
313_D318_A0.5821.00
134_K137_L0.5811.00
62_E216_K0.5801.00
21_Q244_V0.5801.00
162_I173_F0.5791.00
256_E357_L0.5791.00
22_M241_P0.5781.00
110_L115_F0.5761.00
35_S40_G0.5751.00
275_L368_A0.5751.00
84_L221_S0.5741.00
70_G210_G0.5731.00
245_G249_A0.5731.00
98_I122_V0.5711.00
266_S269_A0.5711.00
270_I368_A0.5711.00
76_N80_M0.5711.00
48_D51_R0.5681.00
147_M150_N0.5671.00
202_K352_R0.5671.00
253_S257_R0.5641.00
18_V248_E0.5631.00
246_L250_I0.5621.00
75_D145_T0.5611.00
188_V193_I0.5601.00
267_F359_N0.5581.00
292_L296_L0.5571.00
219_K222_P0.5571.00
278_A282_F0.5571.00
160_E192_H0.5551.00
133_V165_L0.5551.00
185_P190_N0.5551.00
265_Q268_K0.5541.00
24_P46_W0.5521.00
195_L212_L0.5521.00
224_L228_E0.5501.00
125_N288_K0.5501.00
34_S238_E0.5501.00
196_L213_Y0.5491.00
173_F193_I0.5491.00
30_F33_P0.5461.00
127_R155_T0.5461.00
48_D52_A0.5461.00
253_S260_K0.5461.00
77_L223_L0.5441.00
267_F355_F0.5441.00
370_H374_V0.5441.00
252_L357_L0.5431.00
264_Y355_F0.5411.00
207_K240_V0.5341.00
29_S46_W0.5311.00
250_I254_S0.5311.00
46_W247_K0.5301.00
304_S348_T0.5291.00
244_V247_K0.5291.00
274_T364_V0.5291.00
111_E119_Y0.5271.00
25_H29_S0.5261.00
268_K291_S0.5261.00
87_K115_F0.5251.00
251_K254_S0.5231.00
261_N264_Y0.5231.00
70_G73_E0.5211.00
235_A238_E0.5191.00
305_V309_L0.5161.00
267_F270_I0.5141.00
60_A188_V0.5141.00
236_G239_N0.5131.00
300_F308_L0.5121.00
30_F34_S0.5101.00
235_A240_V0.5081.00
203_L253_S0.5081.00
159_I193_I0.5071.00
103_V107_C0.5071.00
308_L312_L0.5061.00
246_L249_A0.5061.00
73_E77_L0.5061.00
25_H241_P0.5061.00
275_L371_V0.5051.00
263_K361_A0.5041.00
52_A63_Q0.5031.00
230_E234_R0.5021.00
305_V321_S0.5021.00
41_R44_R0.5011.00
22_M25_H0.5001.00
148_Y177_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4isyA 2 0.971 100 0.352 Contact Map
1eg5A 2 0.9551 100 0.359 Contact Map
3vaxA 2 0.9208 100 0.364 Contact Map
4hvkA 2 0.9631 100 0.367 Contact Map
3a9zA 2 0.9789 100 0.376 Contact Map
3lvmA 2 0.9763 100 0.378 Contact Map
3e9kA 2 0.9208 100 0.383 Contact Map
4ixoA 2 0.9367 100 0.392 Contact Map
1kmjA 2 0.9604 100 0.392 Contact Map
3caiA 2 0.942 100 0.399 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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