GREMLIN Database
GUAD - Guanine deaminase
UniProt: O34598 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (144)
Sequences: 6155 (4241)
Seq/√Len: 353.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_R39_E3.4571.00
9_R12_T2.6291.00
49_D60_R2.6181.00
73_D96_K2.6131.00
75_I99_F2.4491.00
100_Y103_E2.4201.00
75_I97_A2.4121.00
43_N47_S2.4011.00
13_L39_E2.2561.00
13_L16_E2.0961.00
8_K132_F2.0781.00
9_R36_I2.0401.00
43_N57_T2.0341.00
6_F31_V2.0341.00
76_L90_I2.0031.00
30_I58_A1.9741.00
103_E129_T1.9441.00
137_L141_L1.8931.00
97_A126_E1.8851.00
75_I96_K1.7731.00
32_K35_A1.7331.00
90_I98_V1.7331.00
13_L41_Q1.7141.00
6_F36_I1.6781.00
101_A136_T1.6731.00
32_K74_C1.6631.00
138_T142_S1.6391.00
115_S118_Y1.6371.00
132_F135_V1.6261.00
97_A128_R1.6161.00
18_V146_A1.5961.00
45_T69_Y1.5111.00
31_V77_Y1.5091.00
16_E41_Q1.4931.00
40_G57_T1.4601.00
80_C140_H1.4531.00
38_A61_K1.4251.00
20_A41_Q1.3761.00
15_C139_E1.3471.00
38_A65_V1.3401.00
50_P63_C1.3381.00
30_I62_A1.3381.00
133_Y137_L1.3071.00
9_R13_L1.2951.00
44_V69_Y1.2741.00
8_K135_V1.2491.00
43_N46_T1.2491.00
56_V89_A1.2451.00
111_G115_S1.2431.00
100_Y129_T1.2311.00
136_T139_E1.2181.00
142_S145_Q1.2171.00
17_G41_Q1.1981.00
5_T9_R1.1851.00
51_T89_A1.1771.00
26_F80_C1.1761.00
37_I74_C1.1701.00
32_K37_I1.1691.00
38_A58_A1.1561.00
32_K73_D1.1541.00
30_I74_C1.1421.00
114_D119_K1.1351.00
61_K65_V1.0981.00
12_T15_C1.0951.00
134_Q138_T1.0941.00
15_C18_V1.0791.00
61_K64_K1.0701.00
142_S146_A1.0661.00
52_A57_T1.0461.00
20_A46_T1.0351.00
28_A76_L1.0271.00
40_G58_A1.0241.00
59_I63_C1.0201.00
11_V15_C1.0091.00
47_S57_T1.0071.00
76_L95_P1.0011.00
15_C19_N0.9991.00
10_A27_G0.9921.00
20_A23_G0.9861.00
11_V139_E0.9781.00
57_T61_K0.9771.00
35_A65_V0.9761.00
52_A60_R0.9541.00
91_Y117_I0.9451.00
102_A144_F0.9421.00
102_A137_L0.9171.00
21_G147_W0.9171.00
33_D73_D0.9131.00
138_T141_L0.9081.00
30_I38_A0.9051.00
10_A79_S0.9001.00
84_P116_F0.8901.00
130_I133_Y0.8891.00
4_E8_K0.8881.00
32_K66_L0.8851.00
11_V136_T0.8801.00
80_C102_A0.8751.00
40_G61_K0.8751.00
113_D119_K0.8691.00
100_Y111_G0.8651.00
44_V92_W0.8621.00
5_T8_K0.8601.00
16_E19_N0.8581.00
36_I39_E0.8541.00
115_S119_K0.8531.00
16_E20_A0.8471.00
49_D52_A0.8331.00
51_T56_V0.8241.00
98_V110_A0.8211.00
110_A117_I0.8211.00
47_S52_A0.8151.00
59_I93_A0.8131.00
88_G116_F0.8121.00
43_N61_K0.8101.00
98_V125_A0.8001.00
8_K12_T0.7971.00
43_N52_A0.7861.00
6_F77_Y0.7851.00
88_G92_W0.7791.00
59_I90_I0.7771.00
7_L10_A0.7731.00
56_V60_R0.7571.00
129_T133_Y0.7551.00
59_I71_L0.7531.00
47_S64_K0.7521.00
12_T16_E0.7421.00
15_C135_V0.7331.00
135_V139_E0.7290.99
117_I125_A0.7200.99
91_Y122_D0.7190.99
8_K136_T0.7150.99
109_E114_D0.7030.99
141_L145_Q0.7030.99
63_C71_L0.6990.99
44_V51_T0.6990.99
87_L117_I0.6980.99
70_Q94_R0.6970.99
51_T60_R0.6930.99
15_C142_S0.6930.99
99_F131_P0.6920.99
87_L91_Y0.6890.99
103_E111_G0.6870.99
37_I65_V0.6860.99
41_Q46_T0.6850.99
84_P114_D0.6840.99
59_I89_A0.6790.99
109_E121_I0.6760.99
72_D96_K0.6750.99
30_I59_I0.6740.99
6_F9_R0.6730.99
66_L74_C0.6700.99
98_V117_I0.6700.99
103_E133_Y0.6580.99
48_N67_G0.6540.99
108_A112_F0.6530.99
128_R131_P0.6520.99
48_N68_A0.6500.99
114_D117_I0.6470.99
99_F128_R0.6470.99
84_P104_H0.6430.99
104_H107_A0.6410.99
4_E132_F0.6410.99
10_A29_V0.6410.99
31_V36_I0.6390.99
109_E116_F0.6300.99
14_A102_A0.6290.99
91_Y121_I0.6290.99
77_Y99_F0.6280.99
28_A54_A0.6260.98
24_G44_V0.6210.98
74_C95_P0.6150.98
18_V142_S0.6150.98
87_L109_E0.6130.98
91_Y125_A0.6110.98
68_A72_D0.6100.98
139_E142_S0.6100.98
29_V36_I0.6070.98
134_Q137_L0.6060.98
29_V39_E0.6060.98
84_P119_K0.6050.98
7_L130_I0.6000.98
45_T68_A0.5910.98
39_E61_K0.5900.98
17_G23_G0.5900.98
94_R123_K0.5770.97
14_A143_P0.5710.97
109_E112_F0.5690.97
80_C104_H0.5660.97
114_D121_I0.5620.97
23_G46_T0.5610.97
78_T98_V0.5570.97
54_A78_T0.5560.97
143_P147_W0.5560.97
62_A71_L0.5530.97
7_L101_A0.5440.96
90_I125_A0.5410.96
110_A113_D0.5390.96
84_P87_L0.5370.96
139_E143_P0.5360.96
135_V138_T0.5360.96
13_L29_V0.5350.96
138_T145_Q0.5320.96
116_F119_K0.5310.96
37_I66_L0.5310.96
76_L98_V0.5210.95
84_P107_A0.5190.95
76_L100_Y0.5190.95
127_E130_I0.5190.95
27_G79_S0.5190.95
56_V85_M0.5160.95
27_G41_Q0.5130.95
140_H143_P0.5100.95
48_N69_Y0.5030.94
114_D118_Y0.5020.94
131_P136_T0.5010.94
133_Y136_T0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z3aA 2 0.9679 100 0.197 Contact Map
2nx8A 2 0.9936 100 0.205 Contact Map
2b3jA 2 0.9615 100 0.206 Contact Map
1wwrA 3 0.9615 100 0.224 Contact Map
3dh1A 2 0.9295 100 0.228 Contact Map
2a8nA 2 0.891 100 0.245 Contact Map
1wkqA 2 0.9679 100 0.252 Contact Map
2g84A 2 0.9872 100 0.258 Contact Map
1p6oA 2 0.9103 100 0.321 Contact Map
2b3zA 3 0.9038 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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