GREMLIN Database
YOBK - Antitoxin YobK
UniProt: O34596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (137)
Sequences: 220 (167)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_T78_K4.0681.00
42_S111_P3.9791.00
52_A68_A3.3480.99
19_F53_G3.0590.98
25_H48_E2.9400.97
75_N79_E2.8720.97
61_L68_A2.4850.93
6_V9_F2.4240.92
21_E51_G2.1750.86
105_M110_C2.0390.82
61_L73_R2.0100.81
61_L96_F1.9200.78
92_D96_F1.8050.74
62_G74_T1.8000.74
100_L109_E1.7710.72
28_I44_K1.7430.71
10_I19_F1.7310.70
42_S110_C1.6810.68
104_K108_G1.6790.68
126_A135_N1.6550.67
100_L112_V1.6510.67
9_F14_K1.6240.65
46_F51_G1.5790.63
75_N78_K1.5580.62
39_L78_K1.5310.61
63_Y87_L1.5010.59
35_L47_L1.4570.57
6_V102_T1.4560.57
68_A72_N1.4270.55
53_G129_F1.4110.54
85_D138_Q1.3830.53
54_G61_L1.3740.52
32_E83_L1.3680.52
127_D131_E1.3540.51
12_E15_Q1.3200.49
87_L92_D1.3180.49
91_E94_D1.3140.49
34_N75_N1.2950.48
5_K25_H1.2860.47
40_P102_T1.2740.47
112_V128_S1.2700.46
98_Y140_A1.2520.46
23_A131_E1.2280.44
102_T112_V1.2170.44
8_N11_N1.2140.43
81_Y95_Y1.1910.42
84_T113_V1.1870.42
47_L128_S1.1820.42
63_Y68_A1.1730.41
39_L134_Y1.1680.41
131_E135_N1.1620.41
52_A70_V1.1610.41
64_N69_S1.1580.40
88_V112_V1.1410.40
41_N112_V1.1390.39
132_F135_N1.1290.39
42_S109_E1.1240.39
27_N63_Y1.1110.38
55_L94_D1.0840.37
40_P45_W1.0740.36
99_C115_W1.0670.36
38_D128_S1.0650.36
15_Q29_G1.0610.35
69_S117_R1.0510.35
112_V130_I1.0370.34
84_T87_L1.0360.34
29_G36_Q1.0260.34
41_N79_E1.0140.33
50_Y133_F1.0140.33
8_N112_V1.0050.33
25_H71_V1.0050.33
32_E44_K1.0010.33
7_E11_N1.0000.32
83_L103_N0.9960.32
12_E85_D0.9860.32
26_E112_V0.9840.32
24_S112_V0.9720.31
63_Y66_D0.9660.31
6_V132_F0.9460.30
123_D128_S0.9430.30
6_V140_A0.9260.29
22_G86_G0.9220.29
99_C113_V0.9200.29
92_D97_A0.9130.28
105_M111_P0.9060.28
63_Y126_A0.9060.28
5_K33_E0.9010.28
98_Y133_F0.8950.28
21_E74_T0.8900.27
5_K14_K0.8890.27
42_S101_D0.8890.27
103_N132_F0.8880.27
105_M132_F0.8880.27
41_N45_W0.8860.27
63_Y103_N0.8850.27
31_I69_S0.8810.27
17_A39_L0.8810.27
92_D117_R0.8790.27
48_E137_I0.8760.27
35_L129_F0.8640.26
39_L57_G0.8490.26
40_P129_F0.8400.25
102_T109_E0.8370.25
52_A62_G0.8350.25
75_N102_T0.8260.25
52_A59_L0.8250.25
6_V15_Q0.8210.25
85_D133_F0.8180.24
102_T111_P0.8170.24
31_I59_L0.8160.24
90_I96_F0.8120.24
61_L72_N0.8050.24
28_I65_F0.8030.24
14_K79_E0.8020.24
62_G68_A0.7990.24
61_L69_S0.7970.24
100_L135_N0.7970.24
102_T110_C0.7940.23
31_I39_L0.7870.23
28_I51_G0.7850.23
62_G99_C0.7760.23
82_G88_V0.7750.23
73_R76_E0.7750.23
9_F13_N0.7720.23
88_V93_V0.7600.22
11_N41_N0.7510.22
67_H72_N0.7450.22
25_H36_Q0.7380.21
90_I99_C0.7320.21
51_G83_L0.7310.21
9_F139_E0.7280.21
17_A24_S0.7070.20
69_S72_N0.7010.20
51_G74_T0.7000.20
86_G96_F0.6930.20
60_V114_E0.6930.20
123_D133_F0.6820.19
54_G99_C0.6770.19
74_T83_L0.6730.19
5_K36_Q0.6670.19
8_N14_K0.6660.19
47_L137_I0.6650.19
55_L59_L0.6640.19
25_H33_E0.6640.19
5_K112_V0.6620.19
22_G120_G0.6560.18
80_H85_D0.6520.18
21_E115_W0.6480.18
83_L115_W0.6480.18
88_V111_P0.6460.18
48_E90_I0.6450.18
54_G62_G0.6450.18
62_G115_W0.6400.18
34_N48_E0.6390.18
45_W49_K0.6380.18
45_W53_G0.6360.18
92_D138_Q0.6330.18
46_F99_C0.6280.18
104_K111_P0.6230.17
31_I117_R0.6130.17
21_E78_K0.6090.17
69_S126_A0.5980.17
62_G100_L0.5910.16
54_G120_G0.5890.16
29_G133_F0.5850.16
14_K23_A0.5830.16
33_E86_G0.5800.16
21_E62_G0.5790.16
64_N68_A0.5790.16
83_L99_C0.5750.16
117_R122_Q0.5710.16
12_E124_T0.5710.16
18_I59_L0.5700.16
22_G134_Y0.5690.16
108_G113_V0.5690.16
28_I39_L0.5670.16
11_N89_V0.5650.16
36_Q61_L0.5630.16
128_S131_E0.5620.16
87_L99_C0.5590.15
41_N106_K0.5590.15
82_G125_V0.5580.15
27_N125_V0.5540.15
86_G103_N0.5530.15
32_E36_Q0.5450.15
6_V130_I0.5430.15
47_L126_A0.5400.15
101_D110_C0.5390.15
48_E120_G0.5380.15
106_K123_D0.5380.15
48_E65_F0.5340.15
6_V120_G0.5320.15
4_S12_E0.5300.15
37_C120_G0.5300.15
66_D94_D0.5270.15
71_V127_D0.5230.14
32_E75_N0.5190.14
10_I18_I0.5140.14
49_K63_Y0.5110.14
21_E83_L0.5100.14
60_V137_I0.5090.14
45_W130_I0.5070.14
14_K87_L0.5050.14
9_F87_L0.5020.14
64_N72_N0.5010.14
10_I83_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2prvA 2 1 100 0.412 Contact Map
2icgA 1 0.9474 100 0.513 Contact Map
2pagA 1 0.8421 99.9 0.604 Contact Map
3d5pA 2 0.8289 99.7 0.668 Contact Map
3ffvA 1 0.8816 41.4 0.937 Contact Map
3l5lA 2 0.3158 37.6 0.938 Contact Map
3qtmA 1 0.3289 15.6 0.949 Contact Map
3msvA 2 0.3289 14.1 0.949 Contact Map
1kl9A 2 0.5 12.5 0.951 Contact Map
2ivyA 2 0.4211 9.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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