GREMLIN Database
THII - Probable tRNA sulfurtransferase
UniProt: O34595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (383)
Sequences: 1474 (1009)
Seq/√Len: 51.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_L194_G5.8111.00
306_A363_E5.2481.00
376_Q380_D4.5551.00
246_K377_E4.1571.00
229_C332_G3.7031.00
83_S114_Y3.3411.00
274_R376_Q3.1571.00
83_S159_T3.1431.00
128_I152_I2.9201.00
110_T125_N2.8921.00
124_M154_I2.7841.00
107_K143_V2.7761.00
370_D373_P2.7151.00
82_D87_D2.7011.00
377_E381_N2.7011.00
180_A285_I2.6881.00
224_M239_L2.6701.00
108_V132_I2.6621.00
68_Q232_R2.6021.00
110_T124_M2.5371.00
328_S333_T2.4061.00
89_K131_H2.3881.00
229_C336_T2.3591.00
301_M317_I2.3301.00
9_R76_S2.3111.00
9_R74_S2.2161.00
183_M284_I2.2141.00
181_M281_G2.1931.00
196_Y327_K2.1891.00
88_I159_T2.1761.00
87_D90_A2.1571.00
43_Y52_I2.1561.00
96_I150_L2.1331.00
300_S357_P2.1271.00
336_T339_Q2.1231.00
224_M385_M2.0961.00
105_T140_T2.0801.00
221_Q225_D2.0551.00
274_R277_E2.0491.00
273_D308_T2.0471.00
92_A128_I2.0291.00
326_E330_E2.0221.00
109_A149_P2.0201.00
180_A283_A2.0041.00
180_A202_L2.0021.00
255_I263_A1.9831.00
299_E356_R1.9551.00
283_A313_L1.9521.00
270_Q366_E1.9130.99
84_R87_D1.8880.99
131_H135_N1.8870.99
327_K330_E1.8810.99
364_H367_S1.8650.99
119_L127_E1.8530.99
220_K224_M1.8390.99
318_A323_E1.8370.99
37_D65_H1.8290.99
250_L254_Q1.8250.99
278_K380_D1.8170.99
242_V382_I1.8120.99
266_R366_E1.8030.99
110_T154_I1.7970.99
93_L135_N1.7960.99
326_E329_R1.7930.99
282_L299_E1.7890.99
85_L124_M1.7880.99
273_D309_S1.7590.99
88_I128_I1.7370.99
259_Y365_F1.7230.99
93_L131_H1.7200.99
365_F368_F1.7190.99
181_M207_V1.7020.99
67_K75_F1.6940.99
38_Y65_H1.6810.99
256_P365_F1.6360.98
26_R176_S1.6320.98
238_T386_T1.6070.98
179_K205_E1.6050.98
87_D91_T1.6030.98
124_M128_I1.5960.98
195_F233_F1.5760.98
49_R153_E1.5630.98
81_C91_T1.5620.98
225_D339_Q1.5610.98
207_V275_I1.5610.98
379_V382_I1.5270.97
42_K53_T1.4860.97
273_D310_T1.4840.97
267_L371_F1.4800.97
24_I48_D1.4760.97
322_T326_E1.4760.97
150_L161_L1.4640.96
8_I72_I1.4570.96
303_A359_K1.4400.96
154_I159_T1.4340.96
99_Q164_R1.4330.96
80_K158_A1.4300.96
66_L72_I1.4220.96
184_L227_A1.4190.96
371_F375_I1.4120.96
188_F334_Y1.4070.95
225_D228_K1.4040.95
303_A362_I1.4000.95
127_E130_G1.3960.95
142_D145_N1.3860.95
27_L30_N1.3720.95
181_M275_I1.3720.95
267_L369_V1.3690.95
250_L253_K1.3660.95
207_V272_A1.3660.95
306_A359_K1.3650.95
373_P377_E1.3650.95
109_A125_N1.3600.95
359_K362_I1.3600.95
276_R310_T1.3550.94
41_L52_I1.3380.94
11_G73_Q1.3340.94
262_T300_S1.3320.94
241_I385_M1.3250.94
334_Y338_I1.3190.94
206_A237_M1.3080.93
197_A285_I1.3070.93
271_I375_I1.2990.93
259_Y362_I1.2970.93
77_L164_R1.2940.93
290_L317_I1.2850.93
205_E240_H1.2750.92
267_L270_Q1.2670.92
8_I52_I1.2600.92
251_I263_A1.2590.92
111_K153_E1.2510.92
172_L177_A1.2310.91
91_T94_K1.2230.91
214_Y249_E1.2220.91
7_L78_A1.2170.91
90_A94_K1.2170.91
277_E310_T1.2160.90
198_M234_G1.2100.90
319_M327_K1.2040.90
31_I69_V1.1900.89
183_M286_T1.1870.89
67_K166_E1.1840.89
194_G206_A1.1760.89
278_K382_I1.1750.89
25_E29_Q1.1710.89
26_R29_Q1.1710.89
229_C232_R1.1700.89
220_K385_M1.1660.89
31_I43_Y1.1660.89
89_K127_E1.1660.89
40_N57_E1.1640.88
220_K383_E1.1640.88
261_M264_T1.1600.88
108_V150_L1.1590.88
28_K45_S1.1590.88
6_I75_F1.1480.88
96_I132_I1.1280.87
283_A298_L1.1250.87
194_G204_V1.1220.87
337_S340_P1.1150.86
267_L375_I1.1120.86
120_D123_Q1.1080.86
359_K363_E1.1010.85
172_L200_R1.0960.85
238_T384_T1.0940.85
270_Q307_V1.0940.85
74_S165_D1.0880.85
108_V128_I1.0870.85
86_D90_A1.0820.84
313_L317_I1.0750.84
126_A130_G1.0680.84
205_E238_T1.0660.84
25_E45_S1.0620.83
272_A284_I1.0610.83
243_P381_N1.0610.83
92_A132_I1.0510.83
246_K249_E1.0360.82
181_M205_E1.0360.82
243_P246_K1.0340.82
322_T329_R1.0200.81
327_K332_G1.0110.80
360_E363_E1.0110.80
104_D148_I1.0010.79
167_K326_E1.0000.79
93_L136_T0.9970.79
183_M272_A0.9920.79
63_F75_F0.9910.79
275_I382_I0.9890.79
9_R49_R0.9820.78
86_D89_K0.9820.78
95_A161_L0.9810.78
269_L308_T0.9810.78
237_M241_I0.9810.78
84_R89_K0.9780.78
77_L166_E0.9780.78
88_I154_I0.9750.78
303_A357_P0.9740.78
242_V378_A0.9660.77
76_S162_T0.9610.77
244_F264_T0.9600.77
205_E281_G0.9600.77
132_I150_L0.9490.76
269_L288_E0.9400.75
273_D276_R0.9390.75
259_Y354_K0.9360.75
275_I279_R0.9320.74
92_A108_V0.9320.74
304_I313_L0.9260.74
169_A195_F0.9220.74
264_T271_I0.9100.73
354_K357_P0.9100.73
5_H78_A0.8990.72
363_E367_S0.8970.72
4_D54_L0.8970.72
246_K378_A0.8960.71
270_Q375_I0.8950.71
230_L234_G0.8950.71
107_K144_R0.8940.71
96_I148_I0.8930.71
65_H69_V0.8930.71
358_K361_K0.8910.71
197_A318_A0.8890.71
107_K146_P0.8880.71
24_I45_S0.8870.71
195_F327_K0.8820.70
274_R375_I0.8780.70
66_L75_F0.8730.69
182_L206_A0.8720.69
262_T304_I0.8720.69
199_K323_E0.8710.69
257_E351_P0.8610.68
89_K93_L0.8610.68
70_F169_A0.8570.68
372_E376_Q0.8560.68
305_N312_I0.8550.68
225_D336_T0.8530.68
35_L52_I0.8490.67
104_D147_D0.8480.67
237_M240_H0.8450.67
245_T341_F0.8410.67
274_R372_E0.8380.66
302_Y306_A0.8380.66
85_L119_L0.8350.66
286_T316_L0.8350.66
31_I50_M0.8320.66
44_F53_T0.8300.66
64_P67_K0.8300.66
14_S48_D0.8300.66
298_L313_L0.8260.65
290_L313_L0.8230.65
227_A237_M0.8200.65
342_E346_T0.8190.65
9_R162_T0.8190.65
63_F166_E0.8150.64
202_L298_L0.8130.64
208_H344_C0.8100.64
274_R278_K0.8080.63
103_G148_I0.8060.63
129_G147_D0.8050.63
204_V237_M0.8040.63
85_L127_E0.8020.63
188_F338_I0.8010.63
132_I139_L0.7990.63
80_K160_F0.7980.62
274_R379_V0.7940.62
219_A341_F0.7920.62
240_H382_I0.7910.62
196_Y318_A0.7890.62
17_G177_A0.7890.62
30_N174_V0.7880.61
155_R288_E0.7870.61
8_I50_M0.7870.61
26_R355_T0.7850.61
10_F14_S0.7840.61
236_S386_T0.7800.61
38_Y111_K0.7780.61
114_Y117_F0.7770.60
93_L97_K0.7760.60
248_Q343_D0.7740.60
276_R281_G0.7720.60
286_T317_I0.7710.60
97_K136_T0.7680.60
238_T279_R0.7680.60
89_K135_N0.7570.58
247_T378_A0.7570.58
180_A298_L0.7530.58
181_M272_A0.7530.58
92_A161_L0.7520.58
205_E279_R0.7500.58
220_K241_I0.7500.58
35_L62_L0.7480.57
260_T264_T0.7470.57
12_E20_R0.7470.57
202_L290_L0.7450.57
50_M198_M0.7450.57
13_I50_M0.7440.57
19_N23_F0.7390.57
215_T222_K0.7360.56
277_E309_S0.7330.56
179_K203_S0.7300.56
95_A99_Q0.7280.55
375_I379_V0.7250.55
97_K135_N0.7240.55
265_R350_P0.7220.55
14_S24_I0.7190.55
264_T300_S0.7190.55
263_A270_Q0.7180.54
10_F49_R0.7180.54
28_K32_R0.7170.54
309_S312_I0.7160.54
240_H384_T0.7140.54
134_R325_I0.7130.54
64_P232_R0.7110.54
203_S236_S0.7080.53
43_Y50_M0.7080.53
86_D131_H0.7060.53
223_V239_L0.7050.53
31_I66_L0.7050.53
112_R121_T0.7040.53
114_Y156_E0.7040.53
58_D61_A0.7030.53
221_Q224_M0.7030.53
12_E27_L0.7020.53
305_N314_R0.7010.53
106_F141_V0.6990.52
239_L385_M0.6990.52
288_E314_R0.6950.52
340_P345_C0.6940.52
19_N265_R0.6940.52
319_M323_E0.6910.52
219_A340_P0.6900.52
51_T160_F0.6870.51
223_V349_T0.6870.51
129_G141_V0.6860.51
222_K226_L0.6840.51
376_Q379_V0.6840.51
45_S48_D0.6830.51
228_K387_L0.6800.50
57_E84_R0.6790.50
175_G200_R0.6790.50
179_K279_R0.6780.50
208_H219_A0.6780.50
244_F263_A0.6770.50
272_A379_V0.6750.50
213_P343_D0.6740.50
7_L153_E0.6740.50
93_L132_I0.6740.50
6_I63_F0.6730.50
265_R304_I0.6730.50
127_E131_H0.6730.50
114_Y119_L0.6720.50
96_I128_I0.6710.50
224_M241_I0.6710.50
303_A306_A0.6700.49
12_E16_K0.6700.49
207_V242_V0.6690.49
252_Q349_T0.6660.49
105_T133_L0.6640.49
265_R345_C0.6610.48
95_A136_T0.6610.48
41_L62_L0.6610.48
340_P343_D0.6600.48
38_Y55_N0.6590.48
83_S117_F0.6580.48
307_V366_E0.6570.48
197_A202_L0.6550.48
224_M228_K0.6540.48
162_T165_D0.6530.48
48_D349_T0.6510.47
88_I160_F0.6480.47
13_I286_T0.6470.47
122_N125_N0.6450.47
286_T301_M0.6440.47
223_V351_P0.6440.47
217_E221_Q0.6420.47
180_A197_A0.6410.46
70_F331_I0.6410.46
157_E160_F0.6410.46
23_F222_K0.6400.46
123_Q229_C0.6400.46
207_V284_I0.6380.46
128_I131_H0.6380.46
271_I379_V0.6360.46
288_E307_V0.6330.46
123_Q126_A0.6320.45
248_Q348_F0.6310.45
301_M313_L0.6300.45
122_N126_A0.6300.45
48_D162_T0.6290.45
10_F43_Y0.6270.45
40_N55_N0.6260.45
262_T362_I0.6250.45
69_V332_G0.6250.45
301_M308_T0.6240.45
6_I66_L0.6240.45
174_V177_A0.6210.44
251_I255_I0.6190.44
285_I298_L0.6190.44
216_S219_A0.6170.44
377_E380_D0.6170.44
300_S354_K0.6160.44
113_A155_R0.6160.44
208_H283_A0.6140.44
275_I384_T0.6140.44
261_M304_I0.6130.44
84_R164_R0.6110.43
269_L286_T0.6100.43
19_N345_C0.6090.43
130_G134_R0.6090.43
243_P378_A0.6090.43
268_M346_T0.6090.43
266_R270_Q0.6080.43
248_Q346_T0.6070.43
288_E348_F0.6060.43
89_K128_I0.6060.43
364_H368_F0.6060.43
92_A160_F0.6060.43
54_L62_L0.6060.43
261_M265_R0.6050.43
260_T347_I0.6040.43
124_M290_L0.6020.42
260_T349_T0.6020.42
61_A64_P0.6020.42
210_F220_K0.6000.42
301_M311_P0.6000.42
42_K150_L0.5990.42
373_P376_Q0.5990.42
134_R137_E0.5930.41
288_E304_I0.5920.41
345_C348_F0.5920.41
266_R307_V0.5910.41
188_F192_V0.5900.41
28_K48_D0.5890.41
82_D117_F0.5890.41
273_D284_I0.5880.41
181_M194_G0.5880.41
198_M304_I0.5870.41
107_K348_F0.5840.41
269_L312_I0.5840.41
7_L223_V0.5830.40
191_P337_S0.5810.40
288_E305_N0.5810.40
216_S353_P0.5800.40
233_F331_I0.5780.40
208_H349_T0.5780.40
227_A230_L0.5760.40
180_A204_V0.5750.40
151_R165_D0.5740.40
252_Q260_T0.5740.40
136_T140_T0.5740.40
335_E339_Q0.5730.39
61_A65_H0.5720.39
323_E326_E0.5710.39
349_T353_P0.5700.39
65_H280_N0.5690.39
273_D277_E0.5680.39
224_M387_L0.5660.39
105_T146_P0.5660.39
27_L200_R0.5650.39
109_A143_V0.5640.39
325_I341_F0.5640.39
177_A291_G0.5620.38
213_P219_A0.5610.38
191_P333_T0.5610.38
264_T346_T0.5610.38
186_G222_K0.5610.38
285_I318_A0.5600.38
225_D284_I0.5590.38
23_F115_K0.5590.38
15_T281_G0.5590.38
113_A153_E0.5580.38
14_S20_R0.5550.38
9_R155_R0.5550.38
108_V129_G0.5550.38
96_I108_V0.5540.38
313_L316_L0.5530.38
198_M267_L0.5530.38
4_D79_I0.5520.37
294_A350_P0.5520.37
81_C161_L0.5510.37
130_G133_L0.5490.37
254_Q272_A0.5490.37
361_K365_F0.5480.37
265_R343_D0.5470.37
94_K98_D0.5470.37
46_N160_F0.5460.37
240_H279_R0.5450.37
179_K238_T0.5450.37
19_N343_D0.5450.37
284_I310_T0.5430.37
100_Y138_G0.5430.37
195_F331_I0.5420.36
214_Y219_A0.5410.36
248_Q342_E0.5410.36
96_I99_Q0.5410.36
86_D284_I0.5400.36
302_Y363_E0.5400.36
218_R221_Q0.5400.36
177_A301_M0.5390.36
279_R382_I0.5380.36
93_L379_V0.5380.36
50_M304_I0.5380.36
103_G139_L0.5380.36
66_L78_A0.5370.36
261_M269_L0.5360.36
211_S248_Q0.5350.36
11_G14_S0.5350.36
43_Y153_E0.5350.36
19_N222_K0.5350.36
64_P147_D0.5340.36
48_D73_Q0.5320.35
278_K379_V0.5320.35
92_A150_L0.5320.35
151_R162_T0.5310.35
194_G230_L0.5310.35
11_G350_P0.5310.35
10_F212_P0.5300.35
216_S341_F0.5300.35
111_K125_N0.5300.35
21_K25_E0.5290.35
195_F259_Y0.5280.35
72_I169_A0.5280.35
25_E32_R0.5270.35
257_E349_T0.5270.35
214_Y245_T0.5270.35
217_E220_K0.5250.35
264_T349_T0.5230.35
245_T264_T0.5230.35
19_N248_Q0.5220.35
268_M344_C0.5220.35
34_V69_V0.5220.35
212_P348_F0.5200.34
110_T128_I0.5190.34
223_V336_T0.5190.34
70_F155_R0.5190.34
213_P265_R0.5190.34
142_D146_P0.5180.34
344_C349_T0.5180.34
208_H346_T0.5180.34
193_A197_A0.5180.34
176_S351_P0.5170.34
73_Q322_T0.5170.34
35_L39_P0.5170.34
222_K343_D0.5160.34
162_T349_T0.5160.34
204_V386_T0.5150.34
19_N117_F0.5150.34
382_I386_T0.5140.34
109_A122_N0.5130.34
117_F233_F0.5120.34
282_L298_L0.5110.34
81_C159_T0.5110.34
19_N348_F0.5090.33
60_E94_K0.5090.33
277_E306_A0.5090.33
105_T147_D0.5080.33
328_S334_Y0.5080.33
10_F13_I0.5070.33
108_V195_F0.5060.33
219_A245_T0.5060.33
88_I92_A0.5050.33
118_E123_Q0.5050.33
245_T348_F0.5040.33
242_V275_I0.5040.33
7_L160_F0.5040.33
23_F215_T0.5030.33
196_Y199_K0.5030.33
149_P199_K0.5030.33
115_K222_K0.5030.33
222_K338_I0.5020.33
196_Y319_M0.5020.33
274_R330_E0.5020.33
49_R74_S0.5010.33
202_L282_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c5sA 2 0.9277 100 0.345 Contact Map
4kr6A 2 0.9526 100 0.371 Contact Map
1vbkA 2 0.7431 100 0.492 Contact Map
3uowA 2 0.8404 99.9 0.833 Contact Map
1gpmA 3 0.8105 99.9 0.85 Contact Map
2dplA 2 0.5187 99.9 0.852 Contact Map
2ywbA 4 0.8653 99.9 0.855 Contact Map
3tqiA 3 0.8204 99.9 0.856 Contact Map
2derA 1 0.5187 99.8 0.866 Contact Map
2hmaA 2 0.5362 99.8 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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