GREMLIN Database
CY551 - Cytochrome c-551
UniProt: O34594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 112 (92)
Sequences: 5025 (3838)
Seq/√Len: 400.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_E49_Q3.5491.00
105_A109_S2.9041.00
40_T103_V2.6231.00
76_D79_K2.5891.00
97_D100_E2.3351.00
42_S45_E2.2391.00
43_E103_V2.1891.00
48_Y104_I2.1781.00
78_H82_S2.0741.00
77_E102_A2.0681.00
48_Y108_L1.9631.00
99_N103_V1.9201.00
79_K82_S1.8201.00
19_A23_S1.7541.00
81_E85_K1.6881.00
82_S86_N1.6481.00
47_L104_I1.6071.00
100_E103_V1.5741.00
77_E81_E1.5681.00
41_A106_K1.5461.00
80_I105_A1.5181.00
98_D102_A1.4991.00
68_L74_K1.4721.00
85_K98_D1.4371.00
81_E101_A1.4321.00
77_E105_A1.4201.00
81_E102_A1.3761.00
67_N70_E1.3751.00
67_N71_V1.3541.00
89_G93_K1.3321.00
43_E46_E1.2981.00
43_E100_E1.2911.00
22_G25_D1.2891.00
84_I87_G1.2831.00
37_T41_A1.2551.00
20_A23_S1.2021.00
80_I83_I1.1911.00
90_N93_K1.1901.00
99_N102_A1.1901.00
21_C24_N1.1781.00
20_A25_D1.1521.00
21_C25_D1.1511.00
96_V101_A1.1251.00
41_A110_E1.1111.00
67_N72_G1.1011.00
68_L71_V1.1001.00
30_K33_T1.0661.00
84_I101_A1.0531.00
77_E109_S1.0451.00
68_L72_G1.0401.00
33_T36_K1.0181.00
20_A24_N1.0061.00
75_Y79_K0.9871.00
51_S54_G0.9361.00
96_V104_I0.8821.00
37_T40_T0.8761.00
19_A25_D0.8591.00
57_G61_E0.8501.00
38_E42_S0.8411.00
81_E98_D0.8301.00
19_A22_G0.8281.00
77_E106_K0.8251.00
26_A30_K0.8221.00
29_E32_D0.8141.00
77_E101_A0.7931.00
80_I84_I0.7871.00
29_E34_G0.7831.00
25_D28_E0.7761.00
29_E33_T0.7691.00
75_Y91_M0.7641.00
26_A29_E0.7611.00
78_H81_E0.7591.00
40_T106_K0.7571.00
105_A108_L0.7511.00
49_Q53_V0.7421.00
58_K61_E0.7361.00
27_K30_K0.7351.00
34_G37_T0.7331.00
83_I88_R0.7291.00
28_E31_T0.7211.00
85_K101_A0.7211.00
82_S88_R0.7101.00
43_E99_N0.7071.00
83_I89_G0.7051.00
26_A34_G0.7041.00
62_G65_G0.7031.00
64_S72_G0.6861.00
83_I87_G0.6730.99
43_E47_L0.6660.99
94_G100_E0.6550.99
49_Q58_K0.6490.99
46_E49_Q0.6490.99
32_D35_S0.6390.99
81_E86_N0.6290.99
49_Q107_W0.6260.99
39_A43_E0.6230.99
40_T99_N0.6180.99
30_K36_K0.6170.99
102_A106_K0.6170.99
98_D101_A0.6170.99
40_T43_E0.6120.99
106_K109_S0.6030.99
79_K83_I0.6020.99
65_G68_L0.5980.99
50_Q96_V0.5980.99
96_V100_E0.5980.99
47_L50_Q0.5910.99
76_D80_I0.5850.98
19_A24_N0.5840.98
57_G60_L0.5830.98
21_C26_A0.5820.98
53_V57_G0.5700.98
31_T34_G0.5640.98
48_Y53_V0.5540.98
39_A103_V0.5540.98
47_L51_S0.5530.98
83_I93_K0.5520.98
95_L100_E0.5510.98
54_G90_N0.5490.98
23_S26_A0.5480.98
39_A42_S0.5430.97
103_V106_K0.5430.97
89_G92_P0.5430.97
81_E105_A0.5400.97
28_E33_T0.5380.97
52_C56_H0.5340.97
52_C55_C0.5340.97
64_S90_N0.5330.97
79_K84_I0.5260.97
83_I90_N0.5230.97
75_Y83_I0.5190.97
65_G69_Q0.5170.97
95_L104_I0.5120.96
66_P71_V0.5100.96
44_G104_I0.5060.96
50_Q54_G0.5020.96
55_C91_M0.5000.96
56_H91_M0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wfdC 1 1 99.7 0.346 Contact Map
1c75A 1 0.6339 99.6 0.397 Contact Map
3mk7B 1 0.9911 99.6 0.399 Contact Map
3mk7C 2 1 99.6 0.402 Contact Map
1c2nA 1 0.6339 99.6 0.409 Contact Map
4xxlA 1 0.6607 99.6 0.412 Contact Map
1h32B 1 0.875 99.6 0.424 Contact Map
2l4dA 1 0.625 99.6 0.426 Contact Map
1w2lA 1 0.6696 99.6 0.426 Contact Map
2zzsA 4 0.6429 99.6 0.428 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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